Functional characterization of rare FOXP2 variants in
... dimerization, and interaction with other proteins. To shed further light on molecular functions of FOXP2, we characterized the interaction between this transcription factor and co-repressor proteins of the C-terminal binding protein (CTBP) family. Finally, we analysed the functional significance of ...
... dimerization, and interaction with other proteins. To shed further light on molecular functions of FOXP2, we characterized the interaction between this transcription factor and co-repressor proteins of the C-terminal binding protein (CTBP) family. Finally, we analysed the functional significance of ...
Endonucleolytic processing of CCAless tRNA precursors by RNase
... We noticed a relatively good correlation between whether or not a precursor RNA accumulated in the absence of IPTG and whether the corresponding tRNA gene had an encoded CCA motif. With one possible exception, complete maturation of tRNAs with an encoded CCA motif occurred in the absence of IPTG. Th ...
... We noticed a relatively good correlation between whether or not a precursor RNA accumulated in the absence of IPTG and whether the corresponding tRNA gene had an encoded CCA motif. With one possible exception, complete maturation of tRNAs with an encoded CCA motif occurred in the absence of IPTG. Th ...
Sucrose breakdown in the potato tuber - publish.UP
... Then I would like to thank Prof. Thomas Altmann and Prof. David Fell (Oxford) for agreeing to examine this thesis. ...
... Then I would like to thank Prof. Thomas Altmann and Prof. David Fell (Oxford) for agreeing to examine this thesis. ...
... occur, there are a finite number of synaptic modifications that can be established per unit time, above which total comprehension is reduced. Increasing the rate or length of information delivery diminishes the efficiency of learning. Lack of break periods and “all nighters” presage onset of diminis ...
iarc monographs on the evaluation of carcinogenic risks to humans
... Topics are selected on the basis of two main criteria: (a) there is evidence of human exposure, and (b) there is some evidence or suspicion of carcinogenicity. The term ‘agent’ is used to include individual chemical compounds, groups of related chemical compounds, physical agents (such as radiation) ...
... Topics are selected on the basis of two main criteria: (a) there is evidence of human exposure, and (b) there is some evidence or suspicion of carcinogenicity. The term ‘agent’ is used to include individual chemical compounds, groups of related chemical compounds, physical agents (such as radiation) ...
Mesenchymal Dysplasia: A Recessive Mutation
... human conditions (Winter 1988). With the rapidly expanding mouse genetic map, the structural genes for many mutations causing such syndromes are now being identified. Thus, each new mouse mutation that causes congenital malformations provides the potential of identifying the gene affected in compara ...
... human conditions (Winter 1988). With the rapidly expanding mouse genetic map, the structural genes for many mutations causing such syndromes are now being identified. Thus, each new mouse mutation that causes congenital malformations provides the potential of identifying the gene affected in compara ...
Mathematical Models of Cell Cycle Progression
... The aim of this thesis is to develop mathematical models of cell cycle progression which can be used in conjunction with biological experiments. The thesis focusses on modelling processes which have biological relevance, and uses mathematics to investigate biological hypotheses about mechanisms whic ...
... The aim of this thesis is to develop mathematical models of cell cycle progression which can be used in conjunction with biological experiments. The thesis focusses on modelling processes which have biological relevance, and uses mathematics to investigate biological hypotheses about mechanisms whic ...
AHRQ Healthcare Horizon Scanning System – Status Updates
... by into four main topic-status sections and then by priority condition within each section. Topics are listed in tables pertaining to each AHRQ priority condition. The table of contents provides links directly to each section’s priority condition tables. Topics that were already in the system are pr ...
... by into four main topic-status sections and then by priority condition within each section. Topics are listed in tables pertaining to each AHRQ priority condition. The table of contents provides links directly to each section’s priority condition tables. Topics that were already in the system are pr ...
Sacubitril valsartan for treating symptomatic chronic heart failure
... The overall safety profile of sacubitril valsartan was comparable to that of the ACE inhibitor, enalapril, during the double-blind trial period of PARADIGM-HF. Compared with the enalapril group, fewer patients in the sacubitril valsartan group experienced 1 or more treatment-related adverse events, ...
... The overall safety profile of sacubitril valsartan was comparable to that of the ACE inhibitor, enalapril, during the double-blind trial period of PARADIGM-HF. Compared with the enalapril group, fewer patients in the sacubitril valsartan group experienced 1 or more treatment-related adverse events, ...
Selective Disruption of Aurora C Kinase Reveals Distinct Functions
... Centromere Protein (INCENP), Survivin, and Borealin [18–20]. Meiotic cells, however, contain another enzymatic subunit, Aurora C kinase (AURKC), that can function in the CPC in place of AURKB [6,21–25]. AURKB and AURKC are members of a conserved serine-threonine protein kinase family, and are highly ...
... Centromere Protein (INCENP), Survivin, and Borealin [18–20]. Meiotic cells, however, contain another enzymatic subunit, Aurora C kinase (AURKC), that can function in the CPC in place of AURKB [6,21–25]. AURKB and AURKC are members of a conserved serine-threonine protein kinase family, and are highly ...
NANOS/AGS Collaborative Session Glaucoma: The Other Optic
... advantage over visual field testing since it is less subjective and not as dependent upon patient “performance”. Newer iterations of electrophysiology instruments have improved discriminatory ability but are not as commonly available as perimetry instruments and not as widely used. In experimental g ...
... advantage over visual field testing since it is less subjective and not as dependent upon patient “performance”. Newer iterations of electrophysiology instruments have improved discriminatory ability but are not as commonly available as perimetry instruments and not as widely used. In experimental g ...
A comparative study for the topical treatment of Aloe ferox Balb/c mice.
... ailments, and is characterised by an itchy, inflammatory skin condition with scaling, lichenification, papules, excoriations and pruritus. In AD patients a chronic relapsing inflammatory condition is seen, associated with IgE hyper production. AD flares are largely triggered by environmental factors ...
... ailments, and is characterised by an itchy, inflammatory skin condition with scaling, lichenification, papules, excoriations and pruritus. In AD patients a chronic relapsing inflammatory condition is seen, associated with IgE hyper production. AD flares are largely triggered by environmental factors ...
Identification of genes that interact with glp-1, a gene
... and dpy-10; mnCl, a balancer for half of LG/7 including the mnDJ30 region, carries a dpy-10 mutation. q291 and q292 were placed over mnDf30 by mating q291/+ or q292/+ males to mnDf30/mnCl hermaphrodites. Construction of double mutants Double mutants with glp-1 (ts) and one of several mutations that ...
... and dpy-10; mnCl, a balancer for half of LG/7 including the mnDJ30 region, carries a dpy-10 mutation. q291 and q292 were placed over mnDf30 by mating q291/+ or q292/+ males to mnDf30/mnCl hermaphrodites. Construction of double mutants Double mutants with glp-1 (ts) and one of several mutations that ...
specialist discussion guide
... difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treat ...
... difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treat ...
Article PDF
... concentrations than the plasma at 5.5 and 8 hours, respectively.49 Concentrations of ganciclovir in the aqueous humor and the vitreous body have been reported to be 0.4 and 0.6 higher, than concurrent plasma concentrations at 2.5 hours following IV administration.49 Ganciclovir has a similar ant ...
... concentrations than the plasma at 5.5 and 8 hours, respectively.49 Concentrations of ganciclovir in the aqueous humor and the vitreous body have been reported to be 0.4 and 0.6 higher, than concurrent plasma concentrations at 2.5 hours following IV administration.49 Ganciclovir has a similar ant ...
1. TRADE NAME OF THE MEDICINAL PRODUCT ABITREXATE 25
... inadequate response to other forms of antirheumatic therapy, including full dose NSAIDs and usually a trial of at least one or more disease-modifying antirheumatic drugs. 4.2 Posology and method of administration WARNINGS The dose must be adjusted carefully depending on the body surface area if meth ...
... inadequate response to other forms of antirheumatic therapy, including full dose NSAIDs and usually a trial of at least one or more disease-modifying antirheumatic drugs. 4.2 Posology and method of administration WARNINGS The dose must be adjusted carefully depending on the body surface area if meth ...
Regulation of limb bud initiation and limbtype
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
Attachment 2.2 Sequencing results
... On the other hand, AHR deficient mice have a reduced body weight, display reduced fecundity and are defective in development of both liver and immune system. In these mice fetal vascular structures are found in the eyes, kidneys and liver. [1] Objective: to study the conservation of the AHR gene and ...
... On the other hand, AHR deficient mice have a reduced body weight, display reduced fecundity and are defective in development of both liver and immune system. In these mice fetal vascular structures are found in the eyes, kidneys and liver. [1] Objective: to study the conservation of the AHR gene and ...
PDF (Paediatric drug development)
... for taste assessment of pharmaceutical preparations resulting in early stage research into a novel in vitro cell based assay. The formulations developed in the initial phase of the research were used as model formulations investigating microarray application in an in vitro-in vivo correlation for ca ...
... for taste assessment of pharmaceutical preparations resulting in early stage research into a novel in vitro cell based assay. The formulations developed in the initial phase of the research were used as model formulations investigating microarray application in an in vitro-in vivo correlation for ca ...
LEVAQUIN Tablets/Injection
... Klebsiella pneumoniae As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with levofloxacin. Other microorganisms Chlamydia pneumoniae Mycoplasma pneumoniae The following in vitro data are available, but their clinical sign ...
... Klebsiella pneumoniae As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with levofloxacin. Other microorganisms Chlamydia pneumoniae Mycoplasma pneumoniae The following in vitro data are available, but their clinical sign ...
Ret/PTC3 is the most frequent form of gene rearrangement
... papillary thyroid carcinomas only for ret/PTC1 rearrangements and found no rearrangement; Ishizaka et al. (1991) found one ret/PTC1 rearrangement among 11 carcinomas, and Wajjwalku et al. (1992) found only one such alteration among 38 carcinomas. On the basis of those observations, RET gene rearrang ...
... papillary thyroid carcinomas only for ret/PTC1 rearrangements and found no rearrangement; Ishizaka et al. (1991) found one ret/PTC1 rearrangement among 11 carcinomas, and Wajjwalku et al. (1992) found only one such alteration among 38 carcinomas. On the basis of those observations, RET gene rearrang ...