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2009-06-NCBO-Peters - National Center for Biomedical Ontology
2009-06-NCBO-Peters - National Center for Biomedical Ontology

... • The IEDB catalogs experiments defining immune epitopes  Large amounts of complex data, which ...
31.1 Pathogens and Human Illness
31.1 Pathogens and Human Illness

... 31.1 Pathogens and Human Illness • Allergens can cause anaphylaxis. – Anaphylaxis is an extreme inflammation response. – Blood vessels and airways become too porous. – If not treated immediately, anaphylaxis can cause death. ...
HIV and Malnutrition: Effects on Immune System (PDF
HIV and Malnutrition: Effects on Immune System (PDF

Response of the Innate Immune System to Pathogens
Response of the Innate Immune System to Pathogens

... 60-kDa serum glycoprotein that binds with high affinity to LPS Sequence homology to bactericidal/permeability increasing protein Acute phase protein secreted by hepatocytes  Serum levels between 1 and 10 ug/ml in normal human serum  Concentrations >300 ug/ml in acute phase serum Critical for rapid ...
Infection
Infection

... Treatment of diarrhea • < 5%: dietary measures (treatment at home): NO COCA COLA!!!! • 5-10%: Compliance, assure that fluid intake is guaranteed, vigilance/GC • > 10%: acute life-threating, immediate parenteral substitution (e.g. 0,9% NaCl 20ml/kg BW) ...
Chapter 43 - Immune system
Chapter 43 - Immune system

... mark pathogens for destruction • In neutralization, antibodies bind to viral surface proteins preventing infection of a host cell • Antibodies may also bind to toxins in body fluids and prevent them from entering body cells ...
Combination Antibiotics
Combination Antibiotics

... • Pelvic infection • Mixed aerobic and anaerobic organism • Availability of broad spectrum antibiotics such as carbapenems and -lactam-  lactamase inhibitors restrict the use of combination antibiotics ...
The lymphoid organs
The lymphoid organs

... ‰ Proliferation of clones of antigen-specific T cells is one of the most important events during a primary immune response. ‰ The key molecule that regulates T cell proliferation is the soluble cytokine IL-2. ¾ IL-2 produced by activated T cells induces expansion through interaction with its recepto ...
NewLink Genetics to Present at the XVIth International Congress of
NewLink Genetics to Present at the XVIth International Congress of

... immune system to recognize and attack cancer cells. HyperAcute product candidates are composed of human cancer cells that are tumor specific, but not patient specific. These cells have been modified to express alpha-gal, a carbohydrate for which humans have pre-existing immunity. These alpha-gal-mod ...
The immunotherapy of cancer, past, present and next frontier
The immunotherapy of cancer, past, present and next frontier

... the lab from clinical studies is needed to bring benefit to an ever greater number of patients Rapid clinical progress and new response patterns have created a critical need for new approaches to regulatory ...
Echinococcus granulosus
Echinococcus granulosus

ABSTRACT
ABSTRACT

... syndrome (SARS). Individuals infected with SARS present with fever, cough and myalgia that may progress to lung inflammation including acute respiratory distress syndrome. We analyzed tissue and blood samples collected longitudinally from suspect or probable SARS patients during the prodrome, acute ...
slides - Smith Lab
slides - Smith Lab

... -In plasma, circulating C3 spontaneously undergoes hydrolysis to form C3(H2O) which binds factor B -Factor B on C3(H2O) is cleaved by Factor D to form C3(H2O)Bb, a C3 convertase -C3b is deposited on the cell surface ...
Multicenter phase II study of matured dendritic cells pulsed with
Multicenter phase II study of matured dendritic cells pulsed with

... significantly higher number of IFN-γ positive CD8+ CD3+ cells than the negative control HIV pool by the Chi-square test, provided that the Chi square test was applicable between test sample and negative control samples since the number of events was sufficient. Second, the test sample displayed a s ...
The effect of tobacco smoke ingredients on immunity
The effect of tobacco smoke ingredients on immunity

Immune Globulin (Human)
Immune Globulin (Human)

... globulin for intramuscular administration; it contains no preservative. GamaSTAN S/D is prepared by cold ethanol fractionation from human plasma. The immune globulin is isolated from solubilized Cohn fraction II. The fraction II solution is adjusted to a final concentration of 0.3% tri-n-butyl phosp ...
Aalborg Universitet Molecular Pathogenesis of Spondyloarthritis Carlsen, Thomas Gelsing
Aalborg Universitet Molecular Pathogenesis of Spondyloarthritis Carlsen, Thomas Gelsing

... antigenic presentation of peptides to CD8+ T cells and autoimmune reactions born from protein homology to exploring the presence of single nucleotide polymorphisms (SNP) in the genotype of SpA through genome-wide association studies. The polygenic nature of these diseases is a challenge, as the gene ...
Endemic Treponematoses
Endemic Treponematoses

... in palms & soles { CRAB YAWS } ,lesions may ulcerate.  Saber shin due to chronic untreated osteoperiostitis. ...
PLoS Pathog
PLoS Pathog

Allergens and Respiratory Pollutants. Woodhead Publishing Series in Biomedicine Brochure
Allergens and Respiratory Pollutants. Woodhead Publishing Series in Biomedicine Brochure

... expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to amb ...
immuniosuppression-protocol-WORD
immuniosuppression-protocol-WORD

... reviewing its policies for patients waiting for kidney transplants. We have decided to offer patients who do not have immunity to chickenpox a vaccination against chickenpox. This is because chickenpox infection after a kidney transplant can sometimes be a serious disease. Your blood tests show that ...
Anemia, Thrombocytes, and Blood Parasites
Anemia, Thrombocytes, and Blood Parasites

... • Antibodies directed against RBC membrane antigens and Ab- coated RBC’s are removed from circulation. • Hemolytic process results in varying degrees of anemia depending on antibody type, speed of development, and duration of the disease process. • Female dogs are more commonly affected than males. ...
Immunological Tolerance PP - The University of Arizona
Immunological Tolerance PP - The University of Arizona

... Tolerance to tissue and cell antigens can be induced by injection of hemopoietic (stem) cells in neonatal or severely immunocompromised (by lethal irradiation or drug treatment) animals. Also, grafting of allogeneic bone marrow or thymus in early life results in tolerance to the donor type cells and ...
The Adaptive Immune Response: T lymphocytes
The Adaptive Immune Response: T lymphocytes

... virus. Viruses infect nearly every tissue of the body, so all these tissues must necessarily be able to express class I MHC or no T cell response can be made. On the other hand, class II MHC molecules are expressed only on the cells of the immune system, specically cells that aect other arms of th ...
PDF
PDF

... and thus the antigen is present on the precursor cells for both the germ cell and follicle cell lineages. As DOV 1 labels follicle cells and does not appear to label other mesodermally derived cells in the adult ovary it was possible that DOV 1 might provide a marker for the localization of the pre- ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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