data sheet
... As with other benzodiazepines, overdose should not present a threat to life unless combined with other CNS depressants (including alcohol). In the management of overdose with any medicinal product, it should be borne in mind that multiple agents may have been taken. Following overdose with oral benz ...
... As with other benzodiazepines, overdose should not present a threat to life unless combined with other CNS depressants (including alcohol). In the management of overdose with any medicinal product, it should be borne in mind that multiple agents may have been taken. Following overdose with oral benz ...
563 kB - recent advances remifentanil mgmc
... maximum of 3 mg per hour. • It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5ml ...
... maximum of 3 mg per hour. • It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5ml ...
Антиепилептични лекарства
... ▼BENZODIAZEPINES (in status epilepticus) •Diazepam given intravenously or rectally is highly effective for stopping continuous seizure activity, especially generalized tonicclonic status epilepticus. The drug is occasionally given orally on a long-term basis, although it is not considered very effe ...
... ▼BENZODIAZEPINES (in status epilepticus) •Diazepam given intravenously or rectally is highly effective for stopping continuous seizure activity, especially generalized tonicclonic status epilepticus. The drug is occasionally given orally on a long-term basis, although it is not considered very effe ...
Prescribing and Tapering Benzodiazepines
... Pregnancy and Elderly Renal, Hepatic, and/or respiratory deficiency ...
... Pregnancy and Elderly Renal, Hepatic, and/or respiratory deficiency ...
WHY ARE WE STILL STUCK AROUND BENZODIAZEPINES? Introduction SMMGP Manchester, October 2013
... dependence and withdrawal symptoms were common in those taking BZs long-term During 1970s and 1980s prescribing increased dramatically Over last decade, prescribing has remained stable but that of BZs used for anxiety has steadily risen ...
... dependence and withdrawal symptoms were common in those taking BZs long-term During 1970s and 1980s prescribing increased dramatically Over last decade, prescribing has remained stable but that of BZs used for anxiety has steadily risen ...
anesthetic agents - hsvma-ravs
... May be less likely to cause tachycardia and cardiac arrhythmias than atropine Can cause an initial paradoxical bradycardia and AV block when given IV. This effect is usually overcome as plasma levels become therapeutic Note: Hypothermia results in decreased depolarization of cardiac pacemaker ...
... May be less likely to cause tachycardia and cardiac arrhythmias than atropine Can cause an initial paradoxical bradycardia and AV block when given IV. This effect is usually overcome as plasma levels become therapeutic Note: Hypothermia results in decreased depolarization of cardiac pacemaker ...
Mammy`s Little Helper - How should we deal with anxiety disorders
... of the Faculty of Addiction at the College of Psychiatrists of Ireland; Dr Ide Delargy, general practitioner; Ms Noeleen Harvey, community pharmacist; and Dr Keith Gaynor, senior clinical psychologist at Saint John of God Hospital, Dublin. The panel agreed that, when used appropriately for short pe ...
... of the Faculty of Addiction at the College of Psychiatrists of Ireland; Dr Ide Delargy, general practitioner; Ms Noeleen Harvey, community pharmacist; and Dr Keith Gaynor, senior clinical psychologist at Saint John of God Hospital, Dublin. The panel agreed that, when used appropriately for short pe ...
7-antianxiety-20142015-10
... Panic disorder with depression Alprazolam (antidepressant effect) Benzodiazepines are fast acting—typically bringing relief within thirty minutes to an hour. ...
... Panic disorder with depression Alprazolam (antidepressant effect) Benzodiazepines are fast acting—typically bringing relief within thirty minutes to an hour. ...
Drug withdrawal syndromes cs
... Substitute abused drug with same/ similar class (a cross tolerant agonist is less likely to be abused, has longer ½ life) Substitute abused drug with one that blocks its reinforcing effects (antagonist) PREFERRED DRUG CLASS/ DRUG (where appropriate) with INTERACTIONS, DOSING SUGGESTIONS etc. Alcohol ...
... Substitute abused drug with same/ similar class (a cross tolerant agonist is less likely to be abused, has longer ½ life) Substitute abused drug with one that blocks its reinforcing effects (antagonist) PREFERRED DRUG CLASS/ DRUG (where appropriate) with INTERACTIONS, DOSING SUGGESTIONS etc. Alcohol ...
Benzodiazepines - SWLA Center for Health Services
... the half-life of the benzodiazepine. With shorter-acting benzodiazepines (e.g., alprazolam), withdrawal symptoms may occur 2–3 days after ceasing the medication, but with longer-acting ones such as diazepam, symptoms may not emerge until 1–2 weeks later. Withdrawal symptoms from benzodiazepines incl ...
... the half-life of the benzodiazepine. With shorter-acting benzodiazepines (e.g., alprazolam), withdrawal symptoms may occur 2–3 days after ceasing the medication, but with longer-acting ones such as diazepam, symptoms may not emerge until 1–2 weeks later. Withdrawal symptoms from benzodiazepines incl ...
Benzodiazepine Pharmacology and Central Nervous System
... Benzodiazepines (BZDs) are one of the most widely prescribed pharmacologic agents in the United States (more than 112 million prescriptions in 2007).1 BZDs are used for numerous indications, including anxiety, insomnia, muscle relaxation, relief from spasticity caused by central nervous system patho ...
... Benzodiazepines (BZDs) are one of the most widely prescribed pharmacologic agents in the United States (more than 112 million prescriptions in 2007).1 BZDs are used for numerous indications, including anxiety, insomnia, muscle relaxation, relief from spasticity caused by central nervous system patho ...
Benzodiazepines - Dr Anthony (Tony) Mander
... Yes. Around 4 in every 10 people who take them continuously for more than 6 weeks will get withdrawal symptoms. These include difficulty in sleeping, feeling tense and agitated – rather like the return of the symptoms the medication was originally prescribed for. You can also get dizziness, metallic ...
... Yes. Around 4 in every 10 people who take them continuously for more than 6 weeks will get withdrawal symptoms. These include difficulty in sleeping, feeling tense and agitated – rather like the return of the symptoms the medication was originally prescribed for. You can also get dizziness, metallic ...
SEDATIVE-HYPNOTIC DRUGS
... • These adverse effects are more common with benzodiazepines that have active metabolites with long half-lives (eg, diazepam, flurazepam), – but can also occur after a single dose of a short-acting benzodiazepine such as triazolam. ...
... • These adverse effects are more common with benzodiazepines that have active metabolites with long half-lives (eg, diazepam, flurazepam), – but can also occur after a single dose of a short-acting benzodiazepine such as triazolam. ...
Pharmacology—Clinical Uses of Sedatives
... 2) Gradually taper dose to avoid. Adverse Effects 1) CNS depression – drowsiness, sedation, 3) Hallucination impaired muscle coordination, confusion, 4) Paradoxical CNS stimulation memory loss, and development of tolerance 5) GI effects 2) Blurred vision 6) ALL effects are additive with alcohol 7) O ...
... 2) Gradually taper dose to avoid. Adverse Effects 1) CNS depression – drowsiness, sedation, 3) Hallucination impaired muscle coordination, confusion, 4) Paradoxical CNS stimulation memory loss, and development of tolerance 5) GI effects 2) Blurred vision 6) ALL effects are additive with alcohol 7) O ...
Pharmacology II - 3-14
... Irreversibly inhibits the benzodiazepine binding site on the GABA-A receptor b. Competitively inhibits the benzodiazepine binding site on the GABA-A receptor c. Irreversibly inhibits the benzodiazepine binding site on the GABA-B receptor d. Competitively inhibits the benzodiazepine binding site on t ...
... Irreversibly inhibits the benzodiazepine binding site on the GABA-A receptor b. Competitively inhibits the benzodiazepine binding site on the GABA-A receptor c. Irreversibly inhibits the benzodiazepine binding site on the GABA-B receptor d. Competitively inhibits the benzodiazepine binding site on t ...
SEDATIVE/HYPNOTICS (Antianxiety Drugs)
... and include: drowsiness, excess sedation, impaired coordination, nausea, vomiting, confusion and memory loss. Tolerance develops to most of these effects. • Dependence with these drugs may develop. • Serious withdrawal syndrome can include convulsions and death. ...
... and include: drowsiness, excess sedation, impaired coordination, nausea, vomiting, confusion and memory loss. Tolerance develops to most of these effects. • Dependence with these drugs may develop. • Serious withdrawal syndrome can include convulsions and death. ...
Pharmacology tutoring for antianxiety agents
... Which of the following drugs is not used often for anxiety because of its danger of fatal overdose in single-agent usage and its contraindication in individuals with cardiac abnormalities, prostatic hyperplasia, narrow-angle glaucoma and a variety of other conditions? ...
... Which of the following drugs is not used often for anxiety because of its danger of fatal overdose in single-agent usage and its contraindication in individuals with cardiac abnormalities, prostatic hyperplasia, narrow-angle glaucoma and a variety of other conditions? ...
anxiolytics2011-09
... 1. Toxic Effects Resulting from Acute Over Dosage Severe overdoses resulting in sleep prolongation, but in the presence of other CNS depressants, such as alcohol, antihistamines, or anticholinergic drugs , severe respiratory depression may occur. 2. Side Effects During Therapeutic Use: The clinical ...
... 1. Toxic Effects Resulting from Acute Over Dosage Severe overdoses resulting in sleep prolongation, but in the presence of other CNS depressants, such as alcohol, antihistamines, or anticholinergic drugs , severe respiratory depression may occur. 2. Side Effects During Therapeutic Use: The clinical ...
Restoril (temazepam)
... Restoril may affect alertness and coordination the next day after taking a single bedtime dose. Patients should exercise caution when driving or performing other tasks requiring alertness while taking this medication. Seniors may be more adversely affected, because it may affect their coordination a ...
... Restoril may affect alertness and coordination the next day after taking a single bedtime dose. Patients should exercise caution when driving or performing other tasks requiring alertness while taking this medication. Seniors may be more adversely affected, because it may affect their coordination a ...
Mode of action
... because of addiction potential. The longer acting agents such as diazepam, are often preferred in those patients with anxiety that may require treatment for prolonged periods of time. The antianxiety effects of the benzodiazepines are less subject to tolerance than the sedative and hypnotic effects. ...
... because of addiction potential. The longer acting agents such as diazepam, are often preferred in those patients with anxiety that may require treatment for prolonged periods of time. The antianxiety effects of the benzodiazepines are less subject to tolerance than the sedative and hypnotic effects. ...
ProSom (estazolam)
... ProSom may affect alertness and coordination the next day after taking a single bedtime dose. Patients should exercise caution when driving or performing other tasks requiring alertness while taking this medication. Seniors may be more adversely affected, because it may affect their coordination and ...
... ProSom may affect alertness and coordination the next day after taking a single bedtime dose. Patients should exercise caution when driving or performing other tasks requiring alertness while taking this medication. Seniors may be more adversely affected, because it may affect their coordination and ...
CNS Depressants and Antidepressants
... 2-4 times more likely to cause an automobile accident at higher doses of diazepam (≥ 20 mg/day) At low doses, likelihood of accident no higher than non-drug control ...
... 2-4 times more likely to cause an automobile accident at higher doses of diazepam (≥ 20 mg/day) At low doses, likelihood of accident no higher than non-drug control ...
SEDATIVE/HYPNOTICS (Antianxiety Drugs)
... and include: drowsiness, excess sedation, impaired coordination, nausea, vomiting, confusion and memory loss. Tolerance develops to most of these effects. • Dependence with these drugs may develop. • Serious withdrawal syndrome can include convulsions and death. ...
... and include: drowsiness, excess sedation, impaired coordination, nausea, vomiting, confusion and memory loss. Tolerance develops to most of these effects. • Dependence with these drugs may develop. • Serious withdrawal syndrome can include convulsions and death. ...
anxiolytics & hypnotics
... Clinical uses:1- Hypnotic[insomnia] 2-Anxiolytic{severe anxiety} 3- Preoperative sedation 4-for alcohol withdrawal. ...
... Clinical uses:1- Hypnotic[insomnia] 2-Anxiolytic{severe anxiety} 3- Preoperative sedation 4-for alcohol withdrawal. ...
Diazepam
Diazepam, first marketed as Valium, is a medication of the benzodiazepine type that alters the function of the brain. It is commonly used to treat a range of conditions including anxiety, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, seizures, trouble sleeping, and restless legs syndrome. It may also be used to cause memory loss during certain medical procedures. It can be taken by mouth, inserted into the rectum, injected into muscle, or injected into a vein. When given into a vein, effects begin in one to five minutes and last up to an hour. By mouth, effects may take 40 minutes to begin.Common side effects include sleepiness and trouble with coordination. Serious side effects are rare. They include suicide, decreased breathing, and an increased risk of seizures if used too frequently in those with epilepsy. Occasionally excitement or agitation may occur. Long term use can result in tolerance, dependence, and withdrawal upon dose reduction. Abrupt stopping after long term use can be potentially dangerous. After stopping cognitive problems may persist for six months or longer. They are not recommended during pregnancy or breastfeeding. Its mechanism of action is by increasing the effect of the neurotransmitter gamma-Aminobutyric acid (GABA).Diazepam was first synthesized by Leo Sternbach, and was first manufactured by Hoffmann-La Roche. It has been one of the most frequently prescribed medications in the world since its launch in 1963. In the United States it was the highest selling medication between 1968 and 1982, selling more than two billion tablets in 1978 alone. In 1985 the patent ended, and there are now more than 500 brands available on the market. Diazepam is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.