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- Journal of Clinical Investigation
- Journal of Clinical Investigation

... a potential role for viral infections in the progression and/or exacerbation of lung fibrosis (10, 11). Viruses and other intracellular pathogens can cause apoptosis of alveolar epithelial cells, which is implicated in the pathogenesis of lung fibrosis (12). However, at present, it is unclear to wha ...
Neuropathy News ® Together, we can beat this disease
Neuropathy News ® Together, we can beat this disease

Diagnosis, Prevention, and Management of Statin Adverse Effects
Diagnosis, Prevention, and Management of Statin Adverse Effects

... subtopics was identified for specific side effects and their management and a subsequent literature search was undertaken using online databases, including PubMed and Embase, to compile studies of relevance. Through the literature search, Canadian physicians who had either published in the area of s ...
Newborn Skin Disease Part 1 Birthmarks
Newborn Skin Disease Part 1 Birthmarks

... • Its incidence has been reported to be 2.8 cases per 10,000 newborns • It can be an isolated finding or be associated with other developmental anomalies Morphology • Lesions are well demarcated and may be scarred, superficially eroded or deeply ulcerated • Their size varies (vey small to large) and ...
Paget Disease of the Bone, Radiologic and Pathologic Correlation
Paget Disease of the Bone, Radiologic and Pathologic Correlation

... and the United States share a common prevalence of Paget disease. The disease is also common in continental Europe but rare in Asia and Africa. Although there is variation among studies, there is an overall mild male predilection in Paget disease and age of onset is slightly younger in men. Paget di ...
Newborn Skin Disease Part 1 - American Academy of Dermatology
Newborn Skin Disease Part 1 - American Academy of Dermatology

... • Its incidence has been reported to be 2.8 cases per 10,000 newborns • It can be an isolated finding or be associated with other developmental anomalies Morphology • Lesions are well demarcated and may be scarred, superficially eroded or deeply ulcerated • Their size varies (vey small to large) and ...
Pediatric Emergency Medicine Practice Clinical
Pediatric Emergency Medicine Practice Clinical

... • Non-randomized or retrospective studies: historic, cohort, or case Level of Evidence: ...
AusPAR: Aflibercept (rch) - Therapeutic Goods Administration
AusPAR: Aflibercept (rch) - Therapeutic Goods Administration

... At the time this application was under consideration, a similar application was approved in the USA (August 2012) and was under review in Canada, Switzerland and the European ...
Transcranial magnetic stimulation for the treatment of major
Transcranial magnetic stimulation for the treatment of major

... disorders (eg, bipolar disorder, schizophrenia, pain disorders) may also benefit from this strategy.4,5 In the context of depression, various neuromodulation devices appear to impact areas of the brain (eg, mesocortical limbic mood circuit) implicated in its pathophysiology. The prototypic example i ...
Hepatitis C Virus Empowerment Groups in Methadone Maintenance
Hepatitis C Virus Empowerment Groups in Methadone Maintenance

... Recent, albeit limited, experience has demonstrated the feasibility and effectiveness of treating chronic hepatitis C in people who use illicit injection drugs, known as injection drug users (IDUs). ...
Clinical Fluid and Electrolyte Management
Clinical Fluid and Electrolyte Management

... Fluid and electrolytes required to replace daily losses and to maintain an overall net balance of zero gained or lost are often referred to as “maintenance” needs. These needs vary from day to day and from individual to individual. A. Daily water requirements Historically, daily water needs have bee ...
COPD Exacerbation
COPD Exacerbation

... Antibiotics • Common pathogens recovered from lower airways of patients with COPD exacerbation are S. pneumoniae, H. influenzae, and M. catarrhalis • Most studies were done in chronic bronchitis and recommend 3-7 days of treatment ...
Prognosis and Complications
Prognosis and Complications

... • Worldwide, the total number of FA patients has not been reported • Researchers estimate that carrier frequency for FA ranges between 1 per 600 and 1 per 100 • Case data on more than 3000 patients is maintained at the International Fanconi Anemia Registry at The Rockefeller University in New York, ...
Pompholyx and eczematous reactions associated with intravenous
Pompholyx and eczematous reactions associated with intravenous

... alone or a combination of pompholyx on the hands or feet and two or fewer additional body surfaces involved. The majority of reported cases (75%) experienced the eczematous reaction after their first IVIG treatment. Neurologic conditions were the most common (85.9%) diseases for which IVIG was used. ...
Trevor Lyons Introduction to Protozoa and Fungi in Periodontal
Trevor Lyons Introduction to Protozoa and Fungi in Periodontal

... utilize amino acids and produce ammonia and urea as metabolic biproducts. This in turn results in haemostasis, inflammation, immune response and progressive tissue destruction. More recently, attention has been directed toward identifying specific bacterial species which might be prime etiological ...
diseases of endocrine system. chronic insufficiency of adrenal cortex
diseases of endocrine system. chronic insufficiency of adrenal cortex

Nonfasting Sample for the Determination of Routine Lipid Profile: Is
Nonfasting Sample for the Determination of Routine Lipid Profile: Is

... TG-bound glycerol, with some assays measuring total glycerol and others measuring only glycerol bound to fatty acids. About 5% of total glycerol is derived from free glycerol, except in certain diseases and conditions where glycerol values can be increased such as in Hirschsprung’s disease or after ...
Management of Sickle Cell Disease Summary of
Management of Sickle Cell Disease Summary of

... in patients hospitalized for a vasoocclusive crisis. Strong recommendations for chronic complications include use of analgesics and physical therapy for treatment of avascular necrosis, and use of angiotensin-converting enzyme inhibitor therapy for microalbuminuria in adults with SCD. Strong recomme ...
abstract - National University of Natural Medicine
abstract - National University of Natural Medicine

... problems, from addiction, anxiety and depression, ADD/HD and PTSD to epilepsy, stroke, pain control, and brain trauma from any source. Psychological healing is now possible in many of those conditions previously thought to be treatable only with medication, surgery or electric shock therapy, all of ...
SERIES ‘‘MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE’’ Edited by J. Mu
SERIES ‘‘MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE’’ Edited by J. Mu

... knockout mice have reduced cellular recruitment to the granuloma [46]. Administration of BB-94, an MMP inhibitor which also inhibits tumour necrosis factor-a converting enzyme (ADAM-17) led to a deviation in the immune response to a T-helper cell type 2 profile [49]. However, the mouse does not deve ...
New York Chapter ACP Resident and Medical Student Forum
New York Chapter ACP Resident and Medical Student Forum

... further management. She was found to have an antiaquaporin 4 antibody. NMO-IgG was elevated which is highly specific to Neuromyletis optica. The presence of myelitis in this patient is a major criteria for the diagnosis of NMO for which NMO-IgG is positive and confirmed with MRI. Treatment for this ...
e Nanobac Life Sciences, Inc. Scott Davidson, CFA Quick Facts
e Nanobac Life Sciences, Inc. Scott Davidson, CFA Quick Facts

... the formation of membranes would lead to self-encapsulated cell structures. To regulate the passage of material through the cell's membrane, tiny bacteria may have formed on the membrane of the cell. Over time, these miniscule organisms may have used the abundance of calcium and phosphate in the hot ...
Closing the Global Health Innovation Gap
Closing the Global Health Innovation Gap

... for developing protein drugs such as human growth hormone and monoclonal antibodies, they are also now leading innovators in small molecule drugs—the type of therapeutic best suited to meet developing-world needs for oral delivery, thermostability, and affordability. The challenge is to bring the bi ...
Gaucher iPSC-Derived Macrophages Produce Elevated Levels of
Gaucher iPSC-Derived Macrophages Produce Elevated Levels of

... On the other hand, in a small clinical study of patients with the common N370S mutation, ambroxol was reported to improve disease manifestations including splenomegaly [15], suggesting that ambroxol may be a promising treatment for type 1 GD. Gaucher macrophages for disease modeling can be obtained ...
PROSTATITIS: PREVALENCE, HEALTH IMPACT AND QUALITY
PROSTATITIS: PREVALENCE, HEALTH IMPACT AND QUALITY

... closely related to lifestyle, diet, smoking, gastrointestinal or anorectal disease and impaired sexual function (17). Other reported studies concluded that 11% of Europeans had symptomatic prostatitis (1). Among urological outpatients in Canada with an average age of 50 years 2.7% were identified wi ...
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Multiple sclerosis research

Treatments under investigation for multiple sclerosis may improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis. There are also trials involving the combination of drugs that are already in use for multiple sclerosis. Finally, there are also many basic investigations that try to understand better the disease and in the future may help to find new treatments.
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