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D’accord study (Dasatinib Combination for CLL with Refractory Disease)
D’accord study (Dasatinib Combination for CLL with Refractory Disease)

... resulted in response rates in up to 70% of patients, but did not improve survival2. Treatment regimens with the nucleoside (purine) analogs, such as fludarabine monophosphate (fludarabine) or pentostatin, were found to yield higher response rates and to provide for longer progression-free survival3, ...
2014 Late Breaking Abstracts - American Association of Clinical
2014 Late Breaking Abstracts - American Association of Clinical

... the care of persons with diabetes frequently focus on avoiding unnecessary hospitalizations, decreasing length of stay and avoiding readmission to hospital following discharge. Additionally, as reimbursement shifts towards ...
Research Related To Treatment Effects Using AK Methods: Clinical
Research Related To Treatment Effects Using AK Methods: Clinical

... Attention Deficit Hyperactivity Disorder (ADHD). Most, is in the area of pharmacological therapies with less emphasis in psychotherapy and psychosocial interventions and even less in the area of complementary and alternative medicine (CAM). The use of CAM has increased over the years, especially for ...
Extract from the Clinical Evaluation Report for Retigabine
Extract from the Clinical Evaluation Report for Retigabine

... lasting seizure-free intervals in some patients, but up to 30% of patients with epilepsy are resistant to drug treatment and continue to have frequent seizures despite treatment.2 Many other patients can only achieve seizure-freedom at the expense of considerable side effects including sedation and ...
Toxoplasma Papillitis and Neuroretinitis Harvey Uy, MD Introduction
Toxoplasma Papillitis and Neuroretinitis Harvey Uy, MD Introduction

... T. gondii was discovered in 1908 inside the brain of a North African rodent, the gondii. It was first recognized to cause ocular disease in 1923. The life cycle of T. gondii is complex. Cats are the definitive hosts. The organism matures and reproduces in the intestines and oocysts are released in t ...
Review of existing experimental methods for assessing the outcome
Review of existing experimental methods for assessing the outcome

... immune function following PFS are summarised in Supplementary Table 2. In order to limit these observations to studies that inherently provide a higher level of confidence, studies in the table represent those based solely on randomised controlled trials. Whilst significant effects were observed in ...
Streptococcus sinensis
Streptococcus sinensis

Abbreviations
Abbreviations

... the drug name used must be on the local approved list of trade name drugs except in the case of multi-ingredient preparations and modified release formulations when the brand names must be used. note: Always document patient drug allergies or idiosyncratic reactions and refer to documented allergies ...
RADIATION THERAPY ONCOLOGY GROUP RTOG HEAD AND NECK CANCER: CONCURRENT RE-IRRADIATION
RADIATION THERAPY ONCOLOGY GROUP RTOG HEAD AND NECK CANCER: CONCURRENT RE-IRRADIATION

... largest experiences is from the University of Chicago, where sequential studies have been done combining altered fractionation radiotherapy with various chemotherapeutic agents.27 In an early report using 5-Fluorouracil/hydroxyrea +/- cisplatin, the five-year survival rate was 14.6%; more recent stu ...
Diagnosis and management of familial Mediterranean fever
Diagnosis and management of familial Mediterranean fever

... (although admittedly, it is difficult for the young child to selfreport the nature of the discomfort). The febrile episodes are usually short-lived (2– 4 days) with full spontaneous recovery but occasionally can last longer than 4 days and end unexpectedly.3 Our own clinical experience would suggest ...
- Sacramento - California State University
- Sacramento - California State University

... difficulties, fatigue, muscle weakness, muscle cramping, numbness, slowness of movement, stiffness, loss of coordination, or even paralysis. Next, imagine having been just informed by a doctor that the symptoms experienced for the past several months are due to a chronic and progressive neuromuscula ...
The PREMIER study: A multicenter, randomized, double
The PREMIER study: A multicenter, randomized, double

... Conclusion. In this population of patients with early, aggressive RA, combination therapy with adalimumab plus MTX was significantly superior to either MTX alone or adalimumab alone in improving signs and symptoms of disease, inhibiting radiographic progression, and effecting clinical remission. Rhe ...
Celiac disease
Celiac disease

... number of undiagnosed cases in a given population at a particular point in time. The area above the waterline—the tip of the iceberg—represents the number of clinically diagnosed cases [8]. The ratio of diagnosed to undiagnosed cases of CD is thought to be highly variable from country to country (1 ...
Objectives
Objectives

... Patients with HIV infection are at 21-34 times increased risk for progression from LTBI to active TB (1)  Because there is no ‘gold standard’ for LTBI, sensitivity comparison of IGRAs is difficult (2)  Studies in HIV-infected populations have shown − IGRAs are less sensitive in HIV-infected patien ...
Treatment of community-acquired lower respiratory tract infections in adults ˚ . O
Treatment of community-acquired lower respiratory tract infections in adults ˚ . O

... AE-CB/COPD, but it is nearly always indicated for CAP, for which a delay in treatment may increase the risk of a fatal outcome. It may be difficult to differentiate between a viral and a bacterial LRTI, or between bronchitis/AE-CB/COPD and CAP. This may be one reason why antibiotics are prescribed t ...
Disorders of pigmentation — Part 1: Hyperpigmentation
Disorders of pigmentation — Part 1: Hyperpigmentation

... is essential in managing this condition if treatment is requested. There are several safe and effective methods that are available to help lighten or reduce the appearance of freckles. Treatment options include bleaching or fading creams (table 4), light application of liquid nitrogen, laser treatme ...
NIAID Strategic Plan for Biodefense Research
NIAID Strategic Plan for Biodefense Research

... NIAID also recognized that developing new medical countermeasures for biodefense and emerging infectious diseases is associated with specific challenges. For example, the basic biology and pathogenesis of threat agents are often not well understood. Many target pathogens must be handled under high l ...
Full Prescribing Information - Products - Bristol
Full Prescribing Information - Products - Bristol

Beyond Appendicitis: Common and Uncom
Beyond Appendicitis: Common and Uncom

... combination with additional postprocessing techniques, such as maximum intensity projection and volume rendering, multiplanar reformation may also improve identification and characterization of other pathologic conditions, sometimes with complex abnormal anatomy (12). There is no consensus in the li ...
Guidelines for treatment of onychomycosis
Guidelines for treatment of onychomycosis

... These guidelines have been prepared for dermatologists on behalf of the British Association of Dermatologists and reflect the best data available at the time the report was prepared. Caution should be exercised in interpreting the data; the results of future studies may require alteration of the con ...
Radiologic Evaluation Of Progressive Multifocal Leukoencephalopathy (PML) In A Patient With Congenital HIV Infection
Radiologic Evaluation Of Progressive Multifocal Leukoencephalopathy (PML) In A Patient With Congenital HIV Infection

... neurons throughout the CNS, explaining the white matter hyperintensity and atrophy, respectively, seen on MRI. (Heald) ...
Introduction Tuberculosis (TB) is a global public health hazard. Out
Introduction Tuberculosis (TB) is a global public health hazard. Out

... bacilli in the sputum yields mostly negative results [4]. Moreover, in most of the children the tuberculosis cases appear as extra pulmonary, hence it becomes more difficult to confirm bacteriologically. Diagnosis in children relies on tuberculin skin testing, chest radiograph and clinical signs and ...
Surgical Management of Implantation
Surgical Management of Implantation

... anterior muscle. One patient was not reimplanted following extraction due to recurrent infections. Conversion to a transvenous ICD was not needed in any patient. CONCLUSIONS In most patients with a complication, S-ICD therapy could be continued after intervention, avoiding the need to convert to a t ...
Extract from the Clinical Evaluation Report for Diemthyl Fumarate
Extract from the Clinical Evaluation Report for Diemthyl Fumarate

... Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that predominantly affects young adults, causing plaques of demyelination. Plaques are most common in the white matter of the brain, spinal cord and optic nerves, but occasionally plaques affect the cerebral grey ...
Indian Journal of Dermatology
Indian Journal of Dermatology

... The information and opinions presented in the Journal reflect the views of the authors and not of the Journal or its Editorial Board or the Publisher or the Supporting company[Ranbaxy Laboratories Ltd]. Publication does not constitute endorsement by the journal. Neither the Indian Journal of Dermato ...
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Multiple sclerosis research

Treatments under investigation for multiple sclerosis may improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis. There are also trials involving the combination of drugs that are already in use for multiple sclerosis. Finally, there are also many basic investigations that try to understand better the disease and in the future may help to find new treatments.
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