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View the article - Jefferson Digital Commons
View the article - Jefferson Digital Commons

seizures - emergency
seizures - emergency

... severe illness, head injury, stroke, prolonged hypoxia, or other disorders. It is most important to prevent injury during the seizure by guiding the patient away from hard structures; do not tightly restrain. Ensure that the airway is open, but do not insert any object into the mouth. There is a goo ...
News Virginia Board of Pharmacy
News Virginia Board of Pharmacy

... 2G-compatible Global System for Mobile communications device that can only communicate via the 2G wireless network. Therefore, when the 2G sunset occurs by January 1, 2017, these security systems will no longer be able to communicate alarm signals. Pharmacies with older alarm systems may still be op ...
13 - epilepsy09
13 - epilepsy09

... increasing brain excitability such as sleep deprivation, drug or alcohol ingestion or withdrawal or hypoglycemia. Rare patients have their seizures provoked consistently by specific sensory stimuli (e.g. flickering lights, video games or television, a specific piece of music, reading, immersion in h ...
How to withdraw - Surviving Antidepressants
How to withdraw - Surviving Antidepressants

... One huge hazard of withdrawal is becoming emotional again, as the numbing effect of SSRIs lifts. Many people or their partners are very frightened by this. 3. Detoxification We do not know what causes withdrawal. It may be that for some people on treatment for years that the drug gets captured in ad ...
Chapter 9 Drug Identification and Toxicology
Chapter 9 Drug Identification and Toxicology

... —NARCOTICS:WHAT IS IT? A narcotic is a drug that is meant to sedate, or induce sleep. In less potent forms, this family of drugs is often used as a pain reliever because of its ability to relax muscles and provide relief as a sedative. Many illegal drugs that people often refer to as narcotics are a ...
Pharmacotherapeutic action of Dasanga Guggulu
Pharmacotherapeutic action of Dasanga Guggulu

... administrate 1 g of Dasanga Guggulu three times a day after meal with lukewarm water. The therapeutic efficacy on hyperlipidemia was tested with using lipid profile and clinical signs mentioned in Madhava Nidana before and after the treatment. Toxicity of the drug was tested by examining kidney func ...
Product Information - PICO
Product Information - PICO

... doses of the saline cathartics (15 g of magnesium sulfate or its equivalent) produces a semifluid or watery evacuation within 3-6 hours or less. The product is not intended for routine use as a laxative. Some absorption of the component ions of the saline cathartics does occur, and in certain instan ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... clinic for treatment of acne vulgaris. The nurse practitioner prescribes benzoyl peroxide topically four times a day. Jane tells the nurse that she wants take the drug more frequently so the acne will go away quickly. What information will the nurse provide to Jane? A. “Improvement is usually seen i ...
1 Revised manuscript Published in Colloids and Surfaces A
1 Revised manuscript Published in Colloids and Surfaces A

... degradation, controlled and sustained release, and various routes of administration, including oral, nasal, intra-ocular or parenteral [1-3]. Furthermore, they offer a means for the localized or targeted delivery of drugs to specific tissue/organ sites of interest. The beneficial consequences of tho ...
Drug treatment of hypertensive emergencies
Drug treatment of hypertensive emergencies

... response is potentially dangerous, possibly leading to ischemic complications such as stroke, myocardial infarction or blindness in some cases. Thus, in patients who are severely hypertensive but asymptomatic, slower reductions in blood pressure should be provided with oral agents (see below). PAREN ...
contaminantion in herbal drug and preparations
contaminantion in herbal drug and preparations

... herbal drugs become contaminated. This article focuses on which type contamination found in herbal drugs. How can we get rid of these contaminations. Because it is a natural therapy having no major side effects so we should remove this contamination from these drugs. Keywords: traditional medicine, ...
Long Term Study of Ritalin
Long Term Study of Ritalin

... Picchietti et al., 1998), and develop substance use disorders in adolescence (Barkley et al., 1990a; Biederman et al., 1999) more often than other children, independent of their exposure to psychostimulants. However, little long-term evidence is available, and controversy remains about whether these ...
pharmaceutical processing
pharmaceutical processing

... • It involves the use of ultrasound with frequencies ranging from 20 kHz to 2000 kHz; this increases the permeability of cell walls and produces cavitation • Although the process is useful its large-scale application is limited due to the higher costs • Disadvantage: deleterious effect of ultrasound ...
Slide 1
Slide 1

... Buprenorphine overdose > Unusual in opioid tolerant [ie opioid dependent] patients. > Can occur in opioid dependent patients if combined with alcohol or benzodiazepines or other sedatives. > Requires high dose naloxone to reverse [up to ...
Levodopa
Levodopa

... Drugs acting directly on postsynaptic dopamine receptors may have a beneficial effect in addition to that of levodopa. Unlike levodopa, they do not require enzymatic conversion to an active metabolite, act directly on the postsynaptic dopamine receptors, have no potentially toxic metabolites, and do ...
FORMULATION AND EVALUATION OF THERMOREVERSIBLE IN
FORMULATION AND EVALUATION OF THERMOREVERSIBLE IN

... The aim of this research is undertaken to formulate thermo sensitive drug delivery system of Clonidine Hydrochloride for glaucoma therapy in in-situ form to overcome the problem of rapid precorneal elimination, poor bioavailability and nasolachrymal drainage exhibited by conventional ocular formulat ...
www.ijpbs.com Rishikesh S Deshmukh*et al Int J Pharm Bio Sci
www.ijpbs.com Rishikesh S Deshmukh*et al Int J Pharm Bio Sci

... more uniform, more stable (in their reactions to high processing temperatures, acids, carbon dioxide, storage and light) and more potent (i.e., less could be used to gain the same effect) than anything seen before, and offered a wider range of shades, so they had great advantages over natural dyes a ...
New anti-tuberculosis drugs and regimens: 2015 update
New anti-tuberculosis drugs and regimens: 2015 update

... clavulanate added to an OBR regimen containing linezolid (at the dose of 1 g three times a day) achieved high smear and culture conversion in MDR/XDR-TB (table 5) [30]. Further studies are presently ongoing to define the role of meropenem/clavulanate within the group 5 drugs. Other drugs Anecdotal r ...
Making a Killing
Making a Killing

... and adults. SSRIs also double the risk of stillbirths, babies of low birth weight and foetal malformations in women who take them during pregnancy. Concentrating on the good news not only pays off for the drug makers, it also means a big payday for publishers of scientific journals. Dr Richard Smith ...
Drug Metabolism Phcy 172 - University of North Carolina at
Drug Metabolism Phcy 172 - University of North Carolina at

... • Aryl hydrocarbon receptor (AHR) is a basic helixloop-helix (bHLH) protein belonging to the PerArnt-Sim (PAS) family of transcription factors • It transcriptionally induces expression of hepatic CYP1A1, CYP1A2, and CYP1B1 , as well as several other genes, including some phase II metabolizing enzyme ...
Cerebral Stimulant and ADHD Drugs Prior Authorization Request
Cerebral Stimulant and ADHD Drugs Prior Authorization Request

... MassHealth reviews requests for prior authorization (PA) on the basis of medical necessity only. If MassHealth approves the request, payment is still subject to all general conditions of MassHealth, including current member eligibility, other insurance, and program restrictions. MassHealth will noti ...
Do You Know... Ketamine
Do You Know... Ketamine

... ·· Like all anesthetics, ketamine prevents users from feeling pain. This means that if injury occurs, a person may not know it. People under its effects may have difficulty standing up and be confused about their surroundings. Ketamine-related injuries and fatalities are often the result of falls an ...
Basics Pharmacology Review
Basics Pharmacology Review

... amount of time in preparation for LMCC • List the four steps of rational prescribing • Understand the pharmacological classes, generic examples and mechanisms of action of important tools in the practice of medicine. • Understand how the kinetics and dynamics of these agents can affect their use • H ...
Prescribing Information
Prescribing Information

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Drug interaction



A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.
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