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An Official ATS Workshop Summary: Recent Advances and Future
An Official ATS Workshop Summary: Recent Advances and Future

... adult mammals, many recent insights into host response have been obtained by studying responses in neonatal mice (11). Pneumocystis is a ubiquitous organism that infects most children, as shown by the prevalence of specific serum antibodies, and so insights from neonatal mice are both clinically and ...
13 20 s si
13 20 s si

... and the DC receptor responsible for an HIV-1 Env-independent uptake mechanism, the fate of the captured HIV-1 particles, and the determinants for an efficient infectious transmission to CD4+ T lymphocytes. Our results provide new insights into contribution of DC to HIV-1 pathogenesis. Maturation of ...
Acute viral hepatitis in Hong Kong: a study of recent
Acute viral hepatitis in Hong Kong: a study of recent

... We used the Corzyme-M assay, which has a relatively high cut-off antibody level (250 units/mL). In previous studies, using a similar method, only 0% to 3% of chronic hepatitis B patients showed positive results.11,12 Six patients with a positive family history of hepatitis B were diagnosed as having ...
Platelets: versatile effector cells in hemostasis, inflammation, and the
Platelets: versatile effector cells in hemostasis, inflammation, and the

... formation—are dynamic features of hemostasis [40]. The interactions of activated platelets with leukocytes, particularly monocytes, amplify the clotting cascade in physiologic and pathologic hemostasis [37]. The intimate and daedal relationships between the coagulation cascade and inflammatory and i ...
Modulation of immune responses by the tumor suppressor p53
Modulation of immune responses by the tumor suppressor p53

... Parainfluenza virus 5 ...
Pathogen-Induced Apoptotic Neutrophils Express Heat
Pathogen-Induced Apoptotic Neutrophils Express Heat

... apoptosis in neutrophils represents a pathogenic strategy for microbes to eliminate these key immune cells and use them as “Trojan horses” to enter M␾. However, in the cited studies, neutrophil apoptosis was induced by age or irradiation; thus, the results may not apply to the very early phase of in ...
A Functional Study of the Drosophila Host Defense
A Functional Study of the Drosophila Host Defense

... ymmärtämään paremmin myös ihmisen synnynnäistä immuunivastetta johtuen ...
Pathogenesis of PSC
Pathogenesis of PSC

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during

... http://www.jimmunol.org/content/191/5/2665.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription ...
Full-Text PDF
Full-Text PDF

lingzhi , reishi (ganoderma lucidum)
lingzhi , reishi (ganoderma lucidum)

... plasma, liver, and bone marrow, hence effectively prevent aging. It is observed that the use of Ganoderma lucidum to prevent aging benefits not only the aged, but also the young, since growth and development process will ultimately lead to aging. 3). Effect on Free Radicals. One cause of aging is th ...
Pathogenesis of prion diseases
Pathogenesis of prion diseases

... Reproduced with permission from Nature Reviews Microbiology REF. 137 © (2004) ...
Spatial and temporal regulation of cytokine expression in Type 2
Spatial and temporal regulation of cytokine expression in Type 2

... conceived of using the huCD2/GFP reporter mice to track allelic expression of IL4. Melanie Prout assisted with intradermal injections of HDM and with harvest, tissue processing and antibody staining of pTh2 samples. Arie Bates-Hermans, Amy Shepherd, Alanna Cameron, Catherine Plunkett and Mali Camber ...
Design of Noninflammatory Synthetic siRNA Mediating Potent Gene
Design of Noninflammatory Synthetic siRNA Mediating Potent Gene

... nucleotides in the sense strand, respectively. This suggests that unmodified U and/or G residues may play a key role in immune recognition of the duplex siRNA. To confirm that this approach to siRNA design would successfully inhibit inflammatory responses to siRNA in vivo, we assessed the immunostim ...
O MHC - Fernando Pessoa University
O MHC - Fernando Pessoa University

... MHC molecules are targets for immune evasion by pathogens • T cells can only be activated by interaction between the antigen receptor and peptide antigen in an MHC molecule • Without T cells there can be no effective immune response • There is strong selective pressure on pathogens to evade the imm ...
alopecia_areata 2012
alopecia_areata 2012

... is its creation of a milieu of relative immune privilege that normally renders unlikely an autoimmune attack on intrafollicularly expressed autoantigens.29-31 This relative immune privilege is established mainly by suppression of the surface molecules required for presenting autoantigens to CD8+ T l ...
35 Kortylewski Nat Biotechnol 2009
35 Kortylewski Nat Biotechnol 2009

... or for 24 h with unconjugated Stat3 siRNA labeled with FITC (bottom left panel), without any transfection reagents. Percentage of FITC-positive CD11c+B220− nonplasmacytoid (mDCs) and CD11c+B220+ plasmacytoid (pDCs) DCs, F4/80+Gr1− macrophages (MACs), B220+CD11c− B cells, Gr1+F4/80− granulocytes and ...
Title: A longitudinal study of BCG vaccination: dynamics
Title: A longitudinal study of BCG vaccination: dynamics

Emerging Role and Therapeutic Implication of Wnt Signaling
Emerging Role and Therapeutic Implication of Wnt Signaling

TOWARDS A DETAILED UNDERSTANDING OF THE RED BLOOD
TOWARDS A DETAILED UNDERSTANDING OF THE RED BLOOD

... Red blood cells (RBCs) are vital for oxygen delivery to tissues and constitute the vast majority of all cells in blood. After leaving the red bone marrow as mature cells, RBCs have a lifespan of approximately 120 days before they are removed from the circulation by macrophages, mainly in the spleen ...
Alopecia Areata - New England Journal of Medicine
Alopecia Areata - New England Journal of Medicine

... is its creation of a milieu of relative immune privilege that normally renders unlikely an autoimmune attack on intrafollicularly expressed autoantigens.29-31 This relative immune privilege is established mainly by suppression of the surface molecules required for presenting autoantigens to CD8+ T l ...
Alice M. Nyakeriga RELATION OF NUTRITIONAL STATUS, IMMUNITY, HEMOGLOBINOPATHY AND
Alice M. Nyakeriga RELATION OF NUTRITIONAL STATUS, IMMUNITY, HEMOGLOBINOPATHY AND

... are involved in antibody production upon activation by an antigen. B cells undergo maturation and differentiation following an antigen encounter to become memory B cells or plasma cells, which produce antibodies. Five main classes of antibodies are produced, namely IgM, IgD, IgG, IgA and IgE. Antibo ...
Pathogenic factors of Pseudomonas aeruginosa – the role of biofilm
Pathogenic factors of Pseudomonas aeruginosa – the role of biofilm

Recent developments in basophil research
Recent developments in basophil research

... resulting in the formation of allergen-specific IgE antibodies. This raises the question which cells are ...
- IRep - Nottingham Trent University
- IRep - Nottingham Trent University

... Abbreviations .................................................................................................................. vi Abstract ..............................................................................................................................1 ...
< 1 2 3 4 5 6 ... 450 >

Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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