Immunodeficiency viruses and prion disease
... the emergence of behavioral symptoms. Secondly, via peritoneally implanted telemetry sensors, core body temperature and activity patterns could be tracked for almost 2 years. This study provided interesting results on behavioral and physiological changes that happened during the course of the prion ...
... the emergence of behavioral symptoms. Secondly, via peritoneally implanted telemetry sensors, core body temperature and activity patterns could be tracked for almost 2 years. This study provided interesting results on behavioral and physiological changes that happened during the course of the prion ...
Biochemistry of neurodegenerative diseases and prions
... The PrPSc attacks the native prion PrPC, changes its conformation into an abnormal form and causes an exponential production of insoluble proteins; they aggregate and form the fibrillar structure ...
... The PrPSc attacks the native prion PrPC, changes its conformation into an abnormal form and causes an exponential production of insoluble proteins; they aggregate and form the fibrillar structure ...
PRNP
Major prion protein (PrP, for prion protein or protease-resistant protein), also known as CD230 (cluster of differentiation 230), is the only known example of a prion protein in animals. In humans, it is encoded by the PRNP gene (PRioN Protein). Expression of the protein is most predominant in the nervous system but occurs in many other tissues throughout the body.The protein can exist in multiple isoforms, the normal PrPC, the disease-causing PrPSc, and an isoform located in mitochondria. The misfolded version PrPSc is associated with a variety of cognitive disorders and neurodegenerative diseases such as Creutzfeldt–Jakob disease, bovine spongiform encephalopathy, Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia, and kuru.