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History of the Glycosaminoglycan Symposia in the Scientific Context
History of the Glycosaminoglycan Symposia in the Scientific Context

Anticoagulants, Thrombolytics Agents and Antiplatelet Drugs
Anticoagulants, Thrombolytics Agents and Antiplatelet Drugs

... highly specific direct inhibitor of thrombin - [Leu1-Thr2]-63desulfohirudin - a recombinant hirudin* derived from yeast cells. polypeptide - 65 amino acids MW=6979.5 identical to natural hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absen ...
1

Antithrombin



Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system. Antithrombin is a glycoprotein produced by the liver and consists of 432 amino acids. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites. A single glycosylation site remains consistently un-occupied in the minor form of antithrombin, β-antithrombin. Its activity is increased manyfold by the anticoagulant drug heparin, which enhances the binding of antithrombin to factor II and factor X.
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