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Title Improving clinical trial efficiency by biomarker
Title Improving clinical trial efficiency by biomarker

... Correspondence address: TNO, Utrechtseweg 48, 3704 HE, Zeist, The Netherlands. ...
CAP : Cyclophosphamide / Doxorubicin / Cisplatin in Malignant
CAP : Cyclophosphamide / Doxorubicin / Cisplatin in Malignant

... 1litre Sodium Chloride 0.9% + 20mmol KCl + 1g MgSO4 IV infusion over 60 minutes Cisplatin, in 1litre Sodium Chloride 0.9% IV over 2 hours 1litre Sodium Chloride 0.9% + 40mmol KCl + 1g MgSO4 IV infusion over 2 hours Then either 500ml Sodium Chloride 0.9% IV infusion over 60 minutes or 500ml drinking ...
Regulation for Oncology Services 2016
Regulation for Oncology Services 2016

... Disabled People (also known as special needs) shall be defined as a personal condition or situation that can make it difficult for a patient to participate fully in their health care, which include disability (physical, intellectual or sensory disability), age affected (either elderly or very young) ...
Terbutaline Sulfate Injection, USP
Terbutaline Sulfate Injection, USP

... should be used with caution in patients with cardiovascular disorders, including ischemic heart disease, hypertension, and cardiac arrhythmias; in patients with hyperthyroidism or diabetes mellitus; and in patients who are unusually responsive to sympathomimetic amines or who have convulsive disorde ...
A Phase I and Pharmacokinetic Study of
A Phase I and Pharmacokinetic Study of

... Drug Preparation and Administration. Sodium phenylacetate for injec tion was prepared from bulk sodium phenylacetate powder supplied by Elan Pharmaceutical Research Co. (Gainesville, GA). The finished injectable stock solution was manufactured by the Pharmaceutical Development Service, Phar macy Dep ...
QA42_7_Opioidconversions
QA42_7_Opioidconversions

... Equivalent doses of opioids are given in Table 1. These are an approximate guide only because comprehensive data are lacking and there is inter-individual variation (3). In addition, it should be noted that sources differ in the equivalent doses they quote. Caution is required and careful monitoring ...
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of

... ranges from 24 to 53 per 100,000 individuals.(1,2) Between 70 and 80% of individuals are successfully treated with one of the more than 20 antiepileptic drugs (AED) now available with success rates primarily depending on the etiology of the seizure disorder. However, 20 to 30% of patients have eithe ...
Clinical Handbook for Heart Failure
Clinical Handbook for Heart Failure

... the Quality-Based Procedures Clinical Handbook and all content in the “Purpose” and “Introduction to QualityBased Procedures” sections were provided in standard form by the Ministry. All other content was developed by Health Quality Ontario with input from the expert advisory panel. As it is based i ...
- Annals of Emergency Medicine
- Annals of Emergency Medicine

... abscesses were randomized to incision and drainage with packing or ultrasonographically guided needle aspiration. Purulence obtained from the abscess was cultured to identify the causative organism. Bedside ultrasonography was performed pre- and postintervention to confirm the presence or absence of ...
Urticaria and Angioedema: A Practical Approach
Urticaria and Angioedema: A Practical Approach

... cal examination findings, especially in patients with chronic urticaria.4,5 Acute urticaria is self-limited and requires minimal laboratory evaluation. In asymptomatic patients with chronic urticaria and minimal history or physical examination findings, clinical practice guidelines suggest considera ...
Article - Mohammed N. Khan, M.D. The NEW ENGLAND JOURNAL
Article - Mohammed N. Khan, M.D. The NEW ENGLAND JOURNAL

... or without the use of antiarrhythmic medications (Fig. 2). At 6 months, there had been eight repeat procedures for recurrent atrial fibrillation (in four patients) and atrial flutter or atrial tachycardia (in four other patients), and 88% of patients in the pulmonary-vein isolation group had freedom ...
Surgical Palliative Care: A Resident`s Guide
Surgical Palliative Care: A Resident`s Guide

... I founded the Cunniff-Dixon Foundation in 2005 to honor my late wife—Carley Cunniff—and the care she received from Peter Dixon, MD, a physician who practices oncology in Lyme, CT. Carley, who was well-regarded on Wall Street for her acumen as an investment analyst and manager, discovered a small lum ...
Triage and Emergency Treatments: Quick Check Essentials
Triage and Emergency Treatments: Quick Check Essentials

... More than one treatment may need to be given as quickly as possible. Several people may need to work together as a team. The person in charge should assign tasks such has placing an IV or giving emergency medications. These guidelines are intended to help guide management of patients with severe ill ...
CHOOSING WISELY table AAFP. 1.2014 pdf
CHOOSING WISELY table AAFP. 1.2014 pdf

... discussions should include the option of deactivating the implantable cardioverterdefibrillator when it no longer supports the patient’s goals. There is no evidence that hypercholesterolemia, or low high-density lipoprotein cholesterol is an important risk factor for all-cause mortality, coronary he ...
Microscopic colitis: an unfamiliar but treatable disease
Microscopic colitis: an unfamiliar but treatable disease

... summarised in a meta-analysis.18 Only one small study examining the use of probiotics was included. In this study, 21 patients used a combination of Lactobacillus acidophilus and Bifidobacterium animalis subspecies Lactis and eight patients were treated with placebo. No statistically significant dif ...
Document
Document

... NMFF, the patient will designate in her signed consent the disposition of the oocytes if she dies, abandons them, or fails to pay her storage fee. Oocytes will be stored at NMFF for a maximum of three years. At the end of three years, if oocytes are still available, subjects will be asked to choose ...
Immune Thrombocytopenia
Immune Thrombocytopenia

... Overall the outcome of ITP is variable, highly individualised and there is no way to predict the course of the disease. Adults are more likely to develop chronic ITP and spontaneous recovery is uncommon.27 Many adult ITP patients, however, experience mild and stable disease requiring no treatment. I ...
12 Medical-Surgical Asepsis and Infection Prevention and Control
12 Medical-Surgical Asepsis and Infection Prevention and Control

... known microorganisms (pathogens) that do cause specific diseases or infections. Any patient entering a health care facility is at a greater risk of developing an infection because of lowered resistance, increased exposure to numbers and types of disease-causing organisms, or the need for an invasive ...
Ibuprofen lysine (NeoProfen) for the treatment of patent ductus
Ibuprofen lysine (NeoProfen) for the treatment of patent ductus

... to the tissue; therefore, it should be administered carefully to avoid extravasation. Ibuprofen is known to displace bilirubin from albumin binding sites and should be used with caution in patients with an elevated total bilirubin level (4). Studies have yet to determine the long-term effects of ibu ...
the impact of intraoperative transoesophageal echocardiography on
the impact of intraoperative transoesophageal echocardiography on

... expanding role in peri-operative management and surgical decision making. Objectives: Studies of the effect of transoesophageal echocardiography (TOE) on intraoperative decision making commonly emphasise major changes in operative plans. We examined more subtle effects using a novel scale, recording ...
Opioid Drugs in Patients With Liver Disease: A Systematic Review
Opioid Drugs in Patients With Liver Disease: A Systematic Review

... contribution of the liver to the metabolism of carbohydrates, protein, drugs and toxins, fats and cholesterol and many other biological processes are still unknown. Liver disorders are classified into two types: acute and chronic. Different drugs are used in liver diseases to treat and control pain. ...
Herbs
Herbs

... Hui K.M., Wang X.H. & Xue H. (2000) Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Medica 66, 91-3. Barceloux D.G. (2008) Medical Toxicology of Natural Substances: Foods, fungi, medicinal herbs, plants, and venomous animals. John Wiley & Sons I ...
brufen sustained release (sr)
brufen sustained release (sr)

... or duration of use, but can occur at any time without warning. Upper GI ulcers, gross bleeding or perforation caused by NSAIDs occur in approximately 1% of patients treated for 3-6 months and in about 2-4% of patients treated for one year. These trends continue with longer duration of use, increasin ...
Lidocaine -An Old Drug for New Indication
Lidocaine -An Old Drug for New Indication

... its anti inflammatory and direct spasmolytic actions. Various clinical studies have been conducted to assess the role of Lidocaine in asthma management with convincing results showing reduction in steroid dose or discontinuation of steroid therapy associated with improvement in quality of life, mark ...
THE FIRST-AND-ONLY ONE DOSE IV treatment for flu
THE FIRST-AND-ONLY ONE DOSE IV treatment for flu

... These highlights do not include all the information needed to use RAPIVAB safely and effectively. See full prescribing information for RAPIVAB. RAPIVAB™ (peramivir injection), for intravenous use Initial U.S. Approval: [2014] ----------------------------INDICATIONS AND USAGE------------------------- ...
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