Full Prescribing Information for CONCERTA® (methylphenidate HCl)
... Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD. Although the role of stimulants in these adult cases is also unknown, adults have a greater likelihood than children of having serious structural cardiac abnormalities, cardi ...
... Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD. Although the role of stimulants in these adult cases is also unknown, adults have a greater likelihood than children of having serious structural cardiac abnormalities, cardi ...
Full Prescribing Information for CONCERTA
... Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD. Although the role of stimulants in these adult cases is also unknown, adults have a greater likelihood than children of having serious structural cardiac abnormalities, cardi ...
... Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD. Although the role of stimulants in these adult cases is also unknown, adults have a greater likelihood than children of having serious structural cardiac abnormalities, cardi ...
QA_18_6_AmlodipinevsfelodipineAUG_15_FINAL
... smaller studies found them to have similar antihypertensive efficacy. It has been suggested that if patients are intermittently compliant, amlodipine may be more suitable than felodipine m/r. This is because the antihypertensive effects of amlodipine last longer and its plasma levels fluctuate less ...
... smaller studies found them to have similar antihypertensive efficacy. It has been suggested that if patients are intermittently compliant, amlodipine may be more suitable than felodipine m/r. This is because the antihypertensive effects of amlodipine last longer and its plasma levels fluctuate less ...
Hypericum perforatum Monograph
... constituent hyperforin to inhibit synaptosomal reuptake of serotonin, norepinephrine, and dopamine.11,12 Two human pharmacological studies demonstrating an increase in cortisol levels following administration of two different St. John’s wort extracts have recently been reported to support this propo ...
... constituent hyperforin to inhibit synaptosomal reuptake of serotonin, norepinephrine, and dopamine.11,12 Two human pharmacological studies demonstrating an increase in cortisol levels following administration of two different St. John’s wort extracts have recently been reported to support this propo ...
Tybost - Gilead Sciences, Inc.
... of creatinine without affecting actual renal glomerular function. This effect should be considered when interpreting changes in estimated creatinine clearance in patients initiating TYBOST, particularly in patients with medical conditions or receiving drugs needing monitoring with estimated creatini ...
... of creatinine without affecting actual renal glomerular function. This effect should be considered when interpreting changes in estimated creatinine clearance in patients initiating TYBOST, particularly in patients with medical conditions or receiving drugs needing monitoring with estimated creatini ...
Neural mechanisms underlying morphine withdrawal in addicted
... ability of maintaining a low constant level of isometric force (impaired motor control) (11,12). It was also demonstrated that morphine plays a crucial role in learning and memory (13). Passive avoidance learning, which is normally assessed by shuttle box (14), is affected by Morphine (15). Morphine ...
... ability of maintaining a low constant level of isometric force (impaired motor control) (11,12). It was also demonstrated that morphine plays a crucial role in learning and memory (13). Passive avoidance learning, which is normally assessed by shuttle box (14), is affected by Morphine (15). Morphine ...
Nicotine and the Central Nervous System
... has a low potential for abuse. According to one study, as the dose of nicotine gum is elevated, its perceived strength and similarity to cigarettes are increased correspondingly [13]. Since the 4 mg dose is associated with decreased patient acceptance and a higher incidence of side effects, compared ...
... has a low potential for abuse. According to one study, as the dose of nicotine gum is elevated, its perceived strength and similarity to cigarettes are increased correspondingly [13]. Since the 4 mg dose is associated with decreased patient acceptance and a higher incidence of side effects, compared ...
Fibromyalgia treatment update Daniel S. Rooks Introduction
... severely impacted by fibromyalgia (FIQ score >60). Another study by Gusi and colleagues [49] using a 12-week training and 24-week detraining period reported that a pool-based, walking intervention improved lowerextremity muscle strength, health-related quality of life and pain in women with fibromya ...
... severely impacted by fibromyalgia (FIQ score >60). Another study by Gusi and colleagues [49] using a 12-week training and 24-week detraining period reported that a pool-based, walking intervention improved lowerextremity muscle strength, health-related quality of life and pain in women with fibromya ...
Propoxyphene Napsylate and Acetaminophen Tablets
... Blood gases, pH, and electrolytes should be monitored in order that acidosis and any electrolyte disturbance present may be corrected promptly. Acidosis, hypoxia, and generalized CNS depression predispose to the development of cardiac arrhythmias. Ventricular fibrillation or cardiac arrest may occur ...
... Blood gases, pH, and electrolytes should be monitored in order that acidosis and any electrolyte disturbance present may be corrected promptly. Acidosis, hypoxia, and generalized CNS depression predispose to the development of cardiac arrhythmias. Ventricular fibrillation or cardiac arrest may occur ...
Extract from Clinical Evaluation Report: Ivacaftor
... from the Clinical Evaluation Report (CER) prepared by the TGA. This extract does not include sections from the CER regarding product documentation or post market activities. Minor errors in this report as notified by the sponsor have been corrected. ...
... from the Clinical Evaluation Report (CER) prepared by the TGA. This extract does not include sections from the CER regarding product documentation or post market activities. Minor errors in this report as notified by the sponsor have been corrected. ...
PDF - SAGE Journals
... the symptoms persist even after the withdrawal of typical antipsychotic drugs, indicating that these drugs produce some long term alterations in brain tasks that are no longer associated with drug usage.4 Recently it has been found that the long term use of some antipsychotic drugs can also produce ...
... the symptoms persist even after the withdrawal of typical antipsychotic drugs, indicating that these drugs produce some long term alterations in brain tasks that are no longer associated with drug usage.4 Recently it has been found that the long term use of some antipsychotic drugs can also produce ...
Target Regimen Profiles for TB Treatment
... individual drugs. The proposed target regimen profiles, which describe prioritized characteristics, take into account the needs of end users, care providers and policy-makers. The novelty of the target profile approach is to have the goal of a treatment regimen in mind very early in the process of d ...
... individual drugs. The proposed target regimen profiles, which describe prioritized characteristics, take into account the needs of end users, care providers and policy-makers. The novelty of the target profile approach is to have the goal of a treatment regimen in mind very early in the process of d ...
AusPAR: Doxycycline monohydrate
... It is claimed that the preferred blood level of doxycycline is between about 0.1 μg/mL and 1.0 μg/mL at steady state in order that the anti-collagenase effect is retained but to avoid antibacterial side effects on intestinal flora. The sponsor undertook a pharmacokinetic study in which the drug was ...
... It is claimed that the preferred blood level of doxycycline is between about 0.1 μg/mL and 1.0 μg/mL at steady state in order that the anti-collagenase effect is retained but to avoid antibacterial side effects on intestinal flora. The sponsor undertook a pharmacokinetic study in which the drug was ...
Japanese Guideline on the Investigation of Drug Interactions, 2014
... conducted as needed during drug development, drug interaction studies carried out as necessary after ...
... conducted as needed during drug development, drug interaction studies carried out as necessary after ...
management of opiate withdrawal
... dispensaries (Lintzeris et al., 2001). In addition, buprenorphine can be prescribed by hospital-based doctors. The use of additional substances, such as opioids, alcohol and benzodiazepines, in combination with buprenorphine can cause respiratory depression, coma and death. Where there is evidence o ...
... dispensaries (Lintzeris et al., 2001). In addition, buprenorphine can be prescribed by hospital-based doctors. The use of additional substances, such as opioids, alcohol and benzodiazepines, in combination with buprenorphine can cause respiratory depression, coma and death. Where there is evidence o ...
Naloxone Hydrochloride Injection MIN-I-JET CONSUMER
... rare occasions the treated person has had a fit but this may not have been due to the naloxone. ...
... rare occasions the treated person has had a fit but this may not have been due to the naloxone. ...
Naloxone - Idaho Society of Health
... • Describe the opioid epidemic • Discuss the role of naloxone for out of hospital use • Identify patient populations at risk for opioid/heroin overdoses • Explain how to administer intranasal and intramuscular preparations of naloxone ...
... • Describe the opioid epidemic • Discuss the role of naloxone for out of hospital use • Identify patient populations at risk for opioid/heroin overdoses • Explain how to administer intranasal and intramuscular preparations of naloxone ...
Meta-analysis of the Effect of CYP3A4*18B Gene Polymorphism on
... to use this drug scientifically is crucial, because low blood concentrations of tacrolimus can lead to rejection, and high blood concentration can lead to toxicosis or infection6, 7. Thus, to avoid the rejection and adverse reaction for organ transplantation patients, achieving the desired target bl ...
... to use this drug scientifically is crucial, because low blood concentrations of tacrolimus can lead to rejection, and high blood concentration can lead to toxicosis or infection6, 7. Thus, to avoid the rejection and adverse reaction for organ transplantation patients, achieving the desired target bl ...
RECHALLENGE WITH LAMOTRIGINE AFTER A RASH
... of starting lamotrigine were identified prospectively between 10/1/2005 and 12/15/2009 in a private outpatient psychiatric practice specializing in bipolar disorder. To rate the rash, an 8point scale was developed based on known risk factors for severe drugrelated dermatological eruptions (Table 1). ...
... of starting lamotrigine were identified prospectively between 10/1/2005 and 12/15/2009 in a private outpatient psychiatric practice specializing in bipolar disorder. To rate the rash, an 8point scale was developed based on known risk factors for severe drugrelated dermatological eruptions (Table 1). ...
Republic of Palau - World Health Organization
... Example: Calculate the dose of drug, based on 5mg per kg body weight, required for a patient weighing 70kg. Dose of drug required = dose (mg/kg) X patient weight (kg) = 5mg/kg X 70 kg ...
... Example: Calculate the dose of drug, based on 5mg per kg body weight, required for a patient weighing 70kg. Dose of drug required = dose (mg/kg) X patient weight (kg) = 5mg/kg X 70 kg ...
Physician`s Labeling Rule_Content
... patients who are not fully awake after taking a sedative-hypnotic. As with sleep-driving, patients usually do not remember these events. It can rarely be determined with certainty whether a particular instance of the abnormal behaviors listed above are drug-induced, spontaneous in origin, or a resul ...
... patients who are not fully awake after taking a sedative-hypnotic. As with sleep-driving, patients usually do not remember these events. It can rarely be determined with certainty whether a particular instance of the abnormal behaviors listed above are drug-induced, spontaneous in origin, or a resul ...
Simeprevir - Therapeutic Goods Administration (TGA)
... With regard to the Phase III capsule (G007), food increased the bioavailability of simeprevir, with AUC0-last, AUC0-∞ and Cmax 1.60, 1.70 and 1.69 fold higher, respectively, after the consumption of a standard breakfast and, respectively, 1.49, 1.66 and 1.61 fold higher after consumption of high-fat ...
... With regard to the Phase III capsule (G007), food increased the bioavailability of simeprevir, with AUC0-last, AUC0-∞ and Cmax 1.60, 1.70 and 1.69 fold higher, respectively, after the consumption of a standard breakfast and, respectively, 1.49, 1.66 and 1.61 fold higher after consumption of high-fat ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.