Antibody-independent B cell effector functions in
... previously activated T cells were used as responders [44]. In addition, EBV þ B cells from melanoma patients expanded in the same fashion were effectively used as APC to generate melanoma-specific, MHC II restricted CD4 þ T cell clones that proliferated and secreted IFNg in response to melanoma antig ...
... previously activated T cells were used as responders [44]. In addition, EBV þ B cells from melanoma patients expanded in the same fashion were effectively used as APC to generate melanoma-specific, MHC II restricted CD4 þ T cell clones that proliferated and secreted IFNg in response to melanoma antig ...
Report Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation Cell Reports
... inflammation by inhibiting tumor necrosis factor a (TNF-a) production and by stimulating interleukin 22 secretion from CD11c+CD11b+ lamina propria cells. Thus, our data uncover a mechanism through which intestinal tissue-expressed B7-H1 functions as an essential ligand for innate immune cells to pre ...
... inflammation by inhibiting tumor necrosis factor a (TNF-a) production and by stimulating interleukin 22 secretion from CD11c+CD11b+ lamina propria cells. Thus, our data uncover a mechanism through which intestinal tissue-expressed B7-H1 functions as an essential ligand for innate immune cells to pre ...
week 13.: autoimmunity i.
... the maturation of some self-antigen specific lymphocytes and by mechanisms that inactivate or delete self-reactive lymphocytes that do mature. Central tolerance mechanisms eliminate newly formed strongly autoreactive lymphocytes. This is an important mechanism of inducing self-tolerance in lymphocyt ...
... the maturation of some self-antigen specific lymphocytes and by mechanisms that inactivate or delete self-reactive lymphocytes that do mature. Central tolerance mechanisms eliminate newly formed strongly autoreactive lymphocytes. This is an important mechanism of inducing self-tolerance in lymphocyt ...
Difference in cytokine production and cell cycle
... characterized by the expression of the latent membrane protein 1 (LMP1) and two other viral proteins, EBNA1 and LMP2 in addition to small RNAs, termed EBER 1 and 2 [2]. LMP1 is a multifunctional oncoprotein essential for EBV-induced B-cell proliferation and transformation in vitro [3], as it shares ...
... characterized by the expression of the latent membrane protein 1 (LMP1) and two other viral proteins, EBNA1 and LMP2 in addition to small RNAs, termed EBER 1 and 2 [2]. LMP1 is a multifunctional oncoprotein essential for EBV-induced B-cell proliferation and transformation in vitro [3], as it shares ...
Understanding the Failure of CD8 T-Cell Vaccination against Simian
... Little is known about the number of viral particles produced per productively infected cell (39). Therefore, the scaled production parameter, p, is varied 100-fold from left to right in Fig. 1 (constraining the initial viral replication rate to 1.5 day⫺1) (see Appendix). The same uncertainty holds f ...
... Little is known about the number of viral particles produced per productively infected cell (39). Therefore, the scaled production parameter, p, is varied 100-fold from left to right in Fig. 1 (constraining the initial viral replication rate to 1.5 day⫺1) (see Appendix). The same uncertainty holds f ...
Nonmalignant Leukocyte Disorders - Cal State LA
... Many bands, metamyelocytes, and myelocytes are seen Occasional promyelocytes and myeloblasts may be seen. This condition resembles a chronic myelocytic leukemia (CML), but can be differentiated from CML based on the fact that in leukemoid reactions: There is no Philadelphia chromosome The ...
... Many bands, metamyelocytes, and myelocytes are seen Occasional promyelocytes and myeloblasts may be seen. This condition resembles a chronic myelocytic leukemia (CML), but can be differentiated from CML based on the fact that in leukemoid reactions: There is no Philadelphia chromosome The ...
Document
... • 2% meiotic recombination rate generates population diversity •Crossover: Haplotypes, normally, are inherited intact and hence antigens encoded by different loci are inherited together (e.g., A2; B27; Cw2; DPw6; DQw9; DRw2). However, on occasions, there is crossing over between two parental chromos ...
... • 2% meiotic recombination rate generates population diversity •Crossover: Haplotypes, normally, are inherited intact and hence antigens encoded by different loci are inherited together (e.g., A2; B27; Cw2; DPw6; DQw9; DRw2). However, on occasions, there is crossing over between two parental chromos ...
Interference of passive and active immunity after vaccination of pigs
... and 14 weeks of age showed antigen-specific proliferation. Similar results were observed with IFN-γ secretion after exposure to live PRV. Following exposure to the PRV a higher number of cells from vaccinated animals expressed the CD25 marker, than those from unvaccinated ones. Summarizing, MDA may ...
... and 14 weeks of age showed antigen-specific proliferation. Similar results were observed with IFN-γ secretion after exposure to live PRV. Following exposure to the PRV a higher number of cells from vaccinated animals expressed the CD25 marker, than those from unvaccinated ones. Summarizing, MDA may ...
Infectious agents and cancer: criteria for a causal - UNC
... In addition to these key biologic properties, EBV encodes multiple viral proteins that have profound effects on cellular expression. The EBV oncogene, LMP1, is essential for EBV transformation of lymphocytes and is the only EBV gene product that has transforming ability in rodent fibroblasts [1]. Th ...
... In addition to these key biologic properties, EBV encodes multiple viral proteins that have profound effects on cellular expression. The EBV oncogene, LMP1, is essential for EBV transformation of lymphocytes and is the only EBV gene product that has transforming ability in rodent fibroblasts [1]. Th ...
Extracellular membrane vesicles as a mechanism of cell-to
... analogous processes of budding from the cell surface, they also vary in molecular composition and function depending on the cell of origin. EVs express an array of proteins that differ from those on the surface of the cells from which they originate. Intracellular factors influence EV shedding, incl ...
... analogous processes of budding from the cell surface, they also vary in molecular composition and function depending on the cell of origin. EVs express an array of proteins that differ from those on the surface of the cells from which they originate. Intracellular factors influence EV shedding, incl ...
David E. Elder, MB, CHB, FRCPA
... seven editions produced by Walter Lever, MD, beginning in 1949 as a 449 page volume with “221 Illustrations Including 8 Subjects in Color on 4 Plates.” Thus, this will be the 11th edition of a book that has been continuously published for more than 65 years! In this second generation of the work, t ...
... seven editions produced by Walter Lever, MD, beginning in 1949 as a 449 page volume with “221 Illustrations Including 8 Subjects in Color on 4 Plates.” Thus, this will be the 11th edition of a book that has been continuously published for more than 65 years! In this second generation of the work, t ...
Express Inducible NKG2D Ligands That Mouse NK Cell Activity
... mediated by CTL in the granule exocytosis pathway (19). Acute HSP70 overexpression can even increase the susceptibility against CTL in vitro (19, 20). The immune system appears to be able to kill target cells undergoing an otherwise protective stress response. Our goal was now to determine the effec ...
... mediated by CTL in the granule exocytosis pathway (19). Acute HSP70 overexpression can even increase the susceptibility against CTL in vitro (19, 20). The immune system appears to be able to kill target cells undergoing an otherwise protective stress response. Our goal was now to determine the effec ...
Current concepts in the pathophysiology of atopic dermatitis in human
... capable to secrete toxins, such as enterotoxin A (SEA) and B (SEB) or toxic shock syndrome toxin-1 at the skin surface, which serve as so-called “superantigens” (37). Staphylococcus aureus superantigens are presented as “ordinary” antigens in the peptidepresenting groove of the major histocompatibil ...
... capable to secrete toxins, such as enterotoxin A (SEA) and B (SEB) or toxic shock syndrome toxin-1 at the skin surface, which serve as so-called “superantigens” (37). Staphylococcus aureus superantigens are presented as “ordinary” antigens in the peptidepresenting groove of the major histocompatibil ...
Immune Recruitment and Therapeutic Synergy: Keys to Optimizing
... Oncolytic viruses consist of a diverse range of DNA and RNA viruses traditionally thought to mediate their effects by exploiting aberrations in tumor pathways, allowing preferential viral replication in, and killing of, tumor cells. Clinical development has progressed to late-phase trials, potential ...
... Oncolytic viruses consist of a diverse range of DNA and RNA viruses traditionally thought to mediate their effects by exploiting aberrations in tumor pathways, allowing preferential viral replication in, and killing of, tumor cells. Clinical development has progressed to late-phase trials, potential ...
Genes that Matter™…
... signaling pathway that ultimately leads to B-cell proliferation and differentiation. Loss-of-function mutations in BTK disrupt this signaling pathway, arresting B-cell development at the pro-B-cell stage. Patients with XLA typically have normal numbers of pro-B cells in the bone marrow, but these ce ...
... signaling pathway that ultimately leads to B-cell proliferation and differentiation. Loss-of-function mutations in BTK disrupt this signaling pathway, arresting B-cell development at the pro-B-cell stage. Patients with XLA typically have normal numbers of pro-B cells in the bone marrow, but these ce ...
Title: Minor population of CD55-CD59- blood cells
... cyclosporin (CsA) is the standard approach to treating acquired aplastic anemia (AA)1-5. Approximately 70% of patients respond to this therapy and achieve remission. However, for the remaining 30%, IST might even be harmful due to an increased risk of opportunistic infections, particularly in the ab ...
... cyclosporin (CsA) is the standard approach to treating acquired aplastic anemia (AA)1-5. Approximately 70% of patients respond to this therapy and achieve remission. However, for the remaining 30%, IST might even be harmful due to an increased risk of opportunistic infections, particularly in the ab ...
Powerpoint - Dinman, Jonathan D.
... National Cancer Institute*, Bethesda, Maryland *The views expressed in this talk are my own and do not necessarily represent the views of the NCI *I receive royalties from inventions related to HPV vaccines ...
... National Cancer Institute*, Bethesda, Maryland *The views expressed in this talk are my own and do not necessarily represent the views of the NCI *I receive royalties from inventions related to HPV vaccines ...
2016 Poster Listing
... Tatsuhiko Ozawa, 1895, A rapid and efficient single-cell manipulation method using microwell array chip (ISAAC) technology for screening antigen-specific cytokines-secreting T-cells ...
... Tatsuhiko Ozawa, 1895, A rapid and efficient single-cell manipulation method using microwell array chip (ISAAC) technology for screening antigen-specific cytokines-secreting T-cells ...
Tibb Position on Autoimmune disease
... 2. Autoimmune diseases often (but not always) co-‐exist with inflammation. From the Tibb perspective inflammation is not a disease, but a normal Physis response to tissue injury, irritation or metabolic abnorma ...
... 2. Autoimmune diseases often (but not always) co-‐exist with inflammation. From the Tibb perspective inflammation is not a disease, but a normal Physis response to tissue injury, irritation or metabolic abnorma ...
Chapter 13 - Faculty Web Sites
... Antibody-mediated immune responses Defend against antigens that are free in body fluids, including toxins or extracellular pathogens Effector B cells (plasma cells) use antibodies (Y-shaped proteins) to neutralize the antigen ...
... Antibody-mediated immune responses Defend against antigens that are free in body fluids, including toxins or extracellular pathogens Effector B cells (plasma cells) use antibodies (Y-shaped proteins) to neutralize the antigen ...
Here is the Original File - University of New Hampshire
... • Timothy Brown was the first person to be cured of HIV infection. • Infected with HIV during the 1990s. • Treated with HAART from 2003-2007. • Diagnosed with acute myeloid leukemia (AML) in 2007. • Bone marrow makes abnormal cells. Standard treatment is chemotherapy then infusing new stem cells fro ...
... • Timothy Brown was the first person to be cured of HIV infection. • Infected with HIV during the 1990s. • Treated with HAART from 2003-2007. • Diagnosed with acute myeloid leukemia (AML) in 2007. • Bone marrow makes abnormal cells. Standard treatment is chemotherapy then infusing new stem cells fro ...