Metabolomics based gene function annotation in Escherichia coli
... accessions/strains, tissues, and cell types of an organism. Once the metabolic diversity has been described, the genetic-basis for the metabolic and/or phenotypic differences can be elucidated using other omics technologies such genomics, transcriptomics, and proteomics. In both strategies, the gene ...
... accessions/strains, tissues, and cell types of an organism. Once the metabolic diversity has been described, the genetic-basis for the metabolic and/or phenotypic differences can be elucidated using other omics technologies such genomics, transcriptomics, and proteomics. In both strategies, the gene ...
Immune Globulin Replacement Therapy
... and subcutaneous use for treatment of PID. [89-91] All three are available as a 10 % solution. SCIG has a lower bioavailability than IVIG, so must be given in higher doses to achieve the same serum IgG concentrations. However, subcutaneous delivery may result in higher steady-state IgG levels due to ...
... and subcutaneous use for treatment of PID. [89-91] All three are available as a 10 % solution. SCIG has a lower bioavailability than IVIG, so must be given in higher doses to achieve the same serum IgG concentrations. However, subcutaneous delivery may result in higher steady-state IgG levels due to ...
Rationale For and Results to Date from Proton Beam
... reported on the MGH series of 200 patients treated by a combination of protons and x rays to a dose of ~72 Gy(RBE) 4 with a 10 year local control rate of 98% [29]. Skull base chordoma. Ares et al. have reported a local control rate at 5 years of 81% following 74 Gy(RBE) in the Paul Scherer Institute ...
... reported on the MGH series of 200 patients treated by a combination of protons and x rays to a dose of ~72 Gy(RBE) 4 with a 10 year local control rate of 98% [29]. Skull base chordoma. Ares et al. have reported a local control rate at 5 years of 81% following 74 Gy(RBE) in the Paul Scherer Institute ...
Detection and copy number estimation of the transgenic nucleotide
... The research and field trials of genetically modified rice in Pakistan began in the early 90s. The main aim then was to introduce resistance against bacterial pathogens in the elite rice cultivars. In 1997, a variety of basmati called ‘Super Basmati’ was transformed by the Xa21 gene using a micro-pr ...
... The research and field trials of genetically modified rice in Pakistan began in the early 90s. The main aim then was to introduce resistance against bacterial pathogens in the elite rice cultivars. In 1997, a variety of basmati called ‘Super Basmati’ was transformed by the Xa21 gene using a micro-pr ...
(S) tet Resistance Determinant Element Containing the Tetracycline
... Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD,1 and Department of Health, London SE1 8UG,2 United Kingdom Received 26 January 2004/Accepted 23 March 2004 ...
... Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD,1 and Department of Health, London SE1 8UG,2 United Kingdom Received 26 January 2004/Accepted 23 March 2004 ...
Ontology Driven Modeling for the Knowledge of Genetic
... The N-ary relations between the basic blocks In Semantic Web languages, such as RDF and OWL, a property is a binary relation: it is used to link two individuals or an individual and a value. However, in some cases, the natural and convenient way to represent certain concepts is to use relations to l ...
... The N-ary relations between the basic blocks In Semantic Web languages, such as RDF and OWL, a property is a binary relation: it is used to link two individuals or an individual and a value. However, in some cases, the natural and convenient way to represent certain concepts is to use relations to l ...
Is myeloma an inherited cancer?
... variations which can increase the likelihood that a person will develop myeloma. However, their effect is very small. This means that individuals may inherit a certain combination of genetic variations that puts them at higher risk of developing myeloma but the inherited genetic variations are only ...
... variations which can increase the likelihood that a person will develop myeloma. However, their effect is very small. This means that individuals may inherit a certain combination of genetic variations that puts them at higher risk of developing myeloma but the inherited genetic variations are only ...
AUTISM AS A PARADIGMATIC COMPLEX GENETIC DISORDER
... gender differential is even higher in milder forms of ASD. There is concern about a possible increase in prevalence, but changes in diagnostic methodology and ascertainment strategy complicate comparisons across time (49). Twin studies show a 60% to 91% concordance rate in monozygotic twins, dependi ...
... gender differential is even higher in milder forms of ASD. There is concern about a possible increase in prevalence, but changes in diagnostic methodology and ascertainment strategy complicate comparisons across time (49). Twin studies show a 60% to 91% concordance rate in monozygotic twins, dependi ...
Information about mosaic Neurofibromatosis type 2
... Our body is made up of thousands of cells. Each cell contains a complete set of genes carrying the instructions that make the cell work correctly. In most people, the genes in every cell will contain the same information, whether they are blood cells, skin cells or cells in other tissues such as spe ...
... Our body is made up of thousands of cells. Each cell contains a complete set of genes carrying the instructions that make the cell work correctly. In most people, the genes in every cell will contain the same information, whether they are blood cells, skin cells or cells in other tissues such as spe ...
RT2 Profiler PCR Arrays: Pathway-focused gene
... disease state. Wells H1 through H5 contain a panel of housekeeping genes (HK1–HK5) used for normalizing the RT2 Profiler PCR Array data. Well H6 contains a Genomic DNA Control (GDC) primer set that specifically detects nontranscribed, repetitive genomic DNA with a high level of sensitivity. Wells H7 ...
... disease state. Wells H1 through H5 contain a panel of housekeeping genes (HK1–HK5) used for normalizing the RT2 Profiler PCR Array data. Well H6 contains a Genomic DNA Control (GDC) primer set that specifically detects nontranscribed, repetitive genomic DNA with a high level of sensitivity. Wells H7 ...
Gene Section NQO1 NAD(P)H dehydrogenase, quinone 1 Atlas of Genetics and Cytogenetics
... the tumor suppressor gene p53 and has been shown to interact with p53 in a protein-protein interaction. Certain compounds such as antitumor quinones, however, can be bioactivated by two electron reduction and in these cases NQO1 serves as an activating enzyme. Because of the high levels of NQO1 in c ...
... the tumor suppressor gene p53 and has been shown to interact with p53 in a protein-protein interaction. Certain compounds such as antitumor quinones, however, can be bioactivated by two electron reduction and in these cases NQO1 serves as an activating enzyme. Because of the high levels of NQO1 in c ...
Mannose-binding lectin (MBL) deficiency
... and meningitis. The exact symptoms caused by infections vary in frequency and severity, depending on the type of infection. Infants and young children with MBL deficiency seem to be more susceptible to infections, but adults can also develop recurrent infections. In addition, affected individuals un ...
... and meningitis. The exact symptoms caused by infections vary in frequency and severity, depending on the type of infection. Infants and young children with MBL deficiency seem to be more susceptible to infections, but adults can also develop recurrent infections. In addition, affected individuals un ...
alpha-amylase from bacillus licheniformis
... active at a relatively low pH and low calcium concentration. These characteristics make the enzyme particularly suitable for use in starch hydrolysis conducted at high temperatures, for example, for starch liquefaction in the production of nutritive sweeteners from starch. The genetically engineered ...
... active at a relatively low pH and low calcium concentration. These characteristics make the enzyme particularly suitable for use in starch hydrolysis conducted at high temperatures, for example, for starch liquefaction in the production of nutritive sweeteners from starch. The genetically engineered ...
SONIC Trial
... * Plus–minus values are means ±SD. † P values are for all comparisons among the three groups. P values for all categorical variables are based on a two-sided chi-square test. P values for continuous variables are based on analysis of variance on the van der Waerden normal scores. ‡ Race was se ...
... * Plus–minus values are means ±SD. † P values are for all comparisons among the three groups. P values for all categorical variables are based on a two-sided chi-square test. P values for continuous variables are based on analysis of variance on the van der Waerden normal scores. ‡ Race was se ...
Conspiracy of silence among repeated transgenes
... conjecture might be correct. When vertebrates are transformed with exogenous DNA, chromosomal insertions almost always consist of long tandem arrays of the transfected transgene-containing DNA.(5) Sometimes transgene arrays can comprise hundreds or even thousands of copies. In a cytologic study of o ...
... conjecture might be correct. When vertebrates are transformed with exogenous DNA, chromosomal insertions almost always consist of long tandem arrays of the transfected transgene-containing DNA.(5) Sometimes transgene arrays can comprise hundreds or even thousands of copies. In a cytologic study of o ...
Chapter 6
... organized up-side down when compared to deuterostomes, such as vertebrates. If this is true, then their respective ventrally (belly-side) and dorsally (back-side) located nervous system are homologous (inherited from a common ancestor, Arendt and Nübler-Jung 1994). Although it has been argued that a ...
... organized up-side down when compared to deuterostomes, such as vertebrates. If this is true, then their respective ventrally (belly-side) and dorsally (back-side) located nervous system are homologous (inherited from a common ancestor, Arendt and Nübler-Jung 1994). Although it has been argued that a ...
Genetic Testing for Epilepsy
... A negative result in an individual with epilepsy does not rule out a genetically inherited epilepsy syndrome. Possible reasons for a negative result could be (1) the patient has a mutation in a gene not included in the testing panel, (2) the patient may have a mutation in a part of an epilepsy gene ...
... A negative result in an individual with epilepsy does not rule out a genetically inherited epilepsy syndrome. Possible reasons for a negative result could be (1) the patient has a mutation in a gene not included in the testing panel, (2) the patient may have a mutation in a part of an epilepsy gene ...
Myb genes enhance tobacco trichome production
... phenotype in Nicotiana tabacum. The data presented herein are in good agreement with their results which indicate that the transgene can also regulate trichome differentiation in tobacco. Suppression of the pleiotropic Arabidopsis ttg1-1 mutant by overexpression of the R gene from maize, a monocot, ...
... phenotype in Nicotiana tabacum. The data presented herein are in good agreement with their results which indicate that the transgene can also regulate trichome differentiation in tobacco. Suppression of the pleiotropic Arabidopsis ttg1-1 mutant by overexpression of the R gene from maize, a monocot, ...
USDA approves next-generation GM potato
... The USDA in November deregulated alfalfa genetically modified to have reduced levels of lignin. The trait, developed by Monsanto and Shoreview, Minnesota–based Forage Genetics International, is intended to give growers greater flexibility in timing the harvest without sacrificing the quality of the ...
... The USDA in November deregulated alfalfa genetically modified to have reduced levels of lignin. The trait, developed by Monsanto and Shoreview, Minnesota–based Forage Genetics International, is intended to give growers greater flexibility in timing the harvest without sacrificing the quality of the ...
Treatment Overview MULTIPLE MYELOMA
... During and after treatment, doctors will monitor the levels of M protein and symptoms. The doctor may also perform some of the same laboratory tests and medical procedures that were done when the patient was initially diagnosed with myeloma, such as blood tests, x–rays, and bone marrow biopsy. All o ...
... During and after treatment, doctors will monitor the levels of M protein and symptoms. The doctor may also perform some of the same laboratory tests and medical procedures that were done when the patient was initially diagnosed with myeloma, such as blood tests, x–rays, and bone marrow biopsy. All o ...
H. pylori Therapeutic Class Review (TCR) January 21, 2013
... Articles were identified through searches performed on PubMed and review of information sent by manufacturers. Search strategy included the FDA-approved use of all drugs in this class. Randomized, controlled, comparative trials are considered the most relevant in this category. Studies included for ...
... Articles were identified through searches performed on PubMed and review of information sent by manufacturers. Search strategy included the FDA-approved use of all drugs in this class. Randomized, controlled, comparative trials are considered the most relevant in this category. Studies included for ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.