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Methylphenidate vs. amphetamine: Comparative
Methylphenidate vs. amphetamine: Comparative

... Table 1 (overleaf) summarizes the 15 reports found on animal research since 1984 that showed clear differences between MPH and AMP. Differences may have shown up in other laboratory studies, but were not reported clearly enough to suit the purposes of this review. Of the 92 articles reviewed, most d ...
COMPARATIVE STUDY ON EFFECT OF DIFERENT TECHNIQUES USED IN THE FORMULATION  OF FELODIPINE FAST DISSOLVING TABLETS 
COMPARATIVE STUDY ON EFFECT OF DIFERENT TECHNIQUES USED IN THE FORMULATION  OF FELODIPINE FAST DISSOLVING TABLETS 

EA_QA68.6_ErythromycinandStatins
EA_QA68.6_ErythromycinandStatins

...  Atorvastatin and erythromycin may be used together with caution. It may be prudent to withhold atorvastatin if erythromycin treatment is required to avoid any potential adverse effects. If concurrent administration is unavoidable, then a lower dose of atorvastatin should be considered.  Fluvastat ...
organic volatile impurities and their regulatory limits
organic volatile impurities and their regulatory limits

... production processes. The organic solvents are widely used in pharmaceutical industry[1]. Residual solvents in pharmaceuticals, commonly known as organic volatile impurities (OVIs), are chemicals that are either used or produced during the manufacture of active pharmaceutical ingredients (APIs), exc ...
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in
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... for the interpretative services are given. Recommendations when to combine TDM with pharmacogenetic tests are also provided. Following the guidelines will help to improve the outcomes of psychopharmacotherapy of many patients especially in case of pharmacokinetic problems. Thereby, one should never ...
Chapter 5.pmd - New Age International
Chapter 5.pmd - New Age International

... of addiction comes from a report issued to the Royal Society of Health and Welfare Canada. In this report, addiction or dependence on a drug is described as a strongly established pattern of behaviour characterized by (1) the repeated self-administration of a drug in amounts which reliably produce r ...
Ahead of print online version Moxidectin causes adult worm
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... responsible for lymphatic filarial disease (LF) in humans. LF affects people living in approximately 73 countries and leaves more than 1.4 billion people at risk and 120 million population already infected (WHO 2013). It is ranked as the second most common cause of permanent and long-term disability ...
Standard operating procedures of the electrochemotherapy
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... Electrochemotherapy is a new tumor ablation modality providing delivery into cell interiors of non-permeant drugs with intracellular targets. It is based on the local application of short and intense electric pulses that transiently permeabilize cells in tissues. To date, its main application has be ...
RUBOXISTAURIN – A PROMISING THERAPY FOR DIABETIC
RUBOXISTAURIN – A PROMISING THERAPY FOR DIABETIC

... Phase III trials are going on with ruboxistaurin and FDA has sent an approvable letter in August 2006 to the innovator of this drug asking for more supporting data to support the clinical evidence presented in the New Drug Application (NDA). According to Eli Lilly, the innovator, FDA requested anoth ...
Insomnia is not just a night-time problem
Insomnia is not just a night-time problem

... Sleep latency – is the time it takes to fall asleep after the lights have been turned out. Sleep latency can be prolonged in insomnia, and treatments for insomnia aim to reduce sleep latency. Sleep efficiency – is the ratio between total sleep time and total time spent in bed (which is ideally more ...
—  Press Release  — March 12, 2014 American Herbal Pharmacopoeia
— Press Release — March 12, 2014 American Herbal Pharmacopoeia

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Role of Pharmacokinetics and Metabolism in Drug Discovery and

... to determine the mechanism of benzodiazepine action were initiated only after their introduction into the clinic. It was not until 1974 that convincing evidence from behavioral, electrophysiological, and biochemical experiments was accumulated to demonstrate that benzodiazepines act specifically at ...
Medicinal Marijuana is a lie . . .
Medicinal Marijuana is a lie . . .

... the wind does not satisfy a man's hunger any more, nor is the wind profitable or beneficial to him any more than wind is to a man that opens his mouth, and fills himself with it. The phrase is expressive of laboring in vain in false worship, Mark 7:7, and of a man's getting nothing by all the pains ...
Opium Abuse and Its Management: Global Scenario
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... other enforcement measures. According to the recently conducted National Household Survey on Drug Abuse in 2002, it was reported that 0.5% of adult males were current (use within last month) opium users in India. The report projected that there were about 1.4 million opiate users in the country. In ...
Patient Information Sheet YOUR PRESCRIPTION FOR BALACET
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... Blood gases, pH, and electrolytes should be monitored in order that acidosis and any electrolyte disturbance present may be corrected promptly. Acidosis, hypoxia, and generalized CNS depression predispose to the development of cardiac arrhythmias. Ventricular fibrillation or cardiac arrest may occur ...
Coupling Data Mining and Laboratory Experiments to Discover Drug
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... constant at 1 m M and increased the dose of cefurox- ...
Buprenorphine dosing every 1, 2, or 3 days in opioid
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... of placebo within the alternative-day group. These findings were systematically replicated in a larger, placebocontrolled, outpatient study that compared the effects of administering 8 mg buprenorphine SL every day with the effects of administering that same buprenorphine dose every other day in two ...
2. tablets
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Antihistamines and driving ability: evidence from on-the
Antihistamines and driving ability: evidence from on-the

... Background: All antihistamines are capable of crossing the blood-brain barrier and thus may cause sedation. Most antihistamine users are ambulatory patients and therefore presumably drive a car. Objective: To summarize the effects of antihistamine drugs on driving ability. Data Sources and Study Sel ...
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of Pharmacy and Pharmacology African Journal

... The most important pathway of metals to transport into human is from soil to plant and from plant to human. The levels of the mineral essential elements (Ca, Mg, Na, K and Fe) detected in the investigated herbal drugs are presented as mg/kg in Table 2. The data revealed that all analyzed elements we ...
SEVREDOL tablets
SEVREDOL tablets

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Chemotherapy Regimens Clinical Coding Standards and Guidance

... The usual cycle length refers to the total number of days in a cycle, including the rest days and is an indicative figure showing when the procurement and delivery codes should next be coded. Sometimes the regimen specifies that the treatment should be repeated a number of times, each of these repet ...
Metabolic Characteristics of Oxcarbazepine (®Trileptal
Metabolic Characteristics of Oxcarbazepine (®Trileptal

... does not alter the amount of the enzyme, but reduces its activity for a certain metabolic reaction. Inducing agents, on the other hand, increase the amount of enzyme by stimulating its biosynthesis (Okey, 1990). This mechanistic difference implies that the pharmacokinetic consequences of enzyme inhi ...
Is prophylactic oxybutynin safe and effective in reducing the severity
Is prophylactic oxybutynin safe and effective in reducing the severity

... compensatory hyperhidrosis after ETS surgery.2 Although not routinely used, anticholinergic medications are being considered as they have been found to decrease sudoresis in patients treated for micturition disorders.2,3,9 These medications will be evaluated in this literature review. OBJECTIVE The ...
Ephedrine and Other Stimulants As Ergogenic Aids
Ephedrine and Other Stimulants As Ergogenic Aids

... stimulants for the treatment of attention deficit and hyperactivity disorder (ADHD) has increased significantly in recent years, probably due to both increased accuracy of diagnosis and increased demand by parents for stimulant treatment [1]. This increased prevalence of use has resulted in sports a ...
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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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