major histocompatibility complex
... They suggested that MHC heterozygotes would have greater T-cell responses than homozygotes, and this could potentially explain both the evolutionary advantage for gene duplication and diversity of MHC genes. Later, MHC molecules were found to be involved in antibody-mediated, as well as cellular res ...
... They suggested that MHC heterozygotes would have greater T-cell responses than homozygotes, and this could potentially explain both the evolutionary advantage for gene duplication and diversity of MHC genes. Later, MHC molecules were found to be involved in antibody-mediated, as well as cellular res ...
CURRICULUM VITAE - GITAM Institute of Science
... Developed type 2 diabetic mouse model and involved in identifying cellular and molecular mechanisms involved in the predisposition of diabetic mice to mycobacterium tuberculosis infection Characterization of Innate memory like Natural Killer cells in BCG vaccine induced protective immunity to M. ...
... Developed type 2 diabetic mouse model and involved in identifying cellular and molecular mechanisms involved in the predisposition of diabetic mice to mycobacterium tuberculosis infection Characterization of Innate memory like Natural Killer cells in BCG vaccine induced protective immunity to M. ...
174 kb
... Living things are similar to each other yet different from nonliving things. The cell is the basic unit of structure and function of living things (cell theory). For all living things, life activities are accomplished at the cellular level. Human beings are an interactive organization of cells, tiss ...
... Living things are similar to each other yet different from nonliving things. The cell is the basic unit of structure and function of living things (cell theory). For all living things, life activities are accomplished at the cellular level. Human beings are an interactive organization of cells, tiss ...
Immune Cells Have Sex and So Should Journal Articles
... when cells of the immune system are exposed to a virus, bacterium, parasite, innocuous allergen, toxin, or self-antigen, innate recognition and responses as well as downstream adaptive immune responses differ between males and females. Females typically develop higher innate (5, 6), cell-mediated (6 ...
... when cells of the immune system are exposed to a virus, bacterium, parasite, innocuous allergen, toxin, or self-antigen, innate recognition and responses as well as downstream adaptive immune responses differ between males and females. Females typically develop higher innate (5, 6), cell-mediated (6 ...
Ribosomes in platelets protect the messenger
... other EBV-associated neoplasia such as nasopharyngeal lesions, gastric carcinoma, and Hodgkin disease. This combination of frequent PDL1 expression and presence of foreign antigen expression on tumor cells makes the use of checkpoint inhibitors very attractive. Kwong and colleagues, on behalf of the ...
... other EBV-associated neoplasia such as nasopharyngeal lesions, gastric carcinoma, and Hodgkin disease. This combination of frequent PDL1 expression and presence of foreign antigen expression on tumor cells makes the use of checkpoint inhibitors very attractive. Kwong and colleagues, on behalf of the ...
The pressure mounts on lung dendritic cells EDITORIAL
... model of PAH, the levels of PAF are greatly increased and a PAF antagonist prevents PAH in this model [14]. It has recently been shown that PAF immobilises DCs in the periphery and is responsible for the accumulation of DCs in the skin and vessel wall of dyslipidaemic ApoE-/- mice, where DCs initiat ...
... model of PAH, the levels of PAF are greatly increased and a PAF antagonist prevents PAH in this model [14]. It has recently been shown that PAF immobilises DCs in the periphery and is responsible for the accumulation of DCs in the skin and vessel wall of dyslipidaemic ApoE-/- mice, where DCs initiat ...
Heart Allograft Tolerance Regulatory Cells: Relevance to
... olid organ and hemopoietic stem cell (HSC)3 transplantation have become common procedures for organ failure and other end-stage diseases. The major limitation, rejection of the allograft by the host’s immune system, can be reduced but not eliminated by various immunosuppressive drugs. Unfortunately, ...
... olid organ and hemopoietic stem cell (HSC)3 transplantation have become common procedures for organ failure and other end-stage diseases. The major limitation, rejection of the allograft by the host’s immune system, can be reduced but not eliminated by various immunosuppressive drugs. Unfortunately, ...
Materials - Web Adventures
... Protozoa – Simple, single-cell organisms such as the amoeba and paramecium. Some have flagella or cilia and are capable of rapid movement. Protozoas can spread through food, water, and animals. ...
... Protozoa – Simple, single-cell organisms such as the amoeba and paramecium. Some have flagella or cilia and are capable of rapid movement. Protozoas can spread through food, water, and animals. ...
Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model
... immune responses towards T-helper cell type 1 (Th1) responses [6–8]. Though Mw favour the induction of Th1 responses [9, 10], it has also been demonstrated that Mw can induce differentiation towards Th2 lymphocytes [11, 12]. To exert immunosuppressive responses Mw secrete anti-inflammatory mediators ...
... immune responses towards T-helper cell type 1 (Th1) responses [6–8]. Though Mw favour the induction of Th1 responses [9, 10], it has also been demonstrated that Mw can induce differentiation towards Th2 lymphocytes [11, 12]. To exert immunosuppressive responses Mw secrete anti-inflammatory mediators ...
Candida albicans Pathogenicity and Epithelial Immunity
... Figure 2. C. albicans recognition and protection at mucosal surfaces. In health (left panel) C. albicans resides in the commensal state, which is characterised by low fungal burdens. C. albicans is recognised but an activation threshold is not reached; thus, the fungus is tolerated without activati ...
... Figure 2. C. albicans recognition and protection at mucosal surfaces. In health (left panel) C. albicans resides in the commensal state, which is characterised by low fungal burdens. C. albicans is recognised but an activation threshold is not reached; thus, the fungus is tolerated without activati ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
... shown that SAP (SLAM-associated protein) plays a central role in CD4 T cell help at the germinal center stage for the development of long term humoral immunity after a viral infection. In this project we study the functional characteristics of CD4 T cells that provide B cell help, and the roles of S ...
... shown that SAP (SLAM-associated protein) plays a central role in CD4 T cell help at the germinal center stage for the development of long term humoral immunity after a viral infection. In this project we study the functional characteristics of CD4 T cells that provide B cell help, and the roles of S ...
A Possible Link Between Autoimmunity and Cancer
... immune response in cancer, immature pDCs are activated by Toll-like receptors, which lead to B- and T-cell immune responses in autoimmune disease (Lang et al., 2005). The immunological tolerance is produced by tumour-derived soluble factors (TDSFs) and immature dendritic cells (iDCs), which inhibit ...
... immune response in cancer, immature pDCs are activated by Toll-like receptors, which lead to B- and T-cell immune responses in autoimmune disease (Lang et al., 2005). The immunological tolerance is produced by tumour-derived soluble factors (TDSFs) and immature dendritic cells (iDCs), which inhibit ...
Perpetuation of immunological memory
... complementary B cells that can react with the idiotypes of Burnet cells. We refer to these second set of complementary B cells as Jerne cells. These cells are pictorially depicted in Fig. 1. The Burnet B cells, which can be triggered by the antigen, can in turn trigger Jerne B cells whose idiotopes ...
... complementary B cells that can react with the idiotypes of Burnet cells. We refer to these second set of complementary B cells as Jerne cells. These cells are pictorially depicted in Fig. 1. The Burnet B cells, which can be triggered by the antigen, can in turn trigger Jerne B cells whose idiotopes ...
Cytochrome P450s in human immune cells regulate IL-22
... The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immunemodulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relev ...
... The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immunemodulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relev ...
Monoclonal Antibodies
... Industrial scale operation 1. Daugherty E (2012) Biotechnology St. Paul: Paradigm Publishing, Inc. ...
... Industrial scale operation 1. Daugherty E (2012) Biotechnology St. Paul: Paradigm Publishing, Inc. ...
Scaling up Delivery Guide
... lump. The learners must firstly do the task on their own – then they must do it as part of a production line (e.g. with one one tearing off plasticine from the large ball into appropriate sizes, one rolling the pieces into balls and the final one squaring them off ). Talk about the division of labou ...
... lump. The learners must firstly do the task on their own – then they must do it as part of a production line (e.g. with one one tearing off plasticine from the large ball into appropriate sizes, one rolling the pieces into balls and the final one squaring them off ). Talk about the division of labou ...
Lamarck and Immunity : Somatic and Germline Evolution of Antibody
... With respect to B cells The Clonal Selection Theory posits an array of B cells emerging early in ontogeny each displaying a different antigen receptor on their surface membrane i.e. “one cell makes one antibody”. Early proof of this concept was provided by Sir Gustav Nossal (Ada & Nossal 1987). Of c ...
... With respect to B cells The Clonal Selection Theory posits an array of B cells emerging early in ontogeny each displaying a different antigen receptor on their surface membrane i.e. “one cell makes one antibody”. Early proof of this concept was provided by Sir Gustav Nossal (Ada & Nossal 1987). Of c ...
Immunoexpression of Interleukin 17, Transforming Growth Factor
... defense response to microbial challenge emanating from the root canal system. Periapical granulomas (PGs) consist of a granulomatous tissue with inflammatory cells, fibroblasts, and a well-developed fibrous capsule. If the antigenic stimulus persists, the epithelial cell rests of Malassez can be sti ...
... defense response to microbial challenge emanating from the root canal system. Periapical granulomas (PGs) consist of a granulomatous tissue with inflammatory cells, fibroblasts, and a well-developed fibrous capsule. If the antigenic stimulus persists, the epithelial cell rests of Malassez can be sti ...
MUTATIONAL HOT SPOTS IN Ig V REGION GENES OF
... in the mouse (1-6). In each case, the analyses were carried out by capturing individual B cells and expanding them in the form of hybridomas . V region genes expressed by these hybridomas were then sequenced. Because of the similarities of their DNA sequences, particularly at the V/D/J or V/J joints ...
... in the mouse (1-6). In each case, the analyses were carried out by capturing individual B cells and expanding them in the form of hybridomas . V region genes expressed by these hybridomas were then sequenced. Because of the similarities of their DNA sequences, particularly at the V/D/J or V/J joints ...
The effect of tobacco smoke ingredients on immunity
... Smoking stimulates aggregation of alveolar macrophages but significantly diminishes their function. Macrophages have an important role in immune response because of their different activites, among which the most important are phagocytosis, haemotaxis, preparation and presentation of antigens for B- ...
... Smoking stimulates aggregation of alveolar macrophages but significantly diminishes their function. Macrophages have an important role in immune response because of their different activites, among which the most important are phagocytosis, haemotaxis, preparation and presentation of antigens for B- ...
Elements of the Immune System and their Roles
... Immunology is the study of the physiological mechanisms that humans and other animals use to defend their bodies from invasion by other organisms. The origins of the subject lie in the practice of medicine and in historical observations that people who survived the ravages of epidemic disease were u ...
... Immunology is the study of the physiological mechanisms that humans and other animals use to defend their bodies from invasion by other organisms. The origins of the subject lie in the practice of medicine and in historical observations that people who survived the ravages of epidemic disease were u ...
Complement-induced regulatory T cells suppress T
... cell sorter (FACS) analysis and enzyme-linked immunosorbent assay (ELISA; BioSource International, Camarillo, CA), respectively. Experiments involving healthy donors were performed at least 3 times using a different donor each time and all activation conditions were performed in triplicate. Interdon ...
... cell sorter (FACS) analysis and enzyme-linked immunosorbent assay (ELISA; BioSource International, Camarillo, CA), respectively. Experiments involving healthy donors were performed at least 3 times using a different donor each time and all activation conditions were performed in triplicate. Interdon ...