SEMINAR ON - Pharmawiki.in
... Transporters and efflux systems Physicochemical properties of drugs Molecular weight Lipophilicity ...
... Transporters and efflux systems Physicochemical properties of drugs Molecular weight Lipophilicity ...
Chapter 5 Drugs for Neoplastic Disorders
... important role technicians have in identifying problem OTC purchases. The technician is often in a position to prevent many potentially serious complications from inappropriate OTC drug use. Often the patient will bring an OTC product to the counter when picking up prescriptions, and the technician ...
... important role technicians have in identifying problem OTC purchases. The technician is often in a position to prevent many potentially serious complications from inappropriate OTC drug use. Often the patient will bring an OTC product to the counter when picking up prescriptions, and the technician ...
IN VITRO ARE YOU READY? DPT Thought Leadership Issue 16
... testing methods have evolved, use of the Franz cell diffusion system for semi-solid dosage forms was suggested in the USP Pharmacopeial Forum. This method was recently published in the USP General Chapter 1724 and is aligned with the FDA’s SUPAC-SS. As a result, regulatory agencies may now request t ...
... testing methods have evolved, use of the Franz cell diffusion system for semi-solid dosage forms was suggested in the USP Pharmacopeial Forum. This method was recently published in the USP General Chapter 1724 and is aligned with the FDA’s SUPAC-SS. As a result, regulatory agencies may now request t ...
KINETIC STUDY OF THE IN VITRO RELEASE AND STABILITY OF... FLOATING BEADS Research Article
... 2%. Light paraffin oil (5-20% w/w) was added to the prepared polymer solution. Theophylline (200 mg) was then added. The mixture was homogenized for 15 minutes and was then extruded through 23G needle at a height of 20 cm in to 5% calcium chloride solution with gentle agitation at room temperature. ...
... 2%. Light paraffin oil (5-20% w/w) was added to the prepared polymer solution. Theophylline (200 mg) was then added. The mixture was homogenized for 15 minutes and was then extruded through 23G needle at a height of 20 cm in to 5% calcium chloride solution with gentle agitation at room temperature. ...
r MAR 03 2004 Memorandum
... 2-0x0- 1-pyrrolidineacetamide,that you intend to market as a new dietary ingredient. The notification statesthat the product will contain Piracetamonly and that the suggesteddosagewill be 2.4 -4.8 grams(g) daily. You statethat your product will not have specific conditions for use and that consultat ...
... 2-0x0- 1-pyrrolidineacetamide,that you intend to market as a new dietary ingredient. The notification statesthat the product will contain Piracetamonly and that the suggesteddosagewill be 2.4 -4.8 grams(g) daily. You statethat your product will not have specific conditions for use and that consultat ...
SSRIs for the treatment of Depression in children and
... NOTE: Fluoxetine, sertraline and citalopram are inhibitors of cytochrome P450 enzyme, so interactions with other drugs are possible. 8. Adverse drug reactions For a comprehensive list (including rare and very rare adverse effects), or if significance of possible adverse event uncertain, consult Summ ...
... NOTE: Fluoxetine, sertraline and citalopram are inhibitors of cytochrome P450 enzyme, so interactions with other drugs are possible. 8. Adverse drug reactions For a comprehensive list (including rare and very rare adverse effects), or if significance of possible adverse event uncertain, consult Summ ...
PowerPoint 簡報
... Fractionating a total dose usually decreases the probability that the total dose will cause toxicity. The reason for this is that the body often can repair the effect of each subtoxic dose if sufficient time passes before receiving the next dose. In such a case, the total dose, harmful if received ...
... Fractionating a total dose usually decreases the probability that the total dose will cause toxicity. The reason for this is that the body often can repair the effect of each subtoxic dose if sufficient time passes before receiving the next dose. In such a case, the total dose, harmful if received ...
Preparation and Evaluation of Minoxidil Gels
... The in vitro release data obtained was treated with Higuchi’s equation (Q=kt1/2) to understand the mechanism of drug release from the formulations. The data was plotted as cumulative percent released vs. square root of time. A close observation of the linear regression results reveals that minoxidil ...
... The in vitro release data obtained was treated with Higuchi’s equation (Q=kt1/2) to understand the mechanism of drug release from the formulations. The data was plotted as cumulative percent released vs. square root of time. A close observation of the linear regression results reveals that minoxidil ...
ARCI-025-020 Medications and Prohibited Substances
... Many are drugs that affect the cardiovascular, pulmonary and autonomic nervous systems. They all have the potential of affecting the performance of a racehorse racing horse. The following groups of drugs are placed in this class: (a) Drugs affecting the autonomic nervous system which that do not hav ...
... Many are drugs that affect the cardiovascular, pulmonary and autonomic nervous systems. They all have the potential of affecting the performance of a racehorse racing horse. The following groups of drugs are placed in this class: (a) Drugs affecting the autonomic nervous system which that do not hav ...
In Vitro and In Vivo Evaluation of Microparticulate Drug
... High drug contents could be obtained. The drug release profiles followed almost pseudo-first-order kinetics, but were quite different between Suc-Ch-MMC and CM-Ch-MMC; that is, the 50 % release time was approximately 180 h and 6 h for Suc-Ch-MMC and CM-Ch-MMC, respectively [58]. As Suc-Ch and CM-Ch ...
... High drug contents could be obtained. The drug release profiles followed almost pseudo-first-order kinetics, but were quite different between Suc-Ch-MMC and CM-Ch-MMC; that is, the 50 % release time was approximately 180 h and 6 h for Suc-Ch-MMC and CM-Ch-MMC, respectively [58]. As Suc-Ch and CM-Ch ...
PULMONARY TUBERCULOSIS
... findings, may have a fluid level, and is not associated with patchy bronchogenic infiltrates. In contrast, physical findings are prominent over tuberculous cavities, fluid levels are rare. And patchy infiltrates elsewhere are the rule. ...
... findings, may have a fluid level, and is not associated with patchy bronchogenic infiltrates. In contrast, physical findings are prominent over tuberculous cavities, fluid levels are rare. And patchy infiltrates elsewhere are the rule. ...
Citalopram (Patient Education - Pediatric Medication) Pronunciation
... •Make sure you have the right drug for your child. •If your child has been taking this drug for many weeks, talk with your child's doctor before stopping. You may want to slowly stop this drug. •Check all drugs your child is taking with your child's doctor. This drug may not mix well with some other ...
... •Make sure you have the right drug for your child. •If your child has been taking this drug for many weeks, talk with your child's doctor before stopping. You may want to slowly stop this drug. •Check all drugs your child is taking with your child's doctor. This drug may not mix well with some other ...
FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM SUSTAINED RELEASE TABLETS Research Article
... Losartan potassium is a potent antihypertensive drug which is a highly specific Angiotensin II Type/AT 1 receptor antagonist. It is readily absorbed from the gastro intestinal tract, having oral bioavailability 33% and plasma elimination half life from 1.5 to 2.5 hours. The present study is an attem ...
... Losartan potassium is a potent antihypertensive drug which is a highly specific Angiotensin II Type/AT 1 receptor antagonist. It is readily absorbed from the gastro intestinal tract, having oral bioavailability 33% and plasma elimination half life from 1.5 to 2.5 hours. The present study is an attem ...
Rapid tranquillisation - The British Journal of Psychiatry
... These treatments are not without sideeffects. A survey of around 100 incidents of rapid tranquillisation conducted by Pilowski et al (1992) found few adverse events, but those reported were potentially serious, including cardiorespiratory probproblems, with cardiac arrests in 2% and cardiovascular c ...
... These treatments are not without sideeffects. A survey of around 100 incidents of rapid tranquillisation conducted by Pilowski et al (1992) found few adverse events, but those reported were potentially serious, including cardiorespiratory probproblems, with cardiac arrests in 2% and cardiovascular c ...
Lipoprotein disorders and cardiovascular disease
... LDL-R increases and the rate of cholesteryl ester formation declines. These homeostatic adjustments to HMG-CoA reductase inhibition increase LDL cholesterol clearance from plasma and decrease hepatic production of VLDL and LDL. Statins may increase HDL cholesterol in part by regulating apo AI transc ...
... LDL-R increases and the rate of cholesteryl ester formation declines. These homeostatic adjustments to HMG-CoA reductase inhibition increase LDL cholesterol clearance from plasma and decrease hepatic production of VLDL and LDL. Statins may increase HDL cholesterol in part by regulating apo AI transc ...
0001104659-17-025291 - ContraVir Pharmaceuticals
... European Association for the Study of the Liver (EASL) in Amsterdam, The Netherlands. Notably, ContraVir was notified by Dr. Laurent Castera, EASL Secretary General, that the poster elucidating the MOA of CRV431 was selected to be included in a 30-minute EASL “poster tour,” during which key global o ...
... European Association for the Study of the Liver (EASL) in Amsterdam, The Netherlands. Notably, ContraVir was notified by Dr. Laurent Castera, EASL Secretary General, that the poster elucidating the MOA of CRV431 was selected to be included in a 30-minute EASL “poster tour,” during which key global o ...
Errors in Patients` Information Leaflets of Marketed Medicines in
... providing of information to patients may reduced compliance, increased anxiety, and/or have more propensity to know about the side effects. The primary source of information in PILs should have knowledge how to take the drug; specific dose; amount of drug per tablet or other dosage form; average dos ...
... providing of information to patients may reduced compliance, increased anxiety, and/or have more propensity to know about the side effects. The primary source of information in PILs should have knowledge how to take the drug; specific dose; amount of drug per tablet or other dosage form; average dos ...
The Opioid Crisis in Indian Country
... • Opioids – Legal and Illegal • Ways to address substance use disorder in Indian Country ...
... • Opioids – Legal and Illegal • Ways to address substance use disorder in Indian Country ...
statement on the use of codeine in children
... the alternative drugs and how to use them effectively and safely. The decisions have been based largely on personal and institutional experience of different drugs, the availability of appropriate formulations of alternative drugs, and local hospital attitudes to the MHRA communication. There are ma ...
... the alternative drugs and how to use them effectively and safely. The decisions have been based largely on personal and institutional experience of different drugs, the availability of appropriate formulations of alternative drugs, and local hospital attitudes to the MHRA communication. There are ma ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... drugs like Meloxicam (preferential COX2 inhibitor) and Etoricoxib (selective COX2 inhibitor). Objectives: To study the analgesic effect of Diacerein. 2.To compare the analgesic effect of Diacerein, Meloxicam and Etoricoxib in albino rats, using digital analgesiometer. Methodology: A Randomized contr ...
... drugs like Meloxicam (preferential COX2 inhibitor) and Etoricoxib (selective COX2 inhibitor). Objectives: To study the analgesic effect of Diacerein. 2.To compare the analgesic effect of Diacerein, Meloxicam and Etoricoxib in albino rats, using digital analgesiometer. Methodology: A Randomized contr ...
A fatal outcome after unintentional overdosing of rivastigmine patches
... Mistakes with application of multiple patches have been described for patches for pain relief [16,17]. This shows that use of this administration route is prone to this specific type of error, especially since the treatment often is indicated in patients with advanced age or patients whose medicatio ...
... Mistakes with application of multiple patches have been described for patches for pain relief [16,17]. This shows that use of this administration route is prone to this specific type of error, especially since the treatment often is indicated in patients with advanced age or patients whose medicatio ...
Alzheimer's Drugs Market, 2012 - 2017 Brochure
... needs represent a huge opportunity for pharmaceutical companies which are developing targeted novel therapies. If successful, they will be in a position to command premium prices and tap the existing opportunity. The pipeline for Alzheimer's drugs is rich, with drug developers looking for drugs with ...
... needs represent a huge opportunity for pharmaceutical companies which are developing targeted novel therapies. If successful, they will be in a position to command premium prices and tap the existing opportunity. The pipeline for Alzheimer's drugs is rich, with drug developers looking for drugs with ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.