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In This Issue - Society of Emergency Medicine Physician Assistants
In This Issue - Society of Emergency Medicine Physician Assistants

... Tissue Infections.” Dr. Seibert is an assistant residency director at Thomas Jefferson University Hospital, Department of Emergency Medicine, Philadelphia, Pennsylvania. Dr. Fernandez is chief resident at Thomas Jefferson University Hospital, Department of Emergency Medicine. Amal Mattu, MD, FACEP, ...
SWALLOWING DISORDERS AND DYSPHAGIA
SWALLOWING DISORDERS AND DYSPHAGIA

... The swallowing center is situated bilaterally, in the reticular substance below the nucleus of the solitary tract, in the brainstem. Efferent fibers from the swallow centers travel to the motor neurons controlling the swallow musculature located in the nucleus ambiguus. Therefore, brainstem strokes ...
this PDF file - Journal of Ayub Medical College Abbottabad
this PDF file - Journal of Ayub Medical College Abbottabad

... Background: Uncomplicated urinary tract infections (UTIs) are the most common bacterial infections among women presenting to primary care causing rapidly increasing strains of resistant bacteria to the growing antibiotic industry. Restricting antibiotics to necessary indications is the only solution ...
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis

... alone can suppress respiratory drive and lead to worsening hypercapnia. Oxygen should be prescribed to ALS patients only as a palliative measure to relieve symptoms of air hunger in the terminal phases of the disease. Managing nutrition is an important aspect of treating ALS patients. Insufficient c ...
Low-dose Naltrexone (LDN) Fact Sheet 2015
Low-dose Naltrexone (LDN) Fact Sheet 2015

... discussion you should have with your doctor. In various studies (and anecdotal accounts), the number of T-Lymphocytes has been shown to dramatically increase when a patient starts on LDN. This may account for some of the benefits patients feel when they are being treated for an autoimmune disease, ...
Brivlera™ (brivaracetam)
Brivlera™ (brivaracetam)

... least one clinically significant decreased white blood cell count (<3.0 x 109/L), and 0.3% of BRIVLERA-treated patients and 0% of placebo-treated patients had at least one clinically significant decreased neutrophil count (<1.0 x 109/L). Hypersensitivity Bronchospasm and Angioedema BRIVLERA can caus ...
Low-dose Naltrexone in the Treatment of Multiple Sclerosis
Low-dose Naltrexone in the Treatment of Multiple Sclerosis

... discussion you should have with your doctor. In various studies (and anecdotal accounts), the number of T-Lymphocytes has been shown to dramatically increase when a patient starts on LDN. This may account for some of the benefits patients feel when they are being treated for an autoimmune disease, ...
inside - Australian Doctor
inside - Australian Doctor

... four in 1000 of the general population and is usually simple to diagnose and treat. Several factors contribute to the development of this condition, all of which promote the growth of bacteria or fungus within the ear canal. As a line of defence, the ear produces cerumen that creates an acidic envir ...
Audit and Review of Adults with Asthma on High Dose
Audit and Review of Adults with Asthma on High Dose

... (particularly in children) have been reported; hyperglycaemia (usually only with high doses), cataracts, skin thinning and bruising have also been reported. High dose inhaled corticosteroids are introduced at step four of the BTS/ SIGN guidelines and are defined in the guidelines (given through mete ...
$doc.title

... Diagnosis  and  discussion   a. The  patient  was  diagnosed  with  an  enhancing  lesion  in  the  left  occipital  lobe.    A  tumor   biopsy  identified  the  mass  as  glioblastoma  multiforme  which  is  a  stage  IV  astrocytoma. ...
Haematology referral management guidelines
Haematology referral management guidelines

... Iron is best replaced orally if possible – suggest Ferrous Sulphate (available as tablets or liquid and can be combined with Vit C to aid absorption). Many patients don’t tolerate oral iron or don’t respond to it - In this circumstance intravenous iron is the best option. Intramuscular iron is probl ...
Company Presentation
Company Presentation

... Active ingredient = anagrelide ...
Northern Cancer Network -Cancer Drugs and Therapeutics Group
Northern Cancer Network -Cancer Drugs and Therapeutics Group

... Cost Neutral ...
Treatment for Lyme and other Tick-borne Diseases at
Treatment for Lyme and other Tick-borne Diseases at

... felt a tick bite nor had a rash, and Lyme may not be considered as a cause of their symptoms for months or years. However, they or other family members can in fact have bona fide Lyme, despite never having seen a tick nor a rash on themselves or a loved one. Often, it is the patient or their family ...
ZINBRYTA Prescribing Information
ZINBRYTA Prescribing Information

... Other Immune-Mediated Disorders Immune-mediated disorders including skin reactions, lymphadenopathy, non-infectious colitis, and other immune-mediated disorders can occur with ZINBRYTA (5.2). These conditions may require treatment with systemic corticosteroids or immunosuppressive medication (5.1, ...
Medicine - Osteoporosis Australia
Medicine - Osteoporosis Australia

... in cancer patients using intravenous bisphosphonates (zoledronic acid and pamidronate) in doses 10-20 times higher than those normally associated with oral bisphosphonates. Cases have also been reported in people taking oral bisphosphonates and denosumab for osteoporosis but it is rare (estimated ri ...
Treatment of Vitamin B12 deficiency
Treatment of Vitamin B12 deficiency

... Check anti-intrinsic factor antibodies and treat as pernicious anaemia if positive. If negative, in order to limit extensive investigation with resultant anxiety, three injections of hydroxocobalamin are suggested to cover the pregnancy, and serum B12 levels checked two months post-partum to ensure ...
A putative founder effect for Parkinson`s disease in South African
A putative founder effect for Parkinson`s disease in South African

... cell injury and death in neurodegenerative disease that advances will be made in therapeutics. One major issue regarding the utility of genetics when applied to neurodegenerative disease is that age is a major risk factor, and many patients may not develop illness simply because they die before the ...
Prescribing Information
Prescribing Information

... Animal reproduction studies have not been conducted with this combination product. It is also not known whether butalbital, acetaminophen and caffeine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. This product should be given to a pregnant woman only ...
A putative founder effect for Parkinson`s disease in South African
A putative founder effect for Parkinson`s disease in South African

... cell injury and death in neurodegenerative disease that advances will be made in therapeutics. One major issue regarding the utility of genetics when applied to neurodegenerative disease is that age is a major risk factor, and many patients may not develop illness simply because they die before the ...
Wegener`s Handbook - St. James`s Hospital
Wegener`s Handbook - St. James`s Hospital

... Nowadays, the outlook is good. Most patients respond successfully to therapy. It is always important to make the diagnosis and start treatment as soon as possible. This will reduce the amount of damage caused by the inflammation. However, some long-term damage to affected tissues may remain and this ...
Offer rufinamide, or topiramate as adjunctive treatment
Offer rufinamide, or topiramate as adjunctive treatment

... In Iraq Accurate estimates of incidence and prevalence of epilepsy are difficult to achieve because people who may have epilepsy try to hide the disease as it is considered stigma especially in females. Good communication between treating physician and epileptic patient and their family is essential ...
Aisha Bano - The Role of KCNQ (Kv7) - e
Aisha Bano - The Role of KCNQ (Kv7) - e

... drugs, phenothaizine and non-phenothiazines. Fifty years later, the primary treatment for schizophrenia remains practically unchanged: clozapine, (developed in 1961), is the most efficacious drug. There have been numerous attempts to mimic a drug of the same result without its “hematological and ort ...
Novel mutations identified in EIF2B5 gene in Kashmiri
Novel mutations identified in EIF2B5 gene in Kashmiri

... eIF2Bε, interaction between different subunits to form the eIF2B complex and interaction with the eIF2 substrate32. Also, it is known that leakage of blood in the brain acts as an early trigger for switching on the brain’s inflammatory response, creating a neurotoxic environment that damages nerve c ...
Insufficiant corticosteroids treatment in children
Insufficiant corticosteroids treatment in children

... inhaled steroids protects against severe exacerbations requiring hospitalization and reduces the likelihood of readmission or death following discharge from hospital. Analysis of the Saskatchewan Health Insurance data indicates that treatment with inhaled steroids also, diminishes the risk of fatal ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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