**z
... similar experimental conditions, either single dose or multiple dose. (生物等效性药品指在相同的试验条件下，单次或 多次给予相同治疗剂量的药物，其吸收的速率和 程度没有显示显著性差异的制剂等效品或制剂替 代品。） ...
... similar experimental conditions, either single dose or multiple dose. (生物等效性药品指在相同的试验条件下，单次或 多次给予相同治疗剂量的药物，其吸收的速率和 程度没有显示显著性差异的制剂等效品或制剂替 代品。） ...
the role of the medicinal chemist in drug discovery — then and now
... and led to the product launching into key European markets in 1980. A detailed history of this 18-year process, including the failures and setbacks along the way, has been described elsewhere12,18, so only a brief outline will be given here. The original research team assigned to produce a new anti- ...
... and led to the product launching into key European markets in 1980. A detailed history of this 18-year process, including the failures and setbacks along the way, has been described elsewhere12,18, so only a brief outline will be given here. The original research team assigned to produce a new anti- ...
BEXXAR therapy
... therapeutic radionuclides. Thyroid-blocking therapy must be initiated at least 24 hour before receiving the dosimetric dose and continued for 14 days after the therapeutic dose of BEXXAR® to decrease the risk of hypothyroidism (See WARNINGS AND PRECAUTIONS, Endocrine and Metabolism and DOSAGE AND AD ...
... therapeutic radionuclides. Thyroid-blocking therapy must be initiated at least 24 hour before receiving the dosimetric dose and continued for 14 days after the therapeutic dose of BEXXAR® to decrease the risk of hypothyroidism (See WARNINGS AND PRECAUTIONS, Endocrine and Metabolism and DOSAGE AND AD ...
StrlSch Unterweisung
... benefiting from treatments Avoiding adverse events in those who will not benefit ...
... benefiting from treatments Avoiding adverse events in those who will not benefit ...
Efflux transporters
... • Drugs that are administered during pregnancy will enter to some degree in the circulation of the fetus via passive diffusion and active transporters located on the fetal and maternal side of the tropoblast layer, p-gp on the maternal side of the tropoblast layer mediates the active efflux of lipo ...
... • Drugs that are administered during pregnancy will enter to some degree in the circulation of the fetus via passive diffusion and active transporters located on the fetal and maternal side of the tropoblast layer, p-gp on the maternal side of the tropoblast layer mediates the active efflux of lipo ...
Drug Metabolism and Variability among Patients in Drug Response
... an increase in heart rate, and an increase in the frequency of vasodilatory adverse effects (e.g., headache), as compared with the administration of felodipine with water (Fig. 2B). Other calcium-channel antagonists (particularly amlodipine, verapamil, and diltiazem but also nisoldipine, nimodipine, ...
... an increase in heart rate, and an increase in the frequency of vasodilatory adverse effects (e.g., headache), as compared with the administration of felodipine with water (Fig. 2B). Other calcium-channel antagonists (particularly amlodipine, verapamil, and diltiazem but also nisoldipine, nimodipine, ...
Equianalgesic Dosing It`s not just about the math
... expected that patients require large doses of oxycodone as they may experience longer periods of rest and effort-dependent pain. They concluded that the 3:1 ratio was more generally acceptable for chronic pain patients and is probably to high for acute post-surgical patient when pain was expected to ...
... expected that patients require large doses of oxycodone as they may experience longer periods of rest and effort-dependent pain. They concluded that the 3:1 ratio was more generally acceptable for chronic pain patients and is probably to high for acute post-surgical patient when pain was expected to ...
The Absorption, Distribution, and Excretion of Drugs
... Knowledge of these processes and the ways that they can vary between individuals is an important part of understanding how and why a drug is selected for a patient. To investigate the pharmacokinetic characteristics of a study drug (drug X), researchers will give a group of healthy adults a standard ...
... Knowledge of these processes and the ways that they can vary between individuals is an important part of understanding how and why a drug is selected for a patient. To investigate the pharmacokinetic characteristics of a study drug (drug X), researchers will give a group of healthy adults a standard ...
Antidepressants - Dr BL Lim Centre for Psychological Wellness
... 1-Least, 3- moderate, 5-most Stephen M. Stahl, M. (2008). Stahl’s Essential Psychopharmacology (3rd ed.). New York, NY: Cambridge University Press. ...
... 1-Least, 3- moderate, 5-most Stephen M. Stahl, M. (2008). Stahl’s Essential Psychopharmacology (3rd ed.). New York, NY: Cambridge University Press. ...
a review on: sustained release technology
... a) Aqueous solubility and pKa A drug to be absorbed it must be dissolved in the aqueous phase surrounding the site of administration and then partition into the absorbing membrane. Two of the most important physicochemical properties of a drug that influence its absorptive behavior are its aqueous s ...
... a) Aqueous solubility and pKa A drug to be absorbed it must be dissolved in the aqueous phase surrounding the site of administration and then partition into the absorbing membrane. Two of the most important physicochemical properties of a drug that influence its absorptive behavior are its aqueous s ...
Nicotinics Monthly
... case in general with nicotinic receptor ligands. Overcoming the loss of effect at higher doses probably reflects desensitization and may introduce problems in therapeutic use. This issue is faced by most stakeholders in the nicotinics field ...
... case in general with nicotinic receptor ligands. Overcoming the loss of effect at higher doses probably reflects desensitization and may introduce problems in therapeutic use. This issue is faced by most stakeholders in the nicotinics field ...
Revance Therapeutics, Inc.
... We disagree that efficacy measurement at “maximum contraction” should be predefined as the appropriate primary endpoint to demonstrate efficacy of botulinum toxin products. This predefined endpoint is not supported by the current best clinical science. While botulinum toxins may be paralytic agents, ...
... We disagree that efficacy measurement at “maximum contraction” should be predefined as the appropriate primary endpoint to demonstrate efficacy of botulinum toxin products. This predefined endpoint is not supported by the current best clinical science. While botulinum toxins may be paralytic agents, ...
Importance of Relative Dose Intensity in Chemotherapy
... Japan.26 In this regimen, tetrahydropyranyl adriamycin (THP-ADM), which exhibits reduced cardiac toxicity, was used instead of ADM, and the doses of CPA and VCR were decreased. Prophylactic use of G-CSF mitigates these risks of RDI reduction. Taken together, these results suggest that administration ...
... Japan.26 In this regimen, tetrahydropyranyl adriamycin (THP-ADM), which exhibits reduced cardiac toxicity, was used instead of ADM, and the doses of CPA and VCR were decreased. Prophylactic use of G-CSF mitigates these risks of RDI reduction. Taken together, these results suggest that administration ...
SAFETY OF ORAL IBUPROFEN ñ ANALYSIS OF DATA FROM THE
... Among the reported cases, the first one occurred due to medical error connected with the incorrect administration of IBUM Forte soft capsules 400 mg. A soft capsule is a pharmaceutical form, which encloses medicines in a relatively stable shell allowing them to be taken orally. It should be swallowe ...
... Among the reported cases, the first one occurred due to medical error connected with the incorrect administration of IBUM Forte soft capsules 400 mg. A soft capsule is a pharmaceutical form, which encloses medicines in a relatively stable shell allowing them to be taken orally. It should be swallowe ...
Application of drugs based on release-active
... 2. the assessment of vital functions: 3.the assessment of main laboratory rangers: clinical blood analysis clinical urine analysis biochemical markers Data from regulatory bodies of countries where the drugs have been registered (15 countries) on adverse events associated with the drug use ...
... 2. the assessment of vital functions: 3.the assessment of main laboratory rangers: clinical blood analysis clinical urine analysis biochemical markers Data from regulatory bodies of countries where the drugs have been registered (15 countries) on adverse events associated with the drug use ...
“Formulation, Development and Evaluation of Controlled and
... Medication basically involves using different drugs like tamoxifen, anastrozole, letrozole to inhibit the growth of cells by acting on the estrogen receptors which releases the growth hormones. Tamoxifen is the most widely used drug which has a dosage regime of 20 mg per day for 5 years before surge ...
... Medication basically involves using different drugs like tamoxifen, anastrozole, letrozole to inhibit the growth of cells by acting on the estrogen receptors which releases the growth hormones. Tamoxifen is the most widely used drug which has a dosage regime of 20 mg per day for 5 years before surge ...
rimadyl once-a-day dosing chart for chewables and caplets
... unique cyclooxygenases have been described in mammals.2 The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought ...
... unique cyclooxygenases have been described in mammals.2 The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... enhanced.Using of Salix aegyptiaca herb extract had been current in the middle ages for treatmentof depression [10, 11]. This extract as a benzodiazepine drughas a proven effects on the central nervous system and the other sideit’s mentioned as an anti-anxiety drug. Diazepam via interactions with th ...
... enhanced.Using of Salix aegyptiaca herb extract had been current in the middle ages for treatmentof depression [10, 11]. This extract as a benzodiazepine drughas a proven effects on the central nervous system and the other sideit’s mentioned as an anti-anxiety drug. Diazepam via interactions with th ...
Different uses of angiostensin - converting enzyme Title inhibitors Author(s)
... in dosage or withdrawal of the drug. It has been suggested that the incidence of dry cough is particularly high in Hong Kong Chinese. The authors' approach is to ascertain that the cough is related to ACEI in the first place. Sometimes, a careful history would reveal that the cough is due to some ot ...
... in dosage or withdrawal of the drug. It has been suggested that the incidence of dry cough is particularly high in Hong Kong Chinese. The authors' approach is to ascertain that the cough is related to ACEI in the first place. Sometimes, a careful history would reveal that the cough is due to some ot ...
Baclofen - UNC School of Medicine
... April 7, 2014 Alcoholism & Drug Abuse Weekly ism using baclofen. However, there have also been reports of people overdosing on baclofen. The most important question for researchers is whether, in fact, there is any truth behind the idea that higher doses are more effective than lower doses, said Le ...
... April 7, 2014 Alcoholism & Drug Abuse Weekly ism using baclofen. However, there have also been reports of people overdosing on baclofen. The most important question for researchers is whether, in fact, there is any truth behind the idea that higher doses are more effective than lower doses, said Le ...
imitrex tablets
... The recommended dose of IMITREX Tablets is 25 mg, 50 mg, or 100 mg. Doses of 50 mg and 100 mg may provide a greater effect than the 25-mg dose, but doses of 100 mg may not provide a greater effect than the 50-mg dose. Higher doses may have a greater risk of adverse reactions [see Clinical Studies (1 ...
... The recommended dose of IMITREX Tablets is 25 mg, 50 mg, or 100 mg. Doses of 50 mg and 100 mg may provide a greater effect than the 25-mg dose, but doses of 100 mg may not provide a greater effect than the 50-mg dose. Higher doses may have a greater risk of adverse reactions [see Clinical Studies (1 ...
the DETROL LA Diary
... In a study of the effect of tolterodine immediate release tablets on the QT interval [see CLINICAL PHARMACOLOGY (12.2)], the effect on the QT interval appeared greater for 8 mg/day (two times the therapeutic dose) compared to 4 mg/day and was more pronounced in CYP2D6 poor metabolizers (PM) than ex ...
... In a study of the effect of tolterodine immediate release tablets on the QT interval [see CLINICAL PHARMACOLOGY (12.2)], the effect on the QT interval appeared greater for 8 mg/day (two times the therapeutic dose) compared to 4 mg/day and was more pronounced in CYP2D6 poor metabolizers (PM) than ex ...
Class Update: Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors
... unknown if the risk reduction would also be seen in T2DM patients without preexisting CV disease. A systematic review and meta‐analysis of dapagliflozin and canagliflozin studies demonstrated inconclusive findings on the effect of SGLT2 inhibitors on CV outcomes (OR 0.89; 95% CI, 0.70 to 1.14).4 Re ...
... unknown if the risk reduction would also be seen in T2DM patients without preexisting CV disease. A systematic review and meta‐analysis of dapagliflozin and canagliflozin studies demonstrated inconclusive findings on the effect of SGLT2 inhibitors on CV outcomes (OR 0.89; 95% CI, 0.70 to 1.14).4 Re ...
TRIZON
... antibiotics. It is contra-indicated in premature infants and neonates with jaundice, hypoalbuminaemia, acidosis or impaired bilirubin binding; concomitant treatment with calcium in neonates & children. ...
... antibiotics. It is contra-indicated in premature infants and neonates with jaundice, hypoalbuminaemia, acidosis or impaired bilirubin binding; concomitant treatment with calcium in neonates & children. ...
Just What the Doctor Ordered: Using SAS to Calculate Patient Drug Dose with Electronic Medical Record (EMR) Prescription Data
... used to treat cancer patients, where each chemotherapy regimen might consist of multiple chemotherapy agents administered with different timings, supportive care for the adverse side effects of chemotherapy, and palliative care for the symptoms of cancer. These complex chemotherapy dosing schedules ...
... used to treat cancer patients, where each chemotherapy regimen might consist of multiple chemotherapy agents administered with different timings, supportive care for the adverse side effects of chemotherapy, and palliative care for the symptoms of cancer. These complex chemotherapy dosing schedules ...