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Down syndrome

... – more frequent among first degree relatives – more common in females than males • The risk of recurrence for NTDs: approximately 2 to 4 percent when there is one affected sibling • With two affected siblings, the risk is approximately: 10 percent ...
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... 1. messenger RNA (mRNA) – what is its role? 2. transfer RNA (tRNA) – what is its role? f. What happens during ht eprocess of protein synthesis? 1. Messenger RNA production 2. Messenger RNA attaches to a ribosome 3. Transfer RNA attaches to messenger RNA 4. Protein production complete g. What is a mu ...
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Biology I ECA Review Standard 7 Genetics

... allelic and polygenic traits and illustrate their inheritance patterns over multiple generations.  7.3 Determine the likelihood of the appearance of a specific trait in an offspring given the genetic make-up of the parents.  7.4 Explain the process by which a cell copies its DNA and identify facto ...
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Mutation



In biology, a mutation is a permanent change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. Mutations result from damage to DNA which is not repaired or to RNA genomes (typically caused by radiation or chemical mutagens), errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity.Mutation can result in several different types of change in sequences. Mutations in genes can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely. Mutations can also occur in nongenic regions. One study on genetic variations between different species of Drosophila suggests that, if a mutation changes a protein produced by a gene, the result is likely to be harmful, with an estimated 70 percent of amino acid polymorphisms that have damaging effects, and the remainder being either neutral or weakly beneficial. Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to prevent or correct mutations by reverting the mutated sequence back to its original state.
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