PubMed-EX: a web browser extension to enhance PubMed search
... adopted by the biomedical research community. Part of the problem may be that all of these advanced services require users to navigate to independent web sites, which have their own search interfaces. If enhanced biomedical information retrieval services could retain the ease of the use of PubMed’s ...
... adopted by the biomedical research community. Part of the problem may be that all of these advanced services require users to navigate to independent web sites, which have their own search interfaces. If enhanced biomedical information retrieval services could retain the ease of the use of PubMed’s ...
empiric antibiotic use in critically ill patients
... increased ventilator days for patients with ventilator-associated pneumonia (VAP) (2). Tailoring of antibiotics once cultures are available may not compensate for initial inadequate therapy (Class II). In a prospective, cohort study of critically ill patients, the relationship between inappropriate ...
... increased ventilator days for patients with ventilator-associated pneumonia (VAP) (2). Tailoring of antibiotics once cultures are available may not compensate for initial inadequate therapy (Class II). In a prospective, cohort study of critically ill patients, the relationship between inappropriate ...
Inheritance of Kernel Color in Corn: Explanations
... learn more about monohybrid and dihybrid crosses by studying the inheritance of kernel colors. The reasons for introducing corn genetics in the classroom are obvious—a single ear holds a large number of progeny and a variety of ears are available that represent basic inheritance patterns, such as th ...
... learn more about monohybrid and dihybrid crosses by studying the inheritance of kernel colors. The reasons for introducing corn genetics in the classroom are obvious—a single ear holds a large number of progeny and a variety of ears are available that represent basic inheritance patterns, such as th ...
Basic Principles of Human Genetics: A Primer for Oral Medicine
... Watson and Crick conclude the following: It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.7 Genes contain the information for proteins. Genes represent hereditary blueprints. All hereditary informati ...
... Watson and Crick conclude the following: It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.7 Genes contain the information for proteins. Genes represent hereditary blueprints. All hereditary informati ...
CHAPTER THREE CYCLIN TRANSFORMATION OF BANANA
... Transformation of Agrobacterium tumefaciens (strain AGL1) was carried out using the heat shock technique (Sambrook, et al., 1989). An empty expression vector pBin19 was used as a control for the over-expression of the banana cyclin. To transform Agrobacterium, 100 µl competent cells from a -80oC sto ...
... Transformation of Agrobacterium tumefaciens (strain AGL1) was carried out using the heat shock technique (Sambrook, et al., 1989). An empty expression vector pBin19 was used as a control for the over-expression of the banana cyclin. To transform Agrobacterium, 100 µl competent cells from a -80oC sto ...
mRNA_bySNP_browser
... name or choose from the list, and click the "Find ID" button on the right. Then you will see a list of 5 probeset IDs in the ProbeID combo box. 204670_x_at is in the current box and followed by 209312_x_at, 215193_x_at, 221491_x_at and 238900_at hidden in the box. If you are interested in the SNPs a ...
... name or choose from the list, and click the "Find ID" button on the right. Then you will see a list of 5 probeset IDs in the ProbeID combo box. 204670_x_at is in the current box and followed by 209312_x_at, 215193_x_at, 221491_x_at and 238900_at hidden in the box. If you are interested in the SNPs a ...
Vertical and horizontal gene transfer in lichens
... ichens are symbiotic organisms with dual nature. They are composed of at least two organisms: a fungus and an alga or cyanobacteria, or, in rare cases, of organisms from all three kingdoms. Lichens are classified as fungi, since fungi are their constant component (1). Simon Schwendener recognized th ...
... ichens are symbiotic organisms with dual nature. They are composed of at least two organisms: a fungus and an alga or cyanobacteria, or, in rare cases, of organisms from all three kingdoms. Lichens are classified as fungi, since fungi are their constant component (1). Simon Schwendener recognized th ...
Genetic and epigenetic dissection of cis regulatory
... identify trans loci that can distinguish and regulate alternative promoters (cis). In addition, the effects of maternal genotype on ASE, i.e. imprinting, can be mapped when the maternal genotype is also included as a cofactor; thus, the loci that regulate imprinting polymorphism can be revealed (Fig ...
... identify trans loci that can distinguish and regulate alternative promoters (cis). In addition, the effects of maternal genotype on ASE, i.e. imprinting, can be mapped when the maternal genotype is also included as a cofactor; thus, the loci that regulate imprinting polymorphism can be revealed (Fig ...
Selected Clinical Genetic Disorders Disorders
... Rene Moreno, subject of "Up Syndrome" - a documentary film about life with Down syndrome. Nigel Hunt, British author (The World Of Nigel Hunt; The Diary Of A Mongoloid Youth - his book was published in 1967, when "mongoloid" was still quite commonly used to refer to people with Down's Syndrome). Hil ...
... Rene Moreno, subject of "Up Syndrome" - a documentary film about life with Down syndrome. Nigel Hunt, British author (The World Of Nigel Hunt; The Diary Of A Mongoloid Youth - his book was published in 1967, when "mongoloid" was still quite commonly used to refer to people with Down's Syndrome). Hil ...
Nucleic Acids Research
... left and nucleotides are numbered below the sequence. polyadenylation signal AATAAA is underlined. E.coli uvrA and uvrC repair proteins is shown in Figure 2A. Despite the differences between both mammalian proteins their extent of homology with the yeast and bacterial proteins is comparable. The pos ...
... left and nucleotides are numbered below the sequence. polyadenylation signal AATAAA is underlined. E.coli uvrA and uvrC repair proteins is shown in Figure 2A. Despite the differences between both mammalian proteins their extent of homology with the yeast and bacterial proteins is comparable. The pos ...
Pelizaeus-Merzbacher Disease, Pelizaeus- Merzbacher
... PMD. Patients with duplications have increased levels of Nacetyl aspartate (NAA),39 whereas patients with other mutations, especially those that lack PLP protein, have reduced NAA levels.36, 40, 41 Most patients with point mutations or duplications have low levels of choline consistent with hypomyel ...
... PMD. Patients with duplications have increased levels of Nacetyl aspartate (NAA),39 whereas patients with other mutations, especially those that lack PLP protein, have reduced NAA levels.36, 40, 41 Most patients with point mutations or duplications have low levels of choline consistent with hypomyel ...
Good antibiotic prescribing
... – Certain antimicrobial agents have been designated as ‘alert’ antimicrobials by the Trust Drugs Committee for reasons of broad spectrum of activity, potential for toxicity, potential for error or prohibitive cost. – Alert antimicrobials should be prescribed in line with trust guidelines or with aut ...
... – Certain antimicrobial agents have been designated as ‘alert’ antimicrobials by the Trust Drugs Committee for reasons of broad spectrum of activity, potential for toxicity, potential for error or prohibitive cost. – Alert antimicrobials should be prescribed in line with trust guidelines or with aut ...
shERWOOD-UltramiR shRNA
... Hannon Elledge (GIPZ) shRNA designs, the Hannon lab (Knott et al 2014) performed a large scale screen using each of these designs to target 2200 genes that were likely to impact growth and survival based on gene ontology. Inclusion as a hit required that at least 2 shRNA for that gene were depleted. ...
... Hannon Elledge (GIPZ) shRNA designs, the Hannon lab (Knott et al 2014) performed a large scale screen using each of these designs to target 2200 genes that were likely to impact growth and survival based on gene ontology. Inclusion as a hit required that at least 2 shRNA for that gene were depleted. ...
Paradox of Animal Sociality,
... succeed, a form of altruism we called “discriminating”. We can tell a nearly well formed Darwinian Story about altruism coming to characterize the species if the population of the species is so organized that altruists find themselves in the company of fellow altruists more often than by chance and ...
... succeed, a form of altruism we called “discriminating”. We can tell a nearly well formed Darwinian Story about altruism coming to characterize the species if the population of the species is so organized that altruists find themselves in the company of fellow altruists more often than by chance and ...
Any empiric antibiotic regimen should be reassessed and tailored as
... increased ventilator days for patients with ventilator-associated pneumonia (VAP) (2). Tailoring of antibiotics once cultures are available may not compensate for initial inadequate therapy (Class II). In a prospective, cohort study of critically ill patients, the relationship between inappropriate ...
... increased ventilator days for patients with ventilator-associated pneumonia (VAP) (2). Tailoring of antibiotics once cultures are available may not compensate for initial inadequate therapy (Class II). In a prospective, cohort study of critically ill patients, the relationship between inappropriate ...
Leukemia and Myeloid Disorders
... Immunotherapy — A method of enhancing the patient’s own immune system to fight cancer. Blood and marrow transplantation (BMT) — A technique for replacing defective bone marrow with new stem cells, which multiply and create a healthy bone marrow. If you have a chronic form of leukemia and no symptoms ...
... Immunotherapy — A method of enhancing the patient’s own immune system to fight cancer. Blood and marrow transplantation (BMT) — A technique for replacing defective bone marrow with new stem cells, which multiply and create a healthy bone marrow. If you have a chronic form of leukemia and no symptoms ...
extracellular polysaccharide colanic acid. cluster responsible for
... suggests that the 21 genes are part of a single large transcription unit, but this has not been tested experimentally. Also, galF is preceeded by a potential promoter sequence (35) and so may also be independently transcribed. orf19, orf20, and orf21 of this study are equivalent to orf0.0, orf1.3, a ...
... suggests that the 21 genes are part of a single large transcription unit, but this has not been tested experimentally. Also, galF is preceeded by a potential promoter sequence (35) and so may also be independently transcribed. orf19, orf20, and orf21 of this study are equivalent to orf0.0, orf1.3, a ...
PDF995, Job 12
... from environmental materials and subsequent screening of expression libraries for the presence of a desired enzyme activity has become a useful tool for the discovery of novel biocatalysts. The collective genomes of microbes indigenous to a certain habitat, now often referred to as the metagenome (H ...
... from environmental materials and subsequent screening of expression libraries for the presence of a desired enzyme activity has become a useful tool for the discovery of novel biocatalysts. The collective genomes of microbes indigenous to a certain habitat, now often referred to as the metagenome (H ...
Characterization and transcript mapping of a bovine herpesvirus
... However, the C A A T box motif identified here m a y not be significant because it has recently been demonstrated that sequences upstream from the T A T A box are dispensable for the transcription of true HSV-I late genes (Steffy & Weir, 1991 ; Kibler et al., 1991). Finally, no polyadenylation conse ...
... However, the C A A T box motif identified here m a y not be significant because it has recently been demonstrated that sequences upstream from the T A T A box are dispensable for the transcription of true HSV-I late genes (Steffy & Weir, 1991 ; Kibler et al., 1991). Finally, no polyadenylation conse ...
Supplementary Data Files Transcriptome Analysis on Monocytes
... Supplementary Tables and Legends Table S1: Genes which were differentially expressed between monocytes of nvAMD patients and controls (P<0.05, RMA-normalized, ANOVA). Data split in tabs of the spreadsheet by fold change (log2 FC): all (2,165 genes), log2 FC>1.2 (506 genes) and log2 FC>1.5 (79 genes) ...
... Supplementary Tables and Legends Table S1: Genes which were differentially expressed between monocytes of nvAMD patients and controls (P<0.05, RMA-normalized, ANOVA). Data split in tabs of the spreadsheet by fold change (log2 FC): all (2,165 genes), log2 FC>1.2 (506 genes) and log2 FC>1.5 (79 genes) ...
- ScholarSphere
... American Society of Human Genetics, in order to diagnose Huntington’s disease, there must be more than 40 tandem repeats for the carrier of this mutation to be completely symptomatic. In these family studies, it found that CAG repeats in HD gene exon 1 was the most important factor; however, there i ...
... American Society of Human Genetics, in order to diagnose Huntington’s disease, there must be more than 40 tandem repeats for the carrier of this mutation to be completely symptomatic. In these family studies, it found that CAG repeats in HD gene exon 1 was the most important factor; however, there i ...
going beyond STATE OF THE ARThritis
... *These modalities are conditionally recommended only when the patient with knee osteoarthritis (OA) has chronic moderate to severe pain and is a candidate for total knee arthroplasty but either is unwilling to undergo the procedure, has comorbid medical conditions, or is taking concomitant medicatio ...
... *These modalities are conditionally recommended only when the patient with knee osteoarthritis (OA) has chronic moderate to severe pain and is a candidate for total knee arthroplasty but either is unwilling to undergo the procedure, has comorbid medical conditions, or is taking concomitant medicatio ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.