Temporal Variation Can Facilitate Niche Evolution in Harsh
... of genetic variation) and permits evaluation of immigration as a process sampling genetic variation from the source. This individual-based model with discrete generations extends a model earlier developed by Bürger and Lynch (1995; Bürger et al. 1989); it is fully described in a previous article ( ...
... of genetic variation) and permits evaluation of immigration as a process sampling genetic variation from the source. This individual-based model with discrete generations extends a model earlier developed by Bürger and Lynch (1995; Bürger et al. 1989); it is fully described in a previous article ( ...
Dynamics of Adaptive Introgression from Archaic to Modern Humans
... exclude archaic human genetic survival. The present evidence indicates that many “archaic” alleles may represent relicts of African archaics, and that some “archaic” variants both inside and outside of Africa have attained relatively high frequencies. Both observations may be surprising under the hy ...
... exclude archaic human genetic survival. The present evidence indicates that many “archaic” alleles may represent relicts of African archaics, and that some “archaic” variants both inside and outside of Africa have attained relatively high frequencies. Both observations may be surprising under the hy ...
Gene mapping of monogenic disorders and complex
... Genetic disorders in humans and animals include illnesses caused by abnormalities in genes or chromosomes, those abnormalities typically existing at birth. Disorders can be passed down from the parents’ genes, or caused by de novo mutations to the DNA loci. Disorders caused by a single mutated gene ...
... Genetic disorders in humans and animals include illnesses caused by abnormalities in genes or chromosomes, those abnormalities typically existing at birth. Disorders can be passed down from the parents’ genes, or caused by de novo mutations to the DNA loci. Disorders caused by a single mutated gene ...
genetics bio 250 module 3
... As an adult learner your approach to learning will be different to that from your school days: you will choose what you want to study, you will have professional and/or personal motivation for doing so and you will most likely be fitting your study activities around other professional or domestic re ...
... As an adult learner your approach to learning will be different to that from your school days: you will choose what you want to study, you will have professional and/or personal motivation for doing so and you will most likely be fitting your study activities around other professional or domestic re ...
Localization of distal regulatory domains in the
... followed by cycles at 94°C for 25 seconds, 50°C for 40 seconds, and 72°C for 40 seconds in a PTC-100 Programmable Thermal Controller (MJ Research, Watertown, MA). At selected cycles aliquots from hPF4 and mPF4 or hPBP and mPBP reactions were removed from the thermocycler and placed on ice. The Cy-5– ...
... followed by cycles at 94°C for 25 seconds, 50°C for 40 seconds, and 72°C for 40 seconds in a PTC-100 Programmable Thermal Controller (MJ Research, Watertown, MA). At selected cycles aliquots from hPF4 and mPF4 or hPBP and mPBP reactions were removed from the thermocycler and placed on ice. The Cy-5– ...
Chapter 12 Is It Possible to Escape Racial Typology in Forensic
... in the test is important. However, on a practical level, when applying the method to one unknown individual, what matters is whether the method can be applied with confidence in that one case. When dealing with a true unknown, for example, a forensic anthropologist in North America has no way of kno ...
... in the test is important. However, on a practical level, when applying the method to one unknown individual, what matters is whether the method can be applied with confidence in that one case. When dealing with a true unknown, for example, a forensic anthropologist in North America has no way of kno ...
Interchromosomal Segmental Duplications Explain the Unusual
... functional trypsins in the digestive tract. PRSS1 and PRSS2 are located on chromosome 7q35, while PRSS3 is found on chromosome 9p13. Here, we report a variation of the theme of new gene creation by duplication: the PRSS3 gene was formed by segmental duplications originating from chromosomes 7q35 and ...
... functional trypsins in the digestive tract. PRSS1 and PRSS2 are located on chromosome 7q35, while PRSS3 is found on chromosome 9p13. Here, we report a variation of the theme of new gene creation by duplication: the PRSS3 gene was formed by segmental duplications originating from chromosomes 7q35 and ...
Quantitative trait locus dissection in congenic strains of the Goto
... and the Brown Norway (BN) control rat, and carried out its genetic and pathophysiological characterization in BN.GK congenic strains. Evidence of glucose intolerance and enhanced insulin secretion in a congenic strain allowed us to localize the underlying diabetes gene(s) in a rat chromosomal interv ...
... and the Brown Norway (BN) control rat, and carried out its genetic and pathophysiological characterization in BN.GK congenic strains. Evidence of glucose intolerance and enhanced insulin secretion in a congenic strain allowed us to localize the underlying diabetes gene(s) in a rat chromosomal interv ...
Article The Developmental Brain Gene NPAS3 Contains the Largest
... sequence leading to the origin of differential protein functional domains or changes in their spatial or temporal expression, respectively. By comparing sequences from ortholog loci of several vertebrate genomes, including the human and chimpanzee, it is possible to identify brain genes and genomic ...
... sequence leading to the origin of differential protein functional domains or changes in their spatial or temporal expression, respectively. By comparing sequences from ortholog loci of several vertebrate genomes, including the human and chimpanzee, it is possible to identify brain genes and genomic ...
Genomic signatures of diet-related shifts during human origins
... There has been an exponential increase in genomic information available for humans and non-human primates in the last decade (reviewed in [57 – 59]). This includes genomic variation between human populations as well as our closest primate relatives. Using these data, a number of studies looked for s ...
... There has been an exponential increase in genomic information available for humans and non-human primates in the last decade (reviewed in [57 – 59]). This includes genomic variation between human populations as well as our closest primate relatives. Using these data, a number of studies looked for s ...
Nonadaptive processes in primate and human evolution
... Put another way, when the selection coefficient of a variant, s, is considerably greater than the reciprocal of the effective population size (i.e., s 1/4Ne), selection is able to largely dominate over genetic drift in determining the fate of the variant. On the other hand, if the selection coeffici ...
... Put another way, when the selection coefficient of a variant, s, is considerably greater than the reciprocal of the effective population size (i.e., s 1/4Ne), selection is able to largely dominate over genetic drift in determining the fate of the variant. On the other hand, if the selection coeffici ...
Specialist Review Epigenetic variation: amount, causes, and
... 1. Introduction The diversity of human phenotypes that we observe is the result of genetic and epigenetic variation and the interaction of these “biological” variables with environmental factors. Both large-scale and small-scale genome sequencing projects, as well as more recent efforts to define st ...
... 1. Introduction The diversity of human phenotypes that we observe is the result of genetic and epigenetic variation and the interaction of these “biological” variables with environmental factors. Both large-scale and small-scale genome sequencing projects, as well as more recent efforts to define st ...
Genetics and the making of Homo sapiens
... stantial relative changes occurred over an extended time span and a significant number of speciation events. There was a marked increase in absolute brain size by the Early Pleistocene and again in the Middle Pleistocene, with a long interval of perhaps 1 Myr during which brain size did not change s ...
... stantial relative changes occurred over an extended time span and a significant number of speciation events. There was a marked increase in absolute brain size by the Early Pleistocene and again in the Middle Pleistocene, with a long interval of perhaps 1 Myr during which brain size did not change s ...
Time travel with the Molecular Clock - Max-Planck
... modern-day humans,” reveals Krause, as he talks about a trick that seems simple enough. “One million single-stranded DNA fragments fixed on a small glass slide recognize their counterpart in the DNA extract from early Homo sapiens and bind to it.” Now all the researchers have to do is pull the DNA t ...
... modern-day humans,” reveals Krause, as he talks about a trick that seems simple enough. “One million single-stranded DNA fragments fixed on a small glass slide recognize their counterpart in the DNA extract from early Homo sapiens and bind to it.” Now all the researchers have to do is pull the DNA t ...
Genetic and physical mapping of human recoverin: a gene
... in the human retina. 8 " It has been reported to stimulate guanylate cyclase in response to the light-generated low calcium concentration in the rod photoreceptor outer segment,211 although new reports suggest that recoverin may not affect guanylate cyclase activity.45 The cGMP-gated calcium/sodium ...
... in the human retina. 8 " It has been reported to stimulate guanylate cyclase in response to the light-generated low calcium concentration in the rod photoreceptor outer segment,211 although new reports suggest that recoverin may not affect guanylate cyclase activity.45 The cGMP-gated calcium/sodium ...
Many human endogenous retrovirus K (HERV-K) proviruses
... during human evolution, we performed PCR using, as template, genomic DNA from humans (Homo sapiens), chimpanzees (Pan troglodytes), bonobos (Pan paniscus), gorillas (Gorilla gorilla) and an orang-utan (Pongo pygmaeus). Products for four of the proviruses are shown as examples (Figure 2). Eight of th ...
... during human evolution, we performed PCR using, as template, genomic DNA from humans (Homo sapiens), chimpanzees (Pan troglodytes), bonobos (Pan paniscus), gorillas (Gorilla gorilla) and an orang-utan (Pongo pygmaeus). Products for four of the proviruses are shown as examples (Figure 2). Eight of th ...
Comparing the human and chimpanzee genomes: Searching for
... environmental influences. It is logical to tackle the genetic aspects via both genome-wide analyses and candidate gene studies. Genome-wide surveys could eliminate the majority of genomic sequence differences from consideration, while simultaneously identifying potential targets of opportunity. Mean ...
... environmental influences. It is logical to tackle the genetic aspects via both genome-wide analyses and candidate gene studies. Genome-wide surveys could eliminate the majority of genomic sequence differences from consideration, while simultaneously identifying potential targets of opportunity. Mean ...
Chromosomal Rearrangements as Barriers to Genetic
... Previous copy number variation (CNV) detection in Neanderthals has focused on coverage changes to identify dozens of duplications in modern and archaic humans (Pr€ufer et al. 2014). Coverage-based assays detect many CNVs with high validation rates (Alkan et al. 2009; Sudmant et al. 2010), but they m ...
... Previous copy number variation (CNV) detection in Neanderthals has focused on coverage changes to identify dozens of duplications in modern and archaic humans (Pr€ufer et al. 2014). Coverage-based assays detect many CNVs with high validation rates (Alkan et al. 2009; Sudmant et al. 2010), but they m ...
Genomic Comparisons of Humans and Chimpanzees
... demonstrated more than 200 genes in regions showing copy-number variation or inversion between human and chimpanzee. These large-scale changes could contribute to species differences through loss or gain of gene copies. Analysis of changes in the number and variety of genes in gene families is of pa ...
... demonstrated more than 200 genes in regions showing copy-number variation or inversion between human and chimpanzee. These large-scale changes could contribute to species differences through loss or gain of gene copies. Analysis of changes in the number and variety of genes in gene families is of pa ...
comparative primate genomics - Max Planck Institute for
... by being less diverse (for reviews, see 63, 64). Only bonobos may carry about as much, or a little more, diversity than humans (21, 65, 141). Thus, humans differ from almost all the apes by having low levels of intraspecific diversity (Figure 4). This is surprising because humans are orders of magni ...
... by being less diverse (for reviews, see 63, 64). Only bonobos may carry about as much, or a little more, diversity than humans (21, 65, 141). Thus, humans differ from almost all the apes by having low levels of intraspecific diversity (Figure 4). This is surprising because humans are orders of magni ...
Measurement of DNA Copy Number at Microsatellite Loci Using
... chromosome 2E has been reported in tumors in F1 crosses of these mice (19, 20). We used QuMA to assess deletions at 27 loci along chromosome 2 using spleen DNA from eight irradiated SJL mice. Six of the eight spleens were comprised mostly of leukemic cells. Fig. 2B shows that these analyses define a ...
... chromosome 2E has been reported in tumors in F1 crosses of these mice (19, 20). We used QuMA to assess deletions at 27 loci along chromosome 2 using spleen DNA from eight irradiated SJL mice. Six of the eight spleens were comprised mostly of leukemic cells. Fig. 2B shows that these analyses define a ...
EVOLUTION OF HUMANS OUTSIDE THE GENOME*
... information is only vertically transmitted from one individual to another through reproduction of the organisms, language-mediated information can be horizontally transmitted from one brain (brain 1 in Figure 1) to another (brain 2) among individuals of the same as well as different generations thro ...
... information is only vertically transmitted from one individual to another through reproduction of the organisms, language-mediated information can be horizontally transmitted from one brain (brain 1 in Figure 1) to another (brain 2) among individuals of the same as well as different generations thro ...
The Promise of Comparative Genomics in Mammals
... pedigree, forensic, and population assessment, because there are over 100,000 nearrandomly dispersed STRs throughout mammal genomes, and because each carries multiple alleles. Type II STRs are less useful for orthologous locus recognition between species of different mammal orders, because the lifet ...
... pedigree, forensic, and population assessment, because there are over 100,000 nearrandomly dispersed STRs throughout mammal genomes, and because each carries multiple alleles. Type II STRs are less useful for orthologous locus recognition between species of different mammal orders, because the lifet ...