(FISH) or Immunohistochemistry (IHC)
... produces too much of the HER-2/protein. Excessive amounts of this protein (overexpression) causes cells to reproduce uncontrollably. Although the HER-2/neu protein is overexpressed in several epithelial cancers including breast, ovarian, thyroid, lung, salivary gland, stomach, colon and prostate can ...
... produces too much of the HER-2/protein. Excessive amounts of this protein (overexpression) causes cells to reproduce uncontrollably. Although the HER-2/neu protein is overexpressed in several epithelial cancers including breast, ovarian, thyroid, lung, salivary gland, stomach, colon and prostate can ...
Metabolic functions of duplicate genes in Saccharomyces cerevisiae
... • 32 are experimentally viable when a single gene member is knocked out. (back-up function) • 2 exhibit back-up function under only two and three conditions • In the remaining 18 essential families, a single member is essential for growth. (specialized function) ...
... • 32 are experimentally viable when a single gene member is knocked out. (back-up function) • 2 exhibit back-up function under only two and three conditions • In the remaining 18 essential families, a single member is essential for growth. (specialized function) ...
Sources of genetic variation
... Chromosome breaks may result in changes in chromosome structure which alter the sequences of genes (lengths of DNA) along the chromosome length. Thus genes may be deleted altogether, or deleted genes may then be inserted in the wrong place, gene sequeneces may become inverted, or gene sequences may ...
... Chromosome breaks may result in changes in chromosome structure which alter the sequences of genes (lengths of DNA) along the chromosome length. Thus genes may be deleted altogether, or deleted genes may then be inserted in the wrong place, gene sequeneces may become inverted, or gene sequences may ...
Paper - BioMed Central
... Transcriptional analysis between two wheat Near-isogenic lines contrasting in aluminium Tolerance under aluminium stress. Molecular Genetics and Genomics (2007) 277: ...
... Transcriptional analysis between two wheat Near-isogenic lines contrasting in aluminium Tolerance under aluminium stress. Molecular Genetics and Genomics (2007) 277: ...
Inherited Neuropathies: New Genes Don`t Fit Old Models
... proteins (Wiggin et al., 2005) as well as structural microtubule-associated proteins (MAPs) (Dehmelt and Halpain, 2004). When the function of these molecules is perturbed, neuronal polarity is disrupted. This type of disruption often results in neurons with multiple axons, multiple dendrites, or man ...
... proteins (Wiggin et al., 2005) as well as structural microtubule-associated proteins (MAPs) (Dehmelt and Halpain, 2004). When the function of these molecules is perturbed, neuronal polarity is disrupted. This type of disruption often results in neurons with multiple axons, multiple dendrites, or man ...
Solution
... 8. (9 points) The gene Sonic Hedgehog (SHH) is required for many developmental processes in vertebrates, including development of the limbs. A limb specific enhancer of the SHH gene maps 1 million base pairs away from the SHH gene, and mutations in this enhancer cause polydactyly (extra fingers) ...
... 8. (9 points) The gene Sonic Hedgehog (SHH) is required for many developmental processes in vertebrates, including development of the limbs. A limb specific enhancer of the SHH gene maps 1 million base pairs away from the SHH gene, and mutations in this enhancer cause polydactyly (extra fingers) ...
PDF
... plastid? Some syntheses other than photosynthesis are only carried out in plastids, probably because one or another feature of the organelle’s environment does not exist elsewhere in the cell. Furthermore, the cytoplasm and chloroplast contain different proteases, and a protein might survive better ...
... plastid? Some syntheses other than photosynthesis are only carried out in plastids, probably because one or another feature of the organelle’s environment does not exist elsewhere in the cell. Furthermore, the cytoplasm and chloroplast contain different proteases, and a protein might survive better ...
Gene Section HMGA2 (high mobility group AT-hook 2) in Oncology and Haematology
... HMGA2 was expressed in 4/6 soft tissue chondromas (all with 12q-rearrangements cytogenetically), three cases showed truncated (exons 1-3) transcripts, one case displayed a t(3;12)(q27;q15) and RT-PCR demonstrated a HMGA2-LPP fusion transcript composed of HMGA2 exons 1-3 and LPP exons 9-11. ...
... HMGA2 was expressed in 4/6 soft tissue chondromas (all with 12q-rearrangements cytogenetically), three cases showed truncated (exons 1-3) transcripts, one case displayed a t(3;12)(q27;q15) and RT-PCR demonstrated a HMGA2-LPP fusion transcript composed of HMGA2 exons 1-3 and LPP exons 9-11. ...
Disease Stratification - Baliga Lab at Institute for Systems Biology
... Classifier is chosen finding the most accurate and robust rule of this type from all possible pairs in the dataset If needed, a set of classifiers of the above form can be used, with final classification resulting from a majority vote (k-TSP) ...
... Classifier is chosen finding the most accurate and robust rule of this type from all possible pairs in the dataset If needed, a set of classifiers of the above form can be used, with final classification resulting from a majority vote (k-TSP) ...
Src
... living and dead retroviruses make up 8%of your genome, with ~100,000 whole or partial copies! ...
... living and dead retroviruses make up 8%of your genome, with ~100,000 whole or partial copies! ...
Mutation Rates
... Ultimately, the source of genetic variation observed among individuals in populations is gene mutation. Mutation generates new alleles, and these are the substance of all evolutionary change. The mutation rate is defined as the probability that a copy of an allele changes to some other allelic form ...
... Ultimately, the source of genetic variation observed among individuals in populations is gene mutation. Mutation generates new alleles, and these are the substance of all evolutionary change. The mutation rate is defined as the probability that a copy of an allele changes to some other allelic form ...
Genetic basis of neural tube defects. I. Regulatory genes for the
... In some lines, mice with different genotypes have the same NTD type suggesting that the development of each part of the neural tube has a polygenic character. Moreover, some mutated genes can also play an important role in the whole neural tube closure (HARRIS, JURILOFF 1997). The environment also h ...
... In some lines, mice with different genotypes have the same NTD type suggesting that the development of each part of the neural tube has a polygenic character. Moreover, some mutated genes can also play an important role in the whole neural tube closure (HARRIS, JURILOFF 1997). The environment also h ...
File S1.
... Evaluating functional similarities between genes To test if CI could be used to evaluate the quality of new experimentally derived PPIs, we sorted the ~18000 validated human PPIs in the STRING database into 5000 gene bins according to their confidence scores and plotted the average CI versus the av ...
... Evaluating functional similarities between genes To test if CI could be used to evaluate the quality of new experimentally derived PPIs, we sorted the ~18000 validated human PPIs in the STRING database into 5000 gene bins according to their confidence scores and plotted the average CI versus the av ...
Layman`s Crash Course in Ball Python Genetics
... “wild type” appearance. Even within this “normal” range, there are so many different genes at work, and in so many different combinations, that the appearance of the animals will always have some variance…especially in a species like the ball python. There are many different looks that are all consi ...
... “wild type” appearance. Even within this “normal” range, there are so many different genes at work, and in so many different combinations, that the appearance of the animals will always have some variance…especially in a species like the ball python. There are many different looks that are all consi ...
El Proyecto Genoma Humano
... • BioProject is an administrative object (defined by goal, target, funding, collaboration) • Genome is a biological object defining an organism at molecular level • Genome assembly is a complex data structure that defines the structure, relative position (scaffold) and chromosome placement of DNA se ...
... • BioProject is an administrative object (defined by goal, target, funding, collaboration) • Genome is a biological object defining an organism at molecular level • Genome assembly is a complex data structure that defines the structure, relative position (scaffold) and chromosome placement of DNA se ...
Gene targeting in mice - University of Utah Health Care
... DNA integration into the host genome, or increasing the probability that the HSV-tk gene, once integrated into the host genome, was expressed in the recipient cells3,9. These experiments were carried out before the concept of gene expression ‘enhancer sequences’ had emerged and contributed to the de ...
... DNA integration into the host genome, or increasing the probability that the HSV-tk gene, once integrated into the host genome, was expressed in the recipient cells3,9. These experiments were carried out before the concept of gene expression ‘enhancer sequences’ had emerged and contributed to the de ...
Severe Combined Immunodeficiency Genetic Testing
... A genetic test called full gene sequencing can be done to confirm a diagnosis of SCID. This test is performed on a sample of blood. It reads the instructions (DNA) that make up the genes known to cause SCID and can identify mutations in those genes. ...
... A genetic test called full gene sequencing can be done to confirm a diagnosis of SCID. This test is performed on a sample of blood. It reads the instructions (DNA) that make up the genes known to cause SCID and can identify mutations in those genes. ...
Homoeotic and atavic mutations in insects Two main types of
... preferentially distal regions (wing, basitarStudies going beyond the general de- sus) of the thoracic appendages. As description of the segment or appendage scribed before, tetraltera (let) shows a transaffected and the type of the transforma- formation of the ventral region of the tion have been ca ...
... preferentially distal regions (wing, basitarStudies going beyond the general de- sus) of the thoracic appendages. As description of the segment or appendage scribed before, tetraltera (let) shows a transaffected and the type of the transforma- formation of the ventral region of the tion have been ca ...
Spring 2008 - Children`s Medical Research Institute
... involves limiting the amount of protein in the child’s diet and/or taking drugs to remove excess ammonium caused by the gene defect. In severe cases only a liver transplant can ensure continued health, but this cannot be performed in the first six months of life and carries significant risks. “If ou ...
... involves limiting the amount of protein in the child’s diet and/or taking drugs to remove excess ammonium caused by the gene defect. In severe cases only a liver transplant can ensure continued health, but this cannot be performed in the first six months of life and carries significant risks. “If ou ...
Protein World
... • This was measured by using the KEGG Pathway map (release 25) • The best, however not completely convincing, result was found using PCP and not ME: ...
... • This was measured by using the KEGG Pathway map (release 25) • The best, however not completely convincing, result was found using PCP and not ME: ...
Identification of porcine Lhx3 and SF1 as candidate genes for QTL
... Accepted for publication 3 July 2001 ...
... Accepted for publication 3 July 2001 ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.