Here - Canada`s Michael Smith Genome Sciences Centre
... In kidney podocytes and other tissues, podocalyxin acts as an anti-adhesive surface protein to promote the formation of lumens and reduce intra- and inter- cellular adhesion. Podocalyxin is normally expressed on vascular endothelia, a sub-set of neurons and hematopoietic stem cells and, at much lowe ...
... In kidney podocytes and other tissues, podocalyxin acts as an anti-adhesive surface protein to promote the formation of lumens and reduce intra- and inter- cellular adhesion. Podocalyxin is normally expressed on vascular endothelia, a sub-set of neurons and hematopoietic stem cells and, at much lowe ...
Role of complement in health and disease
... Role of complement in hypersensitivity reactions • Complement system plays role in type II and type III hypersensitivity reactions. • Type II Reaction: mediated by IgG or IgM to foreign antigens which are bound to cell surfaces or other molecules. • Opsonised antigen stimulates various mechani ...
... Role of complement in hypersensitivity reactions • Complement system plays role in type II and type III hypersensitivity reactions. • Type II Reaction: mediated by IgG or IgM to foreign antigens which are bound to cell surfaces or other molecules. • Opsonised antigen stimulates various mechani ...
Interaction between tumour-infiltrating B cells and T cells controls
... Several B cell activation genes were reported to be downregulated in patients with HCC with poor prognosis suggesting their protective roles in tumour progression.5 Others, however, found that a special subset of B cells defined as regulatory B cells (Bregs) with CD19+CD24hiCD38hi phenotype was enric ...
... Several B cell activation genes were reported to be downregulated in patients with HCC with poor prognosis suggesting their protective roles in tumour progression.5 Others, however, found that a special subset of B cells defined as regulatory B cells (Bregs) with CD19+CD24hiCD38hi phenotype was enric ...
Activated intestinal macrophages in patients with cirrhosis release
... CD14+ and TREM-1 have been associated with inflammation and proinflammatory cytokine production, co-localisation studies were performed. These demonstrated that CD14+ cells were iNOS positive, thus confirming the presence of classically activated intestinal macrophages. Both increased ...
... CD14+ and TREM-1 have been associated with inflammation and proinflammatory cytokine production, co-localisation studies were performed. These demonstrated that CD14+ cells were iNOS positive, thus confirming the presence of classically activated intestinal macrophages. Both increased ...
Vaccines
... contain only the toxin (attenuated) produced by the bacteria and supposed to be responsible for the disease • The attenuation by rapid passage in a culture (BCG by 230 passages in potatoes mixed with beef bile; or measles by 85 passages in chicken fibroblasts) ...
... contain only the toxin (attenuated) produced by the bacteria and supposed to be responsible for the disease • The attenuation by rapid passage in a culture (BCG by 230 passages in potatoes mixed with beef bile; or measles by 85 passages in chicken fibroblasts) ...
Memory and Specificity in the Insect Immune System: Current
... closely related Gram-positive bacteria (Paenibacillus alvei and P. larvae) and subsequent challenging with either the same bacteria (homologous) or one of the two bacteria with which it had not been primed (heterologous) have shown that primed bees can survive a homologous secondary infection signif ...
... closely related Gram-positive bacteria (Paenibacillus alvei and P. larvae) and subsequent challenging with either the same bacteria (homologous) or one of the two bacteria with which it had not been primed (heterologous) have shown that primed bees can survive a homologous secondary infection signif ...
The Influence of 1,25-dihydroxyvitamin D on the Cross-Priming of Lymphocytic
... Therefore, the known immunomodulatory effects of 1,25-(OH)2D3 are ...
... Therefore, the known immunomodulatory effects of 1,25-(OH)2D3 are ...
Tips to Remember: What is an allergic reaction
... allergies is the single most important factor that predisposes a person to develop allergic disease. If one parent has allergic disease, the estimated risk of the child to develop allergies is 48%; the child's risk grows to 70% if both parents have allergies. Types of allergic disease The existence ...
... allergies is the single most important factor that predisposes a person to develop allergic disease. If one parent has allergic disease, the estimated risk of the child to develop allergies is 48%; the child's risk grows to 70% if both parents have allergies. Types of allergic disease The existence ...
Fat Soluble Vitamins
... lutein (also work better when used together) • Antioxidant for lipid peroxides (works with vitamin E) • Lower incidence of atherosclerosis through prevention of oxidation of LDLs ...
... lutein (also work better when used together) • Antioxidant for lipid peroxides (works with vitamin E) • Lower incidence of atherosclerosis through prevention of oxidation of LDLs ...
Pattern Generated by Oxidative Stress Th2
... role for innate immune engagement by lipoxidation- and glycoxidation-derived products (5), in particular aldehyde-modified proteins and phospholipids (7, 8). Such extensive, and in many cases proinflammatory, involvement of innate immunity is likely to provide fertile ground for the elicitation of a ...
... role for innate immune engagement by lipoxidation- and glycoxidation-derived products (5), in particular aldehyde-modified proteins and phospholipids (7, 8). Such extensive, and in many cases proinflammatory, involvement of innate immunity is likely to provide fertile ground for the elicitation of a ...
... amniotic fluid, placenta, umbilical cord, and teeth. MSCs show a high expansion potential, genetic stability, stable phenotype, high proliferation rate as adherent cells, and self-renew capacity and can be easily collected and shipped from the laboratory to the bedside and are compatible with differe ...
A Treatment Protocol for Autistic Spectrum Disorders
... Energy body/soul displaced into the surrounding area near the physical body (huge energy field) Fritz Albert Popp PhD: the bio-photonfield surrounding the physical body is the central regulating agency of all metabolic processes. The signals are received and transmitted via extra-and intracellular t ...
... Energy body/soul displaced into the surrounding area near the physical body (huge energy field) Fritz Albert Popp PhD: the bio-photonfield surrounding the physical body is the central regulating agency of all metabolic processes. The signals are received and transmitted via extra-and intracellular t ...
NOVA Lite™ HEp-2 ANA Kits/Substrate Slides
... are frequently positive, and low ANA titers may be observed in other disease states and in the normal population. Positive ANA results can occur following severe burns or viral infection and have been reported in some normal, healthy people, especially in older populations. Because of this lack of s ...
... are frequently positive, and low ANA titers may be observed in other disease states and in the normal population. Positive ANA results can occur following severe burns or viral infection and have been reported in some normal, healthy people, especially in older populations. Because of this lack of s ...
Chapter 12 ppt
... eukaryotic cells in response to viruses and a variety of natural and synthetic stimuli. There are several different interferons commonly used as therapeutics, termed alpha, beta, and gamma. These peptides are used to treat hairy cell leukemia, AIDS-related Kaposi's sarcoma, laryngeal papillomatosis, ...
... eukaryotic cells in response to viruses and a variety of natural and synthetic stimuli. There are several different interferons commonly used as therapeutics, termed alpha, beta, and gamma. These peptides are used to treat hairy cell leukemia, AIDS-related Kaposi's sarcoma, laryngeal papillomatosis, ...
Cadherin adhesion depends on a salt bridge at the N
... described for a heterogeneous group of proteins and involves mutual exchange of one or more structural components (Liu and Eisenberg, 2002; Rousseau et al., 2003; Yang et al., 2004). It has long been known that correct post-translational processing of cadherin molecules is essential for adhesion (Oz ...
... described for a heterogeneous group of proteins and involves mutual exchange of one or more structural components (Liu and Eisenberg, 2002; Rousseau et al., 2003; Yang et al., 2004). It has long been known that correct post-translational processing of cadherin molecules is essential for adhesion (Oz ...
Antibodies used for the detection of leukocyte subsets - HAL
... peripheral leukocyte independently of their phenotypic traits, we first used a passive transfer strategy which consisted in transferring GFP-tagged T- or B-cells into recombinase activating gene 1 (Rag1)-deficient mice which lack mature lymphocytes. Recipient animals with reconstituted lymphoid orga ...
... peripheral leukocyte independently of their phenotypic traits, we first used a passive transfer strategy which consisted in transferring GFP-tagged T- or B-cells into recombinase activating gene 1 (Rag1)-deficient mice which lack mature lymphocytes. Recipient animals with reconstituted lymphoid orga ...
Role of dopamine in the physiology of T
... MHC complexes (pMHCs). After recognition they mediate killing of those cells by secreting cytotoxic granules (Schoenborn and Wilson, 2007). In addition, by secreting IFN-γ, cytotoxic CD8+ T-cells may also potentiate function of other immune cells, including macrophages and NK cells (Schoenborn and W ...
... MHC complexes (pMHCs). After recognition they mediate killing of those cells by secreting cytotoxic granules (Schoenborn and Wilson, 2007). In addition, by secreting IFN-γ, cytotoxic CD8+ T-cells may also potentiate function of other immune cells, including macrophages and NK cells (Schoenborn and W ...
2.3 Carbon-Based Molecules
... • Lipids are nonpolar molecules that include fats, oils, and cholesterol. – Many contain carbon chains called fatty acids. – Fats and oils contain fatty acids bonded to glycerol. Triglyceride ...
... • Lipids are nonpolar molecules that include fats, oils, and cholesterol. – Many contain carbon chains called fatty acids. – Fats and oils contain fatty acids bonded to glycerol. Triglyceride ...
Nonmalignant Leukocyte Disorders - Cal State LA
... abnormal lysosomes are formed by the fusion of primary granules. These are seen as grayish-green inclusions The cells are ineffective in killing microorganisms and affected individuals often die early in life from pyogenic infections. ...
... abnormal lysosomes are formed by the fusion of primary granules. These are seen as grayish-green inclusions The cells are ineffective in killing microorganisms and affected individuals often die early in life from pyogenic infections. ...
Trends and advances in tumor immunology and lung cancer
... and the multi-functional protein calreticulin) which are recognized by macrophages and lead to tumor cell phagocytosis [38, 39]. In contrast, it has been documented that tumor-associated macrophages type 2 (M2) are responsible for tumor metastasis [40] and progression [41] by promoting the transfer ...
... and the multi-functional protein calreticulin) which are recognized by macrophages and lead to tumor cell phagocytosis [38, 39]. In contrast, it has been documented that tumor-associated macrophages type 2 (M2) are responsible for tumor metastasis [40] and progression [41] by promoting the transfer ...
Improvement of adoptive T-cell therapy for Cancer
... system includes humoral immunity and cell-mediated immunity. In humoral immunity, B-cells interact with a specific antigen via their B-cell receptor (BCR), which leads to proliferation and differentiation to antibody-secreting plasma cells. Antibodies play a crucial role in humoral response by bindi ...
... system includes humoral immunity and cell-mediated immunity. In humoral immunity, B-cells interact with a specific antigen via their B-cell receptor (BCR), which leads to proliferation and differentiation to antibody-secreting plasma cells. Antibodies play a crucial role in humoral response by bindi ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.