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... What was known about the relationship between gut microbiome and obesity before this paper was published? • Gut microorganisms help to extract extra calories from indigestible polysaccharides in our diet. • Studies using germ free mouse have shown that Fiaf, a circulating inhibitor pf lipoprotein l ...
Resource pack: Human genetic variation and disease
Resource pack: Human genetic variation and disease

... genes that influence that phenotype. QTL analysis is particularly useful to study complex traits such as obesity and diabetes. One challenge for QTL studies is that traits can be affected by a combination of factors including genotype, environmental factors and interaction of these with specific gen ...


... were exceeding the speed limit ...
Chapter 16
Chapter 16

... • Gene flow (gene migration) is the movement of alleles among populations by migration of breeding individuals • Gene flow can increase variation within a population by introducing novel alleles produced by mutation in another population • Continued gene flow decreases diversity among populations, c ...
- Norfolk Terrier Club of Great Britain
- Norfolk Terrier Club of Great Britain

... reviewed facts from the USA; do not assume, even then, that the same facts hold true for Norfolks in the UK; remember that we are dealing with a late onset disease (which must always be distinguished from the geriatric disease Norfolks get just because they are terriers); take care not to severely d ...
polygenic and multifactorail inheritance
polygenic and multifactorail inheritance

... The concept of a normal range for traits is fundamental to clinical medicine. However, the distance a measurement is from the mean before it is considered abnormal is somewhat random. In general, a trait is considered abnormal (out of the range of normal values) if the value of the trait is greate ...
Approaches to complex genetic disease
Approaches to complex genetic disease

... Coronary Artery Disease • Major cause of death and disability throughout the world ...
Genetic diseases
Genetic diseases

... • biochemical activity of various enzymes (e.g. TaySachs) • analysis of various specific genes (CF gene - PCR) • sex of the fetus (X-linked disorders - hemophilia) ...
Population Genetics
Population Genetics

... 1. Genetic Drift: This represents random changes in small gene pools due to sampling errors in propagation of alleles. The bottleneck effect and founder effect are prime examples of genetic drift. In either case the number of individuals in a population is drastically reduced distorting the original ...
To Determine the Effects of Copper, Zinc and Magnesium
To Determine the Effects of Copper, Zinc and Magnesium

... with pre-eclampsia. The mean age of control subjects was (25.46±0.85) years, even as for patients it was (25.76±0.73) years the difference was statistically insignificant (p=0.8). The mean difference of Gestational ages of normal healthy pregnant ladies were (36.8±0.27) weeks while for the pre-eclam ...
Considerations for Treating the Pregnant Glaucoma Patient
Considerations for Treating the Pregnant Glaucoma Patient

... to their level of risk. For patients at low risk, he might opt for the watch-andsee approach. “People with elevated eye pressure are at higher risk. The worst possible scenario is a patient who is blind in one eye with glaucoma in the other, on multiple meds controlling her pressure,” he said. “But ...
Basic genetics review  1. Overview a. Meiosis in male and female
Basic genetics review 1. Overview a. Meiosis in male and female

... 15. Multifactorial (polygenic) disorders a. Multiple genes on different chromosomes need to be abnormal b. Environmental factors involved – folic acid deficiency plus a genetic predisposition = neural tube defect c. Recurrence risk = 2-5%, 10-12% after 2 affected d. Examples: Cleft lip and/or palat ...
Diabetes handout - City Tech OpenLab
Diabetes handout - City Tech OpenLab

... Prandin (repaglinide) and Starlix (nateglinide) Adverse Effects: Effects diminish quickly:low blood glucose (less likely than sulfonylureas) Occasionally can interact with alcohol and cause vomiting, flushing, sickness. ...
New York Times - Molecular and Cell Biology
New York Times - Molecular and Cell Biology

... Approximately 15 months earlier, mild chronic gastrointestinal symptoms, including dyspepsia, heartburn, and midabdominal discomfort, increased in severity and began to occur daily. The symptoms did not resolve with antacid therapy. She had lost approximately 2.3 kg (5 lb) during this time, which sh ...
Page 1 Chapter 7
Page 1 Chapter 7

... • Injuries are the leading cause of death for people between 1 to 45 years of age – AIDS – Highly preventable by changing lifestyle behavioral factors – China and smoking cessation programs – Getting children involved – Stanford three community study – Success in reducing risk of heart disease; focu ...
No Slide Title
No Slide Title

... High level of population polymorphism ...
Pharmacologic Implications for Special Patient Populations:
Pharmacologic Implications for Special Patient Populations:

... heart is most sensitive during the 3rd and 4th weeks of gestation, external genitalia are most sensitive during the 8th and 9th weeks brain and skeleton are sensitive from the beginning of the 3rd week to the end of pregnancy and into the neonatal period. ...
Favorite Five for April 2007a
Favorite Five for April 2007a

... Cook in the April 2007 on-line edition of the British Medical Journal found, “Sodium reduction, previously shown to lower blood pressure, may also reduce long term risk of cardiovascular events (strokes and heart attacks).” This paper looks at the results of the two Trials of Hypertension Prevention ...
Treatment in Cardiac disease - Barwon Division of General Practice
Treatment in Cardiac disease - Barwon Division of General Practice

...  Diabetic ketoacidosis (DKA) was diagnosed and the patient was started on an insulin drip. Two days later the drip was discontinued and she was started on Novomix 30 twice daily and regular coverage. Despite increasing the daily doses of insulin to 112 IU daily, her glucose continued to increase in ...
Chapter Outline
Chapter Outline

... intense inbreeding when populations were reduced in earlier times. c. The founder effect is an example of genetic drift where rare alleles or combinations occur in higher frequency in a population isolated from the general population. i. This is due to founding individuals containing a fraction of t ...
genetics case study - microcephaly
genetics case study - microcephaly

... on his milestones. Samina tells you that she is keen to find out more about what to expect in the future. 1. What support is available to her locally and nationally? ...
Full Article
Full Article

... epirubicin reaches 4 ± 1.6% compared with the maternal concentrations [22]. It should be noted that the doses used in clinical practice are lower than the test doses; therefore, extrapolation of these experimental findings to human therapeutic treatment may not be valid. Teratogenic effects depend o ...
2 MB - obesity - morbid
2 MB - obesity - morbid

... ■ BMI of 18–25 = normal ■ BMI of 25.0–30 = overweight ■ BMI of 30.0–35 = class I obesity ■ BMI of 35.0–40 = class II obesity ■ BMI of 40 or greater = class III obesity. 20% of adults are obese and 1% morbidly obese ...
LECTURE OUTLINE Cell Structure & Function DNA Replication
LECTURE OUTLINE Cell Structure & Function DNA Replication

... code that all living cells use to translate the series of bases in their DNA into instructions for the production of proteins. ...
Grade 10 Biology Assessment 1 Cover Sheet 2016/17 File
Grade 10 Biology Assessment 1 Cover Sheet 2016/17 File

... generation to the next? c. Select two examples of heritable characteristics: What part of the human chromosome does it get carried on and how is it passed from one generation to the next? (only father? Dominant or recessive?) 3. Select one example of a heritable disease: a. Name of the heritable dis ...
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Fetal origins hypothesis

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