Postnatal Development of the Corticospinal Tract in the Reeler Mouse
... were anesthetized with 3.5% chloral hydrate by intraperitoneal injection and clamped in a stereotactic apparatus with auxiliary devices. Following an incision of skin, a small bur hole was made in the left parietal bone using a dental drill. A single injection of 0.1 l of 10% DiI solution dissolved ...
... were anesthetized with 3.5% chloral hydrate by intraperitoneal injection and clamped in a stereotactic apparatus with auxiliary devices. Following an incision of skin, a small bur hole was made in the left parietal bone using a dental drill. A single injection of 0.1 l of 10% DiI solution dissolved ...
Postnatal characterization of cells in the accessory olfactory bulb of
... this arrangement was disrupted in reeler (Figure 4V, arrows). Periglomerular cells expressing TH were confined to the edges of the AOB glomeruli at all postnatal ages (Figure 4, TH) and no differences were detected between wt (Figures 4E,K,Q,W) and reeler mice (Figures 4F,L,R,X). With respect to CB ...
... this arrangement was disrupted in reeler (Figure 4V, arrows). Periglomerular cells expressing TH were confined to the edges of the AOB glomeruli at all postnatal ages (Figure 4, TH) and no differences were detected between wt (Figures 4E,K,Q,W) and reeler mice (Figures 4F,L,R,X). With respect to CB ...
BDNF-modulated Spatial Organization of Cajal
... the upper cortical layers, which most likely requires the presence of reelin-secreting interneurons in layers V--VI. We propose that in addition to modulating reelin expression, BDNF regulates the patched distribution of CR and GABAergic neurons in the MZ, and that this spatial distribution is invol ...
... the upper cortical layers, which most likely requires the presence of reelin-secreting interneurons in layers V--VI. We propose that in addition to modulating reelin expression, BDNF regulates the patched distribution of CR and GABAergic neurons in the MZ, and that this spatial distribution is invol ...
RESULTATS Capítol 1 __________________________________________________________________________ 71
... by specific signals as the main mechanism by which neuronal connections are first established between brain areas (Huber et al., 2003; Mueller, 1999), while activitydependent plasticity has been proposed as a mechanism for the final refinement and maturation of connections (Katz and Shatz, 1996). A ...
... by specific signals as the main mechanism by which neuronal connections are first established between brain areas (Huber et al., 2003; Mueller, 1999), while activitydependent plasticity has been proposed as a mechanism for the final refinement and maturation of connections (Katz and Shatz, 1996). A ...
Redalyc.Normal neuronal migration
... layer formed by the marginal zone and the subplate. The marginal zone harbors the Cajal-Retzius reelin positive neurons and reelin negative neurons. Reelin, besides signaling stop to migrating neurons, also participates in ordering the cortical layers; it is known that in mutant mice lacking reelin ...
... layer formed by the marginal zone and the subplate. The marginal zone harbors the Cajal-Retzius reelin positive neurons and reelin negative neurons. Reelin, besides signaling stop to migrating neurons, also participates in ordering the cortical layers; it is known that in mutant mice lacking reelin ...
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... Fig. 2. a–c: Specificity of Dab1 immunoreactivity in the mouse brain. a: Anti-Dab1 C-terminus antibody shows a specific signal in cortical neurons of reeler mouse. There is an intense staining in the cytoplasm in neurons. b: Black arrow indicates a cell with intense staining in plasma membrane. c: T ...
... Fig. 2. a–c: Specificity of Dab1 immunoreactivity in the mouse brain. a: Anti-Dab1 C-terminus antibody shows a specific signal in cortical neurons of reeler mouse. There is an intense staining in the cytoplasm in neurons. b: Black arrow indicates a cell with intense staining in plasma membrane. c: T ...
Signaling by truncated Dab1 protein - Development
... 310 C-terminal residues of unknown function. We have generated mutant mice that express only a natural splice form of Dab1, p45, that lacks the C-terminal region of p80. The normal development of these mice implies that the receptor-binding region and tyrosine phosphorylation sites of p80 are suffic ...
... 310 C-terminal residues of unknown function. We have generated mutant mice that express only a natural splice form of Dab1, p45, that lacks the C-terminal region of p80. The normal development of these mice implies that the receptor-binding region and tyrosine phosphorylation sites of p80 are suffic ...
Impaired Reelin-Dab1 Signaling Contributes to
... higher Cul5, Dab1, and pSFK expression in CKO than WT. (D) Western blot does not show abnormal expression of Reelin Dab1 signaling molecules by Tsc2 heterozygote. Scale bar: 40 m. ...
... higher Cul5, Dab1, and pSFK expression in CKO than WT. (D) Western blot does not show abnormal expression of Reelin Dab1 signaling molecules by Tsc2 heterozygote. Scale bar: 40 m. ...
R eelin is expressed in the accessory olfactory system, but is not a
... mutants showed patterns of vomeronasal nerve labeling that were not obviously different from controls (Fig. 2). In reeler mutants and wild-type mice, vomeronasal sensory neurons labeled by the VN12-IRES-lacZ transgene originate in the VNO and soon after leaving the VNO form bundles of axons. Initial ...
... mutants showed patterns of vomeronasal nerve labeling that were not obviously different from controls (Fig. 2). In reeler mutants and wild-type mice, vomeronasal sensory neurons labeled by the VN12-IRES-lacZ transgene originate in the VNO and soon after leaving the VNO form bundles of axons. Initial ...
Reelin and apolipoprotein E receptor 2 in the embryonic and mature
... MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK In the mature cerebral cortex of higher vertebrates, neurons are arranged in layers, each layer containing neurons of the same functional class. The cortical layering pattern is laid down during developme ...
... MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK In the mature cerebral cortex of higher vertebrates, neurons are arranged in layers, each layer containing neurons of the same functional class. The cortical layering pattern is laid down during developme ...
Reelin
Reelin is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like subventricular and subgranular zones. It is found not only in the brain, but also in the spinal cord, blood, and other body organs and tissues.Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has been found to be significantly lower in schizophrenia and psychotic bipolar disorder, but the cause of this observation remains uncertain as studies show that psychotropic medication itself affects reelin expression. Moreover, epigenetic hypotheses aimed at explaining the changed levels of reelin expression are controversial. Total lack of reelin causes a form of lissencephaly. Reelin may also play a role in Alzheimer's disease, temporal lobe epilepsy and autism.Reelin's name comes from the abnormal reeling gait of reeler mice, which were later found to have a deficiency of this brain protein and were homozygous for mutation of the RELN gene.The primary phenotype associated with loss of reelin function is a failure of neuronal positioning throughout the developing central nervous system (CNS). The mice heterozygous for the reelin gene, while having little neuroanatomical defects, display the endophenotypic traits linked to psychotic disorders.