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Role of tumour necrosis factor (TNF)
Role of tumour necrosis factor (TNF)

... M tuberculosis infected macrophages may conceivably be involved in dissemination of mycobacteria from the original site of the lesion, resulting in a relatively high frequency of extrapulmonary disease in treated patients. Etanercept is a dimeric fusion protein comprising the extracellular ligand po ...
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... of cases of acute, nonspecific febrile illness beginning 3 to 5 days later (incubation range, 1-14 days), with pleuropneumonitis developing in a significant proportion of cases during the ensuing days and weeks. Public health authorities would most likely become aware of an outbreak of unusual respi ...
Strep Throat - Sun Prairie Area School District
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... streptococcal pharyngitis, but indicate viral upper respiratory infections. It is important to realize that most sore throats are not due to streptococcal infections. When strep throat is accompanied by a red rash and fever, it is called scarlet fever. If left untreated, streptococcal pharyngitis la ...
Ringworm - Sunrise School Division
Ringworm - Sunrise School Division

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Tularemia as a Biological Weapon
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... continued into the early 1990s and resulted in weapons production of F tularensis strains engineered to be resistant to antibiotics and vaccines.24 In 1969, a World Health Organization expert committee estimated that an aerosol dispersal of 50 kg of virulent F tularensis over a metropolitan area wit ...
Tularemia as a Biological Weapon
Tularemia as a Biological Weapon

... continued into the early 1990s and resulted in weapons production of F tularensis strains engineered to be resistant to antibiotics and vaccines.24 In 1969, a World Health Organization expert committee estimated that an aerosol dispersal of 50 kg of virulent F tularensis over a metropolitan area wit ...
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... indeed taken pla ce, what could have produced it? It has been suggested that the relatively high proportion of people in the piopulation who have serum penicillin levels at any tinne may serve to interrupt the chain of transmission, wrhich is often also associated with enhanced virulenc :e. If this ...
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... such as cattle, sheep, and goats.1 According to the World Health Organization (WHO), anthrax is enzootic in animal populations in much of sub-Saharan Africa and Asia as well as in some southern European countries, parts of the Americas, and some regions in Australia. Outbreaks in animals also occur ...
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Onchocerciasis



Onchocerciasis, also known as river blindness and Robles disease, is a disease caused by infection with the parasitic worm Onchocerca volvulus. Symptoms include severe itching, bumps under the skin, and blindness. It is the second most common cause of blindness due to infection, after trachoma.The parasite worm is spread by the bites of a black fly of the Simulium type. Usually many bites are required before infection occurs. These flies live near rivers, hence the name of the disease. Once inside a person, the worms create larvae that make their way out to the skin. Here they can infect the next black fly that bites the person. There are a number of ways to make the diagnosis including: placing a biopsy of the skin in normal saline and watching for the larva to come out, looking in the eye for larvae, and looking within the bumps under the skin for adult worms.A vaccine against the disease does not exist. Prevention is by avoiding being bitten by flies. This may include the use of insect repellent and proper clothing. Other efforts include those to decrease the fly population by spraying insecticides. Efforts to eradicate the disease by treating entire groups of people twice a year is ongoing in a number of areas of the world. Treatment of those infected is with the medication ivermectin every six to twelve months. This treatment kills the larva but not the adult worms. The medication doxycycline, which kills an associated bacterium called Wolbachia, appears to weaken the worms and is recommended by some as well. Removal of the lumps under the skin by surgery may also be done.About 17 to 25 million people are infected with river blindness, with approximately 0.8 million having some amount of loss of vision. Most infections occur in sub-Saharan Africa, although cases have also been reported in Yemen and isolated areas of Central and South America. In 1915, the physician Rodolfo Robles first linked the worm to eye disease. It is listed by the World Health Organization as a neglected tropical disease.
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