Gemcitabine
... Overall, the Committee noted that there is no evidence gemcitabine (Gemzar) provides added clinical benefit over the current standard treatment. Relevant economic information was also lacking to establish the cost-effectiveness of this drug. The CED worked jointly with a subcommittee involving cance ...
... Overall, the Committee noted that there is no evidence gemcitabine (Gemzar) provides added clinical benefit over the current standard treatment. Relevant economic information was also lacking to establish the cost-effectiveness of this drug. The CED worked jointly with a subcommittee involving cance ...
Enhancement of Dissolution Rate of Naproxen by Lipid Based Solid
... HCL than the 7.4 PH phosphate buffer This might be due to the basic nature of pure drug naproxen. In vitro drug release In vitro drug release studies of all the prepared LBSD’s of naproxen were carried out in 0.1 N HCL and the % of drug release was calculated at various time intervals up to 2h. Grap ...
... HCL than the 7.4 PH phosphate buffer This might be due to the basic nature of pure drug naproxen. In vitro drug release In vitro drug release studies of all the prepared LBSD’s of naproxen were carried out in 0.1 N HCL and the % of drug release was calculated at various time intervals up to 2h. Grap ...
Breakthrough Seizures—Approach to Prevention
... adherence can lead to the emergence of breakthrough seizures and all of the associated complications. When assessing the causes of a breakthrough seizure, the clinician must first establish whether the patient in question has been adherent to the prescribed AEDs. Both patient and medication factors ...
... adherence can lead to the emergence of breakthrough seizures and all of the associated complications. When assessing the causes of a breakthrough seizure, the clinician must first establish whether the patient in question has been adherent to the prescribed AEDs. Both patient and medication factors ...
Glossary of Clinical Trial Terms
... disease (such as leukemia) to a similar group of people without that disease. This type of study compares the levels of exposure (for example, radiation or chemical) each group had before appearance of the disease.1 CLINICAL: Pertaining to or founded on observation and treatment of human participant ...
... disease (such as leukemia) to a similar group of people without that disease. This type of study compares the levels of exposure (for example, radiation or chemical) each group had before appearance of the disease.1 CLINICAL: Pertaining to or founded on observation and treatment of human participant ...
汤慧芳
... active against atypical mycobacteria. Moxifloxacin is the most active against M tuberculosis by weight in vitro. Levofloxacin tends to be slightly more active than ciprofloxacin against M tuberculosis, Ciprofloxacin is slightly more active against atypical mycobacteria. Fluoroquinolones are an impor ...
... active against atypical mycobacteria. Moxifloxacin is the most active against M tuberculosis by weight in vitro. Levofloxacin tends to be slightly more active than ciprofloxacin against M tuberculosis, Ciprofloxacin is slightly more active against atypical mycobacteria. Fluoroquinolones are an impor ...
Germinating seeds of the mung bean, Vigna radiata (Fabaceae), as
... rapid and inexpensive screening of drugs exhibiting cytotoxic properties. Mung beans were allowed to germinate either in tap water or in different drug solutions, and parameters like percent germination, increase in radicle length, change in seedling weight and mitotic index of apical root meristems ...
... rapid and inexpensive screening of drugs exhibiting cytotoxic properties. Mung beans were allowed to germinate either in tap water or in different drug solutions, and parameters like percent germination, increase in radicle length, change in seedling weight and mitotic index of apical root meristems ...
Surrogate End Points
... outcomes”, are often very time consuming and expensive (but not impossible) to study. In a stroke prevention randomised controlled trail (RCT), for example, researchers would have to recruit 10,000 participants and wait for five years for the results. In comparison, surrogate endpoints are much fast ...
... outcomes”, are often very time consuming and expensive (but not impossible) to study. In a stroke prevention randomised controlled trail (RCT), for example, researchers would have to recruit 10,000 participants and wait for five years for the results. In comparison, surrogate endpoints are much fast ...
Drug reaction with eosinophilia and systemic symptoms
... Introduction: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially lifethreatening, drug-induced hypersensitivity reaction that includes skin eruptions, fever, lymphadenopathy, hematological abnormalities, and internal organ involvement. Objective: To present a rare conditi ...
... Introduction: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially lifethreatening, drug-induced hypersensitivity reaction that includes skin eruptions, fever, lymphadenopathy, hematological abnormalities, and internal organ involvement. Objective: To present a rare conditi ...
Basic info about Iboga
... Also important to take into account is that ibogaine has a series of risk factors: it lowers the heart rate and prolongs the QT interval of the EKG. People with pre-existing heart conditions such as vulnerability to heart attacks, arrhythmia or a naturally slow heart rate (e.g. sports heart) should ...
... Also important to take into account is that ibogaine has a series of risk factors: it lowers the heart rate and prolongs the QT interval of the EKG. People with pre-existing heart conditions such as vulnerability to heart attacks, arrhythmia or a naturally slow heart rate (e.g. sports heart) should ...
Xatral (alfuzosin hydrochloride)
... Cardiovascular XATRAL is not indicated for the treatment of hypertension. As with all alpha1-blockers in some patients, in particular, patients receiving antihypertensive medications, postural hypotension with or without dizziness or other symptoms may develop within a few hours following administra ...
... Cardiovascular XATRAL is not indicated for the treatment of hypertension. As with all alpha1-blockers in some patients, in particular, patients receiving antihypertensive medications, postural hypotension with or without dizziness or other symptoms may develop within a few hours following administra ...
Quality Assessment of the Commonly Prescribed Antimicrobial Drug
... calculating the percent of drug released and calibration curve for the dissolution was set. 2.2.5 Assay of ciprofloxacin tablets All the eight drug products were assayed for the drug content according to the method outlined in the individual drug monographs of the British Pharmacopoeia (BP, 2004). T ...
... calculating the percent of drug released and calibration curve for the dissolution was set. 2.2.5 Assay of ciprofloxacin tablets All the eight drug products were assayed for the drug content according to the method outlined in the individual drug monographs of the British Pharmacopoeia (BP, 2004). T ...
Thorough QTc Studies: Patients at Heart...
... avoid biased results due to the autonomic variability in patients with advanced stage Parkinson’s disease. Time – matched QTc changes from baseline at separate data points of the study (ΔQTc values) are also presented. These are more detailed than the normalized areas under the QTc curve. Parallel-g ...
... avoid biased results due to the autonomic variability in patients with advanced stage Parkinson’s disease. Time – matched QTc changes from baseline at separate data points of the study (ΔQTc values) are also presented. These are more detailed than the normalized areas under the QTc curve. Parallel-g ...
"Off-Label" Drug Use - Consumer Reports Health
... To put it very simply, some cancer drugs are quite broad-based and can be used to treat several (or many) different types of cancer (though they may be variously effective). Others are more specific, and target only one or two types of cancer. That was true 30 years ago and is still true today even ...
... To put it very simply, some cancer drugs are quite broad-based and can be used to treat several (or many) different types of cancer (though they may be variously effective). Others are more specific, and target only one or two types of cancer. That was true 30 years ago and is still true today even ...
This PDF is a selection from an out-of-print volume from... of Economic Research
... in the operant chamber. The left panels show the two groups that were exposed to glucose-plussaccharin in the home cage, while the right panels show the groups exposed to only water in the home cage. ...
... in the operant chamber. The left panels show the two groups that were exposed to glucose-plussaccharin in the home cage, while the right panels show the groups exposed to only water in the home cage. ...
Conducting Stability Studies
... also ensure that patients receive a safe and effective medicine. To ensure that this happens, drug manufacturers need to thoroughly follow regulations and guidelines and watch for material study results. Taking particular ...
... also ensure that patients receive a safe and effective medicine. To ensure that this happens, drug manufacturers need to thoroughly follow regulations and guidelines and watch for material study results. Taking particular ...
Pay Attention: Ritalin Acts Much Like Cocaine
... it. They also plan to map dopamine levels in volunteers who have ADHD when they are at rest or while concentrating. Other research will search for molecular tools to screen children for dopamine transporter levels; those with high levels could be identified early and encouraged with behavioral solut ...
... it. They also plan to map dopamine levels in volunteers who have ADHD when they are at rest or while concentrating. Other research will search for molecular tools to screen children for dopamine transporter levels; those with high levels could be identified early and encouraged with behavioral solut ...
Clinical Slide Set. Depression
... television 8.Moving or speaking so slowly that others have noticed, or the opposite ...
... television 8.Moving or speaking so slowly that others have noticed, or the opposite ...
Pharmacotherapy (Non-Opioid)
... When introducing a new treatment, consider overlap with old treatments to avoid deterioration in pain control. If the new medication is well tolerated, then continue to titrate to effective or acceptable pain relief (30% to 50% reduction) Consider adding a second agent with a different mechani ...
... When introducing a new treatment, consider overlap with old treatments to avoid deterioration in pain control. If the new medication is well tolerated, then continue to titrate to effective or acceptable pain relief (30% to 50% reduction) Consider adding a second agent with a different mechani ...
Neurobiological substrates for the dark side of compulsivity in
... 1952). Although Wikler argued that positive reinforcement was retained even in heavily dependent subjects (thrill of the intravenous opioid injection), dependence produced a new source of gratification, that of negative reinforcement (see above). The concept of motivation was linked inextricably with ...
... 1952). Although Wikler argued that positive reinforcement was retained even in heavily dependent subjects (thrill of the intravenous opioid injection), dependence produced a new source of gratification, that of negative reinforcement (see above). The concept of motivation was linked inextricably with ...
4941 MD Advisor
... Drug Safety? Despite the efforts of the FDA to ensure the safety of prescription drugs and oversee the information provided to physicians, there continues to be much information about drug studies that goes undisclosed. While often too complex for patients to understand, clinical trial results are u ...
... Drug Safety? Despite the efforts of the FDA to ensure the safety of prescription drugs and oversee the information provided to physicians, there continues to be much information about drug studies that goes undisclosed. While often too complex for patients to understand, clinical trial results are u ...
Chapter 3: Effects Of Amphetamine-Type Stimulants
... clinically relevant. The authors also highlighted their observation that drug histories were often poorly reported and polydrug use was mostly not controlled. A study by Roiser and Sahakain (2004) compared current and ex-ecstasy users with polydrug users who had never used MDMA and found no signific ...
... clinically relevant. The authors also highlighted their observation that drug histories were often poorly reported and polydrug use was mostly not controlled. A study by Roiser and Sahakain (2004) compared current and ex-ecstasy users with polydrug users who had never used MDMA and found no signific ...
THE ROLE OF LIPIDS IN DRUG ABSORPTION THROUGH THE GIT
... and Muller, 2007). LN can also be composed of PPL, which are used as surfactants surfacing the nanoparticles and stabilizing them in aqueous dispersions. LN are characterized by a solid matrix revealing high physicochemical stability, including the possibility to achieve controlled release and also ...
... and Muller, 2007). LN can also be composed of PPL, which are used as surfactants surfacing the nanoparticles and stabilizing them in aqueous dispersions. LN are characterized by a solid matrix revealing high physicochemical stability, including the possibility to achieve controlled release and also ...
Spiga et al, 2010
... DA outflow in the NAcc shell (Tanda, Loddo & Di Chiara 1999). This functional evidence suggests that cannabinoid withdrawal may structurally alter cellular elements of the mesolimbic system as it was recently shown for opiate dependence (Spiga et al. 2003, 2005; Diana, Spiga & Acquas 2006). Accordin ...
... DA outflow in the NAcc shell (Tanda, Loddo & Di Chiara 1999). This functional evidence suggests that cannabinoid withdrawal may structurally alter cellular elements of the mesolimbic system as it was recently shown for opiate dependence (Spiga et al. 2003, 2005; Diana, Spiga & Acquas 2006). Accordin ...
Results of Some Urological Problems with Cernilton
... The results achieved in the cases presented above are similar to those obtained by the other authors. Allergic reaction to the main substance of the drug (pollen) in some individuals is a very well known factor. Cernilton, being a pollen extract also arouses the same dubious thought. But in 1960 Hel ...
... The results achieved in the cases presented above are similar to those obtained by the other authors. Allergic reaction to the main substance of the drug (pollen) in some individuals is a very well known factor. Cernilton, being a pollen extract also arouses the same dubious thought. But in 1960 Hel ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.