Antiepileptic drugs
... incidence of side-effects, phenytoin, valproate. Use of single drug is preferred when possible, because of risk of pharmacokinetic interactions. • Partial (focal) seizures: carbamazepine, ...
... incidence of side-effects, phenytoin, valproate. Use of single drug is preferred when possible, because of risk of pharmacokinetic interactions. • Partial (focal) seizures: carbamazepine, ...
Which should be the first-line drug for newly diagnosed epilepsy
... partial onset seizures, was compared to that of 4 other anti-epileptic drugs, gabapentin, lamotrigine, oxcarbazepine and topiramate. One thousand seven hundred and twenty-one patients were recruited and randomly assigned to one of the treatments. Primary outcome measures, the same for both arms of t ...
... partial onset seizures, was compared to that of 4 other anti-epileptic drugs, gabapentin, lamotrigine, oxcarbazepine and topiramate. One thousand seven hundred and twenty-one patients were recruited and randomly assigned to one of the treatments. Primary outcome measures, the same for both arms of t ...
Antidepressants: Update on New Agents and Indications
... FEBRUARY 1, 2003 / VOLUME 67, NUMBER 3 ...
... FEBRUARY 1, 2003 / VOLUME 67, NUMBER 3 ...
Flunitrazepam
... used in the vast majority of cases of date-rape. A recent study conducted by doctors in the U.K. found that none of the subjects reporting spiked drinks had any traces of flunitrazepam or other medications popularly believed to be associated with rape such as GHB. The study claims that binge drinkin ...
... used in the vast majority of cases of date-rape. A recent study conducted by doctors in the U.K. found that none of the subjects reporting spiked drinks had any traces of flunitrazepam or other medications popularly believed to be associated with rape such as GHB. The study claims that binge drinkin ...
General Anaesthetics
... The effects of these drugs depend on previous exposure to opioids: In individuals who have not received opioids (naive patients), mixed agonist– antagonists show agonist activity and are used to relieve pain. In the patient with opioid dependence, the agonist–antagonist drugs may show primaril ...
... The effects of these drugs depend on previous exposure to opioids: In individuals who have not received opioids (naive patients), mixed agonist– antagonists show agonist activity and are used to relieve pain. In the patient with opioid dependence, the agonist–antagonist drugs may show primaril ...
Pharmacokinetics
... and it has an extra layer of cells surrounding them (glial cells). However, fever/inflammation can make the membrane more permeable to some drugs. Exception: The placenta has the ability to block SOME drugs from affecting the fetus with its barrier. ...
... and it has an extra layer of cells surrounding them (glial cells). However, fever/inflammation can make the membrane more permeable to some drugs. Exception: The placenta has the ability to block SOME drugs from affecting the fetus with its barrier. ...
a review on drug approval process for us, europe and india
... International Journal of Drug Regulatory Affairs; 2014, 2(1), 1- 11 ...
... International Journal of Drug Regulatory Affairs; 2014, 2(1), 1- 11 ...
The Argyle Care Home Service - Primary Care Pharmacists
... J Am Geriatr Soc. 2011 Aug;59(8):1477-83 ...
... J Am Geriatr Soc. 2011 Aug;59(8):1477-83 ...
Inhalant Abuse - American Psychological Association
... • How strong are the effects and how long do they last? • What types of effects are produced? • Is the intoxication similar to what is produced by better-known drugs of abuse? • Do all inhalants produce the same effects? • What happens when inhalants are taken in combination with alcohol and other d ...
... • How strong are the effects and how long do they last? • What types of effects are produced? • Is the intoxication similar to what is produced by better-known drugs of abuse? • Do all inhalants produce the same effects? • What happens when inhalants are taken in combination with alcohol and other d ...
Our Genes, Our Drugs and our Future
... enzymes, transporters and receptors contribute to variable drug responses (in addition to environmental , physiological & compliance factors) ...
... enzymes, transporters and receptors contribute to variable drug responses (in addition to environmental , physiological & compliance factors) ...
agomelatine - Assets - Cambridge University Press
... be discontinued • Immediate postpartum period is a high-risk time for depression, especially in women who have had prior depressive episodes, so drug may need to be reinstituted late in the third trimester or shortly after childbirth to prevent a recurrence during the postpartum period ...
... be discontinued • Immediate postpartum period is a high-risk time for depression, especially in women who have had prior depressive episodes, so drug may need to be reinstituted late in the third trimester or shortly after childbirth to prevent a recurrence during the postpartum period ...
Research Report Series from the director:
... are likely to be polydrug abusers, or users of more than one substance. The widespread abuse of cocaine has stimulated extensive efforts to develop treatment programs for cocaine. As with any drug addic tion, this is a complex disease that involves biological changes in the brain as well as myriad ...
... are likely to be polydrug abusers, or users of more than one substance. The widespread abuse of cocaine has stimulated extensive efforts to develop treatment programs for cocaine. As with any drug addic tion, this is a complex disease that involves biological changes in the brain as well as myriad ...
India`s Marketing Regulations of Drugs
... combination is being done for the first time, and a claim is being made, and/or the combination is likely to result in a significant interaction of a pharmacodynamic or pharmacokinetic nature, then it is treated in the same way as any other new drug. The period to take approval for a new drug is not ...
... combination is being done for the first time, and a claim is being made, and/or the combination is likely to result in a significant interaction of a pharmacodynamic or pharmacokinetic nature, then it is treated in the same way as any other new drug. The period to take approval for a new drug is not ...
Practice slide 8 tafreeg 2
... basic drugs usually bind to α-glycoprotein acidic drugs usually bind to albumin a great portion of the drugs are bound to proteins in the blood, but a few of them are found in free form. *the degree of protein binding is variable, rarely from less than 10% to 99% or greater The 1% left which is free ...
... basic drugs usually bind to α-glycoprotein acidic drugs usually bind to albumin a great portion of the drugs are bound to proteins in the blood, but a few of them are found in free form. *the degree of protein binding is variable, rarely from less than 10% to 99% or greater The 1% left which is free ...
annexure-ii
... a model drug having high solubility. In placebo -controlled studies in patients with coronary heart disease and exertional anginal, trimetazidine hydrochlorode enhanced exercised tolerance and delayed ischemia onset without significantly modifying heart rate, blood pressure or both4.Because of its h ...
... a model drug having high solubility. In placebo -controlled studies in patients with coronary heart disease and exertional anginal, trimetazidine hydrochlorode enhanced exercised tolerance and delayed ischemia onset without significantly modifying heart rate, blood pressure or both4.Because of its h ...
Drugs That Act in the Central Nervous System
... schizophrenia and hospitalized. Haloperidol was started at a dose of 10 mg/d. On the second day, he was found to develop a “seizure”. His neck was strained backward with his face turned upward toward the ceiling. He was having difficulty speaking but was quite conscious of his surroundings. The atte ...
... schizophrenia and hospitalized. Haloperidol was started at a dose of 10 mg/d. On the second day, he was found to develop a “seizure”. His neck was strained backward with his face turned upward toward the ceiling. He was having difficulty speaking but was quite conscious of his surroundings. The atte ...
Pharm_Essays!
... effects. Some drugs can increase one’s chances of developing other conditions, for example didanosine (ddI) is a risk factor for pancreatitis. Given to an alcoholic, their chances of developing pancreatitis greatly increase. In this situation, another drug from the NRTI category can be selected whic ...
... effects. Some drugs can increase one’s chances of developing other conditions, for example didanosine (ddI) is a risk factor for pancreatitis. Given to an alcoholic, their chances of developing pancreatitis greatly increase. In this situation, another drug from the NRTI category can be selected whic ...
NIDA - Laurel Business Institute
... The Drug Enforcement Agency (DEA) schedule indicates the drug’s acceptable medical use and its potential for abuse or dependence. More information can be found on the DEA website. Alcohol People drink to socialize, celebrate, and relax. Alcohol often has a strong effect on people—and throughout hist ...
... The Drug Enforcement Agency (DEA) schedule indicates the drug’s acceptable medical use and its potential for abuse or dependence. More information can be found on the DEA website. Alcohol People drink to socialize, celebrate, and relax. Alcohol often has a strong effect on people—and throughout hist ...
Appendix J
... The investigation will be conducted under a valid IND number provided by the sponsor, CRO or FDA (Provide a copy of the FDA determination letter if available. Acknowledgement Evidence of the IND number on the Master Protocol serves as a protocol – specific reference and is acceptable evidence of the ...
... The investigation will be conducted under a valid IND number provided by the sponsor, CRO or FDA (Provide a copy of the FDA determination letter if available. Acknowledgement Evidence of the IND number on the Master Protocol serves as a protocol – specific reference and is acceptable evidence of the ...
A REVIEW ON BIOAVAILABILITY AND BIOEQUIVALENCE TRIALS AND ITS NECESSITY
... The study should be designed in such a manner that the formulation effect can be distinguished from other effects. Typically, if two formulations are to be compared, a two‐period, two‐sequence crossover design is the design of choice with the two phases of treatment s ...
... The study should be designed in such a manner that the formulation effect can be distinguished from other effects. Typically, if two formulations are to be compared, a two‐period, two‐sequence crossover design is the design of choice with the two phases of treatment s ...
Uppers, Downers, All Arounders, 7th Edition
... The other major effect of opioids involves endorphins and dopamine and their effect on the reward/control pathway. The normal activation of this system produces a surge of pleasure that encourages repeating the action, such as eating or having sex. Dopamine released in this pathway helps the brain r ...
... The other major effect of opioids involves endorphins and dopamine and their effect on the reward/control pathway. The normal activation of this system produces a surge of pleasure that encourages repeating the action, such as eating or having sex. Dopamine released in this pathway helps the brain r ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.