Product description P003-D1 MLH1-MSH2-v01 - MRC
... containing MLH1 or MSH2 exon deletions or amplifications: http://www.nibsc.org/documents/ifu/11-218xxx.pdf. As an alternative, an artificial positive duplication DNA sample for MLH1 and MSH2 (product name SD027) can be ordered from MRC-Holland. This FOR RESEARCH USE ONLY SD027 DNA will show a duplic ...
... containing MLH1 or MSH2 exon deletions or amplifications: http://www.nibsc.org/documents/ifu/11-218xxx.pdf. As an alternative, an artificial positive duplication DNA sample for MLH1 and MSH2 (product name SD027) can be ordered from MRC-Holland. This FOR RESEARCH USE ONLY SD027 DNA will show a duplic ...
Functional features of RUNX1 mutants in acute
... RUNX1 and CBF are among the most frequent targets in leukemia through chromosomal translocations or gene mutations.10,11 With regard to the RUNX1 gene, different chromosomal translocations have been reported in human acute leukemias such as t(8;21)(q22;q22) generating the RUNX1-ETO fusion gene, t(1 ...
... RUNX1 and CBF are among the most frequent targets in leukemia through chromosomal translocations or gene mutations.10,11 With regard to the RUNX1 gene, different chromosomal translocations have been reported in human acute leukemias such as t(8;21)(q22;q22) generating the RUNX1-ETO fusion gene, t(1 ...
Proof-of-principle rapid noninvasive prenatal diagnosis
... carriers in addition to the mother in family 2 (Figure 1). For family 1, the N370S carrier father was completely homozygous for the entire consensus N370S sequence. This precluded the use of the N370S haplotype for NIPD of his allele. Nonetheless, the familial mutation-linked haplotype of the father ...
... carriers in addition to the mother in family 2 (Figure 1). For family 1, the N370S carrier father was completely homozygous for the entire consensus N370S sequence. This precluded the use of the N370S haplotype for NIPD of his allele. Nonetheless, the familial mutation-linked haplotype of the father ...
Processing the RefSeq and CCDS Annotation Datasets Using the SAS System: Creation of Gene Reference
... is the same, but must account for the reverse compliment for the minus-strand. First it acquires the sequence for the promoter (NN = -50000 to NN = -1). Then it obtains the sequence for the gene. Then it acquires the sequence for the 3’ genomic DNA. The DO-Loop on Lines 4148 cycles through the promo ...
... is the same, but must account for the reverse compliment for the minus-strand. First it acquires the sequence for the promoter (NN = -50000 to NN = -1). Then it obtains the sequence for the gene. Then it acquires the sequence for the 3’ genomic DNA. The DO-Loop on Lines 4148 cycles through the promo ...
NCBI Molecular Biology Resources
... On Jun 26, 2003 this sequence version replaced gi:27804758. ...
... On Jun 26, 2003 this sequence version replaced gi:27804758. ...
Inhibition of RNA Synthesis by Anthracycline Analogs
... mitotic aberrations can be observed by phase microscopy immediately after a sufficient amount of daunomycin is added (DiMarco et al., 1964b). Cytoplasmic changes, such as vacuolization, are moderate and occur only after prolonged treatment with high doses. induce significant alterations in ...
... mitotic aberrations can be observed by phase microscopy immediately after a sufficient amount of daunomycin is added (DiMarco et al., 1964b). Cytoplasmic changes, such as vacuolization, are moderate and occur only after prolonged treatment with high doses. induce significant alterations in ...
Genomic variations and distinct evolutionary rate of rare alleles in
... neutral sites [17]. Hence, critical advances in relevant area are feasible on three basic hypotheses proposed to explain beyond a neutral model. First, it can be expected that low allelic frequency might have arisen from a recent selective sweep of an advantageous allele at a locus [18–21], or from ...
... neutral sites [17]. Hence, critical advances in relevant area are feasible on three basic hypotheses proposed to explain beyond a neutral model. First, it can be expected that low allelic frequency might have arisen from a recent selective sweep of an advantageous allele at a locus [18–21], or from ...
Functional Analysis of Maize RAD51 in Meiosis and
... indicates that RAD51 is required for efficient chromosome pairing and its absence results in nonhomologous pairing and synapsis. These phenotypes differ from those of an Arabidopsis rad51 mutant that exhibits completely disrupted chromosome pairing and synapsis during meiosis. Unexpectedly, survivin ...
... indicates that RAD51 is required for efficient chromosome pairing and its absence results in nonhomologous pairing and synapsis. These phenotypes differ from those of an Arabidopsis rad51 mutant that exhibits completely disrupted chromosome pairing and synapsis during meiosis. Unexpectedly, survivin ...
Parasexual Genetics in Dictyostelium discoideum
... tions affecting pigmentation are known (Sussman & Sussman, 1963) and are useful for monitoring the stability of diploids. The use of these pigmentation markers to recover rare (IO-~)haploids without preselection on drugs is not practical in D. discoideum, although visual selection of haploid segrega ...
... tions affecting pigmentation are known (Sussman & Sussman, 1963) and are useful for monitoring the stability of diploids. The use of these pigmentation markers to recover rare (IO-~)haploids without preselection on drugs is not practical in D. discoideum, although visual selection of haploid segrega ...
Two Waves of Nuclear Factor κB Recruitment to Target Promoters
... quence of the NF-B site in MIP-2 (a gene with immediate NF-B recruitment) is identical to the sequence of one of the two NF-B sites in MCP-1 (a gene with delayed NF-B recruitment). Overall, this suggests that the observed differences in the kinetic of NF-B recruitment to the genes under investi ...
... quence of the NF-B site in MIP-2 (a gene with immediate NF-B recruitment) is identical to the sequence of one of the two NF-B sites in MCP-1 (a gene with delayed NF-B recruitment). Overall, this suggests that the observed differences in the kinetic of NF-B recruitment to the genes under investi ...
Genetic and biochemical analysis of the adenylyl cyclase of
... described (Young et al., 1989). The positions of sites for Stu (St), Pst I (P), Hpa I (Hp), BamHI (B), EcoRl (R), Nco I (N), Hindlil (H), Sph I (Sp), Sal I (S), Xba I (X), Sma I (Sm), Kpn I (K), and Sac I (Sc) are indicated. The sequence encoding the carboxylterminal catalytic region of the protein ...
... described (Young et al., 1989). The positions of sites for Stu (St), Pst I (P), Hpa I (Hp), BamHI (B), EcoRl (R), Nco I (N), Hindlil (H), Sph I (Sp), Sal I (S), Xba I (X), Sma I (Sm), Kpn I (K), and Sac I (Sc) are indicated. The sequence encoding the carboxylterminal catalytic region of the protein ...
Abundant RNA editing sites of chloroplast protein
... To gain further insights into the characteristics of the 255 RNA editing sites in the G. biloba chloroplast genome, we analyzed different types of editing codon positions. There were 63, 174 and 14 editing sites occurring at the first, second and third codon positions, respectively (Fig. 2). Editing ...
... To gain further insights into the characteristics of the 255 RNA editing sites in the G. biloba chloroplast genome, we analyzed different types of editing codon positions. There were 63, 174 and 14 editing sites occurring at the first, second and third codon positions, respectively (Fig. 2). Editing ...
MTHFR C677T and A1298C: Explained In Plain
... Heterozygous A1298C is thought to be of minor consequence (if any), while heterozygous C677T may affect folate metabolism by up to 35% (3, 11). MTHFR mutations that have the greatest influence on health are: Homozygous A1298C (C1298C) and homozygous C677T (T677T) Compound heterozgous A1298C + C677T ...
... Heterozygous A1298C is thought to be of minor consequence (if any), while heterozygous C677T may affect folate metabolism by up to 35% (3, 11). MTHFR mutations that have the greatest influence on health are: Homozygous A1298C (C1298C) and homozygous C677T (T677T) Compound heterozgous A1298C + C677T ...
Pleiotropic effects of the mouse lethal yellow (Ay) mutation
... We have previously described the isolation and structure of cosmid clones that constitute a 60 kb contig containing agouti exons 1B, 1C, 2, 3 and 4 (Miller et al., 1993) (The agouti exon nomenclature used in the present work differs from that used previously; the rationale is summarized in Fig. 1). ...
... We have previously described the isolation and structure of cosmid clones that constitute a 60 kb contig containing agouti exons 1B, 1C, 2, 3 and 4 (Miller et al., 1993) (The agouti exon nomenclature used in the present work differs from that used previously; the rationale is summarized in Fig. 1). ...
Loss of heterozygosity at D8S262: an early genetic event of
... and nodules of altered hepatocytes (NAHs) described previously by Su et al. [2, 3] are often found in cirrhotic liver tissue. Therefore, mounting evidence suggests that SCC represents precursor lesions that are more advanced than LCC in the course of human hepatocarcinogenesis [4]. Foci of altered h ...
... and nodules of altered hepatocytes (NAHs) described previously by Su et al. [2, 3] are often found in cirrhotic liver tissue. Therefore, mounting evidence suggests that SCC represents precursor lesions that are more advanced than LCC in the course of human hepatocarcinogenesis [4]. Foci of altered h ...
Wolbachia John H. Werren and Jeremy D. Bartos
... indicating a high degree of similarity. It should be noted that this high level of similarity includes one of the rapidly evolving hypervariable regions found within wsp [24] and further supports a high phylogenetic affinity between the Wolbachia of N. giraulti and N. longicornis. The 12 sequences f ...
... indicating a high degree of similarity. It should be noted that this high level of similarity includes one of the rapidly evolving hypervariable regions found within wsp [24] and further supports a high phylogenetic affinity between the Wolbachia of N. giraulti and N. longicornis. The 12 sequences f ...
Ethanol exposure affects gene expression in the embryonic
... types during vertebrate embryogenesis (Durston et al., 1998; Means and Gudas, 1995). The importance of RA in normal embryonic development has been demonstrated by treating embryos with RA or inducing Vitamin A deficiency, both resulting in severe teratogenic effects (Cohlan, 1953; Kessel, 1992; Made ...
... types during vertebrate embryogenesis (Durston et al., 1998; Means and Gudas, 1995). The importance of RA in normal embryonic development has been demonstrated by treating embryos with RA or inducing Vitamin A deficiency, both resulting in severe teratogenic effects (Cohlan, 1953; Kessel, 1992; Made ...
Genetic studies of psoriasis and psoriatic arthritis
... PSORS5 yielded no significant association. It is therefore unlikely that they harbor the genetic cause of psoriasis at this locus. Fine-mapping of the PSORS5 region revealed both point-wise and haplotype associations that might contribute to psoriasis susceptibility. The only gene within this region ...
... PSORS5 yielded no significant association. It is therefore unlikely that they harbor the genetic cause of psoriasis at this locus. Fine-mapping of the PSORS5 region revealed both point-wise and haplotype associations that might contribute to psoriasis susceptibility. The only gene within this region ...
Xq28 duplications
... Our bodies are made up of different types of cells, almost all of which contain the same chromosomes. Each chromosome contains hundreds to thousands of genes which may be thought of as individual instruction booklets (or recipes) that contain all the genetic information that tells the body how to de ...
... Our bodies are made up of different types of cells, almost all of which contain the same chromosomes. Each chromosome contains hundreds to thousands of genes which may be thought of as individual instruction booklets (or recipes) that contain all the genetic information that tells the body how to de ...
WOTD - Brookwood High School
... V:multiple alleles refer to a trait (one gene) which is coded for by more than two alleles. ...
... V:multiple alleles refer to a trait (one gene) which is coded for by more than two alleles. ...