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Treatment of gastro-oesophageal reflux disease (GORD)
Treatment of gastro-oesophageal reflux disease (GORD)

... during pregnancy, the initial treatment of GORD should be with lifestyle measures. Add in non-systemic therapy with antacids when necessary. However, recommended therapies, such as ranitidine and omeprazole, are unlikely to be problematic and should be added in when antacids plus lifestyle measures ...
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... is regulated at many stages • All organisms must regulate which genes are expressed at any given time • In multicellular organisms regulation of gene expression is essential for cell specialization ...
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Drug Therapy in the Management of Asthma - CiteSeerX

... ( 8 ) ; reaction to inhaled allergen (9, 10) (alone, rarely precipitates status asthmaticus); reaction to aspirin or indomethacin in susceptible patients; metabolic acidosis (11, 12); and acute emotional stress ( 1 3 ) . The properly managed asthmatic patient should rarely need hospitalization if th ...
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14 Phylogenomic Approach to the Evolutionary Dynamics of Gene

targeted therapy - Lung Cancer Alliance
targeted therapy - Lung Cancer Alliance

Name______________________ The Sickle Cell Gene Background
Name______________________ The Sickle Cell Gene Background

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... Males are hemizygous for X chromosome gene expression, and a mutation of MeCP2 will lead to a loss or partial inactivation of the MeCP2 function. The severe phenotype in males results in early lethality. Theory 2 for female bias: Theory 1 does not explain why there are some males with Rett syndrome, ...


... King Fahad Medical Research Center, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia ...
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Genetics advances and learning disability

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ORF manual_20160301 - Vigene Biosciences

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... dominance can be found on http://pngu.mgh.harvard.edu/~purcell/bgim/index2.html#sgene. In this chapter we will provide an overview of genetic epidemiological methods and developments, in three sections. The first part will describe the estimation of heritability, as well as some more advanced modeli ...
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genetic control of pigment differentiation in somatic cells

... but often the powerful tool of genetic analysis is left unused. One facet of this problem which might be particularly susceptible to analysis by use of genetic techniques is implicit in the title of this paper: the genetic control of pigment differentiation. By the term "genetic control" it is meant ...
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The evolution of large DNA viruses: combining genomic information

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Top Ten Ways to Ensure Valid RNAi Data

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... sequencing the R-PK cDNA, the genomic DNA is more convenient for handling. Recently,we have clarified thestructure of the humanGtype PK (GPK) gene, and it becomes possible to search the mutation in the genomic DNA analysis.' In 1963, five PK-deficient kindred found in the Mifflin County Amish deme i ...
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Sample COLARIS AP LMNs

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Gene therapy



Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.
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