Monitoring phenytoin serum concentrations
... metabolism at therapeutic doses. This means that, strictly speaking, phenytoin does not have a half-life but an ‘apparent half-life’ which varies in relation to serum concentration. This is usually quoted as an ‘average half-life’ of 22 hours but can range from 6 hours, at very low concentrations, t ...
... metabolism at therapeutic doses. This means that, strictly speaking, phenytoin does not have a half-life but an ‘apparent half-life’ which varies in relation to serum concentration. This is usually quoted as an ‘average half-life’ of 22 hours but can range from 6 hours, at very low concentrations, t ...
ToxTidbits: Antidote Facts
... • Fomepizole induces its own metabolism, so after the fourth 10 mg/kg dose, increase the dose to 15 mg/kg IV every 12 hours. • Continue treatment until EG or methanol levels are below 20 mg/dl and the patient is asymptomatic with normal pH. Fomepizole is available in 1.5 ml vials. Dilute each dose i ...
... • Fomepizole induces its own metabolism, so after the fourth 10 mg/kg dose, increase the dose to 15 mg/kg IV every 12 hours. • Continue treatment until EG or methanol levels are below 20 mg/dl and the patient is asymptomatic with normal pH. Fomepizole is available in 1.5 ml vials. Dilute each dose i ...
Ten Minute Toxicology: Valproic Acid
... • Highly protein bound, but dialzyable with levels greater than 850 (remember dialysis corrects acidosis as well as eliminates drug). • L-carnitine ...
... • Highly protein bound, but dialzyable with levels greater than 850 (remember dialysis corrects acidosis as well as eliminates drug). • L-carnitine ...
