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Cockayne Syndrome group B protein interacts
Cockayne Syndrome group B protein interacts

... we report that CSB physically interacts with TRF2, a duplex telomeric DNA binding protein essential for telomere protection. We find that CSB localizes at a small subset of human telomeres and that it is required for preventing the formation of telomere dysfunction-induced foci (TIF) in CS cells. We ...
Assay of ÃŁ-glucuronidase activity in intact
Assay of ÃŁ-glucuronidase activity in intact

... plasmid may have been deleted from most or all of the cells; alternatively the entire construct may have been lost from a small percentage of the cells. The pellets contained appreciable GUS activity (Figure 1), especially if the abrasive was ground glass (Experiment 1, Figure 1) rather than alumina ...
supplementary material
supplementary material

... (MEFs) and splenocytes from i-TERT mice and non-transgenic controls. TERT mRNA was induced in a doxycycline-dependent manner in both MEFs and splenocyte cultures (Fig. S1a). Analysis of metaphase preparations from MEFs and splenocytes showed no end-to-end fusions with TERT induction, indicating that ...
Induced Pluripotent Stem Cell Lines Derived from
Induced Pluripotent Stem Cell Lines Derived from

... medicine once technical limitations (for example, mutation through viral integration) are eliminated. Mammalian embryogenesis elaborates distinct developmental stages in a strict temporal order. Nonetheless, because development is dictated by epigenetic rather than genetic events, differentiation is ...
Mechanisms of cell aging in cell culture
Mechanisms of cell aging in cell culture

... telomerase, which is responsible for the maintenance of telomeres in most immortal cell lines, is also involved. Telomeres are specialized structures at the ends of chromosomes, which consist of tandem repeated DNA sequences - (TTAGGG) and proteins associated with them such as telomeric repeat bindi ...
Document
Document

... We observed high frequencies of chromosome ends with undetectable TTAGGG repeats and extra-chromosomal telomeric DNA signals leading to an excess in the total yield of telomeric signals in FA cells. This result is interpreted as an excess of breaks in telomeric repeat arrays in FA lymphocytes. This ...
Assembly of Mutant-Template Telomerase RNA into Catalytically
Assembly of Mutant-Template Telomerase RNA into Catalytically

... somatic cells, human chromosomes can lose up to 50 to 200 nucleotides of telomeric sequence per cell division (3). Such shortening of telomeres has been proposed to be a mitotic clock that monitors cell divisions; sufficiently short telomeres and lack of telomerase may signal cellular senescence (3, ...
Supplementary Figure and Table Legend (doc 44K)
Supplementary Figure and Table Legend (doc 44K)

... (e) Image shows a representative RT-PCR analysis of expression of stemness-related genes in primary tissue-derived mammospheres and NBLE-derived mammospheres; (n=3). Supplementary Figure S3. (a) Immunocytochemical analysis for CK14 expression in NBLE cells cultured in differentiating conditions comp ...
MCB 135K: Discussion
MCB 135K: Discussion

... double-stranded DNA and has a high affinity for qudruplex "G-DNA", a structure that may form at telomeres, ribosomal DNA [HQ] (rDNA) and other GC-rich sequences ...
aging
aging

... Telomerase = RNA primer 5'-CCCTAA-3' + RT enzyme (elongates the Grich 3'end) + another protein component. Telomerase is a ribonucleoprotein that uses its internal RNA component as a template for the synthesis of DNA on the ends of chromosomes during cell replication. In mammals, telomerase is norma ...
Stem Cells from Skin Cells?!?
Stem Cells from Skin Cells?!?

...  Hwan Woo-Suk’s fake data  Not fully reprogramed ...
Slide 1
Slide 1

... Telomeres are specialized DNA sequences that cap the ends of linear chromosomes and provide protection against gene erosion at cell divisions, chromosomal non-homologous end-joinings and nuclease attacks. ...
Cancer: How many genes does it take?
Cancer: How many genes does it take?

113867_Genetics_of_Cancer_2
113867_Genetics_of_Cancer_2

... cancerous cells • Cells spread via the circulatory or lymphatic system • 99% of cancer cells die en route, but some lodge in capillaries or lymph nodes • Cancer cells can break down material between cells to travel within tissues, leading to new colonies ...
Nature Medicine Research Highlights: New from NPG
Nature Medicine Research Highlights: New from NPG

... stages of Alzheimer’s disease. The researchers found that the human tau was able to cross the synapse into brain regions to which the entorhinal cortex projects, such as the hippocampus, an area of the brain involved in learning and memory. They could also detect human tau in areas of the brain that ...
Researchers Find "Immortality" Enzyme in Cancer Cells Cancer
Researchers Find "Immortality" Enzyme in Cancer Cells Cancer

... The telomere is made up of DNA segments that help control the accuracy of genetic reproduction when a cell divides to create a new cell. In cancer cells, it is thought that the telomere does not erode with each cell division, thus enabling cancer cells, in a sense, to be "immortal." Telomeres in can ...
The Biology of Cancer
The Biology of Cancer

...  Highly repetitive DNA on the ______________________________________________  Protect chromosomes from damage  Get ___________________________________ with each cell division  Healthy cells can only divide approx _________________ times (Hayflick Limit) before the ...
1

Telomerase reverse transcriptase

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.Telomerases are part of a distinct subgroup of RNA-dependent polymerases. Telomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. To be specific, TERT is responsible for catalyzing the addition of nucleotides in a TTAGGG sequence to the ends of a chromosome’s telomeres. This addition of repetitive DNA sequences prevents degradation of the chromosomal ends following multiple rounds of replication.hTERT absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat.
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