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Physiological studies on the sex-linked dwarfism of the fowl: a
Physiological studies on the sex-linked dwarfism of the fowl: a

... characterized by low circulating levels of T3 and IGF-I in spite of normal or even increased levels of T4 and GH. The T3 deficiency is explained by a lower peripheral activity of T4 monodeiodination which could be related to an abnormal T4 uptake by the cell, particularly the hepatocyte. The low pro ...
Full Text  - J
Full Text - J

... were low, while prolactin level was slightly high. The levels of LH and FSH were lower on day 13 as compared to day 2. This might be due to rapid progression of IVLBCL. Low free thyroxin (fT4) and free triiodothyronine (fT3) levels with normal thyroid-stimulating hormone (TSH) suggested central hypo ...
primary effect - Semantic Scholar
primary effect - Semantic Scholar

... characterized by low circulating levels of T3 and IGF-I in spite of normal or even increased levels of T4 and GH. The T3 deficiency is explained by a lower peripheral activity of T4 monodeiodination which could be related to an abnormal T4 uptake by the cell, particularly the hepatocyte. The low pro ...
The Effects of Iodine Deficiency in Pregnancy and Infancy
The Effects of Iodine Deficiency in Pregnancy and Infancy

... child death averted are US$1000 and per Disabilityadjusted life year (DALY) gained are US$34–36.6 However, in some regions, iodisation of salt may not be practical for control of iodine deficiency, at least in the short term. In these areas, iodised oil supplementation can be used. Iodised oil can b ...
Interleukin-6 release from human abdominal adipose cells is
Interleukin-6 release from human abdominal adipose cells is

... (TSH). TSH stimulates interleukin-6 (IL-6) release from adipocytes. We examined TSH responsiveness as a function of stage of differentiation or adipose tissue depot in cultured adipose cells and determined the effect of TSH on extrathyroidal IL-6 production in vivo. Stromal preadipocytes, isolated f ...
Endocrinology II
Endocrinology II

... receiving suboptimal cortisol or cortisone replacement may be at risk of developing symptoms of cortisol deficiency when growth hormone therapy is initiated. This is due to the inhibitory effect of growth hormone on 11-beta-hydroxysteroid dehydrogenase type 1, the enzyme that converts cortisone to c ...
Interleukin-6 release from human abdominal adipose cells is
Interleukin-6 release from human abdominal adipose cells is

... (TSH). TSH stimulates interleukin-6 (IL-6) release from adipocytes. We examined TSH responsiveness as a function of stage of differentiation or adipose tissue depot in cultured adipose cells and determined the effect of TSH on extrathyroidal IL-6 production in vivo. Stromal preadipocytes, isolated f ...
Transcript I
Transcript I

... minutes before inactivation and/or removal by tissues like the liver, kidney, or lungs or even the cells themselves that they bind too.  The reason for all this is that the body must retain tight control over its functions—so synthesis and release can take place very quickly in an active state.  O ...
Thyroid Hormone Regulation of Peptidylglycine a
Thyroid Hormone Regulation of Peptidylglycine a

... 3). The antiserum used to visualize PAM proteins was raised to a synthetic peptide [bPAM-(561-579)] located in the intragranular domain of the bovine PAM precursor protein and was affinity purified before use. The major PAM protein in all of the anterior pituitary particulate fractions had a mass of ...
Hypopituitarism
Hypopituitarism

... one or more anterior pituitary hormones. The clinical presentation depends on how rapidly the anterior lobe is affected, the specific cells involved, and the severity of the functional impairment. In the classic case of anterior pituitary hormone loss, gonadotropins are affected first, followed by g ...
Effect of intravenous dopamine infusion on pituitary and thyroid
Effect of intravenous dopamine infusion on pituitary and thyroid

... the previously published studies reporting a decrease of thyroid hormone levels in severely ill patients regardless of a treatment modality. Euthyroid sick syndrome diagnosed in these patients is characterized by low levels of FT3 and FT4 due to various extrathyroidal factors, such as systemic disea ...
Pituitary Disorders - Patient Education Institute
Pituitary Disorders - Patient Education Institute

... The cause of pituitary gland tumors is not known. Although pituitary tumors can happen at any age, they are most likely to happen in older adults. People with a family history of pituitary tumors are at an increased risk. Treatment for pituitary tumors may include: • Removing the tumor. • Controlli ...
The Calciotropic Hormones
The Calciotropic Hormones

... Role of Parathyroid Hormone Target Tissues • Under normal circumstances, PTH prevents serum calcium from falling below physiologic concentrations by stimulating calcium movement from intestinal and renal tubular lumina and from the bone fluid compartment into the blood. • Its effects on bone and ki ...
Effects of Pesticides on Haematology, Thyroid Stimulating Hormone
Effects of Pesticides on Haematology, Thyroid Stimulating Hormone

... Blood transports food and oxygen to all cells of the human body and removes their waste products. It also helps to maintain body temperature, transports hormones, and fights infections. Two main constituents of blood are the blood cells or corpuscles (45%) and plasma (55%) (Dainty, 2006). The pale-y ...
Adaptive Innovations in Medicine: Vitamin D, Iodine
Adaptive Innovations in Medicine: Vitamin D, Iodine

... Kingdoms of Life ...
this PDF file
this PDF file

... knows. I have found in my practice that more than 80 % of today’s patients are suffering from symptoms created by medicines which must be treated first. Thereafter, the normal homeopathic treatment can follow with the same number of remedies that Hahnemann used 200 years ago. ...
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)

... and within species in T4 activity may be due to factors that affect thyroid function such as seasonal cyclicity in feed intake, body weight and reproductive status [52,53,54]. In general, seasonal variation in thyroid gland activity with maximal T4 concentrations in colder than hotter months had bee ...
Hormonal Profile among Amenorrheic Sudanese Women under 40
Hormonal Profile among Amenorrheic Sudanese Women under 40

... of regulatory hormones occurs in males when the testes develop abnormally or anorchia exists. High concentrations of LH may also be found in primary testicular failure and Klinefelter syndrome, although LH levels will not necessarily be elevated if the secretion of androgens continues. Increased con ...
Vitiligo - SouthDerm
Vitiligo - SouthDerm

... parts of your body. This is also known as a loss of pigment. The affected areas may appear lighter in colour or become completely white. Some people find that the lighter patches are itchy or painful. The condition may remain unchanged for years or progress and cover larger areas of skin over time. ...
effect of metformin on thyroid stimulating hormone in euthyroid type
effect of metformin on thyroid stimulating hormone in euthyroid type

... ABSTRACT: BACKGROUND AND RATIONALE: Metformin use is reported to be associated with reduction in serum thyroid stimulating hormone (TSH) levels. However, recent reports suggest that the effect of metformin on TSH is seen only in those who have hypothyroidism and not in those who are euthyroid. OBJEC ...
Seasonality_and_T3_manuscript_revision
Seasonality_and_T3_manuscript_revision

... of multiple aspects of immune function, including T3 enhanced T-cell dependent (Type IV) ...
SMALL ANIMAL CLINICAL ENDOCRINOLOGY Volume
SMALL ANIMAL CLINICAL ENDOCRINOLOGY Volume

... magnetic resonance imaging were treated with external beam megavoltage radiation using a linear accelerator. Eight cats were castrated males, and four were spayed females. Ages ranged from 5 to 15 years with a mean of 9.8 years. Four of the cats had solely central nervous signs, and eight of the cat ...
Slide 1
Slide 1

... • Fluid deprivation test for 8 to 12 hours. • The patient is weighed frequently during the test. • Perform plasma and urine osmolality studies before and after the test. • Low specific gravity and weight loss, rising serum osmolality, and elevated serum sodium levels. • Terminate the test if tachyca ...
Hypopituitarism in Childhood
Hypopituitarism in Childhood

... reflect a layer of fat within or around the posterior pituitary. In some cases of congenital hypopituitarism, this “bright spot” is completely absent and correlates well with the clinical presence of diabetes insipidus (DI). In other cases of congenital hypopituitarism, the “bright spot” is found ec ...
A Rat Neurodevelopmental Evaluation of Offspring
A Rat Neurodevelopmental Evaluation of Offspring

... Until recently, a paucity of toxicity data suitable for risk assessment purposes has been available on ammonium perchlorate. In 1997, an external peer review panel of risk assessors, perchlorate experts, and thyroid experts convened to help identify data needed to derive a reference dose (RfD) for c ...
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Graves' disease



Graves' disease, also known as toxic diffuse goiter and Flajani-Basedow-Graves disease, is an autoimmune disease that affects the thyroid. It frequently results in hyperthyroidism and an enlarged thyroid. Signs and symptoms of hyperthyroidism may include irritability, muscle weakness, sleeping problems, a fast heartbeat, poor tolerance of heat, diarrhea, and weight loss. Other symptoms may include thickening of the skin on the shins, known as pretibial myxedema, and eye problems such as bulging, a condition known as Graves' ophthalmopathy. About 25% to 80% of people develop eye problems.The exact cause is unclear; however, it is believed to involve a combination of genetic and environmental factors. A person is more likely to be affected if they have a family member with the disease. If one twin is affected there is a 30% chance the other twin will also have the disease. The onset of disease may be triggered by stress, infection, or giving birth. Those with other autoimmune diseases such as type 1 diabetes and rheumatoid arthritis are more likely to be affected. Smoking increases the risk of disease and may make the eye problems worse. The disorder results from an antibody, called thyroid stimulating immunoglobulin (TSI), that has a similar effect to thyroid stimulating hormone (TSH). These antibodies cause the thyroid gland to produce excess thyroid hormone. The diagnosis may be suspected based on symptoms with blood tests and radioiodine uptake used to confirm the disease. Typically blood tests show a raised T3 and T4, low TSH, increased radioiodine uptake in all areas of the thyroid, and TSI antibodies.There are three treatment options: radioiodine therapy, medications, and thyroid surgery. Radioiodine therapy involves taking iodine-131 by mouth which is then concentrated in and destroys the thyroid over weeks to months. The resulting hypothyroidism is treated with synthetic thyroid hormone. Medications such as beta blockers may control the symptoms and anti-thyroid medications such as methimazole may temporarily help people while other treatments are having effect. Surgery to remove the thyroid is another option. Eye problems may require additional treatments.Graves' disease occurs in about 0.5% of people. It occurs about 7.5 times more often in women than men. Often it starts between the ages of forty and sixty. It is the most common cause of hyperthyroidism in the United States (about 50% to 80% of cases). The condition is named after Robert Graves who described it in 1835. A number of prior descriptions also exist.
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