DNA microarray - Creighton Chemistry Webserver
... Nonhomologous recombination occurs frequently If disrupt essential genes - cell functions/protein altered New evidence that integration events can sometimes activate genes that stimulate cell division (CANCER ENSUES!) Site of integration can have an effect on expression of gene (No way to control th ...
... Nonhomologous recombination occurs frequently If disrupt essential genes - cell functions/protein altered New evidence that integration events can sometimes activate genes that stimulate cell division (CANCER ENSUES!) Site of integration can have an effect on expression of gene (No way to control th ...
S90 T4 Notes WEARING YOUR GENES p
... Our DNA can be changed by factors in the environment (mutagens), such as Xrays, UV rays, cosmic rays, and chemicals in the environment such as pollutants. Our DNA can also be changed simply by random errors in its duplication. These changes are called mutations. Mutations can cause cancer – the muta ...
... Our DNA can be changed by factors in the environment (mutagens), such as Xrays, UV rays, cosmic rays, and chemicals in the environment such as pollutants. Our DNA can also be changed simply by random errors in its duplication. These changes are called mutations. Mutations can cause cancer – the muta ...
lay-person-summary
... contained within a long strand. It is the specific sequence of these that controls cell development – this is known as ‘genetics’. Abnormal changes in the sequence are called mutations. DNA also has markers attached to it called methyl groups: These can regulate how much gene products are being made ...
... contained within a long strand. It is the specific sequence of these that controls cell development – this is known as ‘genetics’. Abnormal changes in the sequence are called mutations. DNA also has markers attached to it called methyl groups: These can regulate how much gene products are being made ...
Glossary - Heart UK
... The term homozygous FH will be used to cover all these possibilities in this toolkit. Index individual The original patient who is the starting point for follow-up of other members of a family when investigating possible genetic factors that are responsible for the presenting condition. Mutation (ge ...
... The term homozygous FH will be used to cover all these possibilities in this toolkit. Index individual The original patient who is the starting point for follow-up of other members of a family when investigating possible genetic factors that are responsible for the presenting condition. Mutation (ge ...
chapter_07a
... duplicate cultures with the same genetic background should show different numbers of T1 resistant cells. ...
... duplicate cultures with the same genetic background should show different numbers of T1 resistant cells. ...
MLH1 gene - MyriadPro
... Men and women with Lynch syndrome due to mutations in MLH1 have a high risk of developing colorectal cancer, often at young ages. Colorectal cancer in patients with Lynch syndrome develops from adenomatous polyps which progress to cancer more quickly than polyps in individuals who do not have Lynch ...
... Men and women with Lynch syndrome due to mutations in MLH1 have a high risk of developing colorectal cancer, often at young ages. Colorectal cancer in patients with Lynch syndrome develops from adenomatous polyps which progress to cancer more quickly than polyps in individuals who do not have Lynch ...
Supreme Court Invalidates Patents on DNA
... investing significant time, energy and funds into identifying DNA markers for commercially relevant traits. Finally, and probably more importantly, the Myriad ruling will allow genomics companies to discover and offer tests for multiple gene pairs relevant to a given trait without fear of incurring ...
... investing significant time, energy and funds into identifying DNA markers for commercially relevant traits. Finally, and probably more importantly, the Myriad ruling will allow genomics companies to discover and offer tests for multiple gene pairs relevant to a given trait without fear of incurring ...
Document
... • A single C region gene encoded in the GERMLINE and separate from the V region genes • Multiple choices of V region genes available • A mechanism to rearrange V and C genes in the genome so that they can fuse to form a complete Immunoglobulin gene. ...
... • A single C region gene encoded in the GERMLINE and separate from the V region genes • Multiple choices of V region genes available • A mechanism to rearrange V and C genes in the genome so that they can fuse to form a complete Immunoglobulin gene. ...
Molecular testing in non-syndromic hearing loss
... In patients with severe-to-profound HL, where no mutation can be identified in the genes listed above, Usher syndrome should be excluded by an electroretinogram (in patients > 5 years) or molecular testing (in patients < 5 years). A microarray-based test of more than 400 mutations in all 8 Usher dis ...
... In patients with severe-to-profound HL, where no mutation can be identified in the genes listed above, Usher syndrome should be excluded by an electroretinogram (in patients > 5 years) or molecular testing (in patients < 5 years). A microarray-based test of more than 400 mutations in all 8 Usher dis ...
Neuronal Ceroid-Lipofuscinosis type 3 (NCL3)
... rapid. Other clinical features include seizures and psychomotor deterioration; prognosis is poor. The differential diagnosis of NCL3 from the other NCL types is based on age of onset, clinical phenotype and ultra structural characterisation of the storage material. NCL3 is characterised by the accum ...
... rapid. Other clinical features include seizures and psychomotor deterioration; prognosis is poor. The differential diagnosis of NCL3 from the other NCL types is based on age of onset, clinical phenotype and ultra structural characterisation of the storage material. NCL3 is characterised by the accum ...
张咸宁-模块1-第2周
... (Shh)-Patched (Ptch)-Gli pathway and connection with disease. Different elements in the pathway act as activators (arrows) or inhibitors (bars). The Shh protein is initially cleaved to an active N-terminal form, which is then modified by the addition of cholesterol. The normal action of Ptch is to i ...
... (Shh)-Patched (Ptch)-Gli pathway and connection with disease. Different elements in the pathway act as activators (arrows) or inhibitors (bars). The Shh protein is initially cleaved to an active N-terminal form, which is then modified by the addition of cholesterol. The normal action of Ptch is to i ...
TUMOR REGISTRIES
... A tumor registry is a cancer data system that provides continued follow-up care on all cancer patients in a given location, hospital, or state. A tumor registry documents and stores all significant elements of a patient’s history and treatment. Many registry databases include information concerning ...
... A tumor registry is a cancer data system that provides continued follow-up care on all cancer patients in a given location, hospital, or state. A tumor registry documents and stores all significant elements of a patient’s history and treatment. Many registry databases include information concerning ...
Index case of acute myeloid leukemia in a family
... To identify somatic mutations that might have contributed to the development of AML in our patient, we conducted whole-exome sequencing (WES) of AML cells collected at diagnosis, using skin fibroblasts as a control. We focused analysis on somatic variants predicted to have a high impact on protein f ...
... To identify somatic mutations that might have contributed to the development of AML in our patient, we conducted whole-exome sequencing (WES) of AML cells collected at diagnosis, using skin fibroblasts as a control. We focused analysis on somatic variants predicted to have a high impact on protein f ...
document
... with early onset lung cancer were shown to have a greater risk of developing the disease • Black participants in the study were found to be more susceptible to the onset of lung cancer than their white counterparts. ...
... with early onset lung cancer were shown to have a greater risk of developing the disease • Black participants in the study were found to be more susceptible to the onset of lung cancer than their white counterparts. ...
Exam 2 - Faculty
... E. Eukaryotic cell division: meiosis (when and where does meiosis occur?) 1. Overview of meiosis a. Difference between diploid vs. haploid cells; homologous chromosomes (how do you know if two chromosomes are homologous?); which chromosomes determine sex b. Two characteristics of gametes that make t ...
... E. Eukaryotic cell division: meiosis (when and where does meiosis occur?) 1. Overview of meiosis a. Difference between diploid vs. haploid cells; homologous chromosomes (how do you know if two chromosomes are homologous?); which chromosomes determine sex b. Two characteristics of gametes that make t ...
Gene Section MYC (v-myc myelocytomatosis viral oncogene
... phases of the cell cycle. If absent, cells with damaged DNA arrest not in GI but in a G2-like state from which they can pass through additional S phases without intervening normal mitoses (the deformed polyploid cells that result may then die by apoptosis). The uncoupling of S and M may contribute t ...
... phases of the cell cycle. If absent, cells with damaged DNA arrest not in GI but in a G2-like state from which they can pass through additional S phases without intervening normal mitoses (the deformed polyploid cells that result may then die by apoptosis). The uncoupling of S and M may contribute t ...
Lab 11: Simple genomic data analysis using R 1. UCSC genome
... Lab 11: Simple genomic data analysis using R The main purpose of this lab is to get student familiar with analyzing genome sequence file in R. ...
... Lab 11: Simple genomic data analysis using R The main purpose of this lab is to get student familiar with analyzing genome sequence file in R. ...
幻灯片 1 - TUST
... the array of proteins they encode. c). Comparative genomics is third area of study, in which genomes from different organisms are compared to look for significant differences and similarities. This helps identify important, conserved portions of the genome and discern patterns in function and regula ...
... the array of proteins they encode. c). Comparative genomics is third area of study, in which genomes from different organisms are compared to look for significant differences and similarities. This helps identify important, conserved portions of the genome and discern patterns in function and regula ...
Libby_Hereditary Colon Cancer
... • Sulindac and celecoxib (Celebrex) can reduce number of polyps • They do not reduce the overall incidence of cancer, or need for colectomy • May have role in reducing duodenal or rectal adenomas ...
... • Sulindac and celecoxib (Celebrex) can reduce number of polyps • They do not reduce the overall incidence of cancer, or need for colectomy • May have role in reducing duodenal or rectal adenomas ...
Gene Section AF10 (ALL1 fused gene from chromosome 10)
... the translocation. Hybrid/Mutated Gene 5’ MLL - 3’ AF10; breakpoints are at variable places along AF10. Abnormal Protein N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF10. ...
... the translocation. Hybrid/Mutated Gene 5’ MLL - 3’ AF10; breakpoints are at variable places along AF10. Abnormal Protein N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF10. ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.