A review of the human vs. porcine female genital tract
... human female genital tract and associated immune system in the perspective of genital Chlamydia infection. The comparison of women and sows has shown that despite some gross anatomical differences, the structures and proportion of layers undergoing cyclic alterations are very similar. Reproductive h ...
... human female genital tract and associated immune system in the perspective of genital Chlamydia infection. The comparison of women and sows has shown that despite some gross anatomical differences, the structures and proportion of layers undergoing cyclic alterations are very similar. Reproductive h ...
3d bio-printing - Ulster Institutional Repository
... animal models to clinical trials are not very encouraging; at present not more than 8%[4]. Animal models have the restricted ability to mimic the complex process of human cell proliferation and pathophysiology conditions. In oncology research, studies on cell culture and animal models are critical i ...
... animal models to clinical trials are not very encouraging; at present not more than 8%[4]. Animal models have the restricted ability to mimic the complex process of human cell proliferation and pathophysiology conditions. In oncology research, studies on cell culture and animal models are critical i ...
Chimeric CLL-1 Antibody Fusion Proteins Containing Granulocyte
... by dose-limiting thrombocytopenia or more severely by the presence of bone marrow disease. In these settings, effective therapy with unconjugated MoAbs would be desirable for the induction of tumor remission. For this purpose, the combination of MoAbs and biologic response modifiers has been investi ...
... by dose-limiting thrombocytopenia or more severely by the presence of bone marrow disease. In these settings, effective therapy with unconjugated MoAbs would be desirable for the induction of tumor remission. For this purpose, the combination of MoAbs and biologic response modifiers has been investi ...
Cell-Mediated Immunity to Bordetella pertussis: Role of Thl
... for high levels of morbidity and mortality in children worldwide. Although the organism colonizes by attachment to ciliated respiratory epithelial cells and is considered to be noninvasive (3, 41, 61), a number of recent reports have suggested that it can be taken up by and survive within mammalian ...
... for high levels of morbidity and mortality in children worldwide. Although the organism colonizes by attachment to ciliated respiratory epithelial cells and is considered to be noninvasive (3, 41, 61), a number of recent reports have suggested that it can be taken up by and survive within mammalian ...
The machinery of programmed cell death
... However, apoptosis is also involved in a wide range of pathological conditions. Apoptotic cells may be characterized by specific morphological and biochemical changes, including cell shrinkage, chromatin condensation, and internucleosomal cleavage of genomic DNA. At the molecular level, apoptosis is ...
... However, apoptosis is also involved in a wide range of pathological conditions. Apoptotic cells may be characterized by specific morphological and biochemical changes, including cell shrinkage, chromatin condensation, and internucleosomal cleavage of genomic DNA. At the molecular level, apoptosis is ...
Cytokine function of heat shock proteins - AJP
... colocalizes with human Hsp60 in macrophages of atherosclerotic plaques (39). Induction of proinflammatory cytokine release from macrophages by chlamydial Hsp60 would provide a potential mechanism by which chlamydial infections may promote atherogenesis and precipitate acute ischemic events (37, 39). ...
... colocalizes with human Hsp60 in macrophages of atherosclerotic plaques (39). Induction of proinflammatory cytokine release from macrophages by chlamydial Hsp60 would provide a potential mechanism by which chlamydial infections may promote atherogenesis and precipitate acute ischemic events (37, 39). ...
In Focus Autoantibodies in anti-neutrophil cytoplasm antibody
... acute phase reactant ceruloplasmin in ANCA-negative patients [16]. Nevertheless, it seems highly likely that additional factors other than the classical ANCA are required for the full expression of AAV and this coincides with the need for a critical analysis of the role of more recently described au ...
... acute phase reactant ceruloplasmin in ANCA-negative patients [16]. Nevertheless, it seems highly likely that additional factors other than the classical ANCA are required for the full expression of AAV and this coincides with the need for a critical analysis of the role of more recently described au ...
Chapter 16
... of virus mutants and the diverse population of HIV-specific helper T cell V regions. This constitutes a non-linear selection process, the outcome of which can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within population ...
... of virus mutants and the diverse population of HIV-specific helper T cell V regions. This constitutes a non-linear selection process, the outcome of which can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within population ...
Chapter 16
... of virus mutants and the diverse population of HIV-specific helper T cell V regions. This constitutes a non-linear selection process, the outcome of which can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within population ...
... of virus mutants and the diverse population of HIV-specific helper T cell V regions. This constitutes a non-linear selection process, the outcome of which can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within population ...
Characterisation of the immune response after - diss.fu
... lymphocytes, marked with the lineage surface marker CD19, are the main modulators of a humoral immunity. Their activation and differentiation into antibody secreting plasma cells and thus developing a humoral memory is triggered by the antigen itself and in most cases require the help of T cells. B ...
... lymphocytes, marked with the lineage surface marker CD19, are the main modulators of a humoral immunity. Their activation and differentiation into antibody secreting plasma cells and thus developing a humoral memory is triggered by the antigen itself and in most cases require the help of T cells. B ...
Slide 1
... blood typing? • Antigen - a foreign substance, often a polysaccharide or a protein, that stimulates an immune response • Antibody – proteins made in response to an antigen in the body and bind to that antigen • Blood transfusion – transfer of blood from one individual into another individual ...
... blood typing? • Antigen - a foreign substance, often a polysaccharide or a protein, that stimulates an immune response • Antibody – proteins made in response to an antigen in the body and bind to that antigen • Blood transfusion – transfer of blood from one individual into another individual ...
Signalling drought in guard cells
... Upon exposure to water stress, genes whose products are involved in cell protection from osmotic stress are often activated so that more osmolytes can be synthesized or more water channels produced. When this inducible programme is understood at molecular, cellular and wholeplant levels, it will be ...
... Upon exposure to water stress, genes whose products are involved in cell protection from osmotic stress are often activated so that more osmolytes can be synthesized or more water channels produced. When this inducible programme is understood at molecular, cellular and wholeplant levels, it will be ...
Chapter 13
... immunizations with allogeneic189 lymphocytes can cause the production of another antibody called anti-I-Jk, that had very interesting properties.190 Anti-I-Jk antibodies made in an MHCb mouse bind to antigen-specific suppressor T cell factors made by k haplotype mice, but not those made by b haploty ...
... immunizations with allogeneic189 lymphocytes can cause the production of another antibody called anti-I-Jk, that had very interesting properties.190 Anti-I-Jk antibodies made in an MHCb mouse bind to antigen-specific suppressor T cell factors made by k haplotype mice, but not those made by b haploty ...
Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway
... syndrome. THP-1 cells (16106 cells?mL-1) were stimulated with lysates of PA clinical isolates (A–I) and a lab reference strain (NCTC10662) lysate (all 12.5 mL?mL-1) for 24 h (n53), and the production of tumour necrosis factor (TNF)-a, interleukin (IL)-8 and IL-1b was analysed by ELISA. All clinical ...
... syndrome. THP-1 cells (16106 cells?mL-1) were stimulated with lysates of PA clinical isolates (A–I) and a lab reference strain (NCTC10662) lysate (all 12.5 mL?mL-1) for 24 h (n53), and the production of tumour necrosis factor (TNF)-a, interleukin (IL)-8 and IL-1b was analysed by ELISA. All clinical ...
Introduction: Biology Today Chapter 1
... Innate immunity does not recognize specific microbes—its mechanisms respond to all microbes in the same manner and with similar actions. Microbe = a very tiny form of life. Microbes include bacteria, fungi, and protozoan parasites, They are best visualized under a light microscope. ...
... Innate immunity does not recognize specific microbes—its mechanisms respond to all microbes in the same manner and with similar actions. Microbe = a very tiny form of life. Microbes include bacteria, fungi, and protozoan parasites, They are best visualized under a light microscope. ...
Really Essential Medical Immunology Arthur Rabson
... major line of defense is of course the skin which, when ...
... major line of defense is of course the skin which, when ...
Low Counts of B Cells, Natural Killer Cells, Monocytes, Dendritic
... related donor (compared with a matched sib donor), cord blood or marrow graft (compared to mobilized blood stem cell graft), T celledepleted graft, and the presence of significant graft-versus-host disease (GVHD) [5-7]. However, these known predictive factors cannot reliably distinguish between pati ...
... related donor (compared with a matched sib donor), cord blood or marrow graft (compared to mobilized blood stem cell graft), T celledepleted graft, and the presence of significant graft-versus-host disease (GVHD) [5-7]. However, these known predictive factors cannot reliably distinguish between pati ...
Agglutination Reactions
... 1. Serial dilutions of serum from a patient suspected to be infected with a given bacterium in tubes. 2. Addition of bacteria to these tubes with constant concentration (same amount and concentration for all tubes). 3. If the person was infected with these bacteria, a visible agglutination will form ...
... 1. Serial dilutions of serum from a patient suspected to be infected with a given bacterium in tubes. 2. Addition of bacteria to these tubes with constant concentration (same amount and concentration for all tubes). 3. If the person was infected with these bacteria, a visible agglutination will form ...
PDF + SI - The Journal of Immunology
... and defined antiviral actions that interfere with virus infection (2, 3). Hence, they assigned the name “interferon” to what is now known as the IFN family of cytokines. How did they discover the interferon? At the time, Alick Isaacs was studying the infection properties of IAV and other RNA viruses ...
... and defined antiviral actions that interfere with virus infection (2, 3). Hence, they assigned the name “interferon” to what is now known as the IFN family of cytokines. How did they discover the interferon? At the time, Alick Isaacs was studying the infection properties of IAV and other RNA viruses ...
Author`s personal copy
... maturation of infected dendritic cells, which undergo apoptosis. The dendritic cells display impaired ability to upregulate cell surface expression of costimulatory, maturation, and major histocompatibility complex molecules, resulting in reduced T cell stimulatory capacity. There is also an impaire ...
... maturation of infected dendritic cells, which undergo apoptosis. The dendritic cells display impaired ability to upregulate cell surface expression of costimulatory, maturation, and major histocompatibility complex molecules, resulting in reduced T cell stimulatory capacity. There is also an impaire ...
Hemocompatibility of medical devices, blood products
... The complement cascade (figure was adaped from Rutkowski et al. (2010)) [4]. The classical pathway is activated by the Fc portion of immunoglobulins bound to antigen, apoptotic cells, Gram-negative bacteria, and viruses. The C1 complex, made up of C1q, C1r, and C1s subunits, initiates the downstream ...
... The complement cascade (figure was adaped from Rutkowski et al. (2010)) [4]. The classical pathway is activated by the Fc portion of immunoglobulins bound to antigen, apoptotic cells, Gram-negative bacteria, and viruses. The C1 complex, made up of C1q, C1r, and C1s subunits, initiates the downstream ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.