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... Nasal PD measurement has been put forward over recent years as a method of measuring CFTR function in CF patients. There is some evidence that it may be useful in diagnosing CF patients [10] and, recently, as an efficacy measure of gene expression in clinical studies of gene therapy for CF lung dise ...
The Plan for Promotion of Medical Research and Development
The Plan for Promotion of Medical Research and Development

... link R&D to innovation. Accordingly, it is vital to establish a social system that will enable this to be achieved. Research that involves deploying the results of basic life science research in the development of medical technology has come to be called translational research (TR) in recent years. ...
Position Paper on the Implications of the EMF Directive 2004/40/EC
Position Paper on the Implications of the EMF Directive 2004/40/EC

... this Directive, due to the impact on MRI research. Not only would this Directive have an impact on scientific research and healthcare but also on education, with students choosing other fields, potentially leading to a ‘brain drain’ of MRI scientists from Europe. Finally, the European economy will a ...
Guideline Newsletter - NHS Greater Glasgow and Clyde
Guideline Newsletter - NHS Greater Glasgow and Clyde

... applying the evidence may be amplified due to variability of disease conditions, feasibility of intervention and patient's preferences. Guidelines are recommendations, based as much as possible on evidence, aimed at supporting clinical judgement/diagnostic skills/treatment decisions in everyday prac ...
Chapter 3
Chapter 3

... Twenty-nine of the 37 patients starting bosentan and 16 of the 37 starting epoprostenol were in WHO FC III at the start of treatment. The demographic characteristics appear somewhat similar in these patients (Table 1). Hemodynamics at start of first-line therapy in WHO FC III patients are displayed ...
treatment of Multiple sclerosis With Chinese scalp Acupuncture
treatment of Multiple sclerosis With Chinese scalp Acupuncture

... Multiple sclerosis (MS) is a progressive disease of the central nervous system in which communication between the brain and other parts of the body is disrupted. Its effects can range from relatively benign in most cases to somewhat disabling and then to devastating for some people. During an MS att ...
PEGASYS Product Monograph
PEGASYS Product Monograph

... Physicians should inform patients of the possible development of depression prior to initiation of PEGASYS therapy, and patients should report any sign or symptom of depression immediately. If severe symptoms persist, therapy should be stopped and psychiatric intervention sought (see ADVERSE REACTI ...
revlimid - Celgene
revlimid - Celgene

... of thromboembolism. Physicians should make the decision when to discontinue therapy of erythropoietic or other agents that may increase the risk of thrombosis based on best clinical practice. Patients should be instructed to seek medical care if they develop symptoms such as a sudden shortness of br ...
Red blood cell alloimmunization in sickle cell disease
Red blood cell alloimmunization in sickle cell disease

... initial trigger for alloimmunization. In SCD, multiple studies have shown that alloimmunization risk increases with an increasing number of transfusions.6-11 In addition, women show a higher rate of alloimmunization,11 partially explained by exposure through pregnancy.12 Not all patients develop all ...
Papulopustular or `pimply` rashes on the face
Papulopustular or `pimply` rashes on the face

... often successful in mild to moderate acne and can be used for months or years if required to maintain the improvement. For more moderate to severe acne, you may have to add in an oral anti-acne agent for at least the first three to six months such as lymecycline or trimethoprim. Once the acne is con ...
Product Monograph
Product Monograph

... immediate discontinuation of the injection. In case of shock, standard medical treatment should be administered. There is clinical evidence of an association between the administration of immunoglobulins and thromboembolic events such as myocardial infarction, stroke, pulmonary embolism and deep vei ...
The Periodontal Disease Classification System of the
The Periodontal Disease Classification System of the

... The reported prevalence of periodontal disease varies depending on the criteria (depth of pockets or clinical attachment level and number of teeth involved), but it is generally accepted that 813% of North Americans have periodontal bone loss.3 Adult periodontitis has traditionally been defined as h ...
Secondary cytoreductive surgery followed by
Secondary cytoreductive surgery followed by

... chemotherapy [40]. Not statistically significant difference in terms of median survival emerged between the 32 optimally resected (<2cm) patients and those left with larger residual tumor (12 moths each). Thus, there is little evidence to support a role for secondary CRS in the setting of progressiv ...
AMERICAN GASTROENTEROLOGICAL ASSOCIATION DIGESTIVE
AMERICAN GASTROENTEROLOGICAL ASSOCIATION DIGESTIVE

... The absence of an early virological response (EVR) is the most robust means of identifying nonresponders. Data from two retrospective analyses of multicenter trials indicated that failure to decrease serum HCV RNA by 2 logs or more at treatment week 12 correlated strongly with nonresponse in treatme ...
Revised Treatment Guidelines of AES including JE
Revised Treatment Guidelines of AES including JE

... clinically similar neurologic manifestation caused by several different viruses, bacteria, fungus, parasites, spirochetes, chemical/ toxins etc. There is seasonal and geographical variation in the causative organism. The outbreak of JE usually coincides with the monsoon and post monsoon period when ...
– Criteria for Coverage of Exception Status Drugs Appendix III
– Criteria for Coverage of Exception Status Drugs Appendix III

... - maximum dosage approved: 50mg biweekly for the initial 12 weeks then 50mg weekly thereafter Infliximab - initial approval for a maximum of 12 weeks - dosage restricted to infliximab 5mg/kg 0, 2 and 6 weeks then every 8 weeks Psoriatic Arthritis (Adalimumab, Golimumab) - for patients with active ps ...
VOLUME 149 - No. 3 - JUNE 2014 OFFICIAL
VOLUME 149 - No. 3 - JUNE 2014 OFFICIAL

... Submission of the manuscript means that the paper is original and has not yet been totally or partially published and, if accepted, will not be published elsewhere either wholly or in part. All illustrations should be original. Illustrations taken from other publications must be accompanied by the p ...
ESCMID* guideline for the diagnosis and management of Candida
ESCMID* guideline for the diagnosis and management of Candida

... Leuven, Belgium, 19) 4th Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, ‘‘ATTIKON’’ Hospital, RIMINI 1 – Haidari, Athens, Greece, 20) Mycology Reference Centre, University Hospital of South Manchester and Manchester Academic Health Science Centre ...
Program Book
Program Book

... cleavage site (D4K). This DNA construct was inserted into the kluyveromyces lactis (K. lactis) pKLAC1 vector, downstream of the alpha mating factor which directs proteins for secretion and sequenced to confirm its correct construction. Protease deficient YAP-3 and YPS-7 strains of K. lactis were tra ...
Swallowing Problems - Dr.Jayashree Bhat
Swallowing Problems - Dr.Jayashree Bhat

... affect the flow of saliva in the mouth and throat – for example, some anticholinergic drugs, some antihistamines, antidepressants, diuretics and calcium channel blockers used to treat high blood pressure. Another type of dysphagia originates in the esophagus itself. There may be structural abnormali ...
Living with Crohn`s Disease - Colitis
Living with Crohn`s Disease - Colitis

y 7 - DocCheck
y 7 - DocCheck

... the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the ...
Low Dose Naltrexone and Autoimmune Diseases: Emerging
Low Dose Naltrexone and Autoimmune Diseases: Emerging

... month after discontinuation of therapy. Eighty-nine percent of patients had some response to therapy and 67% achieved a remission. The most common side effect was sleep disturbances, which occurred in seven patients. They concluded that LDN therapy is safe and effective in people with active Crohn's ...
policy on approval of diagnostic procedures involving embryos
policy on approval of diagnostic procedures involving embryos

... for and discussed relevant issues with the participants requesting the testing. 17. In making its determination the Council should also take into account that the genetic abnormality or disease in the embryo is not simply a defect in the genetic material, but is one associated with a known clinical ...
Atrial Fibrillation
Atrial Fibrillation

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Multiple sclerosis research

Treatments under investigation for multiple sclerosis may improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis. There are also trials involving the combination of drugs that are already in use for multiple sclerosis. Finally, there are also many basic investigations that try to understand better the disease and in the future may help to find new treatments.
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