Session 238 Lens development and molecular cell biology
... Purpose: Celastrol, also known as tripterine, is isolated from the traditional Chinese medicine ‘Thunder of God Vine’. It shows significant activities in the treatment of chronic inflammatory, cancer and diabetic activity. Capsule opacification is the most common complication after cataract surgery. ...
... Purpose: Celastrol, also known as tripterine, is isolated from the traditional Chinese medicine ‘Thunder of God Vine’. It shows significant activities in the treatment of chronic inflammatory, cancer and diabetic activity. Capsule opacification is the most common complication after cataract surgery. ...
A proteomic chronology of gene expression through the cell cycle in
... of different human cell lines and independently concluded that the minimum number of proteins expressed in each cell line is on the order of 10,000 (Beck et al., 2011; Nagaraj et al., 2011). In a more recent study, the proteomes of 11 cell lines were profiled to a similar depth (Geiger et al., 2012) ...
... of different human cell lines and independently concluded that the minimum number of proteins expressed in each cell line is on the order of 10,000 (Beck et al., 2011; Nagaraj et al., 2011). In a more recent study, the proteomes of 11 cell lines were profiled to a similar depth (Geiger et al., 2012) ...
medline:93194904
... Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter. The CD20(B1) encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation. Studies with 5' deletion ...
... Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter. The CD20(B1) encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation. Studies with 5' deletion ...
Involvement of retinoic acid-inducible gene- BEAS-2B cells
... [4], c-Met/hepatocyte growth factor receptor [5], fractalkine [6], p11 [7] and eotaxin [8]. Expression of these IFN-c-stimulated genes is known to be mediated through the signalling pathway of Janus kinase (JAK) 1/2/signal transducer and activator of transcription 1 (STAT1) [9]. Expression of STAT1 ...
... [4], c-Met/hepatocyte growth factor receptor [5], fractalkine [6], p11 [7] and eotaxin [8]. Expression of these IFN-c-stimulated genes is known to be mediated through the signalling pathway of Janus kinase (JAK) 1/2/signal transducer and activator of transcription 1 (STAT1) [9]. Expression of STAT1 ...
PROTEIN DEPHOSPHORYLATION AND THE INTRACELLULAR
... phosphatases may be negative regulators of cell growth and/or proliferation (6). In the years that followed, hundreds of studies appeared that used OA and other phosphatase inhibitors to establish a role for protein phosphorylation in virtually every cellular process — or so it seems. In many of the ...
... phosphatases may be negative regulators of cell growth and/or proliferation (6). In the years that followed, hundreds of studies appeared that used OA and other phosphatase inhibitors to establish a role for protein phosphorylation in virtually every cellular process — or so it seems. In many of the ...
Distinct cathepsins control necrotic cell death
... has been linked to microbial pathogenesis, ischemic stroke, and induction of adaptive immune responses.20,27,30,33,46,52 While most attention has focused on apoptotic cell death, recent evidence suggests that necrotic, like apoptotic cell death is a highly regulated process.3,7,13,18,22,34 Unlike ap ...
... has been linked to microbial pathogenesis, ischemic stroke, and induction of adaptive immune responses.20,27,30,33,46,52 While most attention has focused on apoptotic cell death, recent evidence suggests that necrotic, like apoptotic cell death is a highly regulated process.3,7,13,18,22,34 Unlike ap ...
Understanding P53-Mdm2 Interactions: Future Prospect of Anti
... inactivating P53 in the process of transformation, their by effectively inhibiting over production of P53. Some tumors contain both high levels of MDM2 and mutations in the P53 gene. The reasons for activation of the two components of the same pathway are unclear but it possibly suggests that MDM2 m ...
... inactivating P53 in the process of transformation, their by effectively inhibiting over production of P53. Some tumors contain both high levels of MDM2 and mutations in the P53 gene. The reasons for activation of the two components of the same pathway are unclear but it possibly suggests that MDM2 m ...
K-ras modulates the cell cycle via both positive and negative
... cycle regulators. In addition, activated K-ras upregulates bcl-2 but has no eect on bax or bcl-x expression. Taken together, these data indicate that activated K-ras aects the cell cycle by modulating both positive and negative cell cycle regulatory pathways. Keywords: ras; cell cycle; gene regula ...
... cycle regulators. In addition, activated K-ras upregulates bcl-2 but has no eect on bax or bcl-x expression. Taken together, these data indicate that activated K-ras aects the cell cycle by modulating both positive and negative cell cycle regulatory pathways. Keywords: ras; cell cycle; gene regula ...
... 18]. SHP-2 then dephosphorylates TCR-associated CD-3ζ and ZAP70 [18], resulting in inhibition of downstream signaling. Specifically, activation of phosphatidylinositol 3kinase (PI3K) is blocked, which affects upregulation of the cell survival gene Bcl-X L and decreases IL-2 production and glucose met ...
The roles of microtubules in tropisms
... Plant tropisms, or growth towards or away from a stimulus, usually involve the bending of shoots or roots which reorient growth in a new direction. Plant responses to tropic cues, especially gravity and light, have been active areas of investigation for many years. Despite all of this attention we s ...
... Plant tropisms, or growth towards or away from a stimulus, usually involve the bending of shoots or roots which reorient growth in a new direction. Plant responses to tropic cues, especially gravity and light, have been active areas of investigation for many years. Despite all of this attention we s ...
Apical ectodermal ridge morphogenesis in limb development is
... stratification and AER morphology, but the contribution of active migration, cell intercalation, differential adhesion or cell sorting to this process is not clear (Tickle and Altabef, 1999). The ARID family of transcriptional regulators is an evolutionary conserved group of genes that perform essen ...
... stratification and AER morphology, but the contribution of active migration, cell intercalation, differential adhesion or cell sorting to this process is not clear (Tickle and Altabef, 1999). The ARID family of transcriptional regulators is an evolutionary conserved group of genes that perform essen ...
Document
... • TOR = Target of Rapamycin, originally identified by mutations in yeast that confer resistance to rapamycin ...
... • TOR = Target of Rapamycin, originally identified by mutations in yeast that confer resistance to rapamycin ...
Tcf3: a transcriptional regulator of axis induction in the early embryo
... at these early stages of gestation and suggest the possibility that stabilized β-catenin may be exerting its effects independently of Lef/Tcfs. If Lef/Tcf proteins do play a role in mouse AP axis formation, then the activation or derepression of Lef/Tcf target genes would be expected to accompany Wn ...
... at these early stages of gestation and suggest the possibility that stabilized β-catenin may be exerting its effects independently of Lef/Tcfs. If Lef/Tcf proteins do play a role in mouse AP axis formation, then the activation or derepression of Lef/Tcf target genes would be expected to accompany Wn ...
Structure-Function Relationships of Stem Cell Factor
... HE TYROSINE KINASE receptor, c-kit, is critically involved in the proliferation and differentiation of early hematopoietic progenitor cells. The cloning of this re~eptor’‘~ and its ligand (here termed stem cell factor [SCF], but also known as c-kit ligand, mast cell growth factor and steel factor4-” ...
... HE TYROSINE KINASE receptor, c-kit, is critically involved in the proliferation and differentiation of early hematopoietic progenitor cells. The cloning of this re~eptor’‘~ and its ligand (here termed stem cell factor [SCF], but also known as c-kit ligand, mast cell growth factor and steel factor4-” ...
Immune complexes formed following the binding of
... Treatment of patients with heparin results in PF4-heparin complex formation, and a dramatic increase in blood concentration of PF4. Heparin-PF4 binding is facilitated by the multivalent nature of both heparin and PF4. Whereas PF4 binds heparin with relatively high apparent affinity (Kd, ⬃ 4-20 nM),6 ...
... Treatment of patients with heparin results in PF4-heparin complex formation, and a dramatic increase in blood concentration of PF4. Heparin-PF4 binding is facilitated by the multivalent nature of both heparin and PF4. Whereas PF4 binds heparin with relatively high apparent affinity (Kd, ⬃ 4-20 nM),6 ...
Gene Section AURKB (aurora kinase B) Atlas of Genetics and Cytogenetics
... In mitosis, the chromosomal passenger complex, composed of Aurora B, Survivin, Borealin and INCENP, controls chromosome alignment, histone modification, and cytokinesis (Knauer et al., 2007). Presence of this complex at the right place at the right time is the key to precise control of its enzymatic ...
... In mitosis, the chromosomal passenger complex, composed of Aurora B, Survivin, Borealin and INCENP, controls chromosome alignment, histone modification, and cytokinesis (Knauer et al., 2007). Presence of this complex at the right place at the right time is the key to precise control of its enzymatic ...
Cell Signaling during Cold, Drought, and Salt Stress
... 1998; Stevenson et al., 2000). IP3 levels increase in Arabidopsis plants under salt stress, and the time frame for the increase correlates with changes in cytosolic Ca 2 levels (DeWald et al., 2001). Transient increases in IP 3 levels were also observed in plant tissues or cultured cells during sal ...
... 1998; Stevenson et al., 2000). IP3 levels increase in Arabidopsis plants under salt stress, and the time frame for the increase correlates with changes in cytosolic Ca 2 levels (DeWald et al., 2001). Transient increases in IP 3 levels were also observed in plant tissues or cultured cells during sal ...
TGF-beta SIGNAL TRANSDUCTION - University of Colorado-MCDB
... factors activate receptors at the cell surface and transduce signals to target genes (Figure 1). Some of these genes encode immediate effectors of ultimate cellular responses, such as cell cycle regulators that mediate antiproliferative responses or extracellular matrix components that determine cel ...
... factors activate receptors at the cell surface and transduce signals to target genes (Figure 1). Some of these genes encode immediate effectors of ultimate cellular responses, such as cell cycle regulators that mediate antiproliferative responses or extracellular matrix components that determine cel ...
Relating the mechanics of the primary plant cell
... can occur in protoplasmic or newly secreted RG-IIs but not in those already existing in the cell wall (Chormova et al., 2014). Borate cross-linking is essential for successful expansive growth of cells by providing the cell wall with proper mechanical strength. In the cell wall of Arabidopsis rosett ...
... can occur in protoplasmic or newly secreted RG-IIs but not in those already existing in the cell wall (Chormova et al., 2014). Borate cross-linking is essential for successful expansive growth of cells by providing the cell wall with proper mechanical strength. In the cell wall of Arabidopsis rosett ...
Corticotropin-releasing hormone induces vascular endothelial
... either preformed mediators or cytokines. This effect was mediated through activation of CRH receptor-1 and adenylate cyclase with increased intracellular cAMP. However, the precise mechanism by which CRH induces VEGF secretion has not yet been defined. Here, we show that CRH-induced VEGF release was ...
... either preformed mediators or cytokines. This effect was mediated through activation of CRH receptor-1 and adenylate cyclase with increased intracellular cAMP. However, the precise mechanism by which CRH induces VEGF secretion has not yet been defined. Here, we show that CRH-induced VEGF release was ...
The UDPase activity of the Kluyveromyces lactis Golgi GDPase has
... DataBank shows its homology to apyrases. All these proteins share four apyrase conserved motifs as shown in Figure 1. Sucrose gradient fractionation of wild-type cells showed that the GDPase activity comigrated with Golgi membrane markers and was separated from an ER marker (Figure 2). The catalytic ...
... DataBank shows its homology to apyrases. All these proteins share four apyrase conserved motifs as shown in Figure 1. Sucrose gradient fractionation of wild-type cells showed that the GDPase activity comigrated with Golgi membrane markers and was separated from an ER marker (Figure 2). The catalytic ...
Heterotrimeric G proteins in C. elegans
... exchange of GDP for GTP (2). Additional GEFs have been isolated that act on GDP associated Gα subunits not associated with receptor. Upon binding of GTP, the Gα subunit dissociates from the Gβγ dimmer and these proteins are released from the receptor. Dissociated Gα and Gβγ subunits then interact wi ...
... exchange of GDP for GTP (2). Additional GEFs have been isolated that act on GDP associated Gα subunits not associated with receptor. Upon binding of GTP, the Gα subunit dissociates from the Gβγ dimmer and these proteins are released from the receptor. Dissociated Gα and Gβγ subunits then interact wi ...