Controversial cases of human gender identification by amelogenin test
... Received: October 16, 2007 / Accepted: November 15, 2007 ...
... Received: October 16, 2007 / Accepted: November 15, 2007 ...
apgenetics1206 - cloudfront.net
... 9) The allele for pea comb (P) in chickens is dominant to that for single comb (p), but the alleles black (B) and white (B’) for feather color show partial dominance, B/B’ individuals having “blue” feathers. If birds heterozygous for both alleles are mated, what proportion of the offspring is expec ...
... 9) The allele for pea comb (P) in chickens is dominant to that for single comb (p), but the alleles black (B) and white (B’) for feather color show partial dominance, B/B’ individuals having “blue” feathers. If birds heterozygous for both alleles are mated, what proportion of the offspring is expec ...
Minimal Expensive Treatment in ACS
... b. Enoxaparin administered according to age, weight, and creatinine clearance, given as an intravenous bolus, followed in 15 minutes by subcutaneous injection for the duration of the index hospitalization, up to 8 days or until revascularization; or c. Fondaparinux administered with initial intraven ...
... b. Enoxaparin administered according to age, weight, and creatinine clearance, given as an intravenous bolus, followed in 15 minutes by subcutaneous injection for the duration of the index hospitalization, up to 8 days or until revascularization; or c. Fondaparinux administered with initial intraven ...
Characterization of the neurohypophysial hormone gene loci in
... muscle contraction and maternal behavior. However, oxytocin had been previously purified from the hypothalamus of a holocephalian cartilaginous fish, the ratfish, the only non-mammalian vertebrate to contain oxytocin [14]. The presence of oxytocin gene in elephant shark indicates that oxytocin is mo ...
... muscle contraction and maternal behavior. However, oxytocin had been previously purified from the hypothalamus of a holocephalian cartilaginous fish, the ratfish, the only non-mammalian vertebrate to contain oxytocin [14]. The presence of oxytocin gene in elephant shark indicates that oxytocin is mo ...
Characteristics of the gene encoding pyrroline-5-carboxylate synthase (P5CS) in Glycine max
... mechanisms which modified the structure of the protein P5CS (Boggess et al., 1976a, 1976b) [2], [3]. In Escherichia coli, the synthesis of proline is adjusted through the inhibition of activity of the enzyme γ-GK by the end product of the cycle that is proline, by which the activity of this enzyme i ...
... mechanisms which modified the structure of the protein P5CS (Boggess et al., 1976a, 1976b) [2], [3]. In Escherichia coli, the synthesis of proline is adjusted through the inhibition of activity of the enzyme γ-GK by the end product of the cycle that is proline, by which the activity of this enzyme i ...
Saunders 1..13
... clinical symptoms might not be evident in newborns. Genetic screens performed on newborns are rapid, but are designed to unearth only a few genetic disorders, and serial gene sequencing is too slow to be clinically useful. Together, these complicating factors lead to the administration of treatments ...
... clinical symptoms might not be evident in newborns. Genetic screens performed on newborns are rapid, but are designed to unearth only a few genetic disorders, and serial gene sequencing is too slow to be clinically useful. Together, these complicating factors lead to the administration of treatments ...
p53 AND CANCER - Journal of Chemical and Pharmaceutical
... Trp53 is a master transcription factor which regulates the expression of a plethora of genes involved in the crucial biological processes, many of which encipher proteins that control the cell cycle or induce apoptosis. Because of its critical impact on cell predestination, cellular p53 activity mus ...
... Trp53 is a master transcription factor which regulates the expression of a plethora of genes involved in the crucial biological processes, many of which encipher proteins that control the cell cycle or induce apoptosis. Because of its critical impact on cell predestination, cellular p53 activity mus ...
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... associated with the complex phenotypic trait that are independent of any existing component trait. Conditional analysis methods have also been applied to study the dynamic behavior of developmental traits on time-series datasets in both plants and animals [15,16]. Furthermore, these methods have bee ...
... associated with the complex phenotypic trait that are independent of any existing component trait. Conditional analysis methods have also been applied to study the dynamic behavior of developmental traits on time-series datasets in both plants and animals [15,16]. Furthermore, these methods have bee ...
- bioRxiv
... leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene copy number are important drivers of some human diseases and understanding these effects may have important therapeutic implications. Based on single cell simulations, it was hypo ...
... leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene copy number are important drivers of some human diseases and understanding these effects may have important therapeutic implications. Based on single cell simulations, it was hypo ...
Is there an optimal management for localized prostate cancer?
... immediate intervention. Several other studies have also demonstrated that low-risk patients who delayed prostatectomy for medians of 6 and 22 months did not experience more adverse pathologic outcomes nor a compromised curability.15,16 Patients need to be counseled that AS, as the name implies, is a ...
... immediate intervention. Several other studies have also demonstrated that low-risk patients who delayed prostatectomy for medians of 6 and 22 months did not experience more adverse pathologic outcomes nor a compromised curability.15,16 Patients need to be counseled that AS, as the name implies, is a ...
Utilization of Translational Bioinformatics to Identify Novel
... Multiple myeloma (MM) is an incurable malignant neoplasm hallmarked by a clonal expansion of plasma cells, the presence of a monoclonal protein in the serum and/or urine (M-spike), lytic bone lesions, and end organ damage. Clinical outcomes for patients with MM have improved greatly over the last de ...
... Multiple myeloma (MM) is an incurable malignant neoplasm hallmarked by a clonal expansion of plasma cells, the presence of a monoclonal protein in the serum and/or urine (M-spike), lytic bone lesions, and end organ damage. Clinical outcomes for patients with MM have improved greatly over the last de ...
View PDF - OMICS International
... 17. Azofeifa J, Voit T, Hübner C, Cremer M (1995) X-chromosome methylation in manifesting and healthy carriers of dystrophinopathies: concordance of activation ratios among first degree female relatives and skewed inactivation as cause of the affected phenotypes. Hum Genet 96: 167-176. 18. Yoshioka ...
... 17. Azofeifa J, Voit T, Hübner C, Cremer M (1995) X-chromosome methylation in manifesting and healthy carriers of dystrophinopathies: concordance of activation ratios among first degree female relatives and skewed inactivation as cause of the affected phenotypes. Hum Genet 96: 167-176. 18. Yoshioka ...
SBT-production - Webarchiv ETHZ / Webarchive ETH
... Genome-scale metabolic reconstruction of E.coli as a compendium (iJR904): The 11 metabolites belonging to the SBT path participate in 90 other enzymatic reactions of E.coli. Of the 90 undesired reactions, 73 are probably not problematic since they rely on substrates or cofactors washed out of the SB ...
... Genome-scale metabolic reconstruction of E.coli as a compendium (iJR904): The 11 metabolites belonging to the SBT path participate in 90 other enzymatic reactions of E.coli. Of the 90 undesired reactions, 73 are probably not problematic since they rely on substrates or cofactors washed out of the SB ...
A Study of the Asp110–Glu112 Region of EcoRII Restriction
... sites was proposed: P (E/D) Xn (E/D) Z K. This motif is not completely conservative. For instance, the proline residue may be absent in some restriction endonuclease active sites [2-4]. Also, it is known that both the FokI (a type IIs restriction endonuclease whose crystal structure was recently det ...
... sites was proposed: P (E/D) Xn (E/D) Z K. This motif is not completely conservative. For instance, the proline residue may be absent in some restriction endonuclease active sites [2-4]. Also, it is known that both the FokI (a type IIs restriction endonuclease whose crystal structure was recently det ...
Glutathione S-transferase copy number variation alters lung gene expression M.W. Butler*
... COPD and lung cancer, and that these diseases arise in the SAE and AMs principally due to exposure to cigarette smoke, with its heavy xenobiotic burden, the observation that the SAE and AMs of healthy nonsmokers and smokers exhibits CNVcorrelated levels of GST expression suggests that the mechanisms ...
... COPD and lung cancer, and that these diseases arise in the SAE and AMs principally due to exposure to cigarette smoke, with its heavy xenobiotic burden, the observation that the SAE and AMs of healthy nonsmokers and smokers exhibits CNVcorrelated levels of GST expression suggests that the mechanisms ...
Identification and Functional Analysis of Mutations in the Hepatocyte
... From a large population-based sample from patients with type 1 diabetes all of the antiislet autoantibody-negative, unrelated, new-onset patients (n 5 28; 15 males and 13 females) were selected from 231 (92 males and 139 females; median age of onset, 17.0 yr) type 1 diabetic patients screened for an ...
... From a large population-based sample from patients with type 1 diabetes all of the antiislet autoantibody-negative, unrelated, new-onset patients (n 5 28; 15 males and 13 females) were selected from 231 (92 males and 139 females; median age of onset, 17.0 yr) type 1 diabetic patients screened for an ...
1 Part I: Pompe Disease from Diagnosis to Treatment Operator
... initially the clinical presentation was a moderate elevation of CK, should have already given kind of a suspected diagnosis of Pompe disease, so clearly the muscle biopsy was not indicated, what are you in this case, and confirmatory testing should have been done either on leukocytes, dried blood sp ...
... initially the clinical presentation was a moderate elevation of CK, should have already given kind of a suspected diagnosis of Pompe disease, so clearly the muscle biopsy was not indicated, what are you in this case, and confirmatory testing should have been done either on leukocytes, dried blood sp ...
Martina Šeruga Musić, Mladen Krajačić, Dijana Škorić
... For direct amplification of phytoplasma gene or pseudogene regions, three different primer pairs were used: 16R738f/16R1232r (GIBB et al., 1995), to amplify a part of 16S rRNA gene; fTufu/rTufu (SCHNEIDER et al., 1997), to amplify a part of tuf gene; and G35p/m (DAVIS et al., 1992), to amplify dnaB ...
... For direct amplification of phytoplasma gene or pseudogene regions, three different primer pairs were used: 16R738f/16R1232r (GIBB et al., 1995), to amplify a part of 16S rRNA gene; fTufu/rTufu (SCHNEIDER et al., 1997), to amplify a part of tuf gene; and G35p/m (DAVIS et al., 1992), to amplify dnaB ...
DNA Duplication Associated with Charcot-Marie-Tooth Disease Type 1A. Lupski, et al., 1991 Cell, Vol. 66, 219-232, July 26, 1991,
... suggesting a duplication of this locus in CMTlA patients. Genotypes for RMI I-GT for all seven CMTl A pedigrees are shown in Figure 1 and demonstrate that three RMI lGT alleles are present only in affected individuals and are never observed in 53 unaffected offspring and 31 unaffected spouses. The t ...
... suggesting a duplication of this locus in CMTlA patients. Genotypes for RMI I-GT for all seven CMTl A pedigrees are shown in Figure 1 and demonstrate that three RMI lGT alleles are present only in affected individuals and are never observed in 53 unaffected offspring and 31 unaffected spouses. The t ...
Analysis of Flanking Sequences from Dissociation
... chromosome as that occupied by the donor site. The overall lower number of hits into the NOR2-adjacent region as compared with the NOR4-adjacent region could be due to an unsequenced gap between NOR2 and the closest sequenced BAC clone. Both NOR2 and NOR4 adjoin the telomeres of the chromosomes on w ...
... chromosome as that occupied by the donor site. The overall lower number of hits into the NOR2-adjacent region as compared with the NOR4-adjacent region could be due to an unsequenced gap between NOR2 and the closest sequenced BAC clone. Both NOR2 and NOR4 adjoin the telomeres of the chromosomes on w ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.