S3.03 The maximum degree of local invasion into or through the
... neoplasia has not been shown to have metastatic potential
until it has invaded through the muscularis mucosae.
Therefore, the term pTis is generally avoided in the colorectum
and the term high grade dysplasia is preferred. pTis tumours
should be regarded as adenomas and not as carcinomas for
the pur ...
Supplemental File S7. Predisposition to Cancer
... Exam Question 3 (This questions targets LO2): III-3 has a son with Mohammed who
does not have early onset testicular cancer and no family history of the disease. What is
the chance their son will develop early onset testicular cancer if the disease is fully
Deleted in Colorectal Cancer
Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.Since it was first discovered in a colorectal cancer study in 1990, DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1.More recently DCC has been characterized as a dependence receptor, and many hypotheses have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.