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... A common fungicide (vinclozolin) used on grape plants causes low sperm count, prostate, and kidney disease in laboratory rats. ...
DNA Polymorphism Studies of β-Lactoglobulin Gene in Saudi Goats
DNA Polymorphism Studies of β-Lactoglobulin Gene in Saudi Goats

... world. These facilitate a persistent supply of meat, milk, fibre, and skin and are considered as important revenue generators in small pastoral environments. This study aimed to fingerprint β-LG gene at PCR-RFLP level in native Saudi goat breeds (Ardi, Habsi and Harri) in an attempt to have a prelim ...
The Ins and Outs of Pedigree Analysis, Genetic
The Ins and Outs of Pedigree Analysis, Genetic

... that established breeds are separate entities among themselves, they all are genetically the same species. While a mating within a breed may be considered outbred, it still must be viewed as part of the whole genetic picture: a mating within an isolated, closely related, interbred population. Each b ...
IV Therapy May Tip of the Month - IV
IV Therapy May Tip of the Month - IV

... (PICC) Line Update ...
On the use of population-based registries in the clinical
On the use of population-based registries in the clinical

... For many common adult-onset diseases, this process may take decades of follow-up. Method: We illustrate how clinical validation of new predictive genetic tests can be done retrospectively using case-control studies that are derived from population-based registries of diseases. We use the examples of ...
Analysis of mutant strains
Analysis of mutant strains

... media, can be tailored to support or select against the growth of particular genotypes. In this course, we will use Yeast Complete (YC) medium that supports the growth of most S. cerevisiae strains. The growth rate of wild type strains in YC is somewhat slower than that in rich media like YPD, but t ...
Polyploidy and genome evolution in plants
Polyploidy and genome evolution in plants

CHAPTER 2 - ESSENTIALS OF HUMAN DEVELOPMENT
CHAPTER 2 - ESSENTIALS OF HUMAN DEVELOPMENT

... 2.21. What is polygenic inheritance? a. a particular trait expressed by a single gene pair b. the genetic makeup of a given individual c. a trait that is expressed in the individual d. a trait caused by an interaction of several genes or gene pairs d, factual, easy, p. 50 2.22. What disorder is caus ...
Glossary of Genetic Terms 11Jul15
Glossary of Genetic Terms 11Jul15

... the genetic code. In DNA the code letters are A, T, G and C that stand for the chemicals adenine, thymine, guanine and cytosine respectively. In base pairing, adenine always pairs with thymine and guanine always pairs with cytosine. ...
I. Līduma, T. Tračevska, U. Bērs, A. Žileviča. Phenotypic and Genetic
I. Līduma, T. Tračevska, U. Bērs, A. Žileviča. Phenotypic and Genetic

... Summary. Objective. The most important virulence factor of Staphylococcus epidermidis is their capability to form a biofilm on the surfaces of implanted medical devices. The accumulative phase of biofilm formation is linked to the production of intercellular adhesin encoded by the icaADBC operon and ...
HSV 1 & 2 - Scioto County Medical Society
HSV 1 & 2 - Scioto County Medical Society

... ▪ Example – Staphylococcus aureus and mecA gene cassette ▪ Some organisms such as Streptococcus sp. do not show much genetic change. Others, like influenza viruses, show genetic change more often ...
Cytogenetic Study of 48 Patients with Multiple Myeloma and Related
Cytogenetic Study of 48 Patients with Multiple Myeloma and Related

... between 27% and 46% , but is approximately 40% in most published series. Our data showed that 39.6% of patients had chromosomal changes. These data may depend on the stage of the patients included and on whether the patient received treatment prior to chromosome analysis. Although the initial chromo ...
LA23 Rearrangements in Non-Hodgkin`s Lymphoma
LA23 Rearrangements in Non-Hodgkin`s Lymphoma

... Some patients had missing data for serum albumin and LDH levels. ...
View LRHT Presntation - Hair Loss Treatment Dubai
View LRHT Presntation - Hair Loss Treatment Dubai

... LRHT Hair Therapy is an intense rejuvenation and hair loss prevention program that covers all the bases. It starts by rejuvenating your hair. LRHT works well as a hair loss treatment program to maintain the state of existing hair. The hair therapy regimen is made up of an advanced hair rejuvenation ...
Document
Document

... example of a gene that has two different alleles. One allele of the hemoglobin gene (which we will label AS@) provides the instructions to make a normal hemoglobin protein. Another allele for the hemoglobin gene (which we will label As@) provides instructions to make an abnormal hemoglobin which can ...
Get set for the net
Get set for the net

... The website allows different levels of search - basic, advanced and complex Boolean.2 The basic search involves typing in the name of a disease, a chromosome number or a gene symbol, and clicking on ‘Go’. In fact, almost 1900 entries show up for the word ‘skin’, giving one some idea of how many gene ...
Chapter 8 Patterns of Single-gene Inheritance
Chapter 8 Patterns of Single-gene Inheritance

... muscles also become weak and waste away. Myotonic dystrophy can cause mental deficiency, hair loss and cataracts. Onset of this rare disorder commonly occurs during young adulthood. However, it can occur at any age and is extremely variable in degree of severity.  The myotonic dystrophy gene, found ...
Meiotic markers of gonad development in zebrafish
Meiotic markers of gonad development in zebrafish

... Mechanism of sex determination unknown No sex chromosomes found Possible genetic sex determination influenced by environment ? Juvenile hermaphrodites with separate sexes in adults ...
The hereditary pancreatitis gene maps to long arm of chromosome 7
The hereditary pancreatitis gene maps to long arm of chromosome 7

... Hereditary pancreatitis (HP) described by Comfort and Steinberg in 1952 (1), is a form of chronic pancreatitis often present in childhood. The first description of the disease, named by the authors as hereditary chronic relapsing pancreatitis, was in a family of which four members had a definite pan ...
Estonian HumanGenesResearchAct.
Estonian HumanGenesResearchAct.

... of health shall maintain the confidentiality of the identity of the gene donor, his or her tissue sample, the description of his or her state of health and his or her genealogy and shall deliver the personal data of the gene donor, the tissue sample, the description of his or her state of health and ...
Leukaemia Section inv(3)(q21q26)x2 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section inv(3)(q21q26)x2 Atlas of Genetics and Cytogenetics in Oncology and Haematology

... Inv(3)(q21q26) is recognized as a distinctive entity of acute myeloid leukemia (AML) with recurrent genetic abnormalities of prognostic significance. The molecular consequence is the juxtaposition of the ribophorin I (RPN1) gene (located in band 3q21) with the ecotropic viral integration site 1 (EVI ...
Informed Consent for Feminizing Hormone Therapy The use of
Informed Consent for Feminizing Hormone Therapy The use of

The role of xylulokinase in Saccharomyces cerevisiae xylulose
The role of xylulokinase in Saccharomyces cerevisiae xylulose

... which is closer to the ratio observed for other yeasts. However, despite over-expressing xylulokinase, the growth rate on xylulose is still several fold lower than on glucose. In S. pombe for example, the doubling times on xylulose and glucose are 5 and 3 h, respectively [1]. This means that in S. c ...
Improvement in Skin Elasticity in the Treatment of Cellulite
Improvement in Skin Elasticity in the Treatment of Cellulite

... effects are accompanied by healing processes that have not been precisely specified thus far, but that lead to successful therapy in the treatment of indications such as Peyronie‘s disease12 or cardiologic disorders, such as angina pectoris.13 The observations and results of this study confirm the a ...
Genetic basis for Schizophrenia, Bipolar 1 Disorder, Tourette`s
Genetic basis for Schizophrenia, Bipolar 1 Disorder, Tourette`s

... 3-In a new study, a family in which the father and all eight offspring (six sons and two daughters) have the syndrome. Extensive genetic detective work led them to a mutation in a gene called HDC, which encodes L-histidine decarboxylase, an enzyme involved in the production of histamine, a signalin ...
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Gene therapy



Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.
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