A Novel Mechanism and Treatment Target for Presynaptic
... the brain (Hess et al, 1992). These mice have a regionally specific greater level of noradrenalin but lower glutamate, dopamine, and serotonin neurotransmission, delayed acquisition of motor milestones, and hyperactivity as adults (Heyser et al, 1995; Jones et al, 2001; Raber et al, 1997). Hyperacti ...
... the brain (Hess et al, 1992). These mice have a regionally specific greater level of noradrenalin but lower glutamate, dopamine, and serotonin neurotransmission, delayed acquisition of motor milestones, and hyperactivity as adults (Heyser et al, 1995; Jones et al, 2001; Raber et al, 1997). Hyperacti ...
Increased D-amino acid oxidase
... genotyped two SNPs in each gene. The SNPs were selected based on three pragmatic criteria: a) the SNP is amongst those most strongly associated with schizophrenia in each gene, b) the SNP has a high minor allele frequency, and c) the SNP tags a haplotype block.S8,S10 In DAO, we chose rs2070587 (G/T) ...
... genotyped two SNPs in each gene. The SNPs were selected based on three pragmatic criteria: a) the SNP is amongst those most strongly associated with schizophrenia in each gene, b) the SNP has a high minor allele frequency, and c) the SNP tags a haplotype block.S8,S10 In DAO, we chose rs2070587 (G/T) ...
Advances in schizophrenia
... Since then there have been several other positive linkage results (Table 1). Many of the initial findings, however, have not been fully reproduced. Even in cases where initial observations were confirmed, the LOD scores have been much lower than the initial report22,23. The hunt for schizophrenia ge ...
... Since then there have been several other positive linkage results (Table 1). Many of the initial findings, however, have not been fully reproduced. Even in cases where initial observations were confirmed, the LOD scores have been much lower than the initial report22,23. The hunt for schizophrenia ge ...
1 - edepositIreland
... A recent study from our group by Walters et al. (31) on the neuropsychological effects of rs1344706 offers an alternative account of ZNF804A’s effect on cognition. This study sought to investigate neuropsychological performance in patients and healthy controls on cognitive functions typically impair ...
... A recent study from our group by Walters et al. (31) on the neuropsychological effects of rs1344706 offers an alternative account of ZNF804A’s effect on cognition. This study sought to investigate neuropsychological performance in patients and healthy controls on cognitive functions typically impair ...
Neurodevelopmental mechanisms of schizophrenia: understanding
... Figure 2. Convergence of two pleiotropic pathways, DISC1 and NRG1–ErbB4, which are disturbed in schizophrenia. (a) In neuronal progenitor cells, DISC1 plays an important role in regulating the Wnt pathway by directly binding with GSK3b and modulating the stability of b-catenin. DISC1 is also localiz ...
... Figure 2. Convergence of two pleiotropic pathways, DISC1 and NRG1–ErbB4, which are disturbed in schizophrenia. (a) In neuronal progenitor cells, DISC1 plays an important role in regulating the Wnt pathway by directly binding with GSK3b and modulating the stability of b-catenin. DISC1 is also localiz ...
Slide 1
... perform particular tasks. Under proper conditions, stem cells begin to develop or ‘differentiate’ into specialized cells that carry out a specific function, such as in the skin, muscle or brain. Additionally, stem cells can ‘self-renew,’ that is they can divide and give rise to more stem cells. ...
... perform particular tasks. Under proper conditions, stem cells begin to develop or ‘differentiate’ into specialized cells that carry out a specific function, such as in the skin, muscle or brain. Additionally, stem cells can ‘self-renew,’ that is they can divide and give rise to more stem cells. ...