A Novel Mechanism and Treatment Target for Presynaptic
... the brain (Hess et al, 1992). These mice have a regionally
specific greater level of noradrenalin but lower glutamate,
dopamine, and serotonin neurotransmission, delayed acquisition of motor milestones, and hyperactivity as adults
(Heyser et al, 1995; Jones et al, 2001; Raber et al, 1997).
Increased D-amino acid oxidase
... genotyped two SNPs in each gene. The SNPs were selected based on three pragmatic
criteria: a) the SNP is amongst those most strongly associated with schizophrenia in each
gene, b) the SNP has a high minor allele frequency, and c) the SNP tags a haplotype
block.S8,S10 In DAO, we chose rs2070587 (G/T) ...
Advances in schizophrenia
... Since then there have been several other positive linkage results (Table 1). Many of the initial findings, however, have
not been fully reproduced. Even in cases where initial observations were confirmed, the LOD scores have been much
lower than the initial report22,23.
The hunt for schizophrenia ge ...
1 - edepositIreland
... A recent study from our group by Walters et al. (31) on the neuropsychological effects of
rs1344706 offers an alternative account of ZNF804A’s effect on cognition. This study
sought to investigate neuropsychological performance in patients and healthy controls on
cognitive functions typically impair ...
Neurodevelopmental mechanisms of schizophrenia: understanding
... Figure 2. Convergence of two pleiotropic pathways, DISC1 and NRG1–ErbB4, which are disturbed in schizophrenia. (a) In neuronal progenitor cells, DISC1 plays an
important role in regulating the Wnt pathway by directly binding with GSK3b and modulating the stability of b-catenin. DISC1 is also localiz ...
... perform particular tasks. Under proper conditions,
stem cells begin to develop or ‘differentiate’ into
specialized cells that carry out a specific function,
such as in the skin, muscle or brain. Additionally,
stem cells can ‘self-renew,’ that is they can divide
and give rise to more stem cells.
Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research.