Airways Register Search update 2008
... Abstract: OBJECTIVE: To evaluate the safety and efficacy of sublingual immunotherapy with 'Dermatophagoides Farinae Drops' in D. farinae allergic asthma and/or rhinitis patients. METHODS: A 25-week double-blind, placebo-controlled, multi-centered trail was conducted in 278 children (aged 4 - 18 yr) ...
... Abstract: OBJECTIVE: To evaluate the safety and efficacy of sublingual immunotherapy with 'Dermatophagoides Farinae Drops' in D. farinae allergic asthma and/or rhinitis patients. METHODS: A 25-week double-blind, placebo-controlled, multi-centered trail was conducted in 278 children (aged 4 - 18 yr) ...
Management of Patients with Psychostimulant Toxicity: Guidelines
... d. methamphetamine powder 5. paramethoxyamphetamine (PMA) 6. paramethoxymethamphetamine (PMMA) ...
... d. methamphetamine powder 5. paramethoxyamphetamine (PMA) 6. paramethoxymethamphetamine (PMMA) ...
IN VIVO TABLETS BY HYDROXY PROPYL BETA CYCLODEXTRIN COMPLEXATION Research Article
... uniform volumes of particles. Tablets are intended for oral administration. Some are swallowed as a whole, some after being chewed, some are dissolved or dispersed in water before being administered and some are retained in the mouth where the active substance is liberated [1]. The advantages of thi ...
... uniform volumes of particles. Tablets are intended for oral administration. Some are swallowed as a whole, some after being chewed, some are dissolved or dispersed in water before being administered and some are retained in the mouth where the active substance is liberated [1]. The advantages of thi ...
Serotonergic Modulation of Inspiratory Hypoglossal Motoneurons in
... the neuron. 5-HT (0.5 mM) was dissolved in an artificial cerebrospinal fluid (aCSF) (Stuth et al. 2000). Ketanserin was first dissolved in DMSO to a concentration of 20 mM, which was subsequently diluted to 500 M with aCSF that had previously been adjusted to a pH of ⬃6.0. Although freshly mixed dr ...
... the neuron. 5-HT (0.5 mM) was dissolved in an artificial cerebrospinal fluid (aCSF) (Stuth et al. 2000). Ketanserin was first dissolved in DMSO to a concentration of 20 mM, which was subsequently diluted to 500 M with aCSF that had previously been adjusted to a pH of ⬃6.0. Although freshly mixed dr ...
PGX Test Monographs
... CYP286 enzyme activity defines a normal or an abnormal (intermediate or poor) metabolizer status for a given individual. Several variant alleles have been identified and result in different CYP286 isoforms that functionally are fully active, partially active, inactive, or have increased activity. Th ...
... CYP286 enzyme activity defines a normal or an abnormal (intermediate or poor) metabolizer status for a given individual. Several variant alleles have been identified and result in different CYP286 isoforms that functionally are fully active, partially active, inactive, or have increased activity. Th ...
Full Text - Molecular Cancer Therapeutics
... rates of stage III patients (52%) and significantly worse for stage IV patients (15%). There is clearly a significant need for effective treatments for late-stage breast cancer. Antibody–drug conjugates (ADC) are a relatively new treatment modality that takes advantage of the exquisite specificity o ...
... rates of stage III patients (52%) and significantly worse for stage IV patients (15%). There is clearly a significant need for effective treatments for late-stage breast cancer. Antibody–drug conjugates (ADC) are a relatively new treatment modality that takes advantage of the exquisite specificity o ...
Rewards. - Rimadyl
... activity. Two unique cyclooxygenases have been described in mammals.2 The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX ...
... activity. Two unique cyclooxygenases have been described in mammals.2 The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX ...
Suggestion from clinicians
... We could not pool data, but third tier evidence in individual studies indicated similar efficacy to other active interventions (gabapentin, morphine, chlorimipramine, and amitriptyline), and to placebo in the conditions studied (very low quality evidence). Adverse event reporting was inconsistent an ...
... We could not pool data, but third tier evidence in individual studies indicated similar efficacy to other active interventions (gabapentin, morphine, chlorimipramine, and amitriptyline), and to placebo in the conditions studied (very low quality evidence). Adverse event reporting was inconsistent an ...
Prescribing Information and Medication Guide
... not exclusively, presents with fever, rash, and/or lymphadenopathy in association with other organ system involvement, such as hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection. Eosinophilia is often present. Because this disord ...
... not exclusively, presents with fever, rash, and/or lymphadenopathy in association with other organ system involvement, such as hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection. Eosinophilia is often present. Because this disord ...
Experimental treatments for spinal cord injury
... rehabilitation, the investigators would not know whether any observed improvement was specifically due to the experimental treatment being tested. An exception to the use of a separate control group may be made in a trial where patients have established a very stable level of function (this would no ...
... rehabilitation, the investigators would not know whether any observed improvement was specifically due to the experimental treatment being tested. An exception to the use of a separate control group may be made in a trial where patients have established a very stable level of function (this would no ...
FORMULATION AND EVALUATION OF THERMOSENSITIVE IN SITU GEL OF SALBUTAMOL
... undergoes significant degradation in gastrointestinal tract or metabolized via liver in high degree and gives undesirably slow effects13. For this parenteral route is preferred but it is undesirable or impractical if drug is intended for the treatment of chronic disease, so alternative route is pref ...
... undergoes significant degradation in gastrointestinal tract or metabolized via liver in high degree and gives undesirably slow effects13. For this parenteral route is preferred but it is undesirable or impractical if drug is intended for the treatment of chronic disease, so alternative route is pref ...
Prescribing Information
... sicca, miosis, nausea, skin reactions (including erythema, rash, and vasodilation), and tachycardia. In infants, apnea, bradycardia, coma, hypothermia, hypotonia, lethargy, pallor, respiratory depression, and somnolence have been reported [see Contraindications (4.3) and Use in Specific Populations ...
... sicca, miosis, nausea, skin reactions (including erythema, rash, and vasodilation), and tachycardia. In infants, apnea, bradycardia, coma, hypothermia, hypotonia, lethargy, pallor, respiratory depression, and somnolence have been reported [see Contraindications (4.3) and Use in Specific Populations ...
DYRENIUM® (triamterene USP) Capsules 50 mg and 100 mg
... Human Dose (MRHD) on the basis of body weight, and 6 times the MRHD on the basis of body-surface area, without evidence of harm to the fetus due to triamterene. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly ...
... Human Dose (MRHD) on the basis of body weight, and 6 times the MRHD on the basis of body-surface area, without evidence of harm to the fetus due to triamterene. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly ...
A New Therapeutic Applications for Drug Repositioning
... optimizes resource usage and various pilot projects into pharmaceutical companies that reflect the current trend of a computer model. Widespread adoption of cloud security and data provenance drug Converter is the biggest challenge. Drug discovery and development are a time-consuming, expensive and ...
... optimizes resource usage and various pilot projects into pharmaceutical companies that reflect the current trend of a computer model. Widespread adoption of cloud security and data provenance drug Converter is the biggest challenge. Drug discovery and development are a time-consuming, expensive and ...
Reporting Bias in Clinical Trials Investigating the Efficacy of Second
... study that are “positive” (eg, statistically significant) without publishing “negative” outcomes or switching the status of primary and secondary outcomes based on results.4 Finally, spin occurs when treatments are described by investigators as beneficial, even though published results for primary o ...
... study that are “positive” (eg, statistically significant) without publishing “negative” outcomes or switching the status of primary and secondary outcomes based on results.4 Finally, spin occurs when treatments are described by investigators as beneficial, even though published results for primary o ...
Pharmacology
... knowledge and scientific principals to diseases prevention and rational use of drug. It is also a double bridge that links medicine and pharmacy, basic medicine and clinical medicine. The scope of pharmacology involves function sciences (physiology, pathology, biochemistry and molecular biology), mo ...
... knowledge and scientific principals to diseases prevention and rational use of drug. It is also a double bridge that links medicine and pharmacy, basic medicine and clinical medicine. The scope of pharmacology involves function sciences (physiology, pathology, biochemistry and molecular biology), mo ...
Silkis - Galderma
... Serum calcium levels should be monitored at regular intervals if risk factors for hypercalcemia are present. If the serum calcium level becomes elevated, calcitriol therapy should be discontinued and the serum calcium level monitored in these patients until it returns to normal. Due to the potential ...
... Serum calcium levels should be monitored at regular intervals if risk factors for hypercalcemia are present. If the serum calcium level becomes elevated, calcitriol therapy should be discontinued and the serum calcium level monitored in these patients until it returns to normal. Due to the potential ...
The Effect of Changes in Co-payment and Premium Policies
... Policy makers are well-aware of this evidence, but given the fiscal realities facing provincial drug programs, they see cost-sharing policies, including co-payments, as vital to program sustainability. In the absence of effective measures to control the growth in prescription drug use and overall co ...
... Policy makers are well-aware of this evidence, but given the fiscal realities facing provincial drug programs, they see cost-sharing policies, including co-payments, as vital to program sustainability. In the absence of effective measures to control the growth in prescription drug use and overall co ...
2: Cardiovascular system - Gateshead Health NHS Foundation Trust
... Anti-arrhythmics are complex agents; intravenous injections or infusions should be given according to specialist advice. - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 50 ...
... Anti-arrhythmics are complex agents; intravenous injections or infusions should be given according to specialist advice. - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 50 ...
Sustained-Release Bupropion Overdose: A Case Report
... of neurologic and cardiovascular systems up to at least 12 hours. The treatment is support of ...
... of neurologic and cardiovascular systems up to at least 12 hours. The treatment is support of ...
Peptide-Mediated Targeted Drug Delivery
... to analyze. In addition, peptide–drug conjugates may have lower immunogenicity than protein–drug conjugates.11 The immunogenicity of protein–drug conjugates may arise from the presence of nonnative protein conformers or protein aggregates upon drug conjugation. In many cases, cyclic peptides have hi ...
... to analyze. In addition, peptide–drug conjugates may have lower immunogenicity than protein–drug conjugates.11 The immunogenicity of protein–drug conjugates may arise from the presence of nonnative protein conformers or protein aggregates upon drug conjugation. In many cases, cyclic peptides have hi ...
Dosing Guide For Optimal Management of Opioid
... agonist with a maximal effect less than that of a full mu-opioid agonist (eg, morphine, methadone, heroin), the induction regimen can be more aggressive. The risk of serious adverse effects such as an overdose or treatment dropout is greater if a patient is undertreated with buprenorphine and contin ...
... agonist with a maximal effect less than that of a full mu-opioid agonist (eg, morphine, methadone, heroin), the induction regimen can be more aggressive. The risk of serious adverse effects such as an overdose or treatment dropout is greater if a patient is undertreated with buprenorphine and contin ...
Intravitreal Inserts
... physiologic protective mechanisms such as blood retinal barrier. For ideal drug treatment, the drug should reach the target tissue directly and at the desired time and concentration. For this purpose, liposomes, biodegradable polymers and non degradable implants have been developed in the last 20 ye ...
... physiologic protective mechanisms such as blood retinal barrier. For ideal drug treatment, the drug should reach the target tissue directly and at the desired time and concentration. For this purpose, liposomes, biodegradable polymers and non degradable implants have been developed in the last 20 ye ...
Comparing Treatments for Age-Related Macular Degeneration
... for Avastin. As treatment for AMD continues indefinitely, the financial impact will also continue. The choice of drug and dosing regimen must balance the comparable effects on vision, the possibility of true differences in adverse events, and the 40-fold difference in cost per dose between Avastin a ...
... for Avastin. As treatment for AMD continues indefinitely, the financial impact will also continue. The choice of drug and dosing regimen must balance the comparable effects on vision, the possibility of true differences in adverse events, and the 40-fold difference in cost per dose between Avastin a ...