t The Immune System in the Oldest-Old Clinical and Immunological Studies in
... an increase from 1.5 % fifty years earlier. The immune system undergoes dramatic changes at high age, sometimes referred to as “immunosenescence”. However, the natures of these changes, and in particular, their clinical consequences are incompletely understood. In a previous longitudinal study, a se ...
... an increase from 1.5 % fifty years earlier. The immune system undergoes dramatic changes at high age, sometimes referred to as “immunosenescence”. However, the natures of these changes, and in particular, their clinical consequences are incompletely understood. In a previous longitudinal study, a se ...
Malignant melanoma of the skin – not a sunshine
... radiation in the immediate vicinity of broadcasting antennae yields moderate but statistically significant clastogenicity.” Microwave exposure also affect sperm count, as stated by Weyandt et al. [10]: “The microwave exposed soldiers showed a significant decline in sperm count (p=0.0085).” High-powe ...
... radiation in the immediate vicinity of broadcasting antennae yields moderate but statistically significant clastogenicity.” Microwave exposure also affect sperm count, as stated by Weyandt et al. [10]: “The microwave exposed soldiers showed a significant decline in sperm count (p=0.0085).” High-powe ...
New Approaches for Transplant Patients
... Reduced-intensity Regimen (non-myeloablative or “mini”) • Lower doses of chemotherapy with or without radiation – Main goal: suppressing the recipient immune system to allow donor cells to engraft • Works for patients with: – Slower growing diseases – Who are less likely to tolerate the side effect ...
... Reduced-intensity Regimen (non-myeloablative or “mini”) • Lower doses of chemotherapy with or without radiation – Main goal: suppressing the recipient immune system to allow donor cells to engraft • Works for patients with: – Slower growing diseases – Who are less likely to tolerate the side effect ...
innovative development strategies and applications for bispecific
... for the treatment of malignant ascites. Removab simultaneously targets the epithelial cell adhesion molecule (EpCAM) and CD3. This effectively brings into close proximity tumor cells, which express EpCAM, and T-cells which express CD3. Also, the Fc domain of Removab interacts with other immune syste ...
... for the treatment of malignant ascites. Removab simultaneously targets the epithelial cell adhesion molecule (EpCAM) and CD3. This effectively brings into close proximity tumor cells, which express EpCAM, and T-cells which express CD3. Also, the Fc domain of Removab interacts with other immune syste ...
Th17 development
... cytokines IL-4 and IL-10 can block IL-12 production, thereby reducing differentiation into Th12. This cross-regulation results in a balance between the two subsets with their differential effector mechanisms. Distortion of this balance has been implicated to lie at the basis of diseases like allergy ...
... cytokines IL-4 and IL-10 can block IL-12 production, thereby reducing differentiation into Th12. This cross-regulation results in a balance between the two subsets with their differential effector mechanisms. Distortion of this balance has been implicated to lie at the basis of diseases like allergy ...
Illuminating Neonatal Sepsis as Age-Specific Systemic Inflammatory
... Preterm babies are especially at high risk for fatal courses that directly correspond to severe sepsis associated with so called cytokine storms in adults. Clinically, the hallmark of the neonatal patient group is hyperinflammatory immune responses. These are poorly explained and typically cited as ...
... Preterm babies are especially at high risk for fatal courses that directly correspond to severe sepsis associated with so called cytokine storms in adults. Clinically, the hallmark of the neonatal patient group is hyperinflammatory immune responses. These are poorly explained and typically cited as ...
Bovine mammary gland
... the elevation in phagocytic cells, lymphocytes, immunoglobulins and Lf These changes occur too slowly and their antibacterial action is compromised by other normal events of involution. Treatment of glands at or near drying off with colchicine, endotoxin or the combination of the two compounds resul ...
... the elevation in phagocytic cells, lymphocytes, immunoglobulins and Lf These changes occur too slowly and their antibacterial action is compromised by other normal events of involution. Treatment of glands at or near drying off with colchicine, endotoxin or the combination of the two compounds resul ...
Document
... Associate Professor in the Department of Tropical Medicine, Medical Microbiology and Pharmacology at the Medical School of the University of Hawaii. Research interests Dr. Verma's research interest is to study various host cell-signaling pathways associated with infection with viral pathogens to ult ...
... Associate Professor in the Department of Tropical Medicine, Medical Microbiology and Pharmacology at the Medical School of the University of Hawaii. Research interests Dr. Verma's research interest is to study various host cell-signaling pathways associated with infection with viral pathogens to ult ...
LETTERS
... correlates with their peptide-binding characteristics that affect thymic development. Our results provide a conceptual framework that unifies diverse empirical observations, and have implications for vaccination strategies. HIV infection leads to acute high level viraemia, which is subsequently redu ...
... correlates with their peptide-binding characteristics that affect thymic development. Our results provide a conceptual framework that unifies diverse empirical observations, and have implications for vaccination strategies. HIV infection leads to acute high level viraemia, which is subsequently redu ...
Interferon-gamma deficiency prevents coronary arteriosclerosis but
... teriopathy remain conjectural, they presumably involve multiple factors. For example, immunological differences between host and donor tissues (with resultant cellular and/or humoral immunity) probably contribute to the pathogenesis, although ischemic, infectious, and other etiologies have also been ...
... teriopathy remain conjectural, they presumably involve multiple factors. For example, immunological differences between host and donor tissues (with resultant cellular and/or humoral immunity) probably contribute to the pathogenesis, although ischemic, infectious, and other etiologies have also been ...
Barcelona-Cincinnati technique for limbal transplantation
... cell grafts, especially if a cadaveric donor graft is not required, present a reduced risk of rejection due to the absence of antigen-presenting Langerhan´s cells.13 As a direct relationship between ocular surface stem cell transplantation failure and immune rejection has been reported, it is critic ...
... cell grafts, especially if a cadaveric donor graft is not required, present a reduced risk of rejection due to the absence of antigen-presenting Langerhan´s cells.13 As a direct relationship between ocular surface stem cell transplantation failure and immune rejection has been reported, it is critic ...
Mesenchymal Stem Cells
... [12]. Many reports have also described MSCs as having immunosuppressive properties, specifically that MSCs can modulate many T-cell functions including cell activation [39, 40]. This suppression appears to be independent of MHC matching between the MSCs and the T cells. Some reports have demonstrate ...
... [12]. Many reports have also described MSCs as having immunosuppressive properties, specifically that MSCs can modulate many T-cell functions including cell activation [39, 40]. This suppression appears to be independent of MHC matching between the MSCs and the T cells. Some reports have demonstrate ...
Lexicon for “A.C.T. (Assess, Change, Test) on Molecular Testing”
... cell growth. Mutated (changed) forms of the ALK gene and protein have been found in some types of cancer, including neuroblastoma, non-small cell lung cancer, and anaplastic large cell lymphoma. These changes may increase the growth of cancer cells. Checking for changes in the ALK gene in tumo ...
... cell growth. Mutated (changed) forms of the ALK gene and protein have been found in some types of cancer, including neuroblastoma, non-small cell lung cancer, and anaplastic large cell lymphoma. These changes may increase the growth of cancer cells. Checking for changes in the ALK gene in tumo ...
Negative-Strand RNA Viruses Maturation and Adaptive Immunity by
... The first evidence for viral-induced TLR signaling was the demonstration that the synthetic dsRNA analog poly(I:C), as well as isolated viral dsRNA, could induce the expression of costimulatory molecules on B cells and the secretion of cytokines from APCs through TLR3 signaling (4). Since then, a nu ...
... The first evidence for viral-induced TLR signaling was the demonstration that the synthetic dsRNA analog poly(I:C), as well as isolated viral dsRNA, could induce the expression of costimulatory molecules on B cells and the secretion of cytokines from APCs through TLR3 signaling (4). Since then, a nu ...
Shizuru et al. Hematopoietic Stem and Progenitor Cells: Clinical and
... cell progenitor type (T, B, myeloerythroid) (5–8) and methods to sort cells based on their unique gene expression profiles, as manifested by cell surface proteins and glycoproteins (7–9). Using this approach, both mouse and human HSC were prospectively isolated (8, 9). All HSC activity in adult mous ...
... cell progenitor type (T, B, myeloerythroid) (5–8) and methods to sort cells based on their unique gene expression profiles, as manifested by cell surface proteins and glycoproteins (7–9). Using this approach, both mouse and human HSC were prospectively isolated (8, 9). All HSC activity in adult mous ...
NK Cell Receptors as Tools in Cancer Immunotherapy
... with activated tumor‐infiltrating lymphocytes (TILs) or lymphokine activated killer (LAK) cells have been successful as treatments for some melanoma and renal tumor patients (Dudley and Rosenberg, 2003; Rosenberg et al., 1994; Yannelli and Wroblewski, 2004). In the initial studies, effector cells we ...
... with activated tumor‐infiltrating lymphocytes (TILs) or lymphokine activated killer (LAK) cells have been successful as treatments for some melanoma and renal tumor patients (Dudley and Rosenberg, 2003; Rosenberg et al., 1994; Yannelli and Wroblewski, 2004). In the initial studies, effector cells we ...
Five Prime Therapeutics, Inc.
... This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate" and similar expressions (as well as other words or expressions referencing future events or circumstances) ar ...
... This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate" and similar expressions (as well as other words or expressions referencing future events or circumstances) ar ...
30.6 Lymphatic System KEY CONCEPT The lymphatic system provides another type of
... The lymphatic system provides another type of circulation in the body. ...
... The lymphatic system provides another type of circulation in the body. ...
March 28, 2017 RHD Genotyping for Prenatal Patients with a
... To provide safe and appropriate care for prenatal patients with serologically Weak D phenotype and to standardize care across Canada, we support the implementation of the following guidance statement: Prenatal patients with discrepant, weak or inconclusive serological RhD test results should be fur ...
... To provide safe and appropriate care for prenatal patients with serologically Weak D phenotype and to standardize care across Canada, we support the implementation of the following guidance statement: Prenatal patients with discrepant, weak or inconclusive serological RhD test results should be fur ...