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fast dissolving tablets: preparation, characterization and evaluation
fast dissolving tablets: preparation, characterization and evaluation

... disintegrate in the oral cavity have attracted a great deal of attention2. United States Food and drug administration (FDA) defined fast dissolving tablet (FDT) as “a solid dosage form containing medicinal substance or active ingredient which disintegrate rapidly usually within a matter of seconds w ...
Drug Master Files
Drug Master Files

... normally includes a brief outline of the manufacturing method, information on potential impurities originating from the manufacturing method, from the isolation procedure (natural products) or from degradation and, where applicable, information on the toxicity of specific impurities. ...
Management of Cocaine-Associated Chest Pain and Myocardial Infarction : A
Management of Cocaine-Associated Chest Pain and Myocardial Infarction : A

... (ED), aspirin, nitroglycerin, calcium channel blocker, benzodiazepine, thrombolytics, phentolamine, heparin, primary angioplasty, ECG, and stress testing. Literature citations were generally limited to published articles listed in Index Medicus. The article was reviewed by 4 outside reviewers nomina ...
Improved delivery of fenoterol plus ipratropium bromide using
Improved delivery of fenoterol plus ipratropium bromide using

IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.

... Insomnia is a widespread health complaint and the most common sleep disorders that affect people of all ages around the world [1, 2]. About 10-15% of adult population suffers from chronic insomnia, and additional 25-35% has transient or occasional insomnia [3]. The most widely used drugs in the mana ...


... The Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effectiv ...
Receptor in Baseline State
Receptor in Baseline State

... Implications of the DANDY Findings • Withdrawal symptoms occur before tolerance to nicotine has developed • Tolerance and withdrawal are caused by different physiological mechanisms • The effects of a single cigarette last for days ...
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... Separate specifications control the dispersion and tablets. In each case appearance, identification, assay and degradation products are adequately controlled. The tablets specification includes tests to control uniformity of dosage, dissolution, physical form of the drug substance and microbial qual ...
STABILITY INDICATING HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF
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... Ruggedness of the developed method was established by two different analysts, who assayed the formulations, using similar operational and environmental conditions. The results are summarized Table 4. ...
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Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid

... drugs withdrawn from the market because of IDT, such as hepatotoxicity and anaphylaxis. This category included four drugs: benoxaprofen, fenclofenac, ibufenac, and zomepirac. There was no drug that had a black box warning for IDT in RxList. Data Analysis. The concentrations at four or more time poin ...
prescribe order - Back in the Game
prescribe order - Back in the Game

Use of antihistamines in pediatrics
Use of antihistamines in pediatrics

... in combination with other drugs for the control of asthma and wheezing in children [36]. The review concluded that the scientific evidence derived from randomized controlled trials indicates that ketotifen alone or in combination with other co-interventions effectively improves asthma and wheezing c ...
Drugs working template
Drugs working template

... used for killing P. falciparum gametocytes and the safety of these low doses [Graves, 2015]. An important trial in Uganda showed that a dose of 04.mg/kg was as effective as the WHO recommended dose of 0.75 mg/kg [Eziefula, 2014a], and other trials of low dose regimens are in progress. However, as t ...
FORMULATION AND EVALUATION OF ERGOTAMINE TARTRATE LYOPHILIZED NASAL INSERT
FORMULATION AND EVALUATION OF ERGOTAMINE TARTRATE LYOPHILIZED NASAL INSERT

The mechanism of action of aspirin
The mechanism of action of aspirin

... cascade bioassay system developed by Vane [8] in the middle 1960s for use with blood or artificial salt solution. As expected, Piper and Vane found the release during anaphylaxis of histamine and SRS-A, but they also found some previously unreported substances: PGs, (mainly PGE2 but some PGF2a) and ...
Drugs The Straight Facts, Antidepressants
Drugs The Straight Facts, Antidepressants

... psychoactive substances that are used for medicinal or nonmedicinal purposes. Included in this broad category are substances that are legal or illegal. It is worth noting that humans have used many of these substances for hundreds, if not thousands of years. For example, traces of marijuana and coca ...
Public Summary Document (PSD) March 2016 PBAC Meeting
Public Summary Document (PSD) March 2016 PBAC Meeting

... Patients who fail to achieve a partial Mayo clinic score less than or equal to 2, with no subscore greater than 1, within the first 12 weeks of receiving this drug for UC, or have failed to maintain a partial Mayo clinic score less than or equal to 2, with no subscore greater than 1, with continuing ...
direct-to-consumer advertising
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... drug advertisements found in five of the top seven magazines most likely to be consumed by readers over age 65 was the method of investigation for this study. The time frame of the magazines studied, was, August 2002 to July 2003. Using SPSS and descriptive statistics, results indicated that within ...
Drug situation in Georgia
Drug situation in Georgia

... positive changes achieved within the framework of the programme. The National Focal Point on Drug Information is just such an important institutional coordination unit set up within the framework of the Southern Caucasus Anti Drug Programme. This service has been regularly monitoring the drug situat ...
Diphenhydramine Hydrochloride Injection, USPRx only
Diphenhydramine Hydrochloride Injection, USPRx only

... As in adults, antihistamines may diminish mental alertness in pediatric patients. In the young pediatric patient, particularly, they may produce excitation. Us e in the Elderly (approximately 60 years or older) Antihistamines are more likely to cause dizziness, sedation and hypotension in elderly pa ...
UPDATE OF CANNABIS BACKGROUND PAPER
UPDATE OF CANNABIS BACKGROUND PAPER

... Mäori convictions for cannabis use and cannabis dealing are very high in comparison with the proportion of Mäori in the population. Europeans are the majority of the population, but do not receive a majority of the convictions. Mäori, with only 14.5% of the population, receive 43% of the convictions ...
Effect of Oral Pseudoephedrine on Blood Pressure and Heart Rate
Effect of Oral Pseudoephedrine on Blood Pressure and Heart Rate

... thomimetic agents can raise blood pressure (BP) to dangerous levels, whereas other reviews5,6 suggest that the danger from these medications is exaggerated. In November 2000, the US Food and Drug Administration recommended that medications that contain phenylpropanolamine be voluntarily recalled bec ...
No Slide Title
No Slide Title

... Tardive dyskinesia (TD) is a late-onset movement disorder that can occur with prolonged use of antipsychotics. It can be irreversible and may get worse when treatment stops Around 20% of people on antipsychotics eventually experience TD - older people are more at risk ...
SOLUBILITY AND DISSOLUTION IMPROVEMENT OF KETOPROFEN BY SOLID DISPERSION IN  POLYMER AND SURFACTANT USING SOLVENT EVAPORATION METHOD
SOLUBILITY AND DISSOLUTION IMPROVEMENT OF KETOPROFEN BY SOLID DISPERSION IN  POLYMER AND SURFACTANT USING SOLVENT EVAPORATION METHOD

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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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