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Host Defences, Microbial Evasion & Virulence Factors
Host Defences, Microbial Evasion & Virulence Factors

... Clostridium tetani; Tetanus toxin (neurotoxin) Clostridium botulinum; Botulinum toxin (neurotoxin) Clostridium perfringens: Clostidial toxin (phospholipase activation) Clostridium difficile; Toxin A (enterotoxin), Toxin B (cytotoxin) Streptococcus pyogenes; Erythrogenic toxin (vasodilation) Staphylo ...
Immunology MCQ exam 1. All of the following are true with respect
Immunology MCQ exam 1. All of the following are true with respect

Claire Baldock
Claire Baldock

... T 189/01 – Yeda Research (IFN-beta 2/Il-6R) 15. An antibody against IFN-β2/Il-6R soluble extracellular fragment which specifically recognises said fragment …. (Para. 14) “The notion of specificity does not exclude that an antibody may cross-react with other polypeptides than that against which it ha ...
bacterial agents and in vitro susceptibility patterns
bacterial agents and in vitro susceptibility patterns

... LEAVING THYMUS * Following activation by antigen T cells differentiate into different effector cells * CD8 to cytotoxic T cells * CD4 to * TH1 * TH2 ...
Tumor Escape from Immune Surveillance
Tumor Escape from Immune Surveillance

T lymphocyte
T lymphocyte

... IV. Functions of T cells 1. CD4+ helper T cells (Th) Th0: T cells activated by Ag can secret many CKs in short time Th1: produce IL-2 and IFN-, but not IL-4. They are chiefly responsible for cellmediated immune responses, but can also help B cells to produce IgG2a, but not much IgG1 or IgE; Th2: s ...
61. DNA vaccines based on FMDV minigenes in a mouse model
61. DNA vaccines based on FMDV minigenes in a mouse model

... fusion peptides with the major B cell site from capsid protein VP1(Blanco et al., 2000; 2001). These results opened the possibility of designing subunit vaccines including B and T cell epitopes relevant for the induction of protection against FMDV. As the efficient synthesis of long peptides is stil ...
T cells
T cells

... macromolecules from the intestinal lumen into subepithelial tissues. •They are thought to play an important role in delivering antigen to Peyer’s patches ...
Immune Responses to Viral Infections
Immune Responses to Viral Infections

... • NK cells are present throughout the body, but mainly in the blood. • They recognize changes in the surface molecules of virusinfected cells as a result of infection, though they do not recognize specific antigens. • After recognizing virus-infected cells as target cells, NK cells are able to bind ...
File - Mrs. LeCompte
File - Mrs. LeCompte

... When an antigen first binds to a B cell receptor (BCR), the cell takes in a few of the foreign molecules by receptor-mediated endocytosis. o The B cells to begin the process of clonal selection = when the best match between a specific B cell’s receptor and the antigen is found o cytokines from helpe ...
A System of Many Hats
A System of Many Hats

... When they recognize something non-self (antigen) they signal the release of inflamatory cytokines. Dendritic cells, another type of phagocytic cell, leave the site of infection and migrate to a nearby lymph node. The dendritic cells are collected in a draining lymph node (one or ones nearest the sti ...
Fall 2010 MCB Transcript
Fall 2010 MCB Transcript

... receptors should see, because with twelve receptors they have to see many different microbes,” says MCB Assistant Professor Greg Barton. “They evolved to recognize very conserved features on microbes.” Barton is interested in understanding what the innate immune system’s strategies for general micro ...
BiTEs - CARE
BiTEs - CARE

... -addition of the endodomain of CD28 co-stimulatory molecule increases in vivo persistence by activating the PI3K-AKT-mTOR pathway leading to proliferation and protein synthesis. ...
Types of Hypersensitivity
Types of Hypersensitivity

Lecture 17
Lecture 17

... • Colonization - the first stage of microbial infection - the establishment of the pathogen at the appropriate portal of entry • Adherence (attachment) is often an essential step in bacterial pathogenesis or infection, required for colonizing a new host – Adhesion - Process by which microorganisms a ...
Genetic Vaccines
Genetic Vaccines

... Chow et al...... Demonstrated that injection of a vector that encoded HbsAg and IL-2 on the same plasmid induced marked increase of Ab responses and T-cell proliferation compared to a plasmid encoding HbsAg alone. Taken these results and results from other studies, it is suggested that IL-2 gene co ...
Specific Cellular Defences - Smithycroft Secondary School
Specific Cellular Defences - Smithycroft Secondary School

... I can state that one group of T-lymphocytes destroy infected cells by inducing apoptosis. Another group of T-lymphocytes secrete cytokines that activate B lymphocytes and phagocytes. When pathogens infect tissue, some phagocytes capture the pathogen and display fragments of its antigens on their sur ...


... nomenon. Suppressor cells may slow dowrr formation in HP patients, hence granuJomas prominent as in other disorders, e.g. sru:-co1dOSis.•1 alveolitis is characterized by accumulation lymphocytcs. A significant increase of spontaneous cytotoll observed in HP patients (1]. By contrast, BAL cytes from ...
Ppoint - Dr. Stuart White
Ppoint - Dr. Stuart White

... developed world – the same period marks no rise in the developing world  1 in 7 children born in the developed world will develop allergic asthma  Juvenile Diabetes has risen 5 fold in developed world – no increase in developing world  Environmental pollution has been eliminated as the suspected ...
Graves` Disease - The Interaction of Lymphocytes and Thyroid Cells
Graves` Disease - The Interaction of Lymphocytes and Thyroid Cells

... Rifa’i et al. [Rifa’i et al., 2004] have described subsets of naturally occurring Tregs CD8+CD25+. It is possible that CD8+T cells in contact with thyrocytes play the role of Tregs in the pathogenesis of Graves’ disease. The investigations of Negrini et al. [ Negrini et al. 2006] have characterized ...
Document
Document

... 1. ZAFIRLUKAST (ICI-204219) – INHIBITS LTD4-INDUCED BRONCHOCONSTRICTION, INHIBITS EARLY & LATE RESPONSES TO ALLERGEN, EFFECTIVE AGAINST EXERCISE & COLD INDUCED, & CHRONIC ASTHMA, ...
The Immune System
The Immune System

... 3) The Biology Project. "Introduction to Immunology." The Biology Project. University of Arizona, 10 Nov. 2000. Web. . 4) Dirnberger. "Physiology: Immune System." Biology 2108. Kennesaw State University, n.d. Web. 1 Nov. 2013. ...
Mammalian and Drosophila Blood: Minireview JAK of All Trades?
Mammalian and Drosophila Blood: Minireview JAK of All Trades?

... functions of circulating cells and the signaling pathways involved in hematopoiesis and immune response. Comparison of Drosophila and Human Blood Red cells, white cells, and platelets are the three cellular constituents of mammalian blood. Their roles are to carry oxygen to all tissues, to confer im ...
1 We discussed function of white blood cells ,different type of white
1 We discussed function of white blood cells ,different type of white

... These are the two most important blood groups. There are many several other groups but these are the most important. Know we are going to take about ABO system: as I told you some people on their RBC the have only A antigen, so their blood type is A. at the same time these people who have only A, th ...
Fulltext PDF
Fulltext PDF

... bubbles. The host cell can sacrifice the bubble along with the parasite; new organelles can always be made - sar salamat to pagdee pachaas. 1 However, if a parasite is going to sit in the cytoplasmic fluid of the host cell, there is no way for the host cell to chew it up without destroying its own c ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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