Immunology and Immunotherapy in allergic disease
... 3) Increase IgA and IgM antigen-specific B lymphocytes. They have potential beneficial effects on mucosal immune barrier function and may limit antigen penetration into the body. Multiple studies have been conducted to evaluate the effect of immunotherapy on the Tcell response or cytokine production ...
... 3) Increase IgA and IgM antigen-specific B lymphocytes. They have potential beneficial effects on mucosal immune barrier function and may limit antigen penetration into the body. Multiple studies have been conducted to evaluate the effect of immunotherapy on the Tcell response or cytokine production ...
CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients , S. Boniface*,
... resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs). Monocyte-derived DCs ...
... resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs). Monocyte-derived DCs ...
Rachel M. Dudek - Leonard Lab
... input detection and single output response. An immune cell engineered to recognize a novel stimulus but to respond in an endogenous manner is still subject to regulation by the immunological network surrounding it, potentially accounting for the failure of many autologous cellular immune therapies. ...
... input detection and single output response. An immune cell engineered to recognize a novel stimulus but to respond in an endogenous manner is still subject to regulation by the immunological network surrounding it, potentially accounting for the failure of many autologous cellular immune therapies. ...
Behavioral immunization: immunity to self-antigens
... environment will result in reduced immune activation and thus in reduced immunological memory; such an individual is likely to cope poorly upon exposure to even moderate stress levels. On the other hand, an overwhelmingly stressful experience, as well as chronic stress, could overwhelm the immune re ...
... environment will result in reduced immune activation and thus in reduced immunological memory; such an individual is likely to cope poorly upon exposure to even moderate stress levels. On the other hand, an overwhelmingly stressful experience, as well as chronic stress, could overwhelm the immune re ...
DRiPs and other sources of peptide ligands for MHC class I molecules
... playing field in the ongoing battle between vertebrates and viruses (Janeway and Travers, 1994). The principal method used by the immune system to combat viruses is based on the recognition of small peptide fragments of viral proteins by roving thymus-derived cells (T cells) that express a clonally ...
... playing field in the ongoing battle between vertebrates and viruses (Janeway and Travers, 1994). The principal method used by the immune system to combat viruses is based on the recognition of small peptide fragments of viral proteins by roving thymus-derived cells (T cells) that express a clonally ...
Preparative separation of foreign antigens for highly efficient
... separation of proteins followed by elution, concentration and adsorption of the polypeptide subunits to latex microspheres. Alternatively, where a specific antibody is available, proteins may be affinity-purified from a heterogeneous mixture of antigens, using antibody-coated latex microspheres. Nan ...
... separation of proteins followed by elution, concentration and adsorption of the polypeptide subunits to latex microspheres. Alternatively, where a specific antibody is available, proteins may be affinity-purified from a heterogeneous mixture of antigens, using antibody-coated latex microspheres. Nan ...
Xenopus laevis Antiviral Immunity in the Amphibian Innate T Cells
... the more extensively characterized iVa6 T cells, X. laevis also possesses a population of XNC10-reactive CD8dim+ T cells with a more diverse, albeit iVa6-Ja1.43 biased, TCR repertoire termed XNC10-restricted type II cells. Currently, it is unclear whether these non-invariant type II cells represent ...
... the more extensively characterized iVa6 T cells, X. laevis also possesses a population of XNC10-reactive CD8dim+ T cells with a more diverse, albeit iVa6-Ja1.43 biased, TCR repertoire termed XNC10-restricted type II cells. Currently, it is unclear whether these non-invariant type II cells represent ...
Regulation of type 2 immunity to helminths by mast cells
... cells was found to be sufficient for TSLP production and Th2 priming, signaling through the hematopoietic compartment was needed for optimal responses.19 In this study, dendritic cells were found to be the major hematopoietic cell population required. However, it is still possible that MCs may contr ...
... cells was found to be sufficient for TSLP production and Th2 priming, signaling through the hematopoietic compartment was needed for optimal responses.19 In this study, dendritic cells were found to be the major hematopoietic cell population required. However, it is still possible that MCs may contr ...
Document
... Lymphocytes • Have large, dark-purple, circular nuclei with a thin rim of blue cytoplasm • Found mostly enmeshed in lymphoid tissue (some circulate in the blood) ...
... Lymphocytes • Have large, dark-purple, circular nuclei with a thin rim of blue cytoplasm • Found mostly enmeshed in lymphoid tissue (some circulate in the blood) ...
BBB - Cornell Center for Technology Enterprise and
... The use of adenosine signaling to modulate BBB permeability has many advantages over other approaches to deliver therapeutics to the CNS: 1) It makes use of an endogenous mechanism for BBB control 2) It has the potential for precise time dependent control of BBB permeability 3) The process is revers ...
... The use of adenosine signaling to modulate BBB permeability has many advantages over other approaches to deliver therapeutics to the CNS: 1) It makes use of an endogenous mechanism for BBB control 2) It has the potential for precise time dependent control of BBB permeability 3) The process is revers ...
IMMUNOLOGICAL UNRESPONSIVENESS TO
... Materials and Methods Mice of the following strains were used in the present study: CBA, C57BL, and B10.SM and certain FI hybrids between these strains. Antigens and PolyclonalActivators. Native dextran from L. mesenteroides B512 (average mol wt 5-40 x 106 daltons), was obtained from ICN Pharmaceuti ...
... Materials and Methods Mice of the following strains were used in the present study: CBA, C57BL, and B10.SM and certain FI hybrids between these strains. Antigens and PolyclonalActivators. Native dextran from L. mesenteroides B512 (average mol wt 5-40 x 106 daltons), was obtained from ICN Pharmaceuti ...
File
... 4- Receptors for cytokines: Leukocytes express receptors for cytokines that are produced in response to microbes. One of the most important of these cytokines is interferon-γ (IFN-γ), which is secreted by natural killer cells reacting to microbes and by antigen-activated T lymphocytes during adapti ...
... 4- Receptors for cytokines: Leukocytes express receptors for cytokines that are produced in response to microbes. One of the most important of these cytokines is interferon-γ (IFN-γ), which is secreted by natural killer cells reacting to microbes and by antigen-activated T lymphocytes during adapti ...
everyday immune defence
... importance. This unique ingredients patented, yearround protection is the culmination of more than $300 million in research with leading university and government institutions. It has been clinically proven to prime the immune system. Clinical studies have shown reductions in symptomatic days of upp ...
... importance. This unique ingredients patented, yearround protection is the culmination of more than $300 million in research with leading university and government institutions. It has been clinically proven to prime the immune system. Clinical studies have shown reductions in symptomatic days of upp ...
Licentiate thesis from the Department of Immunology,
... in turn phosphorylate the transcription factor AP-1 that switches on genes encoding the inflammatory cytokines.19 There are three major families of MAPKs; the extracellular signalregulated protein kinases (ERK) and the c-Jun NH2-terminal kinases (JNK) and p38-MAPK that show some overlap in function. ...
... in turn phosphorylate the transcription factor AP-1 that switches on genes encoding the inflammatory cytokines.19 There are three major families of MAPKs; the extracellular signalregulated protein kinases (ERK) and the c-Jun NH2-terminal kinases (JNK) and p38-MAPK that show some overlap in function. ...
PET probes for distinct metabolic pathways have different cell
... where, under normal conditions, it is sequestered in intestinal epithelial cells (21). PET imaging of Dck-knockout mice with [18F]-FAC shows no signal in lymphoid organs or the gastrointestinal tract. [18F]-FAC PET signal in peripheral lymph nodes and spleens of wildtype mice increases with immune s ...
... where, under normal conditions, it is sequestered in intestinal epithelial cells (21). PET imaging of Dck-knockout mice with [18F]-FAC shows no signal in lymphoid organs or the gastrointestinal tract. [18F]-FAC PET signal in peripheral lymph nodes and spleens of wildtype mice increases with immune s ...
Novocastra™ Liquid Mouse Monoclonal Antibody Thyroid
... Alternatively, the variety of different cell types present in most tissue sections frequently offers negative control sites, but this should be verified by the user. Non-specific staining, if present, usually has a diffuse appearance. Sporadic staining of connective tissue may also be observed in se ...
... Alternatively, the variety of different cell types present in most tissue sections frequently offers negative control sites, but this should be verified by the user. Non-specific staining, if present, usually has a diffuse appearance. Sporadic staining of connective tissue may also be observed in se ...
Mistletoe in the treatment of malignant melanoma
... Dendritic cells (DC) are also an important tool for tumor-antigen-specific immunotherapy of cancer because of their critical role in mounting a specific immune response where their intratumoral and peritumoral density as well as their functional status are correlated with clinical staging of the dis ...
... Dendritic cells (DC) are also an important tool for tumor-antigen-specific immunotherapy of cancer because of their critical role in mounting a specific immune response where their intratumoral and peritumoral density as well as their functional status are correlated with clinical staging of the dis ...
PDF full-Text - Journal of Investigational Allergology and Clinical
... influence. The majority of studies in SJS/TEN have been undertaken in skin and blister fluid, where it is more likely to find cytotoxic cells expressing CD8+ T cells. Peripheral blood mononuclear cells and the dermis, in contrast, are predominantly composed of CD4+ T cells [35,36]. Recent studies ha ...
... influence. The majority of studies in SJS/TEN have been undertaken in skin and blister fluid, where it is more likely to find cytotoxic cells expressing CD8+ T cells. Peripheral blood mononuclear cells and the dermis, in contrast, are predominantly composed of CD4+ T cells [35,36]. Recent studies ha ...
Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy
... example, some OVs are engineered to express viral genes essential for replication controlled by tumor-specific promoters [34]. For a cell to effectively function as a carrier system for OVs, it is crucial that it maintains high tumor specific promoter activity and supports viral replication. A cell ...
... example, some OVs are engineered to express viral genes essential for replication controlled by tumor-specific promoters [34]. For a cell to effectively function as a carrier system for OVs, it is crucial that it maintains high tumor specific promoter activity and supports viral replication. A cell ...
Anti-IgE: Beyond Asthma
... Various antigen-presenting cells are also involved in this immunologic process Langerhans cells, dendritic cells, and macrophages Langerhans cells are increased in number in chronic AD lesions, express FcRII and FcRI (high affinity) IgE receptors, and have been found to be carrying IgE antibodies De ...
... Various antigen-presenting cells are also involved in this immunologic process Langerhans cells, dendritic cells, and macrophages Langerhans cells are increased in number in chronic AD lesions, express FcRII and FcRI (high affinity) IgE receptors, and have been found to be carrying IgE antibodies De ...
ark LP 38 FPSS 1 1993 Abstract
... Immune response of common carp (Cyprinus carpio L.) to cortisol simulated stress / Samson Soon Min Ngen. ...
... Immune response of common carp (Cyprinus carpio L.) to cortisol simulated stress / Samson Soon Min Ngen. ...
Immune response of the small intestinal mucosa in children with
... controls. The levels of these two indicators stayed low in treated CD patients, suggesting that impaired capacity of ETCM is an inherent feature of CD. Second, IL-17A, a cytokine involved in both inflammation and anti-bacterial responses, and IFN-γ were both increased in active CD, but normalized in ...
... controls. The levels of these two indicators stayed low in treated CD patients, suggesting that impaired capacity of ETCM is an inherent feature of CD. Second, IL-17A, a cytokine involved in both inflammation and anti-bacterial responses, and IFN-γ were both increased in active CD, but normalized in ...
CARMA1 Is Critical for the Development of Allergic Airway
... CARMA1 in the regulation of the adaptive immune response through its actions in lymphocytes, and suggests that targeted inhibition of CARMA1 would provide a novel means of inhibiting NF-B activation in lymphocytes. In addition, because CARMA1 activation is regulated by protein kinases, it may be qu ...
... CARMA1 in the regulation of the adaptive immune response through its actions in lymphocytes, and suggests that targeted inhibition of CARMA1 would provide a novel means of inhibiting NF-B activation in lymphocytes. In addition, because CARMA1 activation is regulated by protein kinases, it may be qu ...
