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Extract from Clinical Evaluation Report: Riociguat
Extract from Clinical Evaluation Report: Riociguat

... First round benefit-risk assessment ______________________________ 87 11.1. First round assessment of benefits________________________________________ 87 11.2. First round assessment of risks ___________________________________________ 88 11.3. First round assessment of benefit-risk balance ________ ...
Practice Guidelines for Sedation and Analgesia by Non
Practice Guidelines for Sedation and Analgesia by Non

... Sedation and Analgesia : There is insufficient published evidence to evaluate the relationship between sedation / analgesia ...
Current topical and systemic approaches to treatment of rosacea
Current topical and systemic approaches to treatment of rosacea

... regard to effectiveness: metronidazole cream, gel and lotion have been shown to have similar efficacy, regardless of whether a concentration of 0.75% or 1% is chosen or a once-daily or twice-daily regimen.24 The efficacy of topical metronidazole vs. a placebo has been demonstrated in various trials; ...
C Diagnosis and Management of Hiccups in the Patient with Advanced Cancer
C Diagnosis and Management of Hiccups in the Patient with Advanced Cancer

... as within head and neck structures). For instance, irritation of the auricular branch of the vagus nerve (Arnold’s nerve), which innervates the auditory canal, by cerumen, foreign bodies, bugs, and even hair, has resulted in hiccups.16 CNS areas such as the brainstem respiratory center, the reticula ...
BCBSM Prior Authorization and Step Therapy Guidelines
BCBSM Prior Authorization and Step Therapy Guidelines

... authorization. This ensures that you have tried the preferred alternatives — drugs with a proven track record that may be better tolerated, less expensive or less likely to cause interactions — and the drug is being prescribed appropriately. If your doctor doesn’t get prior authorization when requir ...
Int J Tuberc Lung Dis 2004: 8 (11 Suppl 1): S1
Int J Tuberc Lung Dis 2004: 8 (11 Suppl 1): S1

... occurring in 2000, 41% were in Sub-Saharan Africa with a further 34% in South Asia. In sub-Saharan Africa the distribution of deaths was as follows: diarrhoea (20%), pneumonia (21%), malaria (22%), AIDS (8%) and neonatal causes (25%). Pneumonia and diarrhoea account for a large proportion of child d ...
Migraine – More than a Headache
Migraine – More than a Headache

... bring your diary with you to your appointments. It will allow you and your physician to see your progress at a glance. Unusual Forms of Migraine As you understand by now migraine is more than a headache. It is a constellation of symptoms and headache is not necessarily an essential part. It is extre ...
Drug and Alcohol Withdrawal Clinical Practice
Drug and Alcohol Withdrawal Clinical Practice

... The New South Wales drug and alcohol withdrawal clinical practice guidelines provide the most up to date knowledge and current level of best practice for the treatment of withdrawal, also called detoxification, from alcohol and other drugs such as benzodiazepines, heroin and other opioids, cannabis, ...
SERIES ‘‘UPDATE ON TUBERCULOSIS’’ Number 4 in this Series
SERIES ‘‘UPDATE ON TUBERCULOSIS’’ Number 4 in this Series

... the treatment programme. In a cluster randomised controlled trial examining the effectiveness of a strategy to improve adherence to tuberculosis treatment in a resource-poor setting, the intervention package based on improved patient counseling and communication, decentralisation of treatment delive ...
Provincial Guidelines for the Management of Epilepsy in Adults and
Provincial Guidelines for the Management of Epilepsy in Adults and

... 2012). However, not all individuals with epilepsy are candidates for surgery – approximately one third of those suffering from medically refractory epilepsy will not be considered candidates. Despite its effectiveness, surgical treatment is underutilized in Ontario, with only a fraction of the popul ...
Lithium MonitoringAppendices_Final_Version_1_Feb 2012
Lithium MonitoringAppendices_Final_Version_1_Feb 2012

... Lithium is usually best given as a single dose at night. 1 All blood samples taken for monitoring of lithium levels should be done approximately 12-16 hours following the last dose of drug. 2 This is important and failure to do so may result in misleading results and consequently ill informed clinic ...
Treatment with leptin
Treatment with leptin

... of relatively recent onset (<5 years). ...
provincial guidelines for the management of epilepsy in adults and
provincial guidelines for the management of epilepsy in adults and

... 2012). However, not all individuals with epilepsy are candidates for surgery – approximately one third of those suffering from medically refractory epilepsy will not be considered candidates. Despite its effectiveness, surgical treatment is underutilized in Ontario, with only a fraction of the popul ...
PRIAPISM INDUCED WITH SINGLE ORAL DOSE OF SILDENAFIL: A RARE CASE REPORT  Research Article 
PRIAPISM INDUCED WITH SINGLE ORAL DOSE OF SILDENAFIL: A RARE CASE REPORT  Research Article 

... tachycardia, palpitation, anemia and leukopenia are observed .Non‐ arteritic  anterior  ischemic  optic  neuropathy  (NAION),  a  cause  of  decreased  vision  including  permanent  loss  of  vision,  has  been  reported rarely.10  An  extensive  review  of  the  published  medical  literature  and  ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights

... or alcohol abuse or addiction) or mental illness (e.g., major depressive disorder). Routinely monitor all patients receiving KADIAN for signs of misuse, abuse, and addiction during treatment [see Drug Abuse and Dependence (9)]. Life-threatening Respiratory Depression Respiratory depression, includin ...
E - Morgan Joseph
E - Morgan Joseph

... obese (35.7 BMI), had abnormally high cholesterol levels, had a family history of coronary artery disease, and, on further evaluation via angiography, was found to have coronary artery disease. We note that triptans are not recommended for patients who have uncontrolled hypertension, ischemic heart ...
Edited by Scott Cuthbert, DC - International College of Applied
Edited by Scott Cuthbert, DC - International College of Applied

... associated with adrenal dysfunction in AK were the primary muscle/organ relationship found on MMT, and uterine lift technique was also given. Following her first treatment, her next menstrual cycle was 90% pain free for the first time in many years. Four months later the patient’s menstrual cycle wa ...
Section 3: Antiallergics and Medicines Used in Anaphylaxis
Section 3: Antiallergics and Medicines Used in Anaphylaxis

... This application has reviewed the efficacy and safety of first generation antihistamines (FGAHs) - chlorphenamine and diphenhydramine for section 3 of EML and EMLc as requested by the 18th Expert Committee. The application also reviewed the efficacy and safety of three second generation antihistamin ...
Non-steroidal anti-inflammatory drugs (NSAIDs)
Non-steroidal anti-inflammatory drugs (NSAIDs)

... (Grimmer et al 1998). Analgesics and non-steroidal antiinflammatory drugs (NSAIDs) are the most common pharmaceuticals for alleviating the pain and reduced function of musculoskeletal conditions (Moore et al 1998). Concerns have been formally expressed in Australia regarding physiotherapists’ role i ...


... parameters influencing efficiency and limiting APD adequacy. Using NTPD only, patients with a 4-hour creatinine (Cr) D/P > 0.65 and total volumes between 25 L and 30 L per session can reach a peritoneal creatinine clearance (CrCl) higher than 50 L per week (14). This result is also confirmed by Twar ...
The Royal Marsden - Sutton NewApproachComprehensive
The Royal Marsden - Sutton NewApproachComprehensive

Non-invasive ventilation in acute respiratory failure
Non-invasive ventilation in acute respiratory failure

... Knowledge of arterial blood gases is essential before making a decision as to whether NIV is indicated. The patient should first be established on appropriate oxygen therapy and the arterial blood gases interpreted in light of the FiO2. A proportion of patients who fulfil arterial blood gas criteria ...
Full protocol V9 06082013
Full protocol V9 06082013

... Colistin has resurged in the last decade for the treatment of multidrug-resistant Gram-negative bacteria due to lack of other antibiotics. This antibiotic, firstly discovered in 1947, belongs to the polymyxin family and is a mixture of polymyxin E1 and polymyxin E2. The polymyxins act by disrupting ...
Outcomes of heart failure discharge instructions
Outcomes of heart failure discharge instructions

... discharge education, there is little evidence about its impact on patient or readmission outcomes. The purpose of this study was to determine the relationship between the completion of heart failure discharge instructions as defined by the Joint Commission core measure HF1 in a single site, 500 bed ...
National Medical Policy  Subject: Vitiligo
National Medical Policy Subject: Vitiligo

... especially those with moderate-to-severe disease, although it appears to be most efficacious on the face and neck than on other areas of the body. Many studies of treatments for vitiligo are of poor quality and so evidence is limited, particularly for the long-term benefits and safety of therapies. ...
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