Sensitive analysis and isolation of ROR1+ B cells
... Miltenyi Biotec offers an Anti-ROR1 antibody, which increases sensitivity and specificity of flow cytometric B cell analysis in CLL research. It is available as a conjugate with PE, APC, or biotin. For functional studies, the antibody ...
... Miltenyi Biotec offers an Anti-ROR1 antibody, which increases sensitivity and specificity of flow cytometric B cell analysis in CLL research. It is available as a conjugate with PE, APC, or biotin. For functional studies, the antibody ...
Classification of allergens
... of two types – H1 and H2. • Their correlation and spreading on the cells of different cells is different. Stimulation of H1 promotes to contraction of smooth muscles, endothelial cells and postcapillary part of microcirculation. This leads to increasing of permeability of vessels, development of ede ...
... of two types – H1 and H2. • Their correlation and spreading on the cells of different cells is different. Stimulation of H1 promotes to contraction of smooth muscles, endothelial cells and postcapillary part of microcirculation. This leads to increasing of permeability of vessels, development of ede ...
06-Understanding Stress and Disease
... psychological disorders • While stress may increase the risk for physical and mental problems, most people under stress do not develop a disease, and remain ...
... psychological disorders • While stress may increase the risk for physical and mental problems, most people under stress do not develop a disease, and remain ...
Lecture 7: Adaptive immune response
... Innate immune system works rapidly (minutes) and has a broad specificity ...
... Innate immune system works rapidly (minutes) and has a broad specificity ...
Immunesystem - Child Early Intervention Medical Center
... Foreign invaders - viruses, bacteria, allergens, toxins and parasites - constantly bombard our body. ...
... Foreign invaders - viruses, bacteria, allergens, toxins and parasites - constantly bombard our body. ...
Document
... Antigen Encounter and Activation • Clonal selection – Naive lymphocyte's first encounter with antigen selected for further development – If correct signals present, lymphocyte will complete its differentiation ...
... Antigen Encounter and Activation • Clonal selection – Naive lymphocyte's first encounter with antigen selected for further development – If correct signals present, lymphocyte will complete its differentiation ...
PowerPoint 演示文稿
... When a new antibody is generated, the gene segments of different gene libraries are randomly selected and concatenated in a random order, see figure 1. The main idea of this gene expression mechanism is that a vast number of new antibodies can be generated from new combinations of gene segments in t ...
... When a new antibody is generated, the gene segments of different gene libraries are randomly selected and concatenated in a random order, see figure 1. The main idea of this gene expression mechanism is that a vast number of new antibodies can be generated from new combinations of gene segments in t ...
Functions of T lymphocytes
... organs, through which naïve lymphocytes circulate • Display antigens in a form that can be recognized by specific lymphocytes – For T cells: MHC-associated peptides (cytosolic peptides to class I, vesicular peptides to class II) – For B cells: native antigens • Provide “second signals” for T cell ac ...
... organs, through which naïve lymphocytes circulate • Display antigens in a form that can be recognized by specific lymphocytes – For T cells: MHC-associated peptides (cytosolic peptides to class I, vesicular peptides to class II) – For B cells: native antigens • Provide “second signals” for T cell ac ...
Sepsis-induced Innate and Adaptive Immune
... response. Recent adult and pediatric evidence suggests that the immune response is quite dynamic in this setting, often with endogenous innate and adaptive immunosuppression following the onset of sepsis. Sepsis-induced innate immune dysfunction can include reduction in antigen presenting capacity ( ...
... response. Recent adult and pediatric evidence suggests that the immune response is quite dynamic in this setting, often with endogenous innate and adaptive immunosuppression following the onset of sepsis. Sepsis-induced innate immune dysfunction can include reduction in antigen presenting capacity ( ...
HIV/AIDS
... infection and the presence of antibodies to the virus. Once the host cell is active, the infected genetic components replicate, which eventually kills the host cell, releasing HIV elements in the body (McCance and Huether, 2006). The target cell for HIV is primarily the T helper lymphocyte (although ...
... infection and the presence of antibodies to the virus. Once the host cell is active, the infected genetic components replicate, which eventually kills the host cell, releasing HIV elements in the body (McCance and Huether, 2006). The target cell for HIV is primarily the T helper lymphocyte (although ...
Type II hypersensitivity target tissues
... • Type II hypersensitivity is mediated by antibodies binding to specific cells. • Type II hypersensitivity reactions may target cells. • Hemolytic disease of the newborn. • Type II hypersensitivity reactions may target tissues. • The role of autoantibodies in disease is not always ...
... • Type II hypersensitivity is mediated by antibodies binding to specific cells. • Type II hypersensitivity reactions may target cells. • Hemolytic disease of the newborn. • Type II hypersensitivity reactions may target tissues. • The role of autoantibodies in disease is not always ...
BASIS: A Biological Approach to System Information Security
... This description includes the basic immune system response, the major players in this system, and the interaction of these components. 3.1 The basic immune response A basic immune response can consist of one or more of three components [5, 6]. The first component is the innate or non-specific immune ...
... This description includes the basic immune system response, the major players in this system, and the interaction of these components. 3.1 The basic immune response A basic immune response can consist of one or more of three components [5, 6]. The first component is the innate or non-specific immune ...
Chapter 12 - Pearland ISD
... Interferons, by contrast, are proteins released by cells that have been infected with a virus; they interfere with viral replication and spreading and, as such, do not help the already-infected cells. Instead, they help neighboring cells resist viral infection. In short, interferons work without reg ...
... Interferons, by contrast, are proteins released by cells that have been infected with a virus; they interfere with viral replication and spreading and, as such, do not help the already-infected cells. Instead, they help neighboring cells resist viral infection. In short, interferons work without reg ...
Medical Terminology Chapter 3: Bacteria, Blood cells and Diseases
... granules. These cells leave the blood stream and enter tissues to become macrophages. As a monocyte or macrophage, these cells are phagocytic and defend the body against viruses and bacteria. – These cells account for 4-9% of all leukocytes. ...
... granules. These cells leave the blood stream and enter tissues to become macrophages. As a monocyte or macrophage, these cells are phagocytic and defend the body against viruses and bacteria. – These cells account for 4-9% of all leukocytes. ...
Orthosteric, allosteric and metabotropic activity of alpha7 nAChR
... The subtype of nAChR is a unique receptor, widely distributed throughout the brain and expressed in many non-neuronal cells. These receptors function as homopentamers, with five binding sites for orthosteric agonists. Although activatible by acetylcholine (ACh) and the precursor molecule choline, ...
... The subtype of nAChR is a unique receptor, widely distributed throughout the brain and expressed in many non-neuronal cells. These receptors function as homopentamers, with five binding sites for orthosteric agonists. Although activatible by acetylcholine (ACh) and the precursor molecule choline, ...
Blood
... • B cells responsible for production of antibodies – Receptor matches antigen – Cells multiply – Antibodies ...
... • B cells responsible for production of antibodies – Receptor matches antigen – Cells multiply – Antibodies ...
Genetic Disorders
... and/or the result of environmental trigger (microbe). Bind to receptors on (A cytokine acts only on a cell that has a receptor for it). either cell which produced it or another cell. Receptor binding Trigger signal transduction pathways. Signal results in altered pattern of gene expression . Cytokin ...
... and/or the result of environmental trigger (microbe). Bind to receptors on (A cytokine acts only on a cell that has a receptor for it). either cell which produced it or another cell. Receptor binding Trigger signal transduction pathways. Signal results in altered pattern of gene expression . Cytokin ...
Immunology Lecture 3 Feb 7 2013
... Membrane bound structures called endocytic vesicles or phagosomes contain the engulfed material. Phagolysosomes are formed when phagosomes fuse with the acidic contents of lysosomes. ...
... Membrane bound structures called endocytic vesicles or phagosomes contain the engulfed material. Phagolysosomes are formed when phagosomes fuse with the acidic contents of lysosomes. ...
Press Release English - Research Institute of Molecular Pathology
... Plasma cells are key players in this process. They fight infections and establish long-lasting protection against pathogens. Plasma cells are white blood cells that develop from B-cells. They are the effector cells of the humoral immune response. Their main function is to produce antibodies that pat ...
... Plasma cells are key players in this process. They fight infections and establish long-lasting protection against pathogens. Plasma cells are white blood cells that develop from B-cells. They are the effector cells of the humoral immune response. Their main function is to produce antibodies that pat ...
Adaptive immune system
The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.