Table S1. Hypotheses for amphibian abnormalities (adapted from
... can further buffer offspring from UV-B effects by laying eggs in the shade [78]. Several recent studies have shown abnormalities in nature to have complex chains of causation, that several things must go wrong at once to cause high abnormality frequencies [14,79,80]. In some cases, chemicals associa ...
... can further buffer offspring from UV-B effects by laying eggs in the shade [78]. Several recent studies have shown abnormalities in nature to have complex chains of causation, that several things must go wrong at once to cause high abnormality frequencies [14,79,80]. In some cases, chemicals associa ...
Transplacental Action of Diethylstilbestrol on
... and B); and the total tumor incidence in Weeks 1 to 29 postDMBA was elevated significantly in groups which had received two 10-mg doses of DMBA compared to the single-dose groups (G = 79.41, p «0.01). The mean number of tumors per rat at sacrifice was 5.7 ±3.9 for the DES-exposed rats and 5.9 ±3. ...
... and B); and the total tumor incidence in Weeks 1 to 29 postDMBA was elevated significantly in groups which had received two 10-mg doses of DMBA compared to the single-dose groups (G = 79.41, p «0.01). The mean number of tumors per rat at sacrifice was 5.7 ±3.9 for the DES-exposed rats and 5.9 ±3. ...
HYPOTHESES 59
... This “tea” has been used for centuries in religious and medicinal contexts in the rain forest areas of South America and is presently gaining the attention of psychedelic users in North America and Europe. Objectives: In the present study, the psychological effects and tolerability of ayahuasca were ...
... This “tea” has been used for centuries in religious and medicinal contexts in the rain forest areas of South America and is presently gaining the attention of psychedelic users in North America and Europe. Objectives: In the present study, the psychological effects and tolerability of ayahuasca were ...
Kratom Did you know? - Maryland Poison Center
... Kratom Kratom (Mitragyna speciosa) is a plant/tree indigenous to Thailand and Southeast Asia whose leaves have been used for their psychoactive properties since the 19th century in that part of the world. The Maryland Poison Center was consulted on three cases of toxicity from kratom abuse this mont ...
... Kratom Kratom (Mitragyna speciosa) is a plant/tree indigenous to Thailand and Southeast Asia whose leaves have been used for their psychoactive properties since the 19th century in that part of the world. The Maryland Poison Center was consulted on three cases of toxicity from kratom abuse this mont ...
Treatment of Narcolepsy with Methamphetamine
... Furthermore, surveys indicate that narcoleptics receiving pharmacological treatment report that they function poorly at work and in social situations (17,18). It is likely that efforts to eliminate pathological somnolence with central nervous system (CNS) stimulants are not attempted due to physicia ...
... Furthermore, surveys indicate that narcoleptics receiving pharmacological treatment report that they function poorly at work and in social situations (17,18). It is likely that efforts to eliminate pathological somnolence with central nervous system (CNS) stimulants are not attempted due to physicia ...
What’s special about methadone?
... • Case series n=17 – 82% (14/17) had known risk factors for arrhythmias – hypokalemia, concomitant drugs that prolong QT ...
... • Case series n=17 – 82% (14/17) had known risk factors for arrhythmias – hypokalemia, concomitant drugs that prolong QT ...
this PDF file - International Journal of Advances in Medicine
... attached tightly to the hub of the Tuohy needle. The needle was slowly moved until there was loss of resistance. This indicated the epidural space. The catheter was then threaded to the epidural space and the needle was removed. The catheter was then fixed with a transparent occlusive dressing and 1 ...
... attached tightly to the hub of the Tuohy needle. The needle was slowly moved until there was loss of resistance. This indicated the epidural space. The catheter was then threaded to the epidural space and the needle was removed. The catheter was then fixed with a transparent occlusive dressing and 1 ...
Benzodiazepines
... to avoid withdrawal) • Similarly, continuance of use avoids withdrawal • Long-term use is common and associated with: – excessive sedation – cognitive impairment – increased risk of accidents – adverse sleep effects – dependence and withdrawal (even at therapeutic doses) • When used with alcohol and ...
... to avoid withdrawal) • Similarly, continuance of use avoids withdrawal • Long-term use is common and associated with: – excessive sedation – cognitive impairment – increased risk of accidents – adverse sleep effects – dependence and withdrawal (even at therapeutic doses) • When used with alcohol and ...
Principles of Metered-Dose Inhaler Design
... the propellant mixture, the presence of other excipients (surfactants and other inactive components of the formulation), and ambient temperature. Recently, the use of CFCs was banned under international agreement, because the release of chlorine during their degradation damages the ozone layer in th ...
... the propellant mixture, the presence of other excipients (surfactants and other inactive components of the formulation), and ambient temperature. Recently, the use of CFCs was banned under international agreement, because the release of chlorine during their degradation damages the ozone layer in th ...
this Outline - Alcohol Medical Scholars Program
... 13) Portenoy RK, Farrar JT, Backonja MM, Cleeland CS, Yang K, Friedman M, Colucci SV, Richards P. Longterm use of controlled-release oxycodone for non-cancer pain: results of a 3-year registry study. Clin J Pain 2007; 23(4): 287-99. 14) Li L, Setoguchi S, Cabral H, Jick S. Opioid use for noncancer p ...
... 13) Portenoy RK, Farrar JT, Backonja MM, Cleeland CS, Yang K, Friedman M, Colucci SV, Richards P. Longterm use of controlled-release oxycodone for non-cancer pain: results of a 3-year registry study. Clin J Pain 2007; 23(4): 287-99. 14) Li L, Setoguchi S, Cabral H, Jick S. Opioid use for noncancer p ...
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ
... dependent modifications of locomotor activity (Gerlai et al. 2000) and tolerance as has been observed in mammals as well as Drosophila (Scholz et al. 2000). Moreover, ethanolinduced hyperlocomotion can be blocked by the addition of a dopamine antagonist, suggesting the involvement of the brain dopam ...
... dependent modifications of locomotor activity (Gerlai et al. 2000) and tolerance as has been observed in mammals as well as Drosophila (Scholz et al. 2000). Moreover, ethanolinduced hyperlocomotion can be blocked by the addition of a dopamine antagonist, suggesting the involvement of the brain dopam ...
package insert
... anticoagulation, coagulation tests suitable for the anticoagulant used (e.g., aPTT and anti-Factor Xa activity) are to be performed regularly, at close intervals, and in particular in the first hours following the start or withdrawal of ATryn. Additionally, monitor the patients for the occurrence of ...
... anticoagulation, coagulation tests suitable for the anticoagulant used (e.g., aPTT and anti-Factor Xa activity) are to be performed regularly, at close intervals, and in particular in the first hours following the start or withdrawal of ATryn. Additionally, monitor the patients for the occurrence of ...
MELOXICAM Veterinary—Systemic
... Except under special circumstances, this medication should not be used when the following medical problems exist: Bleeding disorders{R-3; 4} (because nonsteroidal anti-inflammatory drugs [NSAIDs] have been associated with inhibition of platelet aggregation and with the potential for gastrointestinal ...
... Except under special circumstances, this medication should not be used when the following medical problems exist: Bleeding disorders{R-3; 4} (because nonsteroidal anti-inflammatory drugs [NSAIDs] have been associated with inhibition of platelet aggregation and with the potential for gastrointestinal ...
SPC - HPRA website
... Administration of zopiclone during the last three months of pregnancy is only allowed on strict medical indication as due to the pharmacological action of the product, effects on the neonate, such as hypothermia, hypnotic and respiratory depression can be expected. Moreover infants born to mothers w ...
... Administration of zopiclone during the last three months of pregnancy is only allowed on strict medical indication as due to the pharmacological action of the product, effects on the neonate, such as hypothermia, hypnotic and respiratory depression can be expected. Moreover infants born to mothers w ...
Report of the Working Party on Statistical Issues in First-in
... doses of an investigational medicinal product by level of a priori assessed risk (Low, Medium High), having regard to the confidence in pre-clinical data (See section 6.3.3.). High a priori risk would rule out participation by healthy volunteers. E.4.6. Besides first-in-man studies of any monoclonal ...
... doses of an investigational medicinal product by level of a priori assessed risk (Low, Medium High), having regard to the confidence in pre-clinical data (See section 6.3.3.). High a priori risk would rule out participation by healthy volunteers. E.4.6. Besides first-in-man studies of any monoclonal ...
B-8 - New Psychiatric Medications
... • Starting dose 1 mg twice daily • Target dosage range 6-12 mg twice daily • Increase by no more than 2 mg twice daily every day until target range – Slow titration due to increased risk of low blood pressure, dizziness, and falls ...
... • Starting dose 1 mg twice daily • Target dosage range 6-12 mg twice daily • Increase by no more than 2 mg twice daily every day until target range – Slow titration due to increased risk of low blood pressure, dizziness, and falls ...
Prescribing Information
... Pregnancy Category C: There are no adequate and well-controlled studies of desloratadine and pseudoephedrine in combination in pregnant women. Neither are there animal reproduction studies conducted with the combination of desloratadine and pseudoephedrine. Desloratadine was not teratogenic in rats ...
... Pregnancy Category C: There are no adequate and well-controlled studies of desloratadine and pseudoephedrine in combination in pregnant women. Neither are there animal reproduction studies conducted with the combination of desloratadine and pseudoephedrine. Desloratadine was not teratogenic in rats ...
Systemic administration of β2-adrenoceptor agonists, formoterol and
... an extended duration of action in relaxing smooth muscle compared with traditional asthma medications, such as albuterol and terbutaline (Löfdahl & Svedmyr, 1989; Roux et al., 1996; Waldeck, 1996). In addition to an extended duration of action, the safety profiles of formoterol and salmeterol, defi ...
... an extended duration of action in relaxing smooth muscle compared with traditional asthma medications, such as albuterol and terbutaline (Löfdahl & Svedmyr, 1989; Roux et al., 1996; Waldeck, 1996). In addition to an extended duration of action, the safety profiles of formoterol and salmeterol, defi ...
prevention of accidental exposure in radiotherapy
... • complications are due to arteriolar / capillary narrowing which occur over time • causes hypoxic damage ...
... • complications are due to arteriolar / capillary narrowing which occur over time • causes hypoxic damage ...
Product Monograph Template - Standard
... patients treated with antiepileptic agents in several indications. Patients with a history of depression and/or suicide attempts should be kept under close supervision. All patients treated with antiepileptic drugs (AEDs), irrespective of indication, should be monitored for signs of suicidal ideatio ...
... patients treated with antiepileptic agents in several indications. Patients with a history of depression and/or suicide attempts should be kept under close supervision. All patients treated with antiepileptic drugs (AEDs), irrespective of indication, should be monitored for signs of suicidal ideatio ...
prevention of accidental exposure in radiotherapy
... • complications are due to arteriolar / capillary narrowing which occur over time • causes hypoxic damage ...
... • complications are due to arteriolar / capillary narrowing which occur over time • causes hypoxic damage ...
Quest For Quality
... Chronic pain: How has pain changed the patient’s life? What could you do before that pain keeps you from doing now? c) End of life: Is there anything you want to accomplish before death that pain would keep you from doing? F. Adjust treatment plan based on response: Level of function/QOL, pain relie ...
... Chronic pain: How has pain changed the patient’s life? What could you do before that pain keeps you from doing now? c) End of life: Is there anything you want to accomplish before death that pain would keep you from doing? F. Adjust treatment plan based on response: Level of function/QOL, pain relie ...
Anti-inflammatory and Analgesic Activity of Methanolic Extract of
... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
Fexofast Presentation
... In a double blind placebo controlled study, 861 patients aged 12 to 65 years were randomised to receive either fexofenadine 120 mg or 180 mg or placebo once daily for a 2-week period. The primary efficacy measure was a change from baseline of average total symptom score. Both doses provided signific ...
... In a double blind placebo controlled study, 861 patients aged 12 to 65 years were randomised to receive either fexofenadine 120 mg or 180 mg or placebo once daily for a 2-week period. The primary efficacy measure was a change from baseline of average total symptom score. Both doses provided signific ...
Autonomic Pharmacology
... in the SA node ACh decreases spontaneous depolarisation, by reducing the rate of phase 4 depolarisation and hyperpolarising the resting cell membrane in atrial muscle, ACh slows conduction, however also reduces the AP duration and the effective refractory period, therefore exacerbating atrial flutte ...
... in the SA node ACh decreases spontaneous depolarisation, by reducing the rate of phase 4 depolarisation and hyperpolarising the resting cell membrane in atrial muscle, ACh slows conduction, however also reduces the AP duration and the effective refractory period, therefore exacerbating atrial flutte ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.