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Supplementary Material and Methods
Supplementary Material and Methods

... performed in parallel with a control reaction without addition of reverse transcriptase (-RT control) using a Roche 1st strand cDNA synthesis kit (Roche, Mannheim, Germany). cDNA was diluted to single molecule level and a PCR with the SNP-specific primers was performed. –RT control reactions were u ...
Title goes here
Title goes here

... • Definition of high quality genome sequence: an example of “finished” JGI genomes - each base is covered by at least two Sanger reads in each direction with a quality of at least Q20 • Definition of “ high quality” metagenome? Too many variables:  species composition/abundance  amount of DNA avai ...
Developmental Biology BY1101 Lecture 2 Model organisms
Developmental Biology BY1101 Lecture 2 Model organisms

Workshop#7
Workshop#7

... The feature CDS is a partial coding sequence formed by joining the indicated elements to form one contiguous sequence encoding a product called T-cell receptor beta-chain. ...
Genetic Transfer in Bacteria
Genetic Transfer in Bacteria

... region of the plasmid . Many genes in the tra region have to do with the synthesis of a surface structure, the sex pilus . Only donor cells have these pili, The pili make specific contact with a receptor on the recipient and then retract, pulling the two cells together. The contacts between the dono ...
Pennisi E
Pennisi E

... previously identified enhancers that control other genes. It also turned up a dozen more clusters containing three or four of dorsal's binding sites. The researchers have since shown that at least two are definitely enhancers. Levine is encouraged: "Sometimes the clustering of a single factor's bind ...
Using recombinant Cas9 nuclease to assess locus
Using recombinant Cas9 nuclease to assess locus

... It is essential to keep the molar ratio of Cas9 and sgRNA per target site at or near 10:10:1 to obtain the best cleavage efficiency. A calculator can be found here. Prepare 1 μM sgRNA by diluting the stock with nuclease-free water on ice. ...
Sem 2 Bio Review Questions
Sem 2 Bio Review Questions

... spots (Y) is dominant over the gene for red spots and the gene for blue skin color (B) is dominant over the gene for green skin color. What is the probability that red spotted, green skinned offspring will be produced in a cross between a parent that has green skin and is heterozygous (hybrid) for y ...
Determinants on Health and Their Interactions Genetic
Determinants on Health and Their Interactions Genetic

... Genetics is the scientific study of heredity and variation in organisms. The founder of genetics was the Austrian biologist Gregor Mendel whose experiments with plants were concerned with inherited variation (1865). The physical cause was unknown but by observing variations it could be deduced that ...
- Environmental Biosafety Research
- Environmental Biosafety Research

... (1) Recombinant nucleic acid techniques involving the formation of new combinations of genetic material by the insertion of nucleic acid molecules produced by whatever means outside an organism, into any virus, bacterial plasmid or other vector system and their incorporation into a host organism in ...
Genetic Test Review Packet What is a Punnet square and what is it
Genetic Test Review Packet What is a Punnet square and what is it

... 19.Purebred – an organism that carries two of the same alleles for a trait, either two dominant alleles, or two recessive alleles. 20.Probability – the likelihood that a particular event will occur. 21.CoDominance – a condition in which neither of 2 alleles of a gene is dominant nor recessive. If th ...
Genetic engineering in animal production: Applications and prospects
Genetic engineering in animal production: Applications and prospects

... individual or group of genes to be isolated from large masses of DNA and produced in virtually unlimited quantities. This is through recombining DNA fragments from one organism and transferring them to another for expression. The hybrid molecule formed when a fragment of DNA from one organism is spl ...
Expressed Sequence Tags: Any Prior Art Effect?
Expressed Sequence Tags: Any Prior Art Effect?

... suggest its homologs because homologs often have similar properties and therefore chemists of ordinary skill would ordinarily contemplate making them to try to obtain compounds with improved properties. Similarly, a known compound may suggest its analogs or isomers, either geometric isomers . . . or ...
A one-step cloning method for the construction of somatic cell gene
A one-step cloning method for the construction of somatic cell gene

... somatic cell lines is assembly of the gene targeting construct. Traditionally, this requires an amplification step to obtain two large homologous fragments of genomic DNA, followed by restriction endonuclease digestion, and then numerous cloning steps. It is an extremely time-consuming process and l ...
Inquiry into Life Twelfth Edition
Inquiry into Life Twelfth Edition

... • lac promoter is somewhat inducible – Stays off until stimulated – Actually repression is incomplete or leaky – Some expression will still occur ...
Molecular Genetics of Inherited Disorders
Molecular Genetics of Inherited Disorders

... product competing with the normal gene product, are included in this category. 5. Neomorphic alleles exhibit a function different from the wild-type. They make either a gene product that is functionally different from that of the wild-type or a normal gene product at the wrong time or in the wrong p ...
Ji et al J Theor Biol 2010
Ji et al J Theor Biol 2010

... such predictive models. Using methods, including K-gram pattern, Z-curve, positionspecific scoring matrix and first-order inhomogeneous Markov sub-model, numerous features were generated and placed in an original feature-space. To select the most useful features, attribute selection algorithms, such ...
Disclaimer: Not ALL of the questions on the midterm will necessarily
Disclaimer: Not ALL of the questions on the midterm will necessarily

... an/or DNA components involved in its function and regulation. Which type of operon is it? ...
Practical Assignment - H3ABioNet training course material
Practical Assignment - H3ABioNet training course material

Supplementary material for "The Plasmodium HU homolog, which
Supplementary material for "The Plasmodium HU homolog, which

Genetics and Genomics in Medicine Chapter 7 Questions Multiple
Genetics and Genomics in Medicine Chapter 7 Questions Multiple

... 5) Sulfhydryl group-containing: cysteine (but not methionine which is a non-polar amino acid) ...
Slide 1
Slide 1

... *Denaturing step - one to several min at 94-96 º C *Annealing step - one to several min at 50-65 º C *Elongation step - one to several min at 72 º C ...
2004-06-GO_labday_aireland
2004-06-GO_labday_aireland

DNA Technology and Genomics  I.
DNA Technology and Genomics I.

... To prepare many copies of the gene itself so that the gene=s nucleotide sequence can be learned or to provide an organism with a new metabolic capability by transferring a gene from another organism. Gene cloning and genetic engineering were made possible by the discovery of restriction enzymes that ...
Example Final Exam
Example Final Exam

... 1 and 4 are allelic 2a. (2 pts). Not including its short life cycle, small size and ease of culture, give two reasons why yeast is a great model organism to isolate mutants in common eukaryotic biochemical pathways and to characterize those pathways using genetics. One feature is important for mutat ...
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Genome editing

Genome editing, or genome editing with engineered nucleases (GEEN) is a type of genetic engineering in which DNA is inserted, replaced, or removed from a genome using artificially engineered nucleases, or ""molecular scissors."" The nucleases create specific double-stranded break (DSBs) at desired locations in the genome, and harness the cell’s endogenous mechanisms to repair the induced break by natural processes of homologous recombination (HR) and nonhomologous end-joining (NHEJ). There are currently four families of engineered nucleases being used: Zinc finger nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), the CRISPR/Cas system, and engineered meganuclease re-engineered homing endonucleases.It is commonly practiced in genetic analysis that in order to understand the function of a gene or a protein function one interferes with it in a sequence-specific way and monitors its effects on the organism. However, in some organisms it is difficult or impossible to perform site-specific mutagenesis, and therefore more indirect methods have to be used, such as silencing the gene of interest by short RNA interference (siRNA) . Yet gene disruption by siRNA can be variable and incomplete. Genome editing with nucleases such as ZFN is different from siRNA in that the engineered nuclease is able to modify DNA-binding specificity and therefore can in principle cut any targeted position in the genome, and introduce modification of the endogenous sequences for genes that are impossible to specifically target by conventional RNAi. Furthermore, the specificity of ZFNs and TALENs are enhanced as two ZFNs are required in the recognition of their portion of the target and subsequently direct to the neighboring sequences.It was chosen by Nature Methods as the 2011 Method of the Year.
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